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2020

Journal Article

RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

Tullett, Kirsteen M., Tan, Peck Szee, Park, Hae-Young, Schittenhelm, Ralf B., Michael, Nicole, Li, Rong, Policheni, Antonia N., Gruber, Emily, Huang, Cheng, Fulcher, Alex J., Danne, Jillian C., Czabotar, Peter E., Wakim, Linda M., Mintern, Justine D., Ramm, Georg, Radford, Kristen J., Caminschi, Irina, O'Keeffe, Meredith, Villadangos, Jose A., Wright, Mark D., Blewitt, Marnie E., Heath, William R., Shortman, Ken, Purcell, Anthony W., Nicola, Nicos A., Zhang, Jian-Guo and Lahoud, Mireille H. (2020). RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells. eLife, 9 e63452, 1-31. doi: 10.7554/eLife.63452

RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

2020

Journal Article

Human CLEC9A antibodies deliver NY-ESO-1 antigen to CD141+ dendritic cells to activate naïve and memory NY-ESO-1-specific CD8+ T cells

Masterman, Kelly-Anne, Haigh, Oscar L., Tullett, Kirsteen M., Leal-Rojas, Ingrid M., Walpole, Carina, Pearson, Frances E., Cebon, Jonathon, Schmidt, Christopher, O'Brien, Liam, Rosendahl, Nikita, Daraj, Ghazal, Caminschi, Irina, Gschweng, Eric H., Hollis, Roger P., Kohn, Donald B., Lahoud, Mireille H. and Radford, Kristen J. (2020). Human CLEC9A antibodies deliver NY-ESO-1 antigen to CD141+ dendritic cells to activate naïve and memory NY-ESO-1-specific CD8+ T cells. Journal for ImmunoTherapy of Cancer, 8 (2) e000691, 1-11. doi: 10.1136/jitc-2020-000691

Human CLEC9A antibodies deliver NY-ESO-1 antigen to CD141+ dendritic cells to activate naïve and memory NY-ESO-1-specific CD8+ T cells

2020

Journal Article

Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1-specific CD8+ T cells

Pearson, Frances E., Tullett, Kirsteen M., Leal-Rojas, Ingrid M., Haigh, Oscar L., Masterman, Kelly-Anne, Walpole, Carina, Bridgeman, John S., McLaren, James E., Ladell, Kristin, Miners, Kelly, Llewellyn-Lacey, Sian, Price, David A., Tunger, Antje, Schmitz, Marc, Miles, John J., Lahoud, Mireille H. and Radford, Kristen J. (2020). Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1-specific CD8+ T cells. Clinical and Translational Immunology, 9 (6) e1141, e1141. doi: 10.1002/cti2.1141

Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1-specific CD8+ T cells

2020

Book Chapter

Unexplored horizons of cDC1 in immunity and tolerance

Balan, Sreekumar, Radford, Kristen J. and Bhardwaj, Nina (2020). Unexplored horizons of cDC1 in immunity and tolerance. Advances in Immunology. (pp. 49-91) San Diego, CA United States: Academic Press. doi: 10.1016/bs.ai.2020.10.002

Unexplored horizons of cDC1 in immunity and tolerance

2019

Journal Article

MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity

Sheng, Yong Hua, Wong, Kuan Yau, Seim, Inge, Wang, Ran, He, Yaowu, Wu, Andy, Patrick, Maya, Lourie, Rohan, Schreiber, Veronika, Giri, Rabina, Ng, Choa Ping, Popat, Amirali, Hooper, John, Kijanka, Gregor, Florin, Timothy H., Begun, Jakob, Radford, Kristen J., Hasnain, Sumaira and McGuckin, Michael A. (2019). MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity. Oncogene, 38 (48), 7294-7310. doi: 10.1038/s41388-019-0951-y

MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity

2019

Journal Article

Can Dendritic Cell vaccination prevent leukemia relapse?

O’Brien, Liam J., Guillerey, Camille and Radford, Kristen J. (2019). Can Dendritic Cell vaccination prevent leukemia relapse?. Cancers, 11 (6) 875, 875. doi: 10.3390/cancers11060875

Can Dendritic Cell vaccination prevent leukemia relapse?

2019

Journal Article

Simple, rapid and inexpensive typing of common HLA class I alleles for immunological studies

Law, Soi Cheng, Haigh, Oscar L., Walpole, Carina M., Keane, Colm, Miles, John, Gandhi, Maher K., Radford, Kristen J. and Steptoe, Raymond J. (2019). Simple, rapid and inexpensive typing of common HLA class I alleles for immunological studies. Journal of Immunological Methods, 465, 72-76. doi: 10.1016/j.jim.2018.12.002

Simple, rapid and inexpensive typing of common HLA class I alleles for immunological studies

2019

Book Chapter

Monitoring dendritic cell activation and maturation

Macri, Christophe, Fancke, Ben, Radford, Kristen J. and O’Keeffe, Meredith (2019). Monitoring dendritic cell activation and maturation. Antigen Processing. (pp. 403-418) edited by Peter van Endert. New York, NY, United States: Humana Press. doi: 10.1007/978-1-4939-9450-2_28

Monitoring dendritic cell activation and maturation

2019

Book Chapter

The role of dendritic cells in cancer

Lee, Yoke Seng and Radford, Kristen J. (2019). The role of dendritic cells in cancer. Immunobiology of Dendritic Cells. Part A. (pp. 123-178) edited by Claire Lhuillier and Lorenzo Galluzzi. Cambridge, MA, United States: Academic Press. doi: 10.1016/bs.ircmb.2019.07.006

The role of dendritic cells in cancer

2018

Conference Publication

Targeting human CD141+DC using CLEC9A antibodies for cancer immunotherapy

Masterman, K-A., Pearson, F. E., Tullett, K., Haigh, O., Walpole, C., Daraj, G., Lahoud, M. H., Rojas, I. Leal and Radford, K. (2018). Targeting human CD141+DC using CLEC9A antibodies for cancer immunotherapy. ESMO Immuno-Oncology Congress, Geneva Switzerland, Dec 13-16, 2018. OXFORD: OXFORD UNIV PRESS.

Targeting human CD141+DC using CLEC9A antibodies for cancer immunotherapy

2018

Conference Publication

Characterising the effects of interferon lambda on dendritic cell function and activation

Pang, E. S., Macri, C., Lundie, R., Pooley, J., Gearing, J., Pupovac, A., Jacobson, K., Hertzog, P., Hochrein, H., Radford, K. and O'Keeffe, M. (2018). Characterising the effects of interferon lambda on dendritic cell function and activation. 15th International Symposium on Dendritic Cells (DC), Aachen Germany, Jun 10-14, 2018. HOBOKEN: WILEY.

Characterising the effects of interferon lambda on dendritic cell function and activation

2018

Journal Article

Activation of human CD141+ and CD1c+ dendritic cells in vivo with combined TLR 3 and TLR 7/8 ligation

Pearson, Frances E., Chang, Karshing, Minoda, Yoshihito, Leal Rojas, Ingrid M., Haigh, Oscar L., Daraj, Ghazal, Tullett, Kirsteen M. and Radford, Kristen J. (2018). Activation of human CD141+ and CD1c+ dendritic cells in vivo with combined TLR 3 and TLR 7/8 ligation. Immunology and Cell Biology, 96 (4), 390-400. doi: 10.1111/imcb.12009

Activation of human CD141+ and CD1c+ dendritic cells in vivo with combined TLR 3 and TLR 7/8 ligation

2018

Conference Publication

Targeting human CD141(+) DC using CLEC9A antibodies for cancer immunotherapy

Pearson, F., Masterman, K. A., Tullett, K., Haigh, O., Walpole, C., Daraj, G., Rojas, Leal, Lahoud, M. H. and Radford, K. (2018). Targeting human CD141(+) DC using CLEC9A antibodies for cancer immunotherapy. 15th International Symposium on Dendritic Cells (DC), Aachen Germany, Jun 10-14, 2018. Hoboken, NJ United States: Wiley.

Targeting human CD141(+) DC using CLEC9A antibodies for cancer immunotherapy

2017

Journal Article

Human CD141(+) dendritic cell and CD1c(+) dendritic cell undergo concordant early genetic programming after activation in humanized mice in vivo

Minoda, Yoshihito, Virshup, Isaac, Rojas, Ingrid Leal, Haigh, Oscar, Wong, Yide, Miles, John J., Wells, Christine A. and Radford, Kristen J. (2017). Human CD141(+) dendritic cell and CD1c(+) dendritic cell undergo concordant early genetic programming after activation in humanized mice in vivo. Frontiers in Immunology, 8 (OCT) 1419, 1419. doi: 10.3389/fimmu.2017.01419

Human CD141(+) dendritic cell and CD1c(+) dendritic cell undergo concordant early genetic programming after activation in humanized mice in vivo

2017

Journal Article

Human blood cD1c+ dendritic cells promote Th1 and Th17 effector function in memory cD4+ T cells

Rojas, Ingrid M. Leal, Mok, Wai-Hong, Pearson, Frances E., Minoda, Yoshihito, Kenna, Tony J., Barnard, Ross T. and Radford, Kristen J. (2017). Human blood cD1c+ dendritic cells promote Th1 and Th17 effector function in memory cD4+ T cells. Frontiers in Immunology, 8 (AUG) 971, 971. doi: 10.3389/fimmu.2017.00971

Human blood cD1c+ dendritic cells promote Th1 and Th17 effector function in memory cD4+ T cells

2016

Journal Article

Targeting CLEC9A delivers antigen to human CD141+ DC for CD4+ and CD8+ T cell recognition

Tullett, Kirsteen M., Leal Rojas, Ingrid M., Minoda, Yoshihito, Tan, Peck S., Zhang, Jian-Guo, Smith, Corey, Khanna, Rajiv, Shortman, Ken, Caminschi, Irina, Lahoud, Mireille H. and Radford, Kristen J. (2016). Targeting CLEC9A delivers antigen to human CD141+ DC for CD4+ and CD8+ T cell recognition. JCI Insight, 1 (7) e87102, e87102. doi: 10.1172/jci.insight.87102

Targeting CLEC9A delivers antigen to human CD141+ DC for CD4+ and CD8+ T cell recognition

2016

Conference Publication

Human dendritic cell interactions with P-falciparum provide insight into the development of host immunity to malaria

Yap, X. Z., Lundie, R. J., Macri, C. F., Rojas, Leal, I, Feng, G., Radford, K. J., Beeson, J. G. and O'Keeffe, M. (2016). Human dendritic cell interactions with P-falciparum provide insight into the development of host immunity to malaria. International Congress of Immunology (ICI), Melbourne Australia, Aug 21-26, 2016. HOBOKEN: WILEY-BLACKWELL.

Human dendritic cell interactions with P-falciparum provide insight into the development of host immunity to malaria

2016

Conference Publication

Characterising the effects of interferon lambda on dendritic cells

Pang, E. S., Macri, C., Pooley, J., Fancke, B., Lundie, R., Hochrein, H., Radford, K. and O'Keeffe, M. (2016). Characterising the effects of interferon lambda on dendritic cells. International Congress of Immunology (ICI), Melbourne Australia, Aug 21-26, 2016. HOBOKEN: WILEY-BLACKWELL.

Characterising the effects of interferon lambda on dendritic cells

2016

Conference Publication

Targeting CLEC9A can deliver antigen to human CD141(+) DC for recognition by both CD4(+) and CD8(+) T cells

Tullett, K. M., Leal Rojas, I. M., Minoda, Y., Tan, P. S., Zhang, J. -G, Smith, C., Khanna, R., Shortman, K., Caminschi, I, Lahoud, M. H. and Radford, K. J. (2016). Targeting CLEC9A can deliver antigen to human CD141(+) DC for recognition by both CD4(+) and CD8(+) T cells. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August, 2016. Weinheim, Germany: Wiley.

Targeting CLEC9A can deliver antigen to human CD141(+) DC for recognition by both CD4(+) and CD8(+) T cells

2016

Conference Publication

Molecular basis for the efficient processing of antigens taken up by Clec9A, a DAMP receptor on dendritic cells

Tan, P. S., Tullett, K., Park, H-Y, Gruber, E., Radford, K., Nicola, N., Zhang, J-G, Shortman, K., Caminschi, I and Lahoud, M. (2016). Molecular basis for the efficient processing of antigens taken up by Clec9A, a DAMP receptor on dendritic cells. International Congress of Immunology (ICI), Melbourne Australia, Aug 21-26, 2016. HOBOKEN: WILEY-BLACKWELL.

Molecular basis for the efficient processing of antigens taken up by Clec9A, a DAMP receptor on dendritic cells