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2016

Journal Article

Diverse cyclic seed peptides in the Mexican zinnia (Zinnia haageana)

Franke, Bastian, Jayasena, Achala S., Fisher, Mark F., Swedberg, Joakim E., Taylor, Nicolas L., Mylne, Joshua S. and Rosengren, K. Johan (2016). Diverse cyclic seed peptides in the Mexican zinnia (Zinnia haageana). Biopolymers, 106 (6), 806-817. doi: 10.1002/bip.22901

Diverse cyclic seed peptides in the Mexican zinnia (Zinnia haageana)

2016

Journal Article

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide

Kwon, Soohyun, Bosmans, Frank, Kaas, Quentin, Cheneval, Olivier, Conibear, Anne C., Rosengren, K. Johan, Wang, Conan K., Schroeder, Christina I. and Craik, David J. (2016). Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. Biotechnology and Bioengineering, 113 (10), 2202-2212. doi: 10.1002/bit.25993

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide

2016

Journal Article

Mature forms of the major seed storage albumins in sunflower: a mass spectrometric approach

Franke, Bastian, Colgrave, Michelle L., Mylne, Joshua S. and Rosengren, K. Johan (2016). Mature forms of the major seed storage albumins in sunflower: a mass spectrometric approach. Journal of Proteomics, 147, 177-186. doi: 10.1016/j.jprot.2016.05.004

Mature forms of the major seed storage albumins in sunflower: a mass spectrometric approach

2016

Journal Article

Development of a single-chain peptide agonist of the relaxin-3 receptor using hydrocarbon stapling

Hojo, Keiko, Hossain, Mohammed Akhter, Tailhades, Julien, Shabanpoor, Fazel, Wong, Lilian L. L., Ong-Palsson, Emma E. K., Kastman, Hanna E., Ma, Sherie, Gundlach, Andrew L., Rosengren, K. Johan, Wade, John D. and Bathgate, Ross A. D. (2016). Development of a single-chain peptide agonist of the relaxin-3 receptor using hydrocarbon stapling. Journal of Medicinal Chemistry, 59 (16), 7445-7456. doi: 10.1021/acs.jmedchem.6b00265

Development of a single-chain peptide agonist of the relaxin-3 receptor using hydrocarbon stapling

2016

Journal Article

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

Hossain, Mohammed Akhter, Kocan, Martina, Yao, Song T., Royce, Simon G., Nair, Vinojini B., Siwek, Christopher, Patil, Nitin A., Harrison, Ian P., Rosengren, K. Johan, Selemidis, Stavros, Summers, Roger J., Wade, John D., Bathgate, Ross A. D. and Samuel, Chrishan S. (2016). A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1. Chemical Science, 7 (6), 3805-3819. doi: 10.1039/c5sc04754d

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

2016

Journal Article

Engineering of a novel simplified human insulin-Like peptide 5 agonist

Patil, Nitin A., Hughes, Richard A., Rosengren, K. Johan, Kocan, Martina, Ang, Sheng Yu, Tailhades, Julien, Separovic, Frances, Summers, Roger J., Grosse, Johannes, Wade, John D., Bathgate, Ross A. D. and Hossain, Mohammed Akhter (2016). Engineering of a novel simplified human insulin-Like peptide 5 agonist. Journal of Medicinal Chemistry, 59 (5), 2118-2125. doi: 10.1021/acs.jmedchem.5b01786

Engineering of a novel simplified human insulin-Like peptide 5 agonist

2016

Journal Article

A tripartite approach identifies the major sunflower seed albumins

Jayasena, Achala S., Franke, Bastian, Rosengren, Johan and Mylne,Joshua S. (2016). A tripartite approach identifies the major sunflower seed albumins. Theoretical and Applied Genetics, 129 (3), 613-629. doi: 10.1007/s00122-015-2653-3

A tripartite approach identifies the major sunflower seed albumins

2016

Journal Article

Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization

Conibear, Anne C., Chaousis, Stephanie, Durek, Thomas, Rosengren, K. Johan, Craik, David J. and Schroeder, Christina I. (2016). Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization. Biopolymers, 106 (1), 89-100. doi: 10.1002/bip.22767

Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization

2016

Conference Publication

Development of peptide therapeutics for iron disorders

Goncalves, Daniela, Rishi, Gautam, Aliyanto, Randy, Rosengren, Johan, Subramaniam, Nathan, Frazer, David and Clark, Richard (2016). Development of peptide therapeutics for iron disorders. 6th Meeting of the International BioIron Society, Zhejiang University, Hangzhou, China, 8-10 September 2015. Hoboken, NJ, United States: John Wiley & Sons.

Development of peptide therapeutics for iron disorders

2016

Conference Publication

Design, synthesis and biological activity of hydrocarbon stapled single-chain relaxin-3 analogue

Hojo, K., Hossain, M. A., Rosengren, K. J., Ma, S., Gundlach, A. L., Tsuda, Y., Hidaka, K., Bathgate, R. A. and Wade, J. D. (2016). Design, synthesis and biological activity of hydrocarbon stapled single-chain relaxin-3 analogue. 34th European Peptide Symposium and 8th International Peptide Symposium, Leipzig, Germany, 4-9 September 2016. Oxford, United Kingdom: John Wiley & Sons.

Design, synthesis and biological activity of hydrocarbon stapled single-chain relaxin-3 analogue

2016

Journal Article

Natural structural diversity within a conserved cyclic peptide scaffold

Elliott, Alysha G., Franke, Bastian, Armstrong, David A., Craik, David J., Mylne, Joshua S. and Rosengren, K. Johan (2016). Natural structural diversity within a conserved cyclic peptide scaffold. Amino Acids, 49 (1), 1-14. doi: 10.1007/s00726-016-2333-x

Natural structural diversity within a conserved cyclic peptide scaffold

2016

Conference Publication

Structural Features of An Unusual Sun-Flower Proalbumin Protein That Gives Rise to a Small Cyclic Peptide and a Seed Storage Protein

Franke, B., James, A., Mobli, M., Mylne, J. S. and Rosengren, K. J. (2016). Structural Features of An Unusual Sun-Flower Proalbumin Protein That Gives Rise to a Small Cyclic Peptide and a Seed Storage Protein. 34th European Peptide Symposium, Leipzig, Germany, 4‐9 September 2016. HOBOKEN: Wiley.

Structural Features of An Unusual Sun-Flower Proalbumin Protein That Gives Rise to a Small Cyclic Peptide and a Seed Storage Protein

2015

Journal Article

Distribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae

Burman, Robert, Yeshak, Mariamawit Y., Larsson, Sonny, Craik, David J., Rosengren, K. Johan and Goeransson, Ulf (2015). Distribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae. Frontiers in Plant Science, 6 (855) 855, 1-13. doi: 10.3389/fpls.2015.00855

Distribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae

2015

Journal Article

Central relaxin-3 receptor (RXFP3) activation reduces elevated, but not basal, anxiety-like behaviour in C57BL/6J mice

Zhang, Carry, Chua, Berenice E., Yang, Annie, Shabanpoor, Fazel, Hossain, Mohammad Akhter, Wade, John D., Rosengren, K. Johan, Smith, Craig M. and Gundlach A.L. (2015). Central relaxin-3 receptor (RXFP3) activation reduces elevated, but not basal, anxiety-like behaviour in C57BL/6J mice. Behavioural Brain Research, 292, 125-132. doi: 10.1016/j.bbr.2015.06.010

Central relaxin-3 receptor (RXFP3) activation reduces elevated, but not basal, anxiety-like behaviour in C57BL/6J mice

2015

Journal Article

Chemically synthesized dicarba H2 relaxin analogues retain strong RXFP1 receptor activity but show an unexpected loss of in vitro serum stability

Hossain, Mohammed Akhter, Haugaard-Kedstrom, Linda M., Rosengren, K. Johan, Bathgate, Ross A. D. and Wade, John D. (2015). Chemically synthesized dicarba H2 relaxin analogues retain strong RXFP1 receptor activity but show an unexpected loss of in vitro serum stability. Organic and Biomolecular Chemistry, 13 (44), 10895-10903. doi: 10.1039/c5ob01539a

Chemically synthesized dicarba H2 relaxin analogues retain strong RXFP1 receptor activity but show an unexpected loss of in vitro serum stability

2015

Journal Article

Isolation, characterization, and synthesis of the barrettides: disulfide-containing peptides from the marine sponge Geodia barretti

Carstens, Bodil B., Rosengren, K. Johan, Gunasekera, Sunithi, Schempp, Stefanie, Bohlin, Lars, Dahlstrom, Mia, Clark, Richard J. and Goransson, Ulf (2015). Isolation, characterization, and synthesis of the barrettides: disulfide-containing peptides from the marine sponge Geodia barretti. Journal of Natural Products, 78 (8), 1886-1893. doi: 10.1021/acs.jnatprod.5b00210

Isolation, characterization, and synthesis of the barrettides: disulfide-containing peptides from the marine sponge Geodia barretti

2015

Journal Article

Identification, Characterization, and Three-Dimensional Structure of the Novel Circular Bacteriocin, Enterocin NKR-5-3B, from Enterococcus faecium

Himeno, Kohei, Rosengren, K. Johan, Inoue, Tomoko, Perez, Rodney H., Colgrave, Michelle L., Lee, Han Siean, Chan, Lai Y., Henriques, Sonia Troeira, Fujita, Koji, Ishibashi, Naoki, Zendo, Takeshi, Wilaipun, Pongtep, Nakayama, Jiro, Leelawatcharamas, Vichien, Jikuya, Hiroyuki, Craik, David J. and Sonomoto, Kenji (2015). Identification, Characterization, and Three-Dimensional Structure of the Novel Circular Bacteriocin, Enterocin NKR-5-3B, from Enterococcus faecium. Biochemistry, 54 (31), 4863-4876. doi: 10.1021/acs.biochem.5b00196

Identification, Characterization, and Three-Dimensional Structure of the Novel Circular Bacteriocin, Enterocin NKR-5-3B, from Enterococcus faecium

2015

Journal Article

Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens

Cardoso, Fernanda C., Deka, Zoltan, Rosengren, K. Johan, Erickson, Andelain, Vetter, Irina, Deuis, Jennifer R., Herzig, Volker, Alewood, Paul F., King, Glenn F. and Lewis, Richard J. (2015). Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens. Molecular Pharmacology, 88 (2), 291-303. doi: 10.1124/mol.115.098178

Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens

2015

Journal Article

Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition

de Veer, Simon J., Swedberg, Joakim E., Akcan, Muharrem, Rosengren, K. Johan, Brattsand, Maria, Craik, David J. and Harris, Jonathan M. (2015). Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition. Biochemical Journal, 469 (2), 243-253. doi: 10.1042/BJ20150412

Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition

2015

Journal Article

Synthesis and pharmacological characterization of a europium-labelled single-chain antagonist for binding studies of the relaxin-3 receptor RXFP3

Haugaard-Kedstrom, Linda M, Wong, Lillian L. L, Bathgate, Ross A. D and Rosengren, K. Johan (2015). Synthesis and pharmacological characterization of a europium-labelled single-chain antagonist for binding studies of the relaxin-3 receptor RXFP3. Amino Acids, 47 (6) 1961, 1267-1271. doi: 10.1007/s00726-015-1961-x

Synthesis and pharmacological characterization of a europium-labelled single-chain antagonist for binding studies of the relaxin-3 receptor RXFP3