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2021

Journal Article

MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography

Clabbers, Max T. B., Holmes, Susannah, Muusse, Timothy W., Vajjhala, Parimala R., Thygesen, Sara J., Malde, Alpeshkumar K., Hunter, Dominic J. B., Croll, Tristan I., Flueckiger, Leonie, Nanson, Jeffrey D., Rahaman, Md. Habibur, Aquila, Andrew, Hunter, Mark S., Liang, Mengning, Yoon, Chun Hong, Zhao, Jingjing, Zatsepin, Nadia A., Abbey, Brian, Sierecki, Emma, Gambin, Yann, Stacey, Katryn J., Darmanin, Connie, Kobe, Bostjan, Xu, Hongyi and Ve, Thomas (2021). MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography. Nature Communications, 12 (1) 2578, 1-14. doi: 10.1038/s41467-021-22590-6

MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography

2015

Journal Article

A novel flow cytometric method to assess inflammasome formation

Sester, David P., Thygesen, Sara J., Sagulenko, Vitaliya, Vajjhala, Parimala R., Cridland, Jasmyn A., Vitak, Nazarii, Chen, Kaiwen W., Osborne, Geoffrey W., Schroder, Kate and Katryn J. Stacey (2015). A novel flow cytometric method to assess inflammasome formation. The Journal of Immunology, 194 (1), 455-462. doi: 10.4049/jimmunol.1401110

A novel flow cytometric method to assess inflammasome formation

2013

Journal Article

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

Sagulenko, V., Thygesen, S. J., Sester, D. P., Idris, A., Cridland, J. A., Vajjhala, P. R., Roberts, T., Schroder, K., Vince, J. E., Hill, J. M., Silke, J. and Stacey, K. J. (2013). AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC. Cell Death and Differentiation, 20 (9), 1149-1160. doi: 10.1038/cdd.2013.37

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

2012

Journal Article

The mammalian PYHIN gene family: Phylogeny, evolution and expression

Cridland, Jasmyn A., Curley, Eva Z., Wykes, Michelle N ., Schroder, Kate, Sweet, Matthew J., Roberts, Tara L., Ragan, Mark A., Kassahn, Karin S. and Stacey, Katryn J. (2012). The mammalian PYHIN gene family: Phylogeny, evolution and expression. BMC Evolutionary Biology, 12 (1) 140, 140.1-140.33. doi: 10.1186/1471-2148-12-140

The mammalian PYHIN gene family: Phylogeny, evolution and expression

2009

Journal Article

HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA

Roberts, Tara L., Idris, Adi, Dunn, Jasmyn A., Kelly, Greg M., Burnton, Carol M., Hodgson, Samantha, Hardy, Lani. L., Garceau, Valerie, Sweet, Matthew J., Ross, Ian L., Hume, David A. and Stacey, Katryn J. (2009). HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science, 323 (5917), 1057-1060. doi: 10.1126/science.1169841

HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA

1996

Journal Article

Macrophages ingest and are activated by bacterial DNA

Stacey, K. J., Sweet, M. J. and Hume, D. A. (1996). Macrophages ingest and are activated by bacterial DNA. Journal of Immunology, 157 (5), 2116-2122.

Macrophages ingest and are activated by bacterial DNA

2024

Journal Article

Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assembly

Li, Y., Pacoste, L. C., Gu, W., Thygesen, S. J., Stacey, K. J., Ve, T., Kobe, B., Xu, H. and Nanson, J. D. (2024). Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assembly. Acta Crystallographica Section D Structural Biology, 80 (9), 699-712. doi: 10.1107/s2059798324008210

Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assembly

2024

Journal Article

o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2

Rahaman, Md. Habibur, Thygesen, Sara J., Maxwell, Michael J., Kim, Hyoyoung, Mudai, Prerna, Nanson, Jeffrey D., Jia, Xinying, Vajjhala, Parimala R., Hedger, Andrew, Vetter, Irina, Haselhorst, Thomas, Robertson, Avril A. B., Dymock, Brian, Ve, Thomas, Mobli, Mehdi, Stacey, Katryn J. and Kobe, Bostjan (2024). o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2. Journal of Enzyme Inhibition and Medicinal Chemistry, 39 (1) 2313055, 2313055. doi: 10.1080/14756366.2024.2313055

o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2

2024

Journal Article

Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophages

Thygesen, Sara J, Burgener, Sabrina S, Mudai, Prerna, Monteleone, Mercedes, Boucher, Dave, Sagulenko, Vitaliya, Schroder, Kate and Stacey, Katryn J (2024). Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophages. European Journal of Immunology, 54 (5) 2350515, e2350515. doi: 10.1002/eji.202350515

Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophages

2023

Journal Article

Kinetics of severe dengue virus infection and development of gut pathology in mice

Pliego Zamora, Adriana, Kim, Jaehyeon, Vajjhala, Parimala R., Thygesen, Sara J., Watterson, Daniel, Modhiran, Naphak, Bielefeldt-Ohmann, Helle and Stacey, Katryn J. (2023). Kinetics of severe dengue virus infection and development of gut pathology in mice. Journal of Virology, 97 (11) ARTN e0125123, e0125123. doi: 10.1128/jvi.01251-23

Kinetics of severe dengue virus infection and development of gut pathology in mice

2023

Conference Publication

Structural evolution of TIR-domain signalosomes in mammalian, plant and bacterial immunity characterized by integrative structural biology

Kobe, Bostjan, Nanson, Jeffrey D., Manik, Mohammad K., Li, Sulin, Gu, Weixi, Pan, Mengqi, Li, Yan, Muusse, Timothy W., Vajjhala, Parimala R, Stacey, Katryn J., Holmes, Susannah, Darmanin, Connie, Clabbers, Max T. B., Xu, Hongyi, Shi, Yun and Ve, Thomas (2023). Structural evolution of TIR-domain signalosomes in mammalian, plant and bacterial immunity characterized by integrative structural biology. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323093658

Structural evolution of TIR-domain signalosomes in mammalian, plant and bacterial immunity characterized by integrative structural biology

2023

Conference Publication

TLR4 TIR domain higher-order assemblies reveal the structural basis of adaptor recruitment in Toll-like receptor signaling pathways

Nanson, J. D., Muusse, T. W., Li, Y., Pan, M., Landsberg, M. J., Vajjhala, P. R., Ve, T., Stacey, K. J. and Kobe, B. (2023). TLR4 TIR domain higher-order assemblies reveal the structural basis of adaptor recruitment in Toll-like receptor signaling pathways. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323086631

TLR4 TIR domain higher-order assemblies reveal the structural basis of adaptor recruitment in Toll-like receptor signaling pathways

2023

Journal Article

TLR4 phosphorylation at tyrosine 672 activates the ERK/c‐FOS signaling module for LPS‐induced cytokine responses in macrophages

Curson, James E. B., Liu, Liping, Luo, Lin, Muusse, Timothy W., Lucas, Richard M., Gunther, Kimberley S., Vajjhala, Parimala R., Abrol, Rishika, Jones, Alun, Kapetanovic, Ronan, Stacey, Katryn J., Stow, Jennifer L. and Sweet, Matthew J. (2023). TLR4 phosphorylation at tyrosine 672 activates the ERK/c‐FOS signaling module for LPS‐induced cytokine responses in macrophages. European Journal of Immunology, 53 (7) e2250056, e2250056. doi: 10.1002/eji.202250056

TLR4 phosphorylation at tyrosine 672 activates the ERK/c‐FOS signaling module for LPS‐induced cytokine responses in macrophages

2023

Journal Article

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

Albornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J. ... Woodruff, Trent M. (2023). SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular Psychiatry, 28 (7), 2878-2893. doi: 10.1038/s41380-022-01831-0

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

2022

Journal Article

Flow cytometric reporter assays provide robust functional analysis of signaling complexes

Muusse, Timothy W., Lee, Morris Y.L., Kim, Hyoyoung, Parat, Marie-Odile, Nanson, Jeffrey D., Kobe, Bostjan, Vajjhala, Parimala R. and Stacey, Katryn J. (2022). Flow cytometric reporter assays provide robust functional analysis of signaling complexes. Journal of Biological Chemistry, 298 (12) 102666, 102666. doi: 10.1016/j.jbc.2022.102666

Flow cytometric reporter assays provide robust functional analysis of signaling complexes

2021

Journal Article

A broadly protective antibody that targets the flavivirus NS1 protein

Modhiran, Naphak, Song, Hao, Liu, Lidong, Bletchly, Cheryl, Brillault, Lou, Amarilla, Alberto A., Xu, Xiaoying, Qi, Jianxun, Chai, Yan, Cheung, Stacey T. M., Traves, Renee, Setoh, Yin Xiang, Bibby, Summa, Scott, Connor A. P., Freney, Morgan E., Newton, Natalee D., Khromykh, Alexander A., Chappell, Keith J., Muller, David A., Stacey, Katryn J., Landsberg, Michael J., Shi, Yi, Gao, George F., Young, Paul R. and Watterson, Daniel (2021). A broadly protective antibody that targets the flavivirus NS1 protein. Science, 371 (6525), 190-194. doi: 10.1126/science.abb9425

A broadly protective antibody that targets the flavivirus NS1 protein

2020

Journal Article

Manipulation of epithelial cell death pathways by Shigella

Thygesen, Sara J., Pliego‐Zamora, Adriana and Stacey, Katryn J. (2020). Manipulation of epithelial cell death pathways by Shigella. The EMBO Journal, 39 (17), e106202. doi: 10.15252/embj.2020106202

Manipulation of epithelial cell death pathways by Shigella

2019

Journal Article

IRF 1 and IRF 2 regulate the non‐canonical inflammasome

Thygesen, Sara J. and Stacey, Katryn J. (2019). IRF 1 and IRF 2 regulate the non‐canonical inflammasome. EMBO reports, 20 (9) e48891, e48891. doi: 10.15252/embr.201948891

IRF 1 and IRF 2 regulate the non‐canonical inflammasome

2019

Journal Article

Dual targeting of dengue virus virions and NS1 protein with the heparan sulfate mimic PG545

Modhiran, Naphak, Gandhi, Neha S., Wimmer, Norbert, Cheung, Stacey, Stacey, Katryn, Young, Paul R., Ferro, Vito and Watterson, Daniel (2019). Dual targeting of dengue virus virions and NS1 protein with the heparan sulfate mimic PG545. Antiviral Research, 168, 121-127. doi: 10.1016/j.antiviral.2019.05.004

Dual targeting of dengue virus virions and NS1 protein with the heparan sulfate mimic PG545

2019

Journal Article

Compromised NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages

Thygesen, Sara J., Takizawa, Karli E., Robertson, Avril A. B., Sester, David P. and Stacey, Katryn J. (2019). Compromised NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages. Immunology and cell biology, 97 (1), 17-28. doi: 10.1111/imcb.12193

Compromised NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages