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2012 Journal Article Interleukin 28B polymorphisms are the only common genetic variants associated with low-density lipoprotein cholesterol (LDL-C) in genotype-1 chronic hepatitis C and determine the association between LDL-C and treatment responseClark, P. J., Thompson, A. J., Zhu, M., Vock, D. M., Zhu, Q., Ge, D., Patel, K., Harrison, S. A., Urban, T. J., Naggie, S., Fellay, J., Tillmann, H. L., Shianna, K., Noviello, S., Pedicone, L. D., Esteban, R., Kwo, P., Sulkowski, M. S., Afdhal, N., Albrecht, J. K., Goldstein, D. B., McHutchison, J. G. and Muir, A. J. (2012). Interleukin 28B polymorphisms are the only common genetic variants associated with low-density lipoprotein cholesterol (LDL-C) in genotype-1 chronic hepatitis C and determine the association between LDL-C and treatment response. Journal of Viral Hepatitis, 19 (5), 332-340. doi: 10.1111/j.1365-2893.2011.01553.x |
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2012 Conference Publication Association of Serum Adipocytokines With IL28B and SVR in Chronic Hepatitis CClark, Paul J., Thompson, Alexander J., Jazwinski, Alison, Tillmann, Hans L., Naggie, Susanna, Muir, Andrew J. and Patel, Keyur (2012). Association of Serum Adipocytokines With IL28B and SVR in Chronic Hepatitis C. Digestive Disease Week (DDW), San Diego Ca, May 19-22, 2012. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC. |
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2012 Journal Article Elevated serum CK18 levels in chronic hepatitis C patients are associated with advanced fibrosis but not steatosisJazwinski, A. B., Thompson, A. J., Clark, P. J., Naggie, S., Tillmann, H. L. and Patel, K. (2012). Elevated serum CK18 levels in chronic hepatitis C patients are associated with advanced fibrosis but not steatosis. Journal of Viral Hepatitis, 19 (4), 278-282. doi: 10.1111/j.1365-2893.2011.01546.x |
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2012 Journal Article Reply to "IL28B polymorphism and hepatitis C: A genetic marker of peginterferon-alpha sensitivity devoid from classical interferon-alpha side effects?"Thompson, A. J., Clark, P. J., Muir, A. J. and Sulkowski, M. S. (2012). Reply to "IL28B polymorphism and hepatitis C: A genetic marker of peginterferon-alpha sensitivity devoid from classical interferon-alpha side effects?". Journal of Hepatology, 56 (3), 742-743. doi: 10.1016/j.jhep.2011.08.011 |
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2012 Journal Article Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patientsThompson, Alexander J., Clark, Paul J., Singh, Abanish, Ge, Dongliang, Fellay, Jacques, Zhu, Mingfu, Zhu, Qianqian, Urban, Thomas J., Patel, Keyur, Tillmann, Hans L., Naggie, Susanna, Afdhal, Nezam H., Jacobson, Ira M., Esteban, Rafael, Poordad, Fred, Lawitz, Eric J., McCone, Jonathan, Shiffman, Mitchell L., Galler, Greg W., King, John W., Kwo, Paul Y., Shianna, Kevin V., Noviello, Stephanie, Pedicone, Lisa D., Brass, Clifford A., Albrecht, Janice K., Sulkowski, Mark S., Goldstein, David B., McHutchison, John G. and Muir, Andrew J. (2012). Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients. Journal of Hepatology, 56 (2), 313-319. doi: 10.1016/j.jhep.2011.04.021 |
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2012 Journal Article Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia in HIV/HCV-coinfected patients with all HCV genotypesNaggie, Susanna, Rallon, Norma I., Benito, Jose M., Morello, Judith, Rodriguez-Novoa, Sonia, Clark, Paul J., Thompson, Alexander J., Shianna, Kevin V., Vispo, Eugenia, McHutchison, John G., Goldstein, David B. and Soriano, Vincent (2012). Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia in HIV/HCV-coinfected patients with all HCV genotypes. Journal of Infectious Diseases, 205 (3), 376-383. doi: 10.1093/infdis/jir754 |
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2012 Journal Article The association of genetic variants with hepatic steatosis in patients with genotype 1 chronic Hepatitis C infectionClark, Paul J., Thompson, Alexander J., Zhu, Qianqian, Vock, David M., Zhu, Mingfu, Patel, Keyur, Harrison, Stephen A., Naggie, Susanna, Ge, Dongliang, Tillmann, Hans L., Urban, Thomas J., Shianna, Kevin, Fellay, Jacques, Goodman, Zachary, Noviello, Stephanie, Pedicone, Lisa D., Afdhal, Nezam, Sulkowski, Mark, Albrecht, Janice K., Goldstein, David B., McHutchison, John G. and Muir, Andrew J. (2012). The association of genetic variants with hepatic steatosis in patients with genotype 1 chronic Hepatitis C infection. Digestive Diseases and Sciences, 57 (8), 2213-2221. doi: 10.1007/s10620-012-2171-y |
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2012 Conference Publication Optimizing ribavirin dose is critical for sustained viral response in patients with thalassemia major treated for chronic hepatitis CClark, Paul J., Santoro, Rosanna, Piazzolla, Valeria, Mottola, Leonardo, Bacca, D., Dello Iacono, N., Grimaldi, Salvatore, Quarta, Antonella, Urban, Thomas J., Naggie, Susanna, Patel, Keyur, Thompson, Alexander J., Muir, Andrew J. and Mangia, Alessandra (2012). Optimizing ribavirin dose is critical for sustained viral response in patients with thalassemia major treated for chronic hepatitis C. 63rd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), Boston Ma, Nov 09-13, 2012. HOBOKEN: WILEY-BLACKWELL. |
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2012 Journal Article Systemic thrombolysis for acute, severe Budd-Chiari syndromeClark, P.J., Slaughter, R.E. and Radford, D.J. (2012). Systemic thrombolysis for acute, severe Budd-Chiari syndrome. Journal of Thrombosis and Thrombolysis, 34 (3), 410-415. doi: 10.1007/s11239-012-0760-4 |
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2012 Journal Article Hepatitis C virus selectively perturbs the distal cholesterol synthesis pathway in a genotype-specific mannerClark, Paul J., Thompson, Alexander J., Vock, David M., Kratz, Lisa E., Tolun, Adviye A., Muir, Andrew J., Mchutchison, John G., Subramanian, Mani, Millington, David M., Kelley, Richard I. and Patel, Keyur (2012). Hepatitis C virus selectively perturbs the distal cholesterol synthesis pathway in a genotype-specific manner. Hepatology, 56 (1), 49-56. doi: 10.1002/hep.25631 |
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2012 Conference Publication Itpa Variants Predict Treatment-Induced Anemia and the Need for Ribavirin Dose Reduction and Erythropoietin SupportClark, P. J., Aghemo, A., Degasperi, E., Galmozzi, E., Thompson, A. J., Patel, K., Rumi, M. Grazia, Prati, G. M., Muir, A. J. and Colombo, M. (2012). Itpa Variants Predict Treatment-Induced Anemia and the Need for Ribavirin Dose Reduction and Erythropoietin Support. 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Barcelona Spain, Apr 18-22, 2012. AMSTERDAM: ELSEVIER SCIENCE BV. doi: 10.1016/S0168-8278(12)61111-8 |
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2012 Conference Publication Targeted proteomics signature identifies corticosteroid binding globulin peptides as highly predictive of treatment response in IL28B unfavorable genotype patientsNaggie, Susanna, Osinusi, Anu, Himmel, Tiffany, Lucas, Joseph, Thompson, J. W., Dubois, Laura G., Moseley, Martin A., Clark, Paul J., Kottilil, Shyam and Patel, Keyur (2012). Targeted proteomics signature identifies corticosteroid binding globulin peptides as highly predictive of treatment response in IL28B unfavorable genotype patients. 63rd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), Boston Ma, Nov 09-13, 2012. HOBOKEN: WILEY-BLACKWELL. |
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2012 Journal Article Lost in translation? IL28B's discovery and the journey back to the patientClark, Paul J. and Muir, Andrew J. (2012). Lost in translation? IL28B's discovery and the journey back to the patient. Hepatology, 56 (1), 5-8. doi: 10.1002/hep.25796 |
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2012 Conference Publication Inosine Triphosphastase (ITPA) Variants Predict Treatment-Induced Anemia, Ribavirin Dose-Reduction and Need for Erythropoietin Support During Peginterferon/Ribavirin Therapy for Chronic HCVClark, Paul J., Aghemo, Alessio, Degasperi, Elisabetta, Galmozzi, Enrico, Thompson, Alexander J., Patel, Keyur, Rumi, Maria Grazia, Prati, G. and Colombo, Massimo (2012). Inosine Triphosphastase (ITPA) Variants Predict Treatment-Induced Anemia, Ribavirin Dose-Reduction and Need for Erythropoietin Support During Peginterferon/Ribavirin Therapy for Chronic HCV. Digestive Disease Week (DDW), San Diego Ca, May 19-22, 2012. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC. |
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2012 Journal Article Host genomics and HCV treatment responseClark, Paul J. and Thompson, Alexander J. (2012). Host genomics and HCV treatment response. Journal of Gastroenterology and Hepatology, 27 (2), 212-222. doi: 10.1111/j.1440-1746.2011.06918.x |
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2012 Conference Publication Analysis of Genotype 1 Hcv Adaptation to Host Il28B Polymorphism - Evidence for Viral Innate Immune Escape PatternsThompson, A. J., Clark, P. J., Patel, K., Tillmann, H. L., Urban, T. J., Shianna, K. V., Goldstein, D. B., McHutchison, J. G., Muir, A. J., James, I., Lucas, M. and Gaudieri, S. (2012). Analysis of Genotype 1 Hcv Adaptation to Host Il28B Polymorphism - Evidence for Viral Innate Immune Escape Patterns. 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Barcelona Spain, Apr 18-22, 2012. AMSTERDAM: ELSEVIER SCIENCE BV. doi: 10.1016/S0168-8278(12)60942-8 |
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2012 Conference Publication MRECIST Criteria Response to Pretransplant Transarterial Chemoembolization (TACE) is Predictive of Improved Survival for Patients With HCV Undergoing Liver Transplantation for Hepatocellular Carcinoma (HCC)Clark, Paul J., Heimbach, Julie K., Rosen, Charles B., Sanchez, William, Gores, Gregory J., Muir, Andrew J. and Charlton, Michael R. (2012). MRECIST Criteria Response to Pretransplant Transarterial Chemoembolization (TACE) is Predictive of Improved Survival for Patients With HCV Undergoing Liver Transplantation for Hepatocellular Carcinoma (HCC). Digestive Disease Week (DDW), San Diego Ca, May 19-22, 2012. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC. |
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2012 Conference Publication Exploration of Serum Adipocytokine Associations with Il28B Genotype in Chronic Hepatitis CClark, P. J., Thompson, A. J., Tillmann, H. L., Jazwinski, A., Naggie, S., Muir, A. J. and Patel, K. (2012). Exploration of Serum Adipocytokine Associations with Il28B Genotype in Chronic Hepatitis C. 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Barcelona Spain, Apr 18-22, 2012. AMSTERDAM: ELSEVIER SCIENCE BV. doi: 10.1016/S0168-8278(12)60896-4 |
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2011 Journal Article Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis CTillmann, Hans L., Patel, Keyur, Muir, Andrew J., Guy, Cynthia D., Li, Josephine H., Lao, Xiang Qian, Thompson, Alexander, Clark, Paul J., Gardner, Stephen D., McHutchison, John G. and McCarthy, Jeanette J. (2011). Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C. Journal of Hepatology, 55 (6), 1195-1200. doi: 10.1016/j.jhep.2011.03.015 |
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2011 Journal Article Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis CGolden-Mason, Lucy, Bambha, Kiran M., Cheng, Linling, Howell, Charles D., Taylor, Milton W., Clark, Paul J., Afdhal, Nezam and Rosen, Hugo R. (2011). Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C. Hepatology, 54 (5), 1559-1569. doi: 10.1002/hep.24556 |
