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2010 Journal Article Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controlsCraddock, Nick, Hurles, Matthew E., Cardin, Niall, Pearson, Richard D., Plagnol, Vincent, Robson, Samuel, Vukcevic, Damjan, Barnes, Chris, Brown, Matthew A., Evans, David M. and The Wellcome Trust Case Control Consortium (2010). Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature, 464 (7289), 713-720. doi: 10.1038/nature08979 |
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2010 Journal Article Functional Gene Group Analysis Reveals a Role of Synaptic Heterotrimeric G Proteins in Cognitive AbilityRuano, Dina, Abecasis, Goncalo R., Glaser, Beate, Lips, Esther S., Cornelisse, L. Niels, de Jong, Arthur P. H., Evans, David M., Smith, George Davey, Timpson, Nicolas J., Smit, August B., Heutink, Peter, Verhage, Mathhijs and Posthuma, Danielle (2010). Functional Gene Group Analysis Reveals a Role of Synaptic Heterotrimeric G Proteins in Cognitive Ability. American Journal of Human Genetics, 86 (2), 113-125. doi: 10.1016/j.ajhg.2009.12.006 |
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2010 Journal Article A new highly penetrant form of obesity due to deletions on chromosome 16p11.2Walters, R. G., Jacquemont, S., Valsesia, A., De Smith, A. J., Martinet, D., Andersson, J., Falchi, M., Chen, F., Andrieux, J., Lobbens, S., Delobel, B., Stutzmann, F., El-Sayed Moustafa, J. S., Chevre, J.-C., Lecoeur, C., Vatin, V., Bouquillon, S., Buxton, J. L., Boute, O., Holder-Espinasse, M., Cuisset, J.-M., Lemaitre, M.-P., Ambresin, A.-E., Brioschi, A., Gaillard, M., Giusti, V., Fellmann, F., Ferrarini, A., Hadjikhani, N. ... Beckmann, J. S. (2010). A new highly penetrant form of obesity due to deletions on chromosome 16p11.2. Nature, 463 (7281), 671-675. doi: 10.1038/nature08727 |
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2010 Journal Article Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility lociReveille, John D., Sims, Anne-Marie, Danoy, Patrick, Evans, David M., Leo, Paul, Pointon, Jennifer J., Jin, Rui, Zhou, Xiaodong, Bradbury, Linda A., Appleton, Louise H., Davis, John C., Diekman, Laura, Doan, Tracey, Dowling, Alison, Duan, Ran, Duncan, Emma L., Farrar, Claire, Hadler, Johanna, Harvey, David, Karaderi, Tugce, Mogg, Rebecca, Pomeroy, Emma, Pryce, Karena, Taylor, Jacqueline, Savage, Laurie, Deloukas, Panos, Kumanduri, Vasudev, Peltonen, Leena, Ring, Sue M. ... Brown, Mathew A. (2010). Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nature Genetics, 42 (2), 123-127. doi: 10.1038/ng.513 |
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2010 Journal Article Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune controlFerreira, Mar, Mangino, M, Brumme, CJ, Zhao, ZZ, Medland, SE, Wright, MJ, Nyholt, DR, Gordon, S, Campbell, M, McEvoy, BP, Henders, A, Evans, DM, Lanchbury, JS, Pereyra, F, Walker, BD, Haas, DW, Soranzo, N, Spector, TD, de Bakker, PIW, Frazer, IH, Montgomery, GW, Martin, NG and Int HIV Controllers Study (2010). Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control. American Journal of Human Genetics, 86 (1), 88-92. doi: 10.1016/j.ajhg.2009.12.008 |
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2010 Journal Article Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individualsHeid, Iris M., Henneman, Peter, Hicks, Andrew, Coassin, Stefan, Winkler, Thomas, Aulchenko, Yurii S., Fuchsberger, Christian, Song, Kijoung, Hivert, Marie-France, Waterworth, Dawn M., Timpson, Nicholas J., Richards, J. Brent, Perry, John R. B., Tanaka, Toshiko, Amin, Najaf, Kollerits, Barbara, Pichler, Irene, Oostra, Ben A., Thorand, Barbara, Frants, Rune R., Illig, Thomas, Dupuis, Josée, Glaser, Beate, Spector, Tim, Guralnik, Jack, Egan, Josephine M., Florez, Jose C., Evans, David M., Soranzo, Nicole ... van Duijn, Cornelia M. (2010). Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals. Atherosclerosis, 208 (2), 412-420. doi: 10.1016/j.atherosclerosis.2009.11.035 |
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2010 Journal Article Triglyceride-mediated pathways and coronary disease: Collaborative analysis of 101 studiesSarwar, N., Sandhu, M. S., Ricketts, S. L., Butterworth, Adam S., Di Angelantonio, Emanuele, Matthijs Boekholdt, S., Ouwehand, W., Watkins, H., Samani, N. J., Saleheen, D., Lawlor, Debbie, Reilly, Muredach P., Hingorani, A. D., Talmud, P. J., Danesh, J., Braund, P. S., Hall, A. S., Thompson, J., Marz, W., Trip, M., Lawlor, D. A., Casas, J. P., Ebrahim, S., Arsenault, B. J., Boekholdt, S. M., Khaw, K. T., Wareham, N. J., Grallert, H., Illig, T. ... Wood, A. M. (2010). Triglyceride-mediated pathways and coronary disease: Collaborative analysis of 101 studies. The Lancet, 375 (9726), 1634-1639. doi: 10.1016/S0140-6736(10)60545-4 |
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2010 Journal Article Genome-wide association study reveals multiple loci associated with primary tooth development during infancyPillas, Demetris, Hoggart, Clive J., Evans, David M., O'Reilly, Paul F., Sipila, Kirsi, Lahdesmaki, Raija, Millwood, Iona Y., Kaakinen, Marika., Netuveli, Gopalakrishnan, Blane, David, Charoen, Pimphen, Sovio, Ulla, Pouta, Anneli, Freimer, Nelson, Hartikainen, Anna-Lisa., Laitinen, Jaana, Vaara, Sarianna, Glaser, Beate, Crawford, Peter, Timpson, Nicholas J., Ring, Susan M., Deng, Guohong, Zhang, Weihua, McCarthy, Mark I., Deloukas, Panos, Peltonen, Leena, Elliott, Paul, Coin, Lachlan J. M., Smith, George D. and Jarvelin, Marjo-Riita (2010). Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. PLoS Genetics, 6 (2) e1000856, e1000856.1-e1000856.7. doi: 10.1371/journal.pgen.1000856 |
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2010 Journal Article Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weightFreathy, Rachel M., Mook-Kanamor, Dennis O., Sovio, Ulla, Prokopenko, Inga, Timpson, Nicholas J., Berry, Diane J., Warrington, Nicole M., Widen, Elisabeth, Hottenga, Jouke Jan, Kaakinen, Marika, Lange, Leslie A., Bradfield, Jonathan P., Kerkhof, Marjan, Marsh, Julie A., Magi, Reedik, Chen, Chih-Mei, Lyon, Helen N., Kirin, Mirna, Adair, Linda S., Aulchenko, Yurii S., Bennett, Amanda J., Borja, Judith B., Bouatia-Naji, Nabila, Charoen, Pimphen, Coin, Lachlan ..J. M., Cousminer, Diana L., De Geus, Eco J. C., Deloukas, Panos, Elliott, Paul ... McCarthy, Mark I. (2010). Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nature Genetics, 42 (5), 430-435. doi: 10.1038/ng.567 |
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2010 Journal Article OPG and RANK polymorphisms are both associated with cortical bone mineral density: Findings from a metaanalysis of the avon longitudinal study of parents and children and Gothenburg osteoporosis and obesity determinants cohortsPaternoster, L., Ohlsson, C., Sayers, A., Vandenput, L., Lorentzon, M., Evans, D. M. and Tobias, J. H. (2010). OPG and RANK polymorphisms are both associated with cortical bone mineral density: Findings from a metaanalysis of the avon longitudinal study of parents and children and Gothenburg osteoporosis and obesity determinants cohorts. Journal of Clinical Endocrinology and Metabolism, 95 (8), 3940-3948. doi: 10.1210/jc.2010-0025 |
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2010 Journal Article Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential Pleiotropic effects on bonePaternoster, Lavinia, Lorentzon, Mattias, Vandenput, Liesbeth, Karlsson, Magnus K., Ljunggren, Osten, Kindmark, Andreas, Mellstrom, Dan, Kemp, John P., Jarett, Caroline E., Holly, Jeff M. P., Sayers, Adrian, St. Pourcain, Beate, Timpson, Nicholas J., Deloukas, Panos, Smith, George Davey, Ring, Ssusan M., Evans, David M., Tobias, Jon H. and Ohlsson, Claes (2010). Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential Pleiotropic effects on bone. PLoS Genetics, 6 (11) e1001217, e1001217.1-e1001217.12. doi: 10.1371/journal.pgen.1001217 |
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2010 Journal Article Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopyBouzigon, Emmanuelle, Forabosco, Paola, Koppelman, Gerard H., Cookson, William O. C. M., Dizier, Marie-Helene, Duffy, David L., Evans, David M., Ferreira, Manuel A. R., Kere, Juha, Laitinen, Tarja, Malerba, Giovanni, Meyers, Deborah A., Moffatt, Miriam, Martin, Nicholas G, Ng, Mandy Y., Pignatti, Pier Franco, Wjst, Mathias, Kauffmann, Francine, Demenais, Florence and Lewis, Cathryn M. (2010). Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy. European Journal of Human Genetics, 18 (6), 700-706. doi: 10.1038/ejhg.2009.224 |
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2009 Journal Article Leveraging therapeutic potential of multi-targeted siRNA inhibitorsGe, Qing, Xu, John J., Evans, David M., Mixson, A. James, Yang, Harry Y. and Lu, Patrick Y. (2009). Leveraging therapeutic potential of multi-targeted siRNA inhibitors. Future Medicinal Chemistry, 1 (9), 1671-1681. doi: 10.4155/fmc.09.131 |
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2009 Journal Article Genome-wide association study identifies five loci associated with lung functionRepapi, E., Sayers, I., Wain, L. V., Burton, P. R., Johnson, T., Obeidat, M., Zhao, J. H., Ramasamy, A., Evans, David M., Wellcome Trust Case Control Consortium, Brown, Matthew A. and Bradbury, Linda (2009). Genome-wide association study identifies five loci associated with lung function. Nature Genetics, 42 (1), 36-45. doi: 10.1038/ng.501 |
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2009 Journal Article Genetic Variant m <i>HK1</i> Is Associated With a Proanemic State and A1C but Not Other Glycemic Control-Related TraitsBonnefond, Amelie, Vaxillaire, Martine, Labrune, Yann, Lecoeur, Cecile, Chevre, Jean-Claude, Bouatia-Naji, Nabila, Cauchi, Stephane, Balkau, Beverley, Marre, Michel, Tichet, Jean, Riveline, Jean-Pierre, Hadjadj, Samy, Gallois, Yves, Czernichow, Sebastien, Hercberg, Serge, Kaakinen, Marika, Wiesner, Susanne, Charpentier, Guillaume, Levy-Marchal, Claire, Elliott, Paul, Jarvelin, Marjo-Riitta, Horber, Fritz, Dina, Christian, Pedersen, Oluf, Sladek, Robert, Meyre, David and Froguel, Philippe (2009). Genetic Variant m HK1 Is Associated With a Proanemic State and A1C but Not Other Glycemic Control-Related Traits. Diabetes, 58 (11), 2687-2697. doi: 10.2337/db09-0652 |
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2009 Journal Article Sequence Variants in Three Loci Influence Monocyte Counts and Erythrocyte VolumeFerreira, MAR, Hottenga, JJ, Warrington, NM, Medland, SE, Willemsen, G, Lawrence, RW, Gordon, S, de Geus, EJC, Henders, AK, Smit, JH, Campbell, MJ, Wallace, L, Evans, DM, Wright, MJ, Nyholt, DR, James, AL, Beilby, JP, Penninx, BW, Palmer, LJ, Frazer, IH, Montgomery, GW, Martin, NG and Boomsma, DI (2009). Sequence Variants in Three Loci Influence Monocyte Counts and Erythrocyte Volume. AMERICAN JOURNAL OF HUMAN GENETICS, 85 (5), 745-749. doi: 10.1016/j.ajhg.2009.10.005 |
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2009 Journal Article Investigating the genetic association between ERAP1 and ankylosing spondylitisHarvey, David, Pointon, Jennifer J., Evans, David M., Karaderi, Tugce, Farrar, Claire, Appleton, Louise H., Sturrock, Roger D., Stone, Millicent A., Oppermann, Udo, Brown, Matthew A. and Wordsworth, B. Paul (2009). Investigating the genetic association between ERAP1 and ankylosing spondylitis. Human Molecular Genetics, 18 (21), 4204-4212. doi: 10.1093/hmg/ddp371 |
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2009 Journal Article Association and interaction analyses of eight genes under asthma linkage peaksFerreira, M. A. R., Zhao, Z. Z., Thomsen, S. F., James, M., Evans, D. M., Postmus, P. E., Kyvik, K. O., Backer, V., Boomsma, D. I., Martin, N. G., Montgomery, G. W. and Duffy, D. L. (2009). Association and interaction analyses of eight genes under asthma linkage peaks. Allergy, 64 (11), 1623-1628. doi: 10.1111/j.1398-9995.2009.02091.x |
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2009 Journal Article Genetic variant near <i>IRS1</i> is associated with type 2 diabetes, insulin resistance and hyperinsulinemiaRung, Johan, Cauchi, Stephane, Albrechtsen, Anders, Shen, Lishuang, Rocheleau, Ghislain, Cavalcanti-Proenca, Christine, Bacot, Francois, Balkau, Beverley, Belisle, Alexandre, Borch-Johnsen, Knut, Charpentier, Guillaume, Dina, Christian, Durand, Emmanuelle, Elliott, Paul, Hadjadj, Samy, Jaervelin, Marjo-Riitta, Laitinen, Jaana, Lauritzen, Torsten, Marre, Michel, Mazur, Alexander, Meyre, David, Montpetit, Alexandre, Pisinger, Charlotta, Posner, Barry, Poulsen, Pernille, Pouta, Anneli, Prentki, Marc, Ribel-Madsen, Rasmus, Ruokonen, Aimo ... Sladek, Robert (2009). Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nature Genetics, 41 (10), 1110-U89. doi: 10.1038/ng.443 |
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2009 Journal Article Association of IL23R and ERAP1 genes with ankylosing spondylitis in a Portuguese populationPimentel-Santos, F. M., Ligeiro, D., Matos, M., Mourao, A. F., Sousa, E., Pinto, P., Ribeiro, A., Sousa, M., Barcelos, A., Godinho, F., Cruz, M., Fonseca, J. E., Guedes-Pinto, H., Trindade, H., Evans, D. M., Brown, M. A. and Branco, J. C. (2009). Association of IL23R and ERAP1 genes with ankylosing spondylitis in a Portuguese population. Clinical And Experimental Rheumatology, 27 (5), 800-806. |
