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2006 Conference Publication Increased hypoxia, HIF-1 alpha protein and VEGF transcripts in bone marrow mobilized with G-CSF or cyclophosphamide (CY)Levesque, Jean-Pierre, Winkler, Ingrid G., Hendy, Jean and Nilsson, Susan K. (2006). Increased hypoxia, HIF-1 alpha protein and VEGF transcripts in bone marrow mobilized with G-CSF or cyclophosphamide (CY). 48th Annual Meeting of the American Society of Hematology, Orlando, FL United States, 9-12 December 2006. Washington, DC United States: American Society of Hematology. |
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2006 Journal Article Mechanisms of hematopoietic stem cell mobilization: When innate immunity assails the cells that make blood and boneWinkler, IG and Levesque, JP (2006). Mechanisms of hematopoietic stem cell mobilization: When innate immunity assails the cells that make blood and bone. Experimental Hematology, 34 (8), 996-1009. doi: 10.1016/j.exphem.2006.04.005 |
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2005 Conference Publication G-CSF potently suppresses osteoblast activity in the bone marrowChristopher, M. J., Liu, F., Short, B., Simmons, P. J., Winkler, I., Levesque, J. P. and Link, D. C. (2005). G-CSF potently suppresses osteoblast activity in the bone marrow. 47th Annual Meeting of the American-Society-of-Hematology, Atlanta, GA, United States, 10-13 December 2005. Washington, DC, United States: American Society of Hematology. |
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2005 Journal Article Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilizationWinkler, IG, Hendy, J, Coughlin, P, Horvath, A and Levesque, JP (2005). Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization. Journal of Experimental Medicine, 201 (7), 1077-1088. doi: 10.1084/jem.20042299 |
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2005 Journal Article Contrasting effects of P-selectin and E-selectin on the differentiation of murine hematopoietic progenitor cellsEto, Tetsuya, Winkler, Ingrid, Purton, Louise E. and Levesque, Jean-Pierre (2005). Contrasting effects of P-selectin and E-selectin on the differentiation of murine hematopoietic progenitor cells. Experimental Hematology, 33 (2), 232-242. doi: 10.1016/j.exphem.2004.10.018 |
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2005 Journal Article G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrowSemerad, CL, Christopher, MJ, Liu, FL, Short, B, Simmons, PJ, Winkler, I, Levesque, JP, Chappel, J, Ross, FP and Link, DC (2005). G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow. Blood, 106 (9), 3020-3027. doi: 10.1182/blood-2004-01-0272 |
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2005 Journal Article Epitope recognition of antibodies that define the sialomucin, endolyn (CD164), a negative regulator of haematopoiesisJorgensen-Tye, B, Levesque, JP, Royle, L, Doyonnas, R, Chan, JYH, Dwek, RA, Rudd, PM, Harvey, DJ, Simmons, PJ and Watt, SM (2005). Epitope recognition of antibodies that define the sialomucin, endolyn (CD164), a negative regulator of haematopoiesis. Tissue Antigens, 65 (3), 220-239. doi: 10.1111/j.1399-0039.2005.00358.x |
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2004 Conference Publication Protease-dependent and protease-independent mechanisms of hematopoietic progenitor cell (HPC) mobilizationLevesque, JP, Liu, F, Winkler, IG, Simmons, PJ, Betsuyaku, T, Senior, R, Pham, C and Link, DC (2004). Protease-dependent and protease-independent mechanisms of hematopoietic progenitor cell (HPC) mobilization. 33rd Annual Meeting of the International Society for Experimental Hematology, New Orleans, LA, United States, 17-20 July 2004. Philadelphia, PA, United States: Elsevier. |
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2004 Journal Article Characterization of hematopoietic progenitor mobilization in protease-deficient miceLevesque, JP, Liu, F, Simmons, PJ, Betsuyaku, T, Senior, RM, Pham, C and Link, DC (2004). Characterization of hematopoietic progenitor mobilization in protease-deficient mice. Blood, 104 (1), 65-72. doi: 10.1182/blood-2003-05-1589 |
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2004 Journal Article Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells independent of PSGL-1Winkler, IG, Snapp, KR, Simmons, PJ and Levesque, JP (2004). Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells independent of PSGL-1. Blood, 103 (5), 1685-1692. doi: 10.1182/blood-2003-06-1921 |
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2003 Conference Publication P-selectin delays the in vitro differentiation of murine lin- Sca-1+c-KIT+ cells whereas E-selectin accelerates their differentiationEto, T, Winkler, , Purton, L, Simmons, P and Levesque, JP (2003). P-selectin delays the in vitro differentiation of murine lin- Sca-1+c-KIT+ cells whereas E-selectin accelerates their differentiation. 32nd Annual Scientific Meeting of the International Society for Experimental Hematology, Paris, France, 5-8 July 2003. Philadelphia, PA, United States: Elsevier. |
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2003 Journal Article Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cellsLevesque, JP, Hendy, J, Winkler, IG, Takamatsu, Y and Simmons, PJ (2003). Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells. Experimental Hematology, 31 (2), 109-117. doi: 10.1016/S0301-472X(02)01028-7 |
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2003 Journal Article Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by gcsf or cyclophosphamideLevesque, JP, Hendy, J, Takamatsu, Y, Simmons, PJ and Bendall, LJ (2003). Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by gcsf or cyclophosphamide. Journal of Clinical Investigation, 111 (2), 187-196. doi: 10.1172/JCI200315994 |
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2002 Conference Publication Proteases that cleave c-KIT receptor (CD117) from the surface of hemopoietic progenitor cells are released in the bone marrow during G-CSF-induced mobilizationLevesque, J. P., Hendy, J., Winkler, I. G., Takamatsu, Y. and Simmons, P. J. (2002). Proteases that cleave c-KIT receptor (CD117) from the surface of hemopoietic progenitor cells are released in the bone marrow during G-CSF-induced mobilization. 44th Annual Meeting of the American-Society-of-Hematology, Philadelphia, PA, United States, 6-10 December 2002. Washington, DC, United States: American Society of Hematology. |
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2002 Journal Article A novel monoclonal antibody recognizing a cation-dependent epitope within the regulatory loop of human beta(1) integrin (CD29)Levesque, JP, Takada, Y, Puzon-McLaughlin, W and Simmons, PJ (2002). A novel monoclonal antibody recognizing a cation-dependent epitope within the regulatory loop of human beta(1) integrin (CD29). Hybridoma and Hybridomics, 21 (4), 253-260. doi: 10.1089/153685902760213868 |
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2002 Journal Article Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environmentLevesque, JP, Hendy, J, Takamatsu, Y, Williams, B, Winkler, IG and Simmons, PJ (2002). Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment. Experimental Hematology, 30 (5), 440-449. doi: 10.1016/S0301-472X(02)00788-9 |
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2001 Conference Publication VCAM-1 cleavage and release of neutrophil serine proteases elastase and cathepsin G in the bone marrow are common features of hemopoietic progenitor cell mobilization induced by G-CSF or chemotherapyLevesque, J. P., Hendy, J., Takamatsu, Y., Williams, B., Winkler, I. G. and Simmons, P. J. (2001). VCAM-1 cleavage and release of neutrophil serine proteases elastase and cathepsin G in the bone marrow are common features of hemopoietic progenitor cell mobilization induced by G-CSF or chemotherapy. *, *, *. Washington, DC, United States: American Society of Hematology. |
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2001 Conference Publication Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cellsWinkler, IG, Eto, T, Purton, LE, Haylock, DN, Snapp, KR, Kansas, GS, Simmons, PJ and Levesque, JP (2001). Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells. Unknown, Unknown, Unknown. Washington, DC United States: American Society of Hematology. |
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2001 Journal Article Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factorLevesque, Jean-Pierre, Takamatsu, Yasushi, Nilsson, Yasushi, Haylock, Yasushi and Simmons, Yasushi (2001). Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor. Blood, 98 (5), 1289-1297. doi: 10.1182/blood.V98.5.1289 |
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2001 Journal Article Role of integrins and selectins in the development and regulation of the hematopoietic systemLévesque, J. P., Takamatsu, Y., Nilsson, S. K., Haylock, D. N. and Simmons, P. J. (2001). Role of integrins and selectins in the development and regulation of the hematopoietic system. Hematologie, 7 (2), 99-109. |
