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2019

Journal Article

Compromised NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages

Thygesen, Sara J., Takizawa, Karli E., Robertson, Avril A. B., Sester, David P. and Stacey, Katryn J. (2019). Compromised NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages. Immunology and cell biology, 97 (1), 17-28. doi: 10.1111/imcb.12193

Compromised NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages

2018

Journal Article

Membrane vesicles from Pseudomonas aeruginosa activate the non-canonical inflammasome through caspase-5 in human monocytes

Bitto, Natalie J., Baker, Paul J., Dowling, Jennifer K., Wray-McCann, Georgie, De Paoli, Amanda, Tran, Le Son, Leung, Pak Ling, Stacey, Katryn J., Mansell, Ashley, Masters, Seth L. and Ferrero, Richard L. (2018). Membrane vesicles from Pseudomonas aeruginosa activate the non-canonical inflammasome through caspase-5 in human monocytes. Immunology and Cell Biology, 96 (10), 1120-1130. doi: 10.1111/imcb.12190

Membrane vesicles from Pseudomonas aeruginosa activate the non-canonical inflammasome through caspase-5 in human monocytes

2018

Journal Article

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

Boucher, Dave, Monteleone, Mercedes, Coll, Rebecca C., Chen, Kaiwen W., Ross, Connie M., Teo, Jessica L., Gomez, Guillermo A., Holley, Caroline L., Bierschenk, Damien, Stacey, Katryn J., Yap, Alpha S., Bezbradica, Jelena S. and Schroder, Kate (2018). Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. The Journal of Experimental Medicine, 215 (3), 827-840. doi: 10.1084/jem.20172222

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

2018

Book Chapter

Plugging the leak in Dengue shock

Watterson, Daniel, Modhiran, Naphak, Muller, David A., Stacey, Katryn J. and Young, Paul R. (2018). Plugging the leak in Dengue shock. Dengue and Zika: Control and Antiviral Treatment Strategies. (pp. 89-106) edited by Rolf Hilgenfeld and Subhash G. Vasudevan. Singapore, Singapore: Springer Nature. doi: 10.1007/978-981-10-8727-1_7

Plugging the leak in Dengue shock

2017

Journal Article

Caspase-1 is an apical caspase leading to caspase-3 cleavage in the AIM2 inflammasome response, independent of caspase-8

Sagulenko, Vitaliya, Vitak, Nazarii, Vajjhala, Parimala, Vince, James E and Stacey, Katryn J (2017). Caspase-1 is an apical caspase leading to caspase-3 cleavage in the AIM2 inflammasome response, independent of caspase-8. Journal of Molecular Biology, 430 (2), 238-247. doi: 10.1016/j.jmb.2017.10.028

Caspase-1 is an apical caspase leading to caspase-3 cleavage in the AIM2 inflammasome response, independent of caspase-8

2017

Journal Article

Bacterial membrane vesicles transport their DNA cargo into host cells

Bitto, Natalie J., Chapman, Ross, Pidot, Sacha, Costin, Adam, Lo, Camden, Choi, Jasmine, D'Cruze, Tanya, Reynolds, Eric C., Dashper, Stuart G., Turnbull, Lynne, Whitchurch, Cynthia B., Stinear, Timothy P., Stacey, Katryn J. and Ferrero, Richard L. (2017). Bacterial membrane vesicles transport their DNA cargo into host cells. Scientific Reports, 7 (1) 7072, 7072. doi: 10.1038/s41598-017-07288-4

Bacterial membrane vesicles transport their DNA cargo into host cells

2017

Journal Article

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

Ve, Thomas, Vajjhala, Parimala, Hedger, Andrew, Croll, Tristan, DiMaio, Frank, Horsefield, Shane, Yu, Xiong, Lavrencic, Peter, Hassan, Zahid, Morgan, Garry P., Mansell, Ashley, Mobli, Mehdi, O'Carroll, Ailis, Chauvin, Brieuc, Gambin, Yann, Sierecki, Emma, Landsberg, Michael J., Stacey, Katryn, Egelman, Edward H. and Kobe, Bostjan (2017). Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling. Nature Structural and Molecular Biology, 24 (9), 743-751. doi: 10.1038/nsmb.3444

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

2017

Journal Article

The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways

Vajjhala, Parimala R., Ve, Thomas, Bentham, Adam, Stacey, Katryn J. and Kobe, Bostjan (2017). The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways. Molecular Immunology, 86, 23-37. doi: 10.1016/j.molimm.2017.02.012

The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways

2017

Journal Article

Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6

Modhiran, Naphak, Watterson, Daniel, Blumenthal, Antje, Baxter, Alan G., Young, Paul R. and Stacey, Katryn J. (2017). Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6. Immunology and Cell Biology, 95 (5), 491-495. doi: 10.1038/icb.2017.5

Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6

2017

Conference Publication

NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages

Thygesen, Sara Judith, Sester, David P. and Stacey, Katryn J. (2017). NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages. 5th Annual Meeting of the International Cytokine and Interferon Society (ICIS), Kanazawa, Japan, 29 October - 2 November 2017. London, United Kingdom: Academic Press. doi: 10.1016/j.cyto.2017.09.010

NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages

2016

Journal Article

Cryo-EM structure of caspase-8 tandem DED filament reveals assembly and regulation mechanisms of the death-inducing signaling complex

Fu, Tian-Min, Li, Yang, Lu, Alvin, Li, Zongli, Vajjhala, Parimala R., Cruz, Anthony C., Srivastava, Devendra B., DiMaio, Frank, Penczek, Pawel A., Siegel, Richard M., Stacey, Katryn J., Egelman, Edward H. and Wu, Hao (2016). Cryo-EM structure of caspase-8 tandem DED filament reveals assembly and regulation mechanisms of the death-inducing signaling complex. Molecular Cell, 64 (2), 236-250. doi: 10.1016/j.molcel.2016.09.009

Cryo-EM structure of caspase-8 tandem DED filament reveals assembly and regulation mechanisms of the death-inducing signaling complex

2016

Journal Article

Programmed death-1 ligand 2-mediated regulation of the PD-L1 to PD-1 axis is essential for establishing CD4+ T cell immunity

Karunarathne, Deshapriya S., Horne-Debets, Joshua M., Huang, Johnny X., Faleiro, Rebecca, Leow, Chiuan Yee, Amante, Fiona, Watkins, Thomas S., Miles, John J., Dwyer, Patrick J., Stacey, Katryn J., Yarski, Michael, Poh, Chek Meng, Lee, Jason S., Cooper, Matthew A., Rénia, Laurent, Richard, Derek, McCarthy, James S., Sharpe, Arlene H. and Wykes, Michelle N. (2016). Programmed death-1 ligand 2-mediated regulation of the PD-L1 to PD-1 axis is essential for establishing CD4+ T cell immunity. Immunity, 45 (2), 333-345. doi: 10.1016/j.immuni.2016.07.017

Programmed death-1 ligand 2-mediated regulation of the PD-L1 to PD-1 axis is essential for establishing CD4+ T cell immunity

2016

Journal Article

Induction of interferon and cell death in response to cytosolic DNA in chicken macrophages

Vitak, Nazarii, Hume, David A., Chappell, Keith J., Sester, David P. and Stacey, Katryn J. (2016). Induction of interferon and cell death in response to cytosolic DNA in chicken macrophages. Developmental and Comparative Immunology, 59, 145-152. doi: 10.1016/j.dci.2016.01.023

Induction of interferon and cell death in response to cytosolic DNA in chicken macrophages

2016

Journal Article

Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages

Kapetanovic, Ronan, Bokil, Nilesh J., Achard, Maud E. S., Ong, Cheryl-lynn Y, Peters, Kate M., Stocks, Claudia J., Phan, Minh-Duy, Monteleone, Mercedes, Schroder, Kate, Irvine, Katharine M., Saunders, Bernadette M., Walker, Mark J., Stacey, Katryn J., McEwan, Alastair G., Schembri, Mark A. and Sweet, Matthew J. (2016). Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages. The FASEB Journal, 30 (5), 1901-1912. doi: 10.1096/fj.201500061

Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages

2016

Journal Article

Correcting the NLRP3 inflammasome deficiency in macrophages from autoimmune NZB mice with exon skipping antisense oligonucleotides

Thygesen, Sara J., Sester, David P., Cridland, Simon O., Wilton, Steve D. and Stacey, Katryn J. (2016). Correcting the NLRP3 inflammasome deficiency in macrophages from autoimmune NZB mice with exon skipping antisense oligonucleotides. Immunology and Cell Biology, 94 (5), 520-524. doi: 10.1038/icb.2016.3

Correcting the NLRP3 inflammasome deficiency in macrophages from autoimmune NZB mice with exon skipping antisense oligonucleotides

2016

Conference Publication

Molecular arrangement and activation of procaspases-1 and-8 at inflammasomes

Vajjhala, P., Lu, A., Brown, D., Sagulenko, V, Schroder, K., Stow, J., Wu, H. and Stacey, K. (2016). Molecular arrangement and activation of procaspases-1 and-8 at inflammasomes. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.

Molecular arrangement and activation of procaspases-1 and-8 at inflammasomes

2016

Conference Publication

Inflammasome function in autoimmunity

Thygesen, S. J., Sester, D. P., Sagulenko, V. and Stacey, K. J. (2016). Inflammasome function in autoimmunity. International Congress of Immunology (ICI), Melbourne, VIC Australia, 21-26 August 2016. Weinheim, Germany: Wiley-Blackwell.

Inflammasome function in autoimmunity

2016

Book Chapter

Assessment of inflammasome formation by flow cytometry

Sester, David P., Zamoshnikova, Alina, Thygesen, Sara J., Vajjhala, Parimala R., Cridland, Simon O., Schroder, Kate and Stacey, Katryn J. (2016). Assessment of inflammasome formation by flow cytometry. Current protocols in immunology. (pp. 14.40.1-14.40.29) edited by Coligan, John E., Bierer, Barbara, Margulies, David H., Shevach, Ethan M. and Strober, Warren. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/cpim.13

Assessment of inflammasome formation by flow cytometry

2016

Conference Publication

Cytosolic DNA, HIN-200 proteins and inflammasome activation

Stacey, K. J., Vajjhala, P. R., Sagulenko, V, Thygesen, S., Vitak, N. and Sester, D. P. (2016). Cytosolic DNA, HIN-200 proteins and inflammasome activation. International Congress of Immunology (ICI), Melbourne, VIC Australia, 21-26 August 2016. Weinheim, Germany: Wiley.

Cytosolic DNA, HIN-200 proteins and inflammasome activation

2016

Book Chapter

Methods for delivering DNA to intracellular receptors

Stacey, Katryn J., Idris, Adi, Sagulenko, Vitaliya, Vitak, Nazarii and Sester, David P. (2016). Methods for delivering DNA to intracellular receptors. Toll-like receptor detection and activation. (pp. 93-106) edited by Claire E. McCoy. New York, NY, United States: Springer Science+Business Media. doi: 10.1007/978-1-4939-3335-8_6

Methods for delivering DNA to intracellular receptors