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2012 Journal Article The association of genetic variants with hepatic steatosis in patients with genotype 1 chronic Hepatitis C infectionClark, Paul J., Thompson, Alexander J., Zhu, Qianqian, Vock, David M., Zhu, Mingfu, Patel, Keyur, Harrison, Stephen A., Naggie, Susanna, Ge, Dongliang, Tillmann, Hans L., Urban, Thomas J., Shianna, Kevin, Fellay, Jacques, Goodman, Zachary, Noviello, Stephanie, Pedicone, Lisa D., Afdhal, Nezam, Sulkowski, Mark, Albrecht, Janice K., Goldstein, David B., McHutchison, John G. and Muir, Andrew J. (2012). The association of genetic variants with hepatic steatosis in patients with genotype 1 chronic Hepatitis C infection. Digestive Diseases and Sciences, 57 (8), 2213-2221. doi: 10.1007/s10620-012-2171-y |
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2012 Conference Publication Optimizing ribavirin dose is critical for sustained viral response in patients with thalassemia major treated for chronic hepatitis CClark, Paul J., Santoro, Rosanna, Piazzolla, Valeria, Mottola, Leonardo, Bacca, D., Dello Iacono, N., Grimaldi, Salvatore, Quarta, Antonella, Urban, Thomas J., Naggie, Susanna, Patel, Keyur, Thompson, Alexander J., Muir, Andrew J. and Mangia, Alessandra (2012). Optimizing ribavirin dose is critical for sustained viral response in patients with thalassemia major treated for chronic hepatitis C. 63rd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), Boston Ma, Nov 09-13, 2012. HOBOKEN: WILEY-BLACKWELL. |
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2012 Journal Article Systemic thrombolysis for acute, severe Budd-Chiari syndromeClark, P.J., Slaughter, R.E. and Radford, D.J. (2012). Systemic thrombolysis for acute, severe Budd-Chiari syndrome. Journal of Thrombosis and Thrombolysis, 34 (3), 410-415. doi: 10.1007/s11239-012-0760-4 |
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2012 Journal Article Hepatitis C virus selectively perturbs the distal cholesterol synthesis pathway in a genotype-specific mannerClark, Paul J., Thompson, Alexander J., Vock, David M., Kratz, Lisa E., Tolun, Adviye A., Muir, Andrew J., Mchutchison, John G., Subramanian, Mani, Millington, David M., Kelley, Richard I. and Patel, Keyur (2012). Hepatitis C virus selectively perturbs the distal cholesterol synthesis pathway in a genotype-specific manner. Hepatology, 56 (1), 49-56. doi: 10.1002/hep.25631 |
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2012 Conference Publication Itpa Variants Predict Treatment-Induced Anemia and the Need for Ribavirin Dose Reduction and Erythropoietin SupportClark, P. J., Aghemo, A., Degasperi, E., Galmozzi, E., Thompson, A. J., Patel, K., Rumi, M. Grazia, Prati, G. M., Muir, A. J. and Colombo, M. (2012). Itpa Variants Predict Treatment-Induced Anemia and the Need for Ribavirin Dose Reduction and Erythropoietin Support. 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Barcelona Spain, Apr 18-22, 2012. AMSTERDAM: ELSEVIER SCIENCE BV. doi: 10.1016/S0168-8278(12)61111-8 |
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2011 Journal Article Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis CTillmann, Hans L., Patel, Keyur, Muir, Andrew J., Guy, Cynthia D., Li, Josephine H., Lao, Xiang Qian, Thompson, Alexander, Clark, Paul J., Gardner, Stephen D., McHutchison, John G. and McCarthy, Jeanette J. (2011). Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C. Journal of Hepatology, 55 (6), 1195-1200. doi: 10.1016/j.jhep.2011.03.015 |
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2011 Journal Article Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis CGolden-Mason, Lucy, Bambha, Kiran M., Cheng, Linling, Howell, Charles D., Taylor, Milton W., Clark, Paul J., Afdhal, Nezam and Rosen, Hugo R. (2011). Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C. Hepatology, 54 (5), 1559-1569. doi: 10.1002/hep.24556 |
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2011 Conference Publication PREDICTORS OF CONSENT TO PHARMACOGENOMICS TESTING IN THE IDEAL STUDYJazwinski, Alison, Clark, Paul J., Thompson, Alexander J., Gordon, Stuart C., Lawitz, Eric, McCone, Jonathan, Noviello, Stephanie, Brass, Clifford A., Pedicone, Lisa, Albrecht, Janice K., Sulkowski, Mark S., Muir, Andrew J. and Jazwinski, Alison (2011). PREDICTORS OF CONSENT TO PHARMACOGENOMICS TESTING IN THE IDEAL STUDY. 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), San Francisco Ca, Nov 04-08, 2011. MALDEN: WILEY-BLACKWELL. |
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2011 Journal Article Characterization of serum proteins associated with IL28B genotype among patients with chronic hepatitis CCyr, Derek D., Lucas, Joseph E., Thompson, J. Will, Patel, Keyur, Clark, Paul J., Thompson, Alexander, Tillmann, Hans L., McHutchison, John G., Moseley, M. Arthur and McCarthy, Jeanette J. (2011). Characterization of serum proteins associated with IL28B genotype among patients with chronic hepatitis C. PLoS One, 6 (7) e21854, 1-6. doi: 10.1371/journal.pone.0021854 |
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2011 Journal Article Insulin resistance is independently associated with significant hepatic fibrosis in Asian chronic hepatitis C genotype 2 or 3 patientsPatel, Keyur, Thompson, Alexander J., Chuang, Wan-Long, Lee, Chuan-Mo, Peng, Chen-Yuan, Shanmuganathan, Ganesananthan, Thongsawat, Satawat, Tanwandee, Tawesak, Mahachai, Varocha, Pramoolsinsap, Chutima, Cho, Mong, Han, Kwang Hyup, Shah, Samir R., Foster, Graham R., Clark, Paul J., Pulkstenis, Erik, Subramanian, G. Mani and McHutchison, John G. (2011). Insulin resistance is independently associated with significant hepatic fibrosis in Asian chronic hepatitis C genotype 2 or 3 patients. Journal of Gastroenterology and Hepatology (Australia), 26 (7), 1182-1188. doi: 10.1111/j.1440-1746.2011.06722.x |
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2011 Conference Publication Phosphodiesterase Polymorphisms May Be Associated with Baseline Thyroid Stimulating Hormone (Tsh) and Peginterferon Treatment Induced Hypothyroidism in Patients with Chronic Hepatitis CClark, P. J., Thompson, A. J., Zhu, M., Ge, D., Shianna, K., Tillmann, H. L., Patel, K., Urban, T., Singh, A., Sulkowski, M., Afdhal, N., Jacobson, I., Esteban, R., Poordad, F., Lawitz, E., McCone, J., Shiffman, M. L., Galler, G., Lee, W. M., Reindollar, R., King, J., Kwo, P., Ghalib, R., Freilich, B., Nyberg, L., Noviello, S., Bopari, N., Koury, K., Pedicone, L. D. ... Muir, A. J. (2011). Phosphodiesterase Polymorphisms May Be Associated with Baseline Thyroid Stimulating Hormone (Tsh) and Peginterferon Treatment Induced Hypothyroidism in Patients with Chronic Hepatitis C. 46th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Berlin Germany, 2011. AMSTERDAM: ELSEVIER SCIENCE BV. doi: 10.1016/S0168-8278(11)60129-3 |
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2011 Conference Publication Nk Inhibitory Receptor Expression Associated with Treatment Failure and Il-28B Genotype in Patients with Chronic Hepatitis CGolden-Mason, Lucy, Bambha, Kiran, Cheng, Linling, Howell, Charles D., Taylor, Milton W., Clark, Paul J., Afdhal, Nezam H. and Rosen, Hugo R. (2011). Nk Inhibitory Receptor Expression Associated with Treatment Failure and Il-28B Genotype in Patients with Chronic Hepatitis C. 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), San Francisco Ca, Nov 04-08, 2011. MALDEN: WILEY-BLACKWELL. |
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2011 Journal Article Inosine triphosphatase genetic variants are protective against anemia during antiviral therapy for HCV2/3 but do not decrease dose reductions of RBV or increase SVRThompson, Alexander J., Santoro, Rosanna, Piazzolla, Valeria, Clark, Paul J., Naggie, Susanna, Tillmann, Hans L., Patel, Keyur, Muir, Andrew J., Shianna, Kevin V., Mottola, Leonardo, Petruzzellis, Daniela, Romano, Mario, Sogari, Fernando, Facciorusso, Domenico, Goldstein, David B., McHutchison, John G. and Mangia, Alessandra (2011). Inosine triphosphatase genetic variants are protective against anemia during antiviral therapy for HCV2/3 but do not decrease dose reductions of RBV or increase SVR. Hepatology, 53 (2), 389-395. doi: 10.1002/hep.24068 |
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2011 Conference Publication Dysregulation of Host Innate Immunity in Hcv Genotype 1 Infected Il28B Ct/tt Haplotype Patients with Depressed Viral Kinetics and Therapeutic ResponseNaggie, S., Osinusi, A., Katsounas, A., Lempicki, R., Herrmann, E., Shivakumar, B., Thompson, A., Clark, P., Patel, K., Muir, A., Mchutchison, J., Goldstein, D., Schlaak, J., Masur, H., Polis, M. and Kottilil, S. (2011). Dysregulation of Host Innate Immunity in Hcv Genotype 1 Infected Il28B Ct/tt Haplotype Patients with Depressed Viral Kinetics and Therapeutic Response. 46th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Berlin Germany, 2011. AMSTERDAM: ELSEVIER SCIENCE BV. doi: 10.1016/S0168-8278(11)61336-6 |
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2011 Conference Publication The Cost-Effectiveness of a Telaprevir-Inclusive Regimen as Initial Therapy for Genotype 1 Hepatitis C Infection in Individuals with the Cc Il-28B PolymorphismGellad, Ziad F., Naggie, Susanna, Reed, Shelby D., Clark, Paul J., Thompson, Alex J., Schulman, Kevin A. and Muir, Andrew J. (2011). The Cost-Effectiveness of a Telaprevir-Inclusive Regimen as Initial Therapy for Genotype 1 Hepatitis C Infection in Individuals with the Cc Il-28B Polymorphism. 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), San Francisco Ca, Nov 04-08, 2011. MALDEN: WILEY-BLACKWELL. |
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2011 Conference Publication Metabolomic Analysis Demonstrates Hepatitis C Virus Genotypes G2/3 Selectively Perturb Distal Steps in Cholesterol BiosynthesisClark, Paul J., Thompson, Alexander J., Vock, David M., Kratz, Lisa E., Tolun, Adviye A., Zhang, Hao Yue, Muir, Andrew J., Subramanian, Mani, McHutchison, John G., Millington, David S., Kelley, Richard I. and Patel, Keyur (2011). Metabolomic Analysis Demonstrates Hepatitis C Virus Genotypes G2/3 Selectively Perturb Distal Steps in Cholesterol Biosynthesis. 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), San Francisco Ca, Nov 04-08, 2011. MALDEN: WILEY-BLACKWELL. |
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2011 Conference Publication Vitamin D and Treatment Response in African American Patients with Hcv Genotype 1Jazwinski, Alison, Clark, Paul J., Tillmann, Hans L., Muir, Andrew J. and Jazwinski, Alison (2011). Vitamin D and Treatment Response in African American Patients with Hcv Genotype 1. 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), San Francisco Ca, Nov 04-08, 2011. MALDEN: WILEY-BLACKWELL. |
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2011 Conference Publication Pnpla3 Genotype Rather Than Race May Explain the Lower Prevalence of Hepatic Steatosis Despite Worse Metabolic Risk Factors in African American Patients with Chronic Hepatitis C (Chc)Clark, Paul J., Thompson, Alexander J., Urban, Thomas J., Patel, Keyur, Vock, David M., Zhu, Qianqian, Jazwinski, Alison, Naggie, Susanna, Tillmann, Hans L., McKenzie, Alexander, Conjeevaram, Hari S., Shianna, Kevin, Goldstein, David B., Afdhal, Nezam H. and Muir, Andrew J. (2011). Pnpla3 Genotype Rather Than Race May Explain the Lower Prevalence of Hepatic Steatosis Despite Worse Metabolic Risk Factors in African American Patients with Chronic Hepatitis C (Chc). 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), San Francisco Ca, Nov 04-08, 2011. MALDEN: WILEY-BLACKWELL. |
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2011 Journal Article Noninvasive tools to assess liver diseaseClark, Paul J. and Patel, Keyur (2011). Noninvasive tools to assess liver disease. Current Opinion in Gastroenterology, 27 (3), 210-216. doi: 10.1097/MOG.0b013e328343e9a3 |
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2011 Conference Publication Il28B C/c Genotype Is Predictive of >= 1 Log10 Iu/ml Reduction in Plasma Hcv Rna After 4 Weeks of Peginterferon (Pegifn) and Ribavirin (Rbv) Therapy: Implications for the Use of the Lead-In Strategy for Direct-Acting Antiviral-Based Treatment RegimensThompson, Alexander J., Clark, Paul J., Tillmann, Hans L., Patel, Keyur, Naggie, Susanna, Poordad, F. Fred, Lawitz, Eric, Bacon, Bruce R., Vierling, John M., Noviello, Stephanie, Brass, Clifford A., Albrecht, Janice K., Goldstein, David B., McHutchison, John G., Sulkowski, Mark S. and Muir, Andrew J. (2011). Il28B C/c Genotype Is Predictive of >= 1 Log10 Iu/ml Reduction in Plasma Hcv Rna After 4 Weeks of Peginterferon (Pegifn) and Ribavirin (Rbv) Therapy: Implications for the Use of the Lead-In Strategy for Direct-Acting Antiviral-Based Treatment Regimens. 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), San Francisco Ca, Nov 04-08, 2011. MALDEN: WILEY-BLACKWELL. |
