|
2025 Journal Article Inducible antibacterial responses in macrophagesSweet, Matthew J., Ramnath, Divya, Singhal, Amit and Kapetanovic, Ronan (2025). Inducible antibacterial responses in macrophages. Nature Reviews Immunology, 25 (2) e12771, 92-107. doi: 10.1038/s41577-024-01080-y |
|
2024 Journal Article CFTR is required for zinc-mediated antibacterial defense in human macrophagesDas Gupta, Kaustav, Curson, James E. B., Tarique, Abdullah A., Kapetanovic, Ronan, Schembri, Mark A., Fantino, Emmanuelle, Sly, Peter D. and Sweet, Matthew J. (2024). CFTR is required for zinc-mediated antibacterial defense in human macrophages. Proceedings of the National Academy of Sciences, 121 (8) e2315190121, 1-11. doi: 10.1073/pnas.2315190121 |
|
2023 Journal Article HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophagesDas Gupta, Kaustav, Ramnath, Divya, von Pein, Jessica B., Curson, James E. B., Wang, Yizhuo, Abrol, Rishika, Kakkanat, Asha, Moradi, Shayli Varasteh, Gunther, Kimberley S., Murthy, Ambika M. V., Stocks, Claudia J., Kapetanovic, Ronan, Reid, Robert C., Iyer, Abishek, Ilka, Zoe C., Nauseef, William M., Plan, Manuel, Luo, Lin, Stow, Jennifer L., Schroder, Kate, Karunakaran, Denuja, Alexandrov, Kirill, Shakespear, Melanie R., Schembri, Mark A., Fairlie, David P. and Sweet, Matthew J. (2023). HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages. Proceedings of the National Academy of Sciences, 120 (4) e2212813120, 1-12. doi: 10.1073/pnas.2212813120 |
|
2020 Journal Article Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defenseBosch, Marta, Sánchez-Álvarez, Miguel, Fajardo, Alba, Kapetanovic, Ronan, Steiner, Bernhard, Dutra, Filipe, Moreira, Luciana, López, Juan Antonio, Campo, Rocío, Marí, Montserrat, Morales-Paytuví, Frederic, Tort, Olivia, Gubern, Albert, Templin, Rachel M., Curson, James E. B., Martel, Nick, Català, Cristina, Lozano, Francisco, Tebar, Francesc, Enrich, Carlos, Vázquez, Jesús, Del Pozo, Miguel A., Sweet, Matthew J., Bozza, Patricia T., Gross, Steven P., Parton, Robert G. and Pol, Albert (2020). Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense. Science, 370 (6514) 8085, 309-+. doi: 10.1126/science.aay8085 |
|
2020 Journal Article Class IIa histone deacetylases drive toll-like receptor-inducible glycolysis and macrophage inflammatory responses via pyruvate kinase M2Das Gupta, Kaustav, Shakespear, Melanie R., Curson, James E.B., Murthy, Ambika M.V., Iyer, Abishek, Hodson, Mark P., Ramnath, Divya, Tillu, Vikas A., von Pein, Jessica B., Reid, Robert C., Tunny, Kathryn, Hohenhaus, Daniel M., Moradi, Shayli Varasteh, Kelly, Gregory M., Kobayashi, Takumi, Gunter, Jennifer H., Stevenson, Alexander J., Xu, Weijun, Luo, Lin, Jones, Alun, Johnston, Wayne A., Blumenthal, Antje, Alexandrov, Kirill, Collins, Brett M., Stow, Jennifer L., Fairlie, David P. and Sweet, Matthew J. (2020). Class IIa histone deacetylases drive toll-like receptor-inducible glycolysis and macrophage inflammatory responses via pyruvate kinase M2. Cell Reports, 30 (8), 2712-2728.e8. doi: 10.1016/j.celrep.2020.02.007 |
|
2019 Journal Article Uropathogenic Escherichia coli employs both evasion and resistance to subvert innate immune-mediated zinc toxicity for disseminationStocks, Claudia J., Phan, Minh-Duy, Achard, Maud E. S., Nhu, Nguyen Thi Khanh, Condon, Nicholas D., Gawthorne, Jayde A., Lo, Alvin W., Peters, Kate M., McEwan, Alastair G., Kapetanovic, Ronan, Schembri, Mark A. and Sweet, Matthew J. (2019). Uropathogenic Escherichia coli employs both evasion and resistance to subvert innate immune-mediated zinc toxicity for dissemination. Proceedings of the National Academy of Sciences, 116 (13), 6341-6350. doi: 10.1073/pnas.1820870116 |
|
Featured 2018 Journal Article Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genesRamnath, Divya, Irvine, Katharine M., Lukowski, Samuel W., Horsfall, Leigh U., Loh, Zhixuan, Clouston, Andrew D., Patel, Preya J., Fagan, Kevin J., Iyer, Abishek, Lampe, Guy, Stow, Jennifer L., Schroder, Kate, Fairlie, David P., Powell, Joseph E., Powell, Elizabeth E. and Sweet, Matthew J. (2018). Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes. JCI Insight, 3 (14) e120274. doi: 10.1172/jci.insight.120274 |
|
2017 Journal Article SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophagesLuo, Lin, Bokil, Nilesh J., Wall, Adam A., Kapetanovic, Ronan, Lansdaal, Natalie M., Marceline, Faustine, Burgess, Belinda J., Tong, Samuel J., Guo, Zhong, Alexandrov, Kirill, Ross, Ian L., Hibbs, Margaret L., Stow, Jennifer L. and Sweet, Matthew J. (2017). SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages. Nature Communications, 8 (1) 14133, 14133. doi: 10.1038/ncomms14133 |
|
2025 Journal Article Histone deacetylase 7 mediates lipopolysaccharide-inducible mitochondrial fission in macrophagesAbrol, Rishika, Afroz, Syeda Farhana, Curson, James E. B., Raven, Karoline D., Das Gupta, Kaustav, Gunther, Kimberley S., Jones, Alun, Reid, Robert C., Xiong, Zherui, Gunter, Jennifer H., Engel, Jessica A., Engwerda, Christian R., Blumenthal, Antje, Fairlie, David P., Parton, Robert G., Zuryn, Steven, Kapetanovic, Ronan, Ramnath, Divya and Sweet, Matthew J. (2025). Histone deacetylase 7 mediates lipopolysaccharide-inducible mitochondrial fission in macrophages. Journal of Cell Science, 138 (19) jcs.264376, 1-14. doi: 10.1242/jcs.264376 |
|
2025 Journal Article Emergence of a carbapenem-resistant atypical uropathogenic Escherichia coli clone as an increasing cause of urinary tract infectionWalker, Lachlan L., Phan, Minh-Duy, Permana, Budi, Lian, Zheng Jie, Nhu, Nguyen Thi Khanh, Cuddihy, Thom, Peters, Kate M., Ramsay, Kay A., Stewart, Chelsea, Pfennigwerth, Niels, Kidd, Timothy J., Harris, Patrick N. A., Paterson, David L., Sweet, Matthew J., Forde, Brian M. and Schembri, Mark A. (2025). Emergence of a carbapenem-resistant atypical uropathogenic Escherichia coli clone as an increasing cause of urinary tract infection. Nature Communications, 16 (1) 8200, 1-10. doi: 10.1038/s41467-025-63477-0 |
|
2025 Journal Article TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activationSchultz, Thomas E., Mathmann, Carmen D., Domínguez Cadena, Leslie C., Muusse, Timothy W., Kim, Hyoyoung, Wells, James W., Ulett, Glen C., Hamerman, Jessica A., Brooks, Andrew J., Kobe, Bostjan, Sweet, Matthew J., Stacey, Katryn J. and Blumenthal, Antje (2025). TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation. EMBO Reports, 26 (10) 2250056, 2740-2766. doi: 10.1038/s44319-025-00444-2 |
|
2025 Journal Article Rational design of advanced gene delivery carriers: Macrophage phenotype mattersWang, Yue, Yao, Yining, Zhang, Yue, Yu, Yingjie, Luo, Jiangqi, Sweet, Matthew J. and Yu, Chengzhong (2025). Rational design of advanced gene delivery carriers: Macrophage phenotype matters. Advanced Materials, 37 (3) e2401504, 1-13. doi: 10.1002/adma.202401504 |
|
2024 Journal Article A novel inhibitor of class IIa histone deacetylases attenuates collagen‐induced arthritisPoon, Eunice K., Liu, Ligong, Wu, Kai‐Chen, Lim, Junxian, Sweet, Matthew J., Lohman, Rink‐Jan, Iyer, Abishek and Fairlie, David P. (2024). A novel inhibitor of class IIa histone deacetylases attenuates collagen‐induced arthritis. British Journal of Pharmacology, 181 (23), 4804-4821. doi: 10.1111/bph.17306 |
|
2024 Journal Article Histone deacetylase 7 activates 6-phosphogluconate dehydrogenase via an enzyme-independent mechanism that involves the N-terminal protein-protein interaction domainWang, Yizhuo, Curson, James E.B., Ramnath, Divya, Das Gupta, Kaustav, Reid, Robert C., Karunakaran, Denuja, Fairlie, David P. and Sweet, Matthew J. (2024). Histone deacetylase 7 activates 6-phosphogluconate dehydrogenase via an enzyme-independent mechanism that involves the N-terminal protein-protein interaction domain. Biochemical Journal, 481 (21), 1569-1584. doi: 10.1042/bcj20240380 |
|
2024 Journal Article The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin openingPatrick, Ralph, Naval-Sanchez, Marina, Deshpande, Nikita, Huang, Yifei, Zhang, Jingyu, Chen, Xiaoli, Yang, Ying, Tiwari, Kanupriya, Esmaeili, Mohammadhossein, Tran, Minh, Mohamed, Amin R., Wang, Binxu, Xia, Di, Ma, Jun, Bayliss, Jacqueline, Wong, Kahlia, Hun, Michael L., Sun, Xuan, Cao, Benjamin, Cottle, Denny L., Catterall, Tara, Barzilai-Tutsch, Hila, Troskie, Robin-Lee, Chen, Zhian, Wise, Andrea F., Saini, Sheetal, Soe, Ye Mon, Kumari, Snehlata, Sweet, Matthew J. ... Nefzger, Christian M. (2024). The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening. Cell Metabolism, 36 (8), 1858-1881.e23. doi: 10.1016/j.cmet.2024.06.006 |
|
2024 Journal Article A convergent evolutionary pathway attenuating cellulose production drives enhanced virulence of some bacteriaNhu, Nguyen Thi Khanh, Rahman, M. Arifur, Goh, Kelvin G. K., Kim, Seung Jae, Phan, Minh-Duy, Peters, Kate M., Alvarez-Fraga, Laura, Hancock, Steven J., Ravi, Chitra, Kidd, Timothy J., Sullivan, Matthew J., Irvine, Katharine M., Beatson, Scott A., Sweet, Matthew J., Irwin, Adam D., Vukovic, Jana, Ulett, Glen C., Hasnain, Sumaira Z. and Schembri, Mark A. (2024). A convergent evolutionary pathway attenuating cellulose production drives enhanced virulence of some bacteria. Nature Communications, 15 (1) 1441, 1441. doi: 10.1038/s41467-024-45176-4 |
|
2023 Journal Article Apical extrusion prevents apoptosis from activating an acute inflammatory program in epitheliaDuszyc, Kinga, von Pein, Jessica B., Ramnath, Divya, Currin-Ross, Denni, Verma, Suzie, Lim, Fayth, Sweet, Matthew J., Schroder, Kate and Yap, Alpha S. (2023). Apical extrusion prevents apoptosis from activating an acute inflammatory program in epithelia. Developmental Cell, 58 (21), 2235-2248.e6. doi: 10.1016/j.devcel.2023.08.009 |
|
2023 Journal Article TLR4 phosphorylation at tyrosine 672 activates the ERK/c‐FOS signaling module for LPS‐induced cytokine responses in macrophagesCurson, James E. B., Liu, Liping, Luo, Lin, Muusse, Timothy W., Lucas, Richard M., Gunther, Kimberley S., Vajjhala, Parimala R., Abrol, Rishika, Jones, Alun, Kapetanovic, Ronan, Stacey, Katryn J., Stow, Jennifer L. and Sweet, Matthew J. (2023). TLR4 phosphorylation at tyrosine 672 activates the ERK/c‐FOS signaling module for LPS‐induced cytokine responses in macrophages. European Journal of Immunology, 53 (7) e2250056, e2250056. doi: 10.1002/eji.202250056 |
|
2023 Journal Article Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and diseaseWang, Yizhuo, Abrol, Rishika, Mak, Jeffrey Y. W., Das Gupta, Kaustav, Ramnath, Divya, Karunakaran, Denuja, Fairlie, David P. and Sweet, Matthew J. (2023). Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease. The FEBS Journal, 290 (11), 2805-2832. doi: 10.1111/febs.16437 |
|
2023 Journal Article Macrophage Nrf 2 the rescueStow, Jennifer L. and Sweet, Matthew J. (2023). Macrophage Nrf 2 the rescue. Journal of Cell Biology, 222 (6) e202305036. doi: 10.1083/jcb.202305036 |
