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2021

Journal Article

Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells

Sun, Xuan, Cao, Benjamin, Naval-Sanchez, Marina, Pham, Tony, Sun, Yu Bo Yang, Williams, Brenda, Heazlewood, Shen Y, Deshpande, Nikita, Li, Jinhua, Kraus, Felix, Rae, James, Nguyen, Quan, Yari, Hamed, Schröder, Jan, Heazlewood, Chad K, Fulton, Madeline, Hatwell-Humble, Jessica, Das Gupta, Kaustav, Kapetanovic, Ronan, Chen, Xiaoli, Sweet, Matthew J, Parton, Robert G, Ryan, Michael T, Polo, Jose M, Nefzger, Christian M and Nilsson, Susan K (2021). Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells. Nature Communications, 12 (1) 2665, 1-17. doi: 10.1038/s41467-021-22863-0

Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells

2021

Journal Article

HDAC7 inhibition by phenacetyl and phenylbenzoyl hydroxamates

Mak, Jeffrey Y. W., Wu, Kai-Chen, Gupta, Praveer K., Barbero, Sheila, McLaughlin, Maddison G., Lucke, Andrew J., Tng, Jiahui, Lim, Junxian, Loh, Zhixuan, Sweet, Matthew J, Reid, Robert C., Liu, Ligong and Fairlie, David P. (2021). HDAC7 inhibition by phenacetyl and phenylbenzoyl hydroxamates. Journal of Medicinal Chemistry, 64 (4), 2186-2204. doi: 10.1021/acs.jmedchem.0c01967

HDAC7 inhibition by phenacetyl and phenylbenzoyl hydroxamates

2021

Journal Article

An alloy of zinc and innate immunity: galvanizing host defence against infection

Pein, Jessica B., Stocks, Claudia J., Schembri, Mark A., Kapetanovic, Ronan and Sweet, Matthew J. (2021). An alloy of zinc and innate immunity: galvanizing host defence against infection. Cellular Microbiology, 23 (1) e13268, 1-11. doi: 10.1111/cmi.13268

An alloy of zinc and innate immunity: galvanizing host defence against infection

2020

Journal Article

KLF3 represses the inflammatory response in macrophages

Salmon, Jessica M., Reed, Casie Leigh, Bender, Maddyson, Mitchell, Helen Lorraine, Fox, Vanessa, Magor, Graham William, Sweet, Matthew and Perkins, Andrew Charles (2020). KLF3 represses the inflammatory response in macrophages. Blood, 136 (Supplement 1), 36-36. doi: 10.1182/blood-2020-142373

KLF3 represses the inflammatory response in macrophages

2020

Journal Article

A sprinkle of salt in the pressure cooker of innate immunity and inflammation

Sweet, Matthew J., Jones, Sarah A. and Harris, James (2020). A sprinkle of salt in the pressure cooker of innate immunity and inflammation. Immunology and Cell Biology, 99 (1) imcb.12413, 9-12. doi: 10.1111/imcb.12413

A sprinkle of salt in the pressure cooker of innate immunity and inflammation

2020

Journal Article

Restriction of chronic Escherichia coli urinary tract infection depends upon T cell-derived interleukin-17, a deficiency of which predisposes to flagella-driven bacterial persistence

Chamoun, Michelle N., Sullivan, Matthew J., Goh, Kelvin G. K., Acharya, Dhruba, Ipe, Deepak S., Katupitiya, Lahiru, Gosling, Dean, Peters, Kate M., Sweet, Matthew J., Sester, David P., Schembri, Mark A. and Ulett, Glen C. (2020). Restriction of chronic Escherichia coli urinary tract infection depends upon T cell-derived interleukin-17, a deficiency of which predisposes to flagella-driven bacterial persistence. FASEB Journal, 34 (11), 14572-14587. doi: 10.1096/fj.202000760R

Restriction of chronic Escherichia coli urinary tract infection depends upon T cell-derived interleukin-17, a deficiency of which predisposes to flagella-driven bacterial persistence

2020

Journal Article

Lipopolysaccharide promotes Drp1‐dependent mitochondrial fission and associated inflammatory responses in macrophages

Kapetanovic, Ronan, Afroz, Syeda Farhana, Ramnath, Divya, Lawrence, Grace M.E.P., Okada, Takashi, Curson, James E.B., Bruin, Jost, Fairlie, David P., Schroder, Kate, St John, Justin C., Blumenthal, Antje and Sweet, Matthew J. (2020). Lipopolysaccharide promotes Drp1‐dependent mitochondrial fission and associated inflammatory responses in macrophages. Immunology and Cell Biology, 98 (7) imcb.12363, 528-539. doi: 10.1111/imcb.12363

Lipopolysaccharide promotes Drp1‐dependent mitochondrial fission and associated inflammatory responses in macrophages

2019

Journal Article

Complex multilevel control of hemolysin production by uropathogenic Escherichia coli

Nhu, Nguyen Thi Khanh, Phan, Minh-Duy, Forde, Brian M., Murthy, Ambika M. V., Peters, Kate M., Day, Christopher J., Poole, Jessica, Kidd, Timothy J., Welch, Rodney A., Jennings, Michael P., Ulett, Glen C., Sweet, Matthew J., Beatson, Scott A. and Schembri, Mark A. (2019). Complex multilevel control of hemolysin production by uropathogenic Escherichia coli. mBio, 10 (5) e02248-19. doi: 10.1128/mbio.02248-19

Complex multilevel control of hemolysin production by uropathogenic Escherichia coli

2019

Journal Article

SCIMP is a universal Toll‐like receptor adaptor in macrophages

Luo, Lin, Curson, James E. B., Liu, Liping, Wall, Adam A., Tuladhar, Neeraj, Lucas, Richard M., Sweet, Matthew J. and Stow, Jennifer L. (2019). SCIMP is a universal Toll‐like receptor adaptor in macrophages. Journal of Leukocyte Biology, 107 (2) JLB.2MA0819-138RR, 251-262. doi: 10.1002/jlb.2ma0819-138rr

SCIMP is a universal Toll‐like receptor adaptor in macrophages

2019

Journal Article

Minocycline prevents the development of mechanical allodynia in mouse models of vincristine-induced peripheral neuropathy

Starobova, H., Mueller, A., Allavena, R., Lohman, R. J., Sweet, M. J. and Vetter, I. (2019). Minocycline prevents the development of mechanical allodynia in mouse models of vincristine-induced peripheral neuropathy. Frontiers in Neuroscience, 13 (JUN) 653, 653. doi: 10.3389/fnins.2019.00653

Minocycline prevents the development of mechanical allodynia in mouse models of vincristine-induced peripheral neuropathy

2019

Journal Article

Inhibitors of class I histone deacetylases attenuate thioacetamide-induced liver fibrosis in mice by suppressing hepatic Type 2 inflammation

Loh, Zhixuan, Fitzsimmons, Rebecca L., Reid, Robert C., Ramnath, Divya, Clouston, Andrew, Gupta, Praveer K., Irvine, Katharine M., Powell, Elizabeth E., Schroder, Kate, Stow, Jennifer L., Sweet, Matthew J., Fairlie, David P. and Iyer, Abishek (2019). Inhibitors of class I histone deacetylases attenuate thioacetamide-induced liver fibrosis in mice by suppressing hepatic Type 2 inflammation. British Journal of Pharmacology, 176 (19) bph.14768, 3775-3790. doi: 10.1111/bph.14768

Inhibitors of class I histone deacetylases attenuate thioacetamide-induced liver fibrosis in mice by suppressing hepatic Type 2 inflammation

2019

Conference Publication

Histone Deacetylase Inhibitors Attenuate Hepatic Fibrosis through Suppression of Group 2 Innate Lymphoid Cells and Type 2 Inflammation

Iyer, Abishek, Loh, Zhixuan, Fitzsimmons, Rebecca L., Reid, Robert C., Ramnath, Divya, Clouston, Andrew, Irvine, Katharine M., Powell, Elizabeth E., Schroder, Kate, Stow, Jennifer L., Sweet, Matthew J. and Fairlie, David P. (2019). Histone Deacetylase Inhibitors Attenuate Hepatic Fibrosis through Suppression of Group 2 Innate Lymphoid Cells and Type 2 Inflammation. Experimental Biology Meeting (EB), Orlando Fl, Apr 06-09, 2019. HOBOKEN: WILEY.

Histone Deacetylase Inhibitors Attenuate Hepatic Fibrosis through Suppression of Group 2 Innate Lymphoid Cells and Type 2 Inflammation

2019

Journal Article

Variation in hemolysin A expression between uropathogenic Escherichia coli isolates determines NLRP3-dependent vs. -independent macrophage cell death and host colonization

Murthy, Ambika M. V., Sullivan, Matthew J., Nhu, Nguyen Thi Khanh, Lo, Alvin W., Phan, Minh-Duy, Peters, Kate M., Boucher, Dave, Schroder, Kate, Beatson, Scott A., Ulett, Glen C., Schembri, Mark A. and Sweet, Matthew J. (2019). Variation in hemolysin A expression between uropathogenic Escherichia coli isolates determines NLRP3-dependent vs. -independent macrophage cell death and host colonization. FASEB Journal : official publication of the Federation of American Societies for Experimental Biology, 33 (6), fj201802100R-7450. doi: 10.1096/fj.201802100R

Variation in hemolysin A expression between uropathogenic Escherichia coli isolates determines NLRP3-dependent vs. -independent macrophage cell death and host colonization

2018

Journal Article

Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps

Chen, Kaiwen W., Monteleone, Mercedes, Boucher, Dave, Sollberger, Gabriel, Ramnath, Divya, Condon, Nicholas D., von Pein, Jessica B., Broz, Petr, Sweet, Matthew J. and Schroder, Kate (2018). Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps. Science Immunology, 3 (26) eaar6676, eaar6676. doi: 10.1126/sciimmunol.aar6676

Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps

2018

Journal Article

Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and -independent secretion

Monteleone, Mercedes, Stanley, Amanda C., Chen, Kaiwen W., Brown, Darren L., Bezbradica, Jelena S., von Pein, Jessica B., Holley, Caroline L., Boucher, Dave, Shakespear, Melanie R., Kapetanovic, Ronan, Rolfes, Verena, Sweet, Matthew J., Stow, Jennifer L. and Schroder, Kate (2018). Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and -independent secretion. Cell Reports, 24 (6), 1425-1433. doi: 10.1016/j.celrep.2018.07.027

Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and -independent secretion

2018

Journal Article

pTRAPs: Transmembrane adaptors in innate immune signaling

Curson, James E. B., Luo, Lin, Sweet, Matthew J. and Stow, Jennifer L. (2018). pTRAPs: Transmembrane adaptors in innate immune signaling. Journal of Leukocyte Biology, 103 (6), 1011-1019. doi: 10.1002/JLB.2RI1117-474R

pTRAPs: Transmembrane adaptors in innate immune signaling

2018

Journal Article

Group A Streptococcus M1T1 intracellular infection of primary tonsil epithelial cells dampens levels of secreted IL-8 through the action of SpyCEP

Soderholm, Amelia T., Barnett, Timothy C., Korn, Othmar, Rivera-Hernandez, Tania, Seymour, Lisa M., Schulz, Benjamin L., Nizet, Victor, Wells, Christine A., Sweet, Matthew J. and Walker, Mark J. (2018). Group A Streptococcus M1T1 intracellular infection of primary tonsil epithelial cells dampens levels of secreted IL-8 through the action of SpyCEP. Frontiers in Cellular and Infection Microbiology, 8 (MAY) 160, 160. doi: 10.3389/fcimb.2018.00160

Group A Streptococcus M1T1 intracellular infection of primary tonsil epithelial cells dampens levels of secreted IL-8 through the action of SpyCEP

2018

Journal Article

Regulation of hemolysin in uropathogenic Escherichia coli fine-tunes killing of human macrophages

Murthy, Ambika M. V., Phan, Minh-Duy, Peters, Kate M., Nhu, Nguyen Thi Khanh, Welch, Rodney A., Ulett, Glen C., Schembri, Mark A. and Sweet, Matthew J. (2018). Regulation of hemolysin in uropathogenic Escherichia coli fine-tunes killing of human macrophages. Virulence, 9 (1), 1-32. doi: 10.1080/21505594.2018.1465786

Regulation of hemolysin in uropathogenic Escherichia coli fine-tunes killing of human macrophages

2018

Journal Article

For when bacterial infections persist: toll-like receptor-inducible direct antimicrobial pathways in macrophages

Stocks, Claudia J., Schembri, Mark A., Sweet, Matthew J. and Kapetanovic, Ronan (2018). For when bacterial infections persist: toll-like receptor-inducible direct antimicrobial pathways in macrophages. Journal of Leukocyte Biology, 103 (1), 35-51. doi: 10.1002/JLB.4RI0917-358R

For when bacterial infections persist: toll-like receptor-inducible direct antimicrobial pathways in macrophages

2018

Conference Publication

RNA-sequencing analysis of biopsies from chronic liver disease patients identifies gene signatures associated with progressive liver disease

Ramnath, D., Irvine, K., Lukowski, S., Horsfall, L., Loh, K., Clouston, A., Patel, P., Iyer, A., Lampe, G., Stow, J., Schroder, K., Fairlie, D., Powell, J., Powell, E. and Sweet, M. (2018). RNA-sequencing analysis of biopsies from chronic liver disease patients identifies gene signatures associated with progressive liver disease. International Liver Congress (ILC), Paris, France, 11-15 April, 2018. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/S0168-8278(18)31040-7

RNA-sequencing analysis of biopsies from chronic liver disease patients identifies gene signatures associated with progressive liver disease