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2011 Journal Article Inosine triphosphatase genetic variants are protective against anemia during antiviral therapy for HCV2/3 but do not decrease dose reductions of RBV or increase SVRThompson, Alexander J., Santoro, Rosanna, Piazzolla, Valeria, Clark, Paul J., Naggie, Susanna, Tillmann, Hans L., Patel, Keyur, Muir, Andrew J., Shianna, Kevin V., Mottola, Leonardo, Petruzzellis, Daniela, Romano, Mario, Sogari, Fernando, Facciorusso, Domenico, Goldstein, David B., McHutchison, John G. and Mangia, Alessandra (2011). Inosine triphosphatase genetic variants are protective against anemia during antiviral therapy for HCV2/3 but do not decrease dose reductions of RBV or increase SVR. Hepatology, 53 (2), 389-395. doi: 10.1002/hep.24068 |
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2011 Conference Publication Dysregulation of Host Innate Immunity in Hcv Genotype 1 Infected Il28B Ct/tt Haplotype Patients with Depressed Viral Kinetics and Therapeutic ResponseNaggie, S., Osinusi, A., Katsounas, A., Lempicki, R., Herrmann, E., Shivakumar, B., Thompson, A., Clark, P., Patel, K., Muir, A., Mchutchison, J., Goldstein, D., Schlaak, J., Masur, H., Polis, M. and Kottilil, S. (2011). Dysregulation of Host Innate Immunity in Hcv Genotype 1 Infected Il28B Ct/tt Haplotype Patients with Depressed Viral Kinetics and Therapeutic Response. 46th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Berlin Germany, 2011. AMSTERDAM: ELSEVIER SCIENCE BV. doi: 10.1016/S0168-8278(11)61336-6 |
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2011 Conference Publication The Cost-Effectiveness of a Telaprevir-Inclusive Regimen as Initial Therapy for Genotype 1 Hepatitis C Infection in Individuals with the Cc Il-28B PolymorphismGellad, Ziad F., Naggie, Susanna, Reed, Shelby D., Clark, Paul J., Thompson, Alex J., Schulman, Kevin A. and Muir, Andrew J. (2011). The Cost-Effectiveness of a Telaprevir-Inclusive Regimen as Initial Therapy for Genotype 1 Hepatitis C Infection in Individuals with the Cc Il-28B Polymorphism. 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), San Francisco Ca, Nov 04-08, 2011. MALDEN: WILEY-BLACKWELL. |
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2011 Conference Publication Metabolomic Analysis Demonstrates Hepatitis C Virus Genotypes G2/3 Selectively Perturb Distal Steps in Cholesterol BiosynthesisClark, Paul J., Thompson, Alexander J., Vock, David M., Kratz, Lisa E., Tolun, Adviye A., Zhang, Hao Yue, Muir, Andrew J., Subramanian, Mani, McHutchison, John G., Millington, David S., Kelley, Richard I. and Patel, Keyur (2011). Metabolomic Analysis Demonstrates Hepatitis C Virus Genotypes G2/3 Selectively Perturb Distal Steps in Cholesterol Biosynthesis. 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), San Francisco Ca, Nov 04-08, 2011. MALDEN: WILEY-BLACKWELL. |
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2011 Conference Publication Vitamin D and Treatment Response in African American Patients with Hcv Genotype 1Jazwinski, Alison, Clark, Paul J., Tillmann, Hans L., Muir, Andrew J. and Jazwinski, Alison (2011). Vitamin D and Treatment Response in African American Patients with Hcv Genotype 1. 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), San Francisco Ca, Nov 04-08, 2011. MALDEN: WILEY-BLACKWELL. |
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2011 Conference Publication Pnpla3 Genotype Rather Than Race May Explain the Lower Prevalence of Hepatic Steatosis Despite Worse Metabolic Risk Factors in African American Patients with Chronic Hepatitis C (Chc)Clark, Paul J., Thompson, Alexander J., Urban, Thomas J., Patel, Keyur, Vock, David M., Zhu, Qianqian, Jazwinski, Alison, Naggie, Susanna, Tillmann, Hans L., McKenzie, Alexander, Conjeevaram, Hari S., Shianna, Kevin, Goldstein, David B., Afdhal, Nezam H. and Muir, Andrew J. (2011). Pnpla3 Genotype Rather Than Race May Explain the Lower Prevalence of Hepatic Steatosis Despite Worse Metabolic Risk Factors in African American Patients with Chronic Hepatitis C (Chc). 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), San Francisco Ca, Nov 04-08, 2011. MALDEN: WILEY-BLACKWELL. |
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2011 Journal Article Noninvasive tools to assess liver diseaseClark, Paul J. and Patel, Keyur (2011). Noninvasive tools to assess liver disease. Current Opinion in Gastroenterology, 27 (3), 210-216. doi: 10.1097/MOG.0b013e328343e9a3 |
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2011 Conference Publication Il28B C/c Genotype Is Predictive of >= 1 Log10 Iu/ml Reduction in Plasma Hcv Rna After 4 Weeks of Peginterferon (Pegifn) and Ribavirin (Rbv) Therapy: Implications for the Use of the Lead-In Strategy for Direct-Acting Antiviral-Based Treatment RegimensThompson, Alexander J., Clark, Paul J., Tillmann, Hans L., Patel, Keyur, Naggie, Susanna, Poordad, F. Fred, Lawitz, Eric, Bacon, Bruce R., Vierling, John M., Noviello, Stephanie, Brass, Clifford A., Albrecht, Janice K., Goldstein, David B., McHutchison, John G., Sulkowski, Mark S. and Muir, Andrew J. (2011). Il28B C/c Genotype Is Predictive of >= 1 Log10 Iu/ml Reduction in Plasma Hcv Rna After 4 Weeks of Peginterferon (Pegifn) and Ribavirin (Rbv) Therapy: Implications for the Use of the Lead-In Strategy for Direct-Acting Antiviral-Based Treatment Regimens. 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), San Francisco Ca, Nov 04-08, 2011. MALDEN: WILEY-BLACKWELL. |
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2011 Conference Publication The Relationship Between Hepatic Steatosis and Il28B Response in Patients with Chronic Hepatitis CTillmann, H. L., Patel, K., Muir, A., Guy, C., Li, J. H., Lao, X. Q., Thompson, A. J., Clark, P. J., Gardner, S. D., McHutchison, J. G. and McCarthy, J. J. (2011). The Relationship Between Hepatic Steatosis and Il28B Response in Patients with Chronic Hepatitis C. 46th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Berlin Germany, 2011. AMSTERDAM: ELSEVIER SCIENCE BV. doi: 10.1016/S0168-8278(11)61348-2 |
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2011 Journal Article IL28B polymorphisms and treatment of hepatitis CClark, Paul J., Thompson, Alexander J. V. and Muir, Andrew J. (2011). IL28B polymorphisms and treatment of hepatitis C. Current Hepatitis Reports, 10 (1), 70-78. doi: 10.1007/s11901-010-0061-3 |
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2011 Journal Article IL28B genomic-based treatment paradigms for patients with chronic hepatitis C infection: The future of personalized HCV therapiesClark, Paul J., Thompson, Alex J. and McHutchison, John G. (2011). IL28B genomic-based treatment paradigms for patients with chronic hepatitis C infection: The future of personalized HCV therapies. American Journal of Gastroenterology, 106 (1), 38-45. doi: 10.1038/ajg.2010.370 |
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2010 Journal Article Hepatitis C trials that combine investigational agents with pegylated interferon should be stratified by interleukin-28B genotypeThomison, Allxander J., Muir, Andrew J., Sulkowski, Mark. S., Path, Keyur, Jilimann, Hans L., Clark, Paul J., Naccie, Susanna, Fellay, Jacques, Ge, Dongliang, McCarthy, Jlanlite J., Goldslin, David B. and McHutchison, John G. (2010). Hepatitis C trials that combine investigational agents with pegylated interferon should be stratified by interleukin-28B genotype. Hepatology, 52 (6), 2243-2244. doi: 10.1002/hep.23826 |
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2010 Conference Publication Variants in the Itpa Gene Protect Against Early Ribavirin-Induced Hemolytic Anemia in Hiv/hcv Co-Infected PatientsNaggie, Susanna, Rallon, Norma I., Benito, Jose M., Morello, Judith, Rodriguez-Novoa, Sonia, Clark, Paul J., Thompson, Alexander J., Shianna, Kevin, Vispo, Eugenia, McHutchison, John G., Goldstein, David B. and Soriano, Vincent (2010). Variants in the Itpa Gene Protect Against Early Ribavirin-Induced Hemolytic Anemia in Hiv/hcv Co-Infected Patients. 61st Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, Boston Ma, Oct 29-Nov 02, 2010. MALDEN: WILEY-BLACKWELL. |
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2010 Journal Article Hepatitis C virus nonstructural protein 5A inhibitors: Novel target - Now for new trials and new treatment strategiesThompson, Alex J., Clark, Paul J. and McHutchison, John G. (2010). Hepatitis C virus nonstructural protein 5A inhibitors: Novel target - Now for new trials and new treatment strategies. Hepatology, 52 (3), 1162-1164. doi: 10.1002/hep.23853 |
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2010 Journal Article The diagnosis and management of hereditary haemochromatosisClark, Paul, Britton, Laurence J. and Powell, Lawrie W. (2010). The diagnosis and management of hereditary haemochromatosis. Clinical Biochemist Reviews, 31 (1), 3-8. |
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2010 Conference Publication HEPATITIS C TRIALS THAT COMBINE INVESTIGATIONAL AGENTS WITH PEGYLATED-INTERFERON-alpha SHOULD BE STRATIFIED BY IL28B GENOTYPEThompson, Alexander J., Muir, Andrew J., Sulkowski, Mark S., Patel, Keyur, Tillmann, Hans L., Clark, Paul J., Naggie, Susanna, Fellay, Jacques, Ge, Dongliang, McCarthy, Jeanette, Goldstein, David B. and McHutchison, John G. (2010). HEPATITIS C TRIALS THAT COMBINE INVESTIGATIONAL AGENTS WITH PEGYLATED-INTERFERON-alpha SHOULD BE STRATIFIED BY IL28B GENOTYPE. 61st Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, Boston Ma, Oct 29-Nov 02, 2010. MALDEN: WILEY-BLACKWELL. |
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2010 Conference Publication Independent Validation of the Safe Biopsy Algorithm: Analysis of the Achieve CohortsThompson, A., Clark, P., Tillmann, H., Torbenson, M., Pulkstenis, E., Subramanian, G. M., McHutchison, J. and Patel, K. (2010). Independent Validation of the Safe Biopsy Algorithm: Analysis of the Achieve Cohorts. 45th Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Vienna Austria, Apr 14-18, 2010. AMSTERDAM: ELSEVIER SCIENCE BV. doi: 10.1016/S0168-8278(10)61085-9 |
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2010 Journal Article Genetic variation in IL28B: Impact on drug development for chronic hepatitis C infectionClark, P. J., Thompson, A. J. V. and McHutchison, J. G. (2010). Genetic variation in IL28B: Impact on drug development for chronic hepatitis C infection. Clinical Pharmacology and Therapeutics, 88 (5), 708-711. doi: 10.1038/clpt.2010.185 |
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2010 Conference Publication Common Genetic Variants Do Not Associate with Ifn-Induced Neutropenia in a Genome-Wide Association Study of Chronic Hepatitis C Patients in the Ideal StudyThompson, Alexander J., Clark, Paul J., Singh, Abanish, Ge, Dongliang, Fellay, Jacques, Sulkowski, Mark S., Muir, Andrew J., Tillman, Hans L., Patel, Keyur, Naggie, Susanna, Shianna, Kevin, Afdhal, Nezam H., Jacobson, Ira M., Esteban, Rafael, Poordad, Fred, Lawitz, Eric, McCone, Jonathan, Shiffman, Mitchell L., Galler, Greg Wayne, King, John W., Kwo, Paul Y., Nyberg, Lisa, Noviello, Stephanie, Boparai, Navdeep, Koury, Kenneth J., Pedicone, Lisa, Brass, Clifford A., Albrecht, Janice K., Goldstein, David B. and McHutchison, John G. (2010). Common Genetic Variants Do Not Associate with Ifn-Induced Neutropenia in a Genome-Wide Association Study of Chronic Hepatitis C Patients in the Ideal Study. 61st Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, Boston Ma, Oct 29-Nov 02, 2010. MALDEN: WILEY-BLACKWELL. |
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2010 Conference Publication Il28B Genetic Polymorphism Has Genome Wide Significant Associations with Serum Low Density Lipoprotein Levels and Hepatic Steatosis in Patients with Genotype 1 Chronic Hepatitis C (Chc)Clark, Paul J., Thompson, Alexander J., Zhu, Mingfu, Zhu, Qianqian, Ge, Dongliang, Sulkowski, Mark S., Tillmann, Hans L., Patel, Keyur, Naggie, Susanna, Muir, Andrew J., Afdhal, Nezam H., Jacobson, Ira M., Esteban, Rafael, Lawitz, Eric, Poordad, Fred, Shiffman, Mitchell L., Galler, Greg Wayne, Harrison, Stephen, King, John W., Kwo, Paul Y., Nyberg, Lisa M., McCone, Jonathan, Lee, William M., Reindollar, Robert, Ghalib, Reem H., Freilich, Bradley, Goodman, Zachary, Boparai, Navdeep, Koury, Kenneth J. ... McHutchison, John G. (2010). Il28B Genetic Polymorphism Has Genome Wide Significant Associations with Serum Low Density Lipoprotein Levels and Hepatic Steatosis in Patients with Genotype 1 Chronic Hepatitis C (Chc). 61st Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, Boston Ma, Oct 29-Nov 02, 2010. MALDEN: WILEY-BLACKWELL. |
