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2026 Journal Article Mitochondrial fission mediates an evolutionarily conserved antibacterial defense responseKapetanovic, Ronan, Afroz, Syeda Farhana, Curson, James E. B., Kirmes, Ina, Ramnath, Divya, Nothjunge, Stephan, Liu, Jinting, Atkinson, Jordan D., Ahier, Arnaud, Raven, Karoline D., Bosch, Marta, Keller, Bernhard, Lawrence, Grace M. E. P., Gupta, Kaustav Das, Shakespear, Melanie R., Ferguson, Charles, Stocks, Claudia J., Bokil, Nilesh J., Matthias, Gabriele, Nguyen, Tam T. K., Khalil, Zeinab G., Reid, Robert C., Hansford, Karl A., Hansbro, Philip M., Cooper, Matthew A., Schembri, Mark A., Blumenthal, Antje, Schroder, Kate, Fairlie, David P. ... Sweet, Matthew J. (2026). Mitochondrial fission mediates an evolutionarily conserved antibacterial defense response. Science Immunology, 11 (118) eaed2623. doi: 10.1126/sciimmunol.aed2623 |
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2026 Journal Article Bacterial reporter–paired scRNA sequencing reveals cross talk between zinc starvation and zinc toxicity in macrophage antibacterial defensevon Pein, Jessica B., Andersen, Stacey B., Xu, Jon, Phan, Minh-Duy, Dalton, Emma K., Koczerka, Michael, Stocks, Claudia J., Curson, James E. B., Vandeleur, Zoe, Condon, Nicholas D., Hancock, Steven J., Nefzger, Christian M., Palpant, Nathan J., Ramnath, Divya, Kapetanovic, Ronan, Schembri, Mark A. and Sweet, Matthew J. (2026). Bacterial reporter–paired scRNA sequencing reveals cross talk between zinc starvation and zinc toxicity in macrophage antibacterial defense. Proceedings of the National Academy of Sciences, 123 (11) e2530503123, 1-12. doi: 10.1073/pnas.2530503123 |
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2025 Journal Article Inducible antibacterial responses in macrophagesSweet, Matthew J., Ramnath, Divya, Singhal, Amit and Kapetanovic, Ronan (2025). Inducible antibacterial responses in macrophages. Nature Reviews Immunology, 25 (2) e12771, 92-107. doi: 10.1038/s41577-024-01080-y |
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2024 Journal Article CFTR is required for zinc-mediated antibacterial defense in human macrophagesDas Gupta, Kaustav, Curson, James E. B., Tarique, Abdullah A., Kapetanovic, Ronan, Schembri, Mark A., Fantino, Emmanuelle, Sly, Peter D. and Sweet, Matthew J. (2024). CFTR is required for zinc-mediated antibacterial defense in human macrophages. Proceedings of the National Academy of Sciences, 121 (8) e2315190121, 1-11. doi: 10.1073/pnas.2315190121 |
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2023 Journal Article HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophagesDas Gupta, Kaustav, Ramnath, Divya, von Pein, Jessica B., Curson, James E. B., Wang, Yizhuo, Abrol, Rishika, Kakkanat, Asha, Moradi, Shayli Varasteh, Gunther, Kimberley S., Murthy, Ambika M. V., Stocks, Claudia J., Kapetanovic, Ronan, Reid, Robert C., Iyer, Abishek, Ilka, Zoe C., Nauseef, William M., Plan, Manuel, Luo, Lin, Stow, Jennifer L., Schroder, Kate, Karunakaran, Denuja, Alexandrov, Kirill, Shakespear, Melanie R., Schembri, Mark A., Fairlie, David P. and Sweet, Matthew J. (2023). HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages. Proceedings of the National Academy of Sciences, 120 (4) e2212813120, 1-12. doi: 10.1073/pnas.2212813120 |
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2020 Journal Article Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defenseBosch, Marta, Sánchez-Álvarez, Miguel, Fajardo, Alba, Kapetanovic, Ronan, Steiner, Bernhard, Dutra, Filipe, Moreira, Luciana, López, Juan Antonio, Campo, Rocío, Marí, Montserrat, Morales-Paytuví, Frederic, Tort, Olivia, Gubern, Albert, Templin, Rachel M., Curson, James E. B., Martel, Nick, Català, Cristina, Lozano, Francisco, Tebar, Francesc, Enrich, Carlos, Vázquez, Jesús, Del Pozo, Miguel A., Sweet, Matthew J., Bozza, Patricia T., Gross, Steven P., Parton, Robert G. and Pol, Albert (2020). Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense. Science, 370 (6514) 8085, 309-+. doi: 10.1126/science.aay8085 |
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2020 Journal Article Class IIa histone deacetylases drive toll-like receptor-inducible glycolysis and macrophage inflammatory responses via pyruvate kinase M2Das Gupta, Kaustav, Shakespear, Melanie R., Curson, James E.B., Murthy, Ambika M.V., Iyer, Abishek, Hodson, Mark P., Ramnath, Divya, Tillu, Vikas A., von Pein, Jessica B., Reid, Robert C., Tunny, Kathryn, Hohenhaus, Daniel M., Moradi, Shayli Varasteh, Kelly, Gregory M., Kobayashi, Takumi, Gunter, Jennifer H., Stevenson, Alexander J., Xu, Weijun, Luo, Lin, Jones, Alun, Johnston, Wayne A., Blumenthal, Antje, Alexandrov, Kirill, Collins, Brett M., Stow, Jennifer L., Fairlie, David P. and Sweet, Matthew J. (2020). Class IIa histone deacetylases drive toll-like receptor-inducible glycolysis and macrophage inflammatory responses via pyruvate kinase M2. Cell Reports, 30 (8), 2712-2728.e8. doi: 10.1016/j.celrep.2020.02.007 |
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2019 Journal Article Uropathogenic Escherichia coli employs both evasion and resistance to subvert innate immune-mediated zinc toxicity for disseminationStocks, Claudia J., Phan, Minh-Duy, Achard, Maud E. S., Nhu, Nguyen Thi Khanh, Condon, Nicholas D., Gawthorne, Jayde A., Lo, Alvin W., Peters, Kate M., McEwan, Alastair G., Kapetanovic, Ronan, Schembri, Mark A. and Sweet, Matthew J. (2019). Uropathogenic Escherichia coli employs both evasion and resistance to subvert innate immune-mediated zinc toxicity for dissemination. Proceedings of the National Academy of Sciences, 116 (13), 6341-6350. doi: 10.1073/pnas.1820870116 |
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Featured 2018 Journal Article Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genesRamnath, Divya, Irvine, Katharine M., Lukowski, Samuel W., Horsfall, Leigh U., Loh, Zhixuan, Clouston, Andrew D., Patel, Preya J., Fagan, Kevin J., Iyer, Abishek, Lampe, Guy, Stow, Jennifer L., Schroder, Kate, Fairlie, David P., Powell, Joseph E., Powell, Elizabeth E. and Sweet, Matthew J. (2018). Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes. JCI Insight, 3 (14) e120274. doi: 10.1172/jci.insight.120274 |
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2017 Journal Article SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophagesLuo, Lin, Bokil, Nilesh J., Wall, Adam A., Kapetanovic, Ronan, Lansdaal, Natalie M., Marceline, Faustine, Burgess, Belinda J., Tong, Samuel J., Guo, Zhong, Alexandrov, Kirill, Ross, Ian L., Hibbs, Margaret L., Stow, Jennifer L. and Sweet, Matthew J. (2017). SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages. Nature Communications, 8 (1) 14133, 14133. doi: 10.1038/ncomms14133 |
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2026 Journal Article Multiple defects in macrophage antibacterial responses support intracellular survival of Mycobacterium abscessus in cystic fibrosisTarique, Abdullah A., Emming, Stefan, Kelk, Dean, Logan, Jayden, Ramanth, Divya, Dalton, Emma K., Das Gupta, Kaustav, Blake, Tamara, Curson, James E. B., Afroz, Syeda Farhana, Sweet, Matthew J., Wainwright, Claire E., Kapetanovic, Ronan, Kremer, Laurent, Bell, Scott C., Fantino, Emmanuelle and Sly, Peter D. (2026). Multiple defects in macrophage antibacterial responses support intracellular survival of Mycobacterium abscessus in cystic fibrosis. Proceedings of the National Academy of Sciences of the United States of America, 123 (22). doi: 10.1073/pnas.2537320123 |
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2026 Journal Article Myeloid HDAC7 drives liver inflammation and systemic glucose dysregulation during diet‐induced obesityWang, Yizhuo, Ramnath, Divya, Das Gupta, Kaustav, Prakrithi, P., Bisht, Kavita, Miller, Gregory C., Xiong, Zherui, Wan, Yujun, Tejo, Ellen N., Curson, James E. B., Abrol, Rishika, Keshvari, Sahar, Gunther, Kimberley S., Atkinson, Jordan D., Loh, Zhixuan, Engel, Jessica A., Engwerda, Christian R., Burgener, Sabrina Sofia, Schroder, Kate, Fairlie, David P., Clouston, Andrew D., Powell, Elizabeth E., Irvine, Katharine M., Sullivan, Mitchell A., Lévesque, Jean‐Pierre, Nguyen, Quan, Sweet, Matthew J. and Karunakaran, Denuja (2026). Myeloid HDAC7 drives liver inflammation and systemic glucose dysregulation during diet‐induced obesity. Clinical and Translational Immunology, 15 (6) e70100, 1-20. doi: 10.1002/cti2.70100 |
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2026 Journal Article Ascites bactericidal capacity in patients with decompensated cirrhosisRatnasekera I, Isanka U., Phan M-D, Min-Duy, Nhu, Nguyen T.K., Jessen, Eline E., Keshvari, Sahar, Ong, Yvette, Kidd, Timothy J., Hancock, Steven J., Morris, Samuel A.S., Sester, David P., Hume, David A., Powell, Elizabeth E., Sweet, Matthew J., Schembri, Mark A. and Irvine, Katharine M. (2026). Ascites bactericidal capacity in patients with decompensated cirrhosis. Cellular and Molecular Gastroenterology and Hepatology, 20 (9) 101812, 101812. doi: 10.1016/j.jcmgh.2026.101812 |
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2026 Conference Publication Ascites bactericidal capacity in patients with decompensated cirrhosisRatnasekera, Isanka, Phan, Min-Duy, Nguyen, Nhu, Jessen, Eline, Keshvari, Sahar, Ong, Yvette, Kidd, Timothy, Hancock, Steven, Hume, David, Powell, Elizabeth, Sweet, Matthew, Schembri, Mark and Irvine, Katharine (2026). Ascites bactericidal capacity in patients with decompensated cirrhosis. 61st Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Vienna Austria, Sep 15-19, 2025. AMSTERDAM: ELSEVIER. |
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2026 Journal Article FRI-403 Ascites bactericidal capacity in patients with decompensated cirrhosisRatnasekera, Isanka, Phan, Min-Duy, Nguyen, Nhu, Jessen, Eline, Keshvari, Sahar, Ong, Yvette, Kidd, Timothy, Hancock, Steven, Hume, David, Powell, Elizabeth, Sweet, Matthew, Schembri, Mark and Irvine, Katharine (2026). FRI-403 Ascites bactericidal capacity in patients with decompensated cirrhosis. Journal of Hepatology, 84, S170-S171. doi: 10.1016/s0168-8278(26)00664-1 |
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2026 Journal Article Skin inflammatory cytokine gene expression in chronic whiplash-associated disorder: a cross-sectional studyFarrell, Scott F., Das Gupta, Kaustav, Schmid, Annina B., Sweet, Matthew J. and Sterling, Michele (2026). Skin inflammatory cytokine gene expression in chronic whiplash-associated disorder: a cross-sectional study. European Spine Journal, 1-10. doi: 10.1007/s00586-026-09927-9 |
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2026 Journal Article NeuO-mediated O-acetylation of uropathogenic Escherichia coli K1 capsule enhances resistance to phage and neutrophil killingWalker, Lachlan L., Nhu, Nguyen Thi Khanh, Lian, Zheng Jie, Peters, Kate M., Monteleone, Mercedes, Connolly, James P. R., Walker, Mark J., Forde, Brian M., Schroder, Kate, Sweet, Matthew J., Phan, Minh-Duy and Schembri, Mark A. (2026). NeuO-mediated O-acetylation of uropathogenic Escherichia coli K1 capsule enhances resistance to phage and neutrophil killing. Journal of Bacteriology, 208 (3) e00610-25, 1-13. doi: 10.1128/jb.00610-25 |
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2025 Journal Article Histone deacetylase 7 mediates lipopolysaccharide-inducible mitochondrial fission in macrophagesAbrol, Rishika, Afroz, Syeda Farhana, Curson, James E. B., Raven, Karoline D., Das Gupta, Kaustav, Gunther, Kimberley S., Jones, Alun, Reid, Robert C., Xiong, Zherui, Gunter, Jennifer H., Engel, Jessica A., Engwerda, Christian R., Blumenthal, Antje, Fairlie, David P., Parton, Robert G., Zuryn, Steven, Kapetanovic, Ronan, Ramnath, Divya and Sweet, Matthew J. (2025). Histone deacetylase 7 mediates lipopolysaccharide-inducible mitochondrial fission in macrophages. Journal of Cell Science, 138 (19) jcs.264376, 1-14. doi: 10.1242/jcs.264376 |
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2025 Journal Article Emergence of a carbapenem-resistant atypical uropathogenic Escherichia coli clone as an increasing cause of urinary tract infectionWalker, Lachlan L., Phan, Minh-Duy, Permana, Budi, Lian, Zheng Jie, Nhu, Nguyen Thi Khanh, Cuddihy, Thom, Peters, Kate M., Ramsay, Kay A., Stewart, Chelsea, Pfennigwerth, Niels, Kidd, Timothy J., Harris, Patrick N. A., Paterson, David L., Sweet, Matthew J., Forde, Brian M. and Schembri, Mark A. (2025). Emergence of a carbapenem-resistant atypical uropathogenic Escherichia coli clone as an increasing cause of urinary tract infection. Nature Communications, 16 (1) 8200, 1-10. doi: 10.1038/s41467-025-63477-0 |
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2025 Journal Article TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activationSchultz, Thomas E., Mathmann, Carmen D., Domínguez Cadena, Leslie C., Muusse, Timothy W., Kim, Hyoyoung, Wells, James W., Ulett, Glen C., Hamerman, Jessica A., Brooks, Andrew J., Kobe, Bostjan, Sweet, Matthew J., Stacey, Katryn J. and Blumenthal, Antje (2025). TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation. EMBO Reports, 26 (10) 2250056, 2740-2766. doi: 10.1038/s44319-025-00444-2 |
