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2014 Journal Article Co-administration of non-carrier nanoparticles boosts antigen immune response without requiring protein conjugationWibowo, Nani, Chuan, Yap P., Seth, Arjun, Cordoba, Yoann, Lua, Linda H. L. and Middelberg, Anton P. J. (2014). Co-administration of non-carrier nanoparticles boosts antigen immune response without requiring protein conjugation. Vaccine, 32 (29), 3664-3669. doi: 10.1016/j.vaccine.2014.04.043 |
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2014 Journal Article Protective efficacy of a bacterially produced modular capsomere presenting M2e from influenza: Extending the potential of broadly cross-protecting epitopesWibowo, Nani, Hughes, Fiona K., Fairmaid, Emily J., Lua, Linda H. L., Brown, Lorena E. and Middelberg, Anton P. J. (2014). Protective efficacy of a bacterially produced modular capsomere presenting M2e from influenza: Extending the potential of broadly cross-protecting epitopes. Vaccine, 32 (29), 3651-3655. doi: 10.1016/j.vaccine.2014.04.062 |
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2014 Journal Article Bioengineering virus-like particles as vaccinesLua, Linda H. L., Connors, Natalie K., Sainsbury, Frank, Chuan, Yap P., Wibowo, Nani and Middelberg, Anton P. J. (2014). Bioengineering virus-like particles as vaccines. Biotechnology and Bioengineering, 111 (3), 425-440. doi: 10.1002/bit.25159 |
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2013 Journal Article Microbially synthesized modular virus-like particles and capsomeres displaying group A streptococcus hypervariable antigenic determinantsChuan, Yap P., Wibowo, Nani, Connors, Natalie K., Wu, Yang, Hughes, Fiona K., Batzloff, Michael R., Lua, Linda H. L. and Middelberg, Anton P. J. (2013). Microbially synthesized modular virus-like particles and capsomeres displaying group A streptococcus hypervariable antigenic determinants. Biotechnology and Bioengineering, Early View (6), 1-9. doi: 10.1002/bit.25172 |
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2013 Journal Article Virus-like particle bioprocessing: challenges and opportunitiesMiddelberg, Anton P. J. and Lua, Linda H. L. (2013). Virus-like particle bioprocessing: challenges and opportunities. Pharmaceutical Bioprocessing, 1 (5), 407-409. doi: 10.4155/pbp.13.49 |
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2013 Journal Article Sensitivity of immune response quality to influenza helix 190 antigen structure displayed on a modular virus-like particleAnggraeni, Melisa R., Connors, Natalie K., Wu, Yang, Chuan, Yap P., Lua, Linda H. L. and Middelberg, Anton P. J. (2013). Sensitivity of immune response quality to influenza helix 190 antigen structure displayed on a modular virus-like particle. Vaccine, 31 (40), 4428-4435. doi: 10.1016/j.vaccine.2013.06.087 |
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2013 Journal Article Improved fusion tag cleavage strategies in the downstream processing of self-assembling virus-like particle vaccinesConnors, Natalie K., Wu, Yang, Lua, Linda H. L. and Middelberg, Anton P. J. (2013). Improved fusion tag cleavage strategies in the downstream processing of self-assembling virus-like particle vaccines. Food and Bioproducts Processing, 92 (2), 143-151. doi: 10.1016/j.fbp.2013.08.012 |
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2013 Journal Article Effects of pre-existing anti-carrier immunity and antigenic element multiplicity on efficacy of a modular virus-like particle vaccineChuan, Yap P., Rivera-Hernandez, Tania, Wibowo, Nani, Connors, Natalie K., Wu, Yang, Hughes, Fiona K., Lua, Linda H. L. and Middelberg, Anton P. J. (2013). Effects of pre-existing anti-carrier immunity and antigenic element multiplicity on efficacy of a modular virus-like particle vaccine. Biotechnology and Bioengineering, 110 (9), 2343-2351. doi: 10.1002/bit.24907 |
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2013 Journal Article Virus-like particle formulation optimization by miniaturized high-throughput screeningMohr, Johannes, Chuan, Yap P., Wu, Yang, Lua, Linda H. L. and Middelberg, Anton P. J. (2013). Virus-like particle formulation optimization by miniaturized high-throughput screening. Methods, 60 (3), 248-256. doi: 10.1016/j.ymeth.2013.04.019 |
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2013 Journal Article Molecular Energetics in the Capsomere of Virus-Like Particle Revealed by Molecular Dynamics SimulationsZhang, Lin, Tang, Ronghong, Bai, Shu, Connors, Natalie K., Lua, Linda H. L., Chuan, Yap P., Middelberg, Anton P. J. and Sun, Yan (2013). Molecular Energetics in the Capsomere of Virus-Like Particle Revealed by Molecular Dynamics Simulations. Journal of Physical Chemistry B, 117 (18), 5411-5421. doi: 10.1021/jp311170w |
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2013 Journal Article Self-adjuvanting modular virus-like particles for mucosal vaccination against group A streptococcus (GAS)Rivera-Hernandez, Tania, Hartas, Jon, Wu, Yang, Chuan, Yap P., Lua, Linda H. L., Good, Michael, Batzloff, Michael R. and Middelberg, Anton P. J. (2013). Self-adjuvanting modular virus-like particles for mucosal vaccination against group A streptococcus (GAS). Vaccine, 31 (15), 1950-1955. doi: 10.1016/j.vaccine.2013.02.013 |
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2013 Other Outputs Immunogenic compositions and methods thereforMiddelberg, Anton P. J. and Lua, Linda H. L (2013). Immunogenic compositions and methods therefor. WO2013020183 A1. |
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2013 Journal Article The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidizedChen, Kai-En, Richards, Ayanthi A., Caradoc-Davies, Tom T., Vajjhala, Parimala R., Robin, Gautier, Lua, Linda H. L., Hill, Justine M., Schroder, Kate, Sweet, Matthew J., Kellie, Stuart, Kobe, Bostjan and Martin, Jennifer (2013). The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized. Acta Crystallographica Section D: Biological Crystallography, 69 (5), 774-784. doi: 10.1107/S0907444913001558 |
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2012 Journal Article Modular engineering of a microbially-produced viral capsomere vaccine for influenzaWibowo, Nani, Chuan, Yap P., Lua, Linda H. L. and Middelberg, Anton P. J. (2012). Modular engineering of a microbially-produced viral capsomere vaccine for influenza. Chemical Engineering Science, 103, 12-20. doi: 10.1016/j.ces.2012.04.001 |
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2012 Book Chapter Advances in protein production technologiesLua, Linda H. L. and Chuan, Yap Pang (2012). Advances in protein production technologies. Biopharmaceutical production technology. (pp. 43-77) edited by Ganapathy Subramanian. Weinheim, Germany: Wiley-VCH. doi: 10.1002/9783527653096.ch2 |
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2012 Book Chapter Virus-like particle bioprocessingChuan, Yap Pang, Lua, Linda H. L. and Middelberg, Anton P. J. (2012). Virus-like particle bioprocessing. Biopharmaceutical production technology. (pp. 139-163) edited by Ganapathy Subramanian. Weinheim, Germany: Wiley-VCH. doi: 10.1002/9783527653096.ch5 |
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2011 Journal Article A microbial platform for rapid and low-cost virus-like particle and capsomere vaccinesMiddelberg, Anton P.J., Rivera-Hernandez, Tania, Wibowo, Nani, Lua, Linda H.L., Fan, Yuanyuan, Magor, Graham, Chang, Cindy, Chuan, Yap P., Good, Michael F. and Batzloff, Michael R. (2011). A microbial platform for rapid and low-cost virus-like particle and capsomere vaccines. Vaccine, 29 (41), 7154-7162. doi: 10.1016/j.vaccine.2011.05.075 |
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2011 Journal Article A new bioproduction route for a novel antimicrobial peptideTay, Derrick Kok Sing, Rajagopalan, Gobinath, Li, Xiang, Chen, Yu, Linda H.L. Lua and Leong, Susanna Su Jan (2011). A new bioproduction route for a novel antimicrobial peptide. Biotechnology and Bioengineering, 108 (3), 572-581. doi: 10.1002/bit.22970 |
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2011 Journal Article Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formationHu, Shu-Hong, Christie, Michelle P., Saez, Natalie J., Latham, Catherine F., Jarrott, Russell, Lua, Linda H. L., Collins, Brett M. and Martin, Jennifer L. (2011). Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation. Proceedings of the National Academy of Sciences of the United States of America, 108 (3), 1040-1045. doi: 10.1073/pnas.0914906108 |
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2010 Journal Article Virus assembly occurs following a pH- or Ca2+-triggered switch in the thermodynamic attraction between structural protein capsomeresChuan, Yap P., Fan, Yuan Y., Lua, Linda H.L. and Middelberg, Anton P.J. (2010). Virus assembly occurs following a pH- or Ca2+-triggered switch in the thermodynamic attraction between structural protein capsomeres. Journal of The Royal Society Interface, 7 (44), 409-421. doi: 10.1098/rsif.2009.0175 |
