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2024 Journal Article Defining mucosal healing in randomized controlled trials of inflammatory bowel disease: a systematic review and future perspectiveParigi, Tommaso Lorenzo, Solitano, Virginia, Armuzzi, Alessandro, Acosta, Manuel Barreiro de, Begun, Jake, Ben-Horin, Shomron, Biedermann, Luc, Colombel, Jean-Frederic, Dignass, Axel, Fumery, Mathurin, Ghosh, Subrata, Kobayashi, Taku, Louis, Edouard, Magro, Fernando, Panaccione, Remo, Rausch, Astrid, Reinisch, Walter, Selinger, Christian, Jairath, Vipul, Danese, Silvio and Peyrin-Biroulet, Laurent (2024). Defining mucosal healing in randomized controlled trials of inflammatory bowel disease: a systematic review and future perspective. United European Gastroenterology Journal, 12 (9), 1266-1279. doi: 10.1002/ueg2.12671 |
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2024 Journal Article International expert guidance for defining and monitoring small bowel strictures in Crohn's disease on intestinal ultrasound: a consensus statementLu, Cathy, Rosentreter, Ryan, Parker, Claire E., Remillard, Julie, Wilson, Stephanie R., Baker, Mark E., Bhatnagar, Gauraang, Begun, Jakob, Bruining, David H., Bryant, Robert V., Christensen, Britt, Feagan, Brian G., Fletcher, Joel G., Gordon, Ilyssa, Henderson, Gaylyn, Jairath, Vipul, Knudsen, John, Kucharzik, Torsten, Lesack, Kyle, Maaser, Christian, Maconi, Giovanni, Novak, Kerri, Rimola, Jordi, Taylor, Stuart A., Wilkens, Rune, Rieder, Florian and on behalf of the Stenosis Therapy and Anti-Fibrotic Research (STAR) consortium (2024). International expert guidance for defining and monitoring small bowel strictures in Crohn's disease on intestinal ultrasound: a consensus statement. The Lancet Gastroenterology & Hepatology, 9 (12), 1101-1110. doi: 10.1016/s2468-1253(24)00265-6 |
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2024 Journal Article Group B Streptococcus vaginal colonisation throughout pregnancy is associated with decreased Lactobacillus crispatus and increased Lactobacillus iners abundance in the vaginal microbial communityMaidment, Toby I., Pelzer, Elise S., Borg, Danielle J., Cheung, Eddie, Begun, Jake, Nitert, Marloes Dekker, Rae, Kym M., Clifton, Vicki L. and Carey, Alison J. (2024). Group B Streptococcus vaginal colonisation throughout pregnancy is associated with decreased Lactobacillus crispatus and increased Lactobacillus iners abundance in the vaginal microbial community. Frontiers in Cellular and Infection Microbiology, 14 1435745, 1-11. doi: 10.3389/fcimb.2024.1435745 |
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2024 Journal Article Reliability of intestinal ultrasound for evaluating Crohn’s disease activity using point-of-care and central readingGoodsall, Thomas M., An, Yoon-Kyo, Andrews, Jane M., Begun, Jakob, Friedman, Antony B., Lee, Andrew, Lewindon, Peter J., Spizzo, Paul, Rodgers, Nick, Taylor, Kirstin M., White, Lauren S., Wilkens, Rune, Wright, Emily K., Zou, Lily, Maguire, Bryan R., Parker, Claire E., Rémillard, Julie, Novak, Kerri L., Panaccione, Remo, Feagan, Brian G., Jairath, Vipul, Ma, Christopher and Bryant, Robert V. (2024). Reliability of intestinal ultrasound for evaluating Crohn’s disease activity using point-of-care and central reading. Clinical Gastroenterology and Hepatology, 23 (9), 1600-1611.e9. doi: 10.1016/j.cgh.2024.08.007 |
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2024 Journal Article A truncation mutant of adenomatous polyposis coli impairs apical cell extrusion through elevated epithelial tissue tensionGan, Wan J., Giri, Rabina, Begun, Jakob, Abud, Helen E., Hardeman, Edna C., Gunning, Peter W., Yap, Alpha S. and Noordstra, Ivar (2024). A truncation mutant of adenomatous polyposis coli impairs apical cell extrusion through elevated epithelial tissue tension. Cytoskeleton, 82 (7), 444-455. doi: 10.1002/cm.21893 |
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2024 Journal Article Impact of a Patient Support Program on time to discontinuation of adalimumab in Australian adult patients with immunemediated inflammatory diseases-an observational studyJones, Graeme, Calao, Miriam, Begun, Jakob, Sin, Shirley, Kouhkamari, Mahsa H., Young, Elisa, Fernández-Peñas, Pablo, Watts, Alan and Östör, Andrew J. (2024). Impact of a Patient Support Program on time to discontinuation of adalimumab in Australian adult patients with immunemediated inflammatory diseases-an observational study. PLoS One, 19 (6 June) e0300624. doi: 10.1371/journal.pone.0300624 |
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2024 Journal Article High technical success rate of endoscopic balloon dilatation reduces surgical requirement for patients with stricturing Crohn’s diseaseLim, Emily, Thai, Maxter, An, Yoon-Kyo, Hendy, Peter, Alchlaihawi, Mahmoud, Leong, Rupert, Connor, Susan, Ng, Watson, Gu, Bonita, Thin, Lena, Sparrow, Miles, Gilmore, Robert, Taylor, Kirstin, Sallis, Olivia, Andrews, Jane M., Daker, Charlotte, Gearry, Richard B., Wark, Gabrielle, Ghaly, Simon, Begun, Matt, Krishnaprasad, Krupa, Wu, Tianhong, Ruddick-Collins, Leonie, Schreiber, Veronika, Okano, Satomi, Radford-Smith, Graham, Schulberg, Julien, van Langenberg, Daniel and Begun, Jakob (2024). High technical success rate of endoscopic balloon dilatation reduces surgical requirement for patients with stricturing Crohn’s disease. GastroHep, 2024 (1) 3686618, 1-10. doi: 10.1155/2024/3686618 |
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2024 Journal Article Systematic review: defining, diagnosing and monitoring small bowel strictures in Crohn's disease on intestinal ultrasoundLu, Cathy, Rosentreter, Ryan, Delisle, Maxime, White, Mattie, Parker, Claire E., Premji, Zahra, Wilson, Stephanie R., Baker, Mark E., Bhatnagar, Gauraang, Begun, Jakob, Bruining, David H., Bryant, Robert, Christensen, Britt, Feagan, Brian G., Fletcher, Joel G., Jairath, Vipul, Knudsen, John, Kucharzik, Torsten, Maaser, Christian, Maconi, Giovanni, Novak, Kerri, Rimola, Jordi, Taylor, Stuart A., Wilkens, Rune, Rieder, Florian and The Stenosis Therapy and Anti‐Fibrotic Research (STAR) consortium (2024). Systematic review: defining, diagnosing and monitoring small bowel strictures in Crohn's disease on intestinal ultrasound. Alimentary Pharmacology and Therapeutics, 59 (8), 928-940. doi: 10.1111/apt.17918 |
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2024 Journal Article Vedolizumab and ustekinumab levels in pregnant women with inflammatory bowel disease and infants exposed in-uteroPrentice, Ralley, Flanagan, Emma, Wright, Emily K., Gibson, Peter R., Rosella, Sam, Rosella, Ourania, Begun, Jakob, An, Yoon-Kyo, Lawrance, Ian C., Kamm, Michael A., Sparrow, Miles, Goldberg, Rimma, Prideaux, Lani, Vogrin, Sara, Kiburg, Katerina V., Ross, Alyson L., Burns, Megan and Bell, Sally J. (2024). Vedolizumab and ustekinumab levels in pregnant women with inflammatory bowel disease and infants exposed in-utero. Clinical Gastroenterology and Hepatology, 23 (1), 124-133.e7. doi: 10.1016/j.cgh.2024.02.025 |
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2024 Journal Article Cannabidiol - help and hype in targeting mucosal diseasesMoniruzzaman, Md, Janjua, Taskeen Iqbal, Martin, Jennifer H., Begun, Jakob and Popat, Amirali (2024). Cannabidiol - help and hype in targeting mucosal diseases. Journal of Controlled Release, 365, 530-543. doi: 10.1016/j.jconrel.2023.11.010 |
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2023 Journal Article Comprehensive systematic review and pooled analysis of real‐world studies evaluating immunomodulator and biologic therapies for chronic pouchitis treatmentKhoo, Emi, Lee, Andrew, Neeman, Teresa, An, Yoon‐Kyo and Begun, Jakob (2023). Comprehensive systematic review and pooled analysis of real‐world studies evaluating immunomodulator and biologic therapies for chronic pouchitis treatment. JGH Open, 7 (12), 899-907. doi: 10.1002/jgh3.13000 |
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2023 Journal Article Guselkumab in patients with moderately to severely active ulcerative colitis: QUASAR phase 2b induction studyPeyrin-Biroulet, Laurent, Allegretti, Jessica R., Rubin, David T., Bressler, Brian, Germinaro, Matthew, Huang, Kuan-Hsiang (Gary), Shipitofsky, Nicole, Zhang, Hongyan, Wilson, Rebbecca, Han, Chenglong, Feagan, Brian G., Sandborn, William J., Panés, Julian, Hisamatsu, Tadakazu, Lichtenstein, Gary R., Sands, Bruce E., Dignass, Axel, Abrahamovych, Orest, Afanasieva, Halyna, Aitova, Lilia, Altintas, Engin, Altwegg, Romain, Andreev, Pavel, Aomatsu, Kazuki, Augustyn, Monika, Balestrieri, Paola, Begun, Jakob, Brunatto, Luciana, Bulgheroni, Diego ... QUASAR Study Group (2023). Guselkumab in patients with moderately to severely active ulcerative colitis: QUASAR phase 2b induction study. Gastroenterology, 165 (6), 1443-1457. doi: 10.1053/j.gastro.2023.08.038 |
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2023 Journal Article Pre-existing tissue mechanical hypertension at adherens junctions disrupts apoptotic extrusion in epitheliaMann, Zoya, Lim, Fayth, Verma, Suzie, Nanavati, Bageshri N., Davies, Julie M., Begun, Jakob, Hardeman, Edna C., Gunning, Peter W., Subramanyam, Deepa, Yap, Alpha S. and Duszyc, Kinga (2023). Pre-existing tissue mechanical hypertension at adherens junctions disrupts apoptotic extrusion in epithelia. Molecular Biology of the Cell, 35 (1) br3, 1-12. doi: 10.1091/mbc.e23-08-0337 |
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2023 Journal Article MUC13 cell surface mucin limits Salmonella Typhimurium infection by protecting the mucosal epithelial barrierMcGuckin, Michael A., Davies, Julie M., Felgner, Pascal, Wong, Kuan Yau, Giri, Rabina, He, Yaowu, Moniruzzaman, Md., Kryza, Thomas, Sajiir, Haressh, Hooper, John D., Florin, Timothy H., Begun, Jakob, Oussalah, Abderrahim, Hasnain, Sumaira Z., Hensel, Michael and Sheng, Yong H. (2023). MUC13 cell surface mucin limits Salmonella Typhimurium infection by protecting the mucosal epithelial barrier. Cellular and Molecular Gastroenterology and Hepatology, 16 (6), 985-1009. doi: 10.1016/j.jcmgh.2023.08.011 |
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2023 Journal Article Protocol for a single-arm feasibility study of photobiomodulation for fatigue, depression, and pain in inflammatory bowel diseaseEwais, Tatjana, Begun, Jakob and Laakso, E-Liisa (2023). Protocol for a single-arm feasibility study of photobiomodulation for fatigue, depression, and pain in inflammatory bowel disease. Biomedicines, 11 (8) 2179, 1-11. doi: 10.3390/biomedicines11082179 |
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2023 Journal Article Upadacitinib salvage therapy for infliximab experienced patients with acute severe ulcerative colitisGilmore, Robert, Tan, Lian, Fernandes, Richard, An, Yoon-Kyo and Begun, Jakob (2023). Upadacitinib salvage therapy for infliximab experienced patients with acute severe ulcerative colitis. Journal of Crohn's and Colitis, 17 (12), 2033-2036. doi: 10.1093/ecco-jcc/jjad115 |
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2023 Journal Article Upadacitinib induction and maintenance therapy for Crohn's diseaseLoftus, Edward V., Panés, Julian, Lacerda, Ana P., Peyrin-Biroulet, Laurent, D'Haens, Geert, Panaccione, Remo, Reinisch, Walter, Louis, Edouard, Chen, Minhu, Nakase, Hiroshi, Begun, Jakob, Boland, Brigid S., Phillips, Charles, Mohamed, Mohamed-Eslam F, Liu, Jianzhong, Geng, Ziqian, Feng, Tian, Dubcenco, Elena and Colombel, Jean-Frederic (2023). Upadacitinib induction and maintenance therapy for Crohn's disease. The New England journal of medicine, 388 (21), 1966-1980. doi: 10.1056/NEJMoa2212728 |
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2023 Journal Article Guselkumab plus golimumab combination therapy versus guselkumab or golimumab monotherapy in patients with ulcerative colitis (VEGA): a randomised, double-blind, controlled, phase 2, proof-of-concept trialFeagan, Brian G, Sands, Bruce E, Sandborn, William J, Germinaro, Matthew, Vetter, Marion, Shao, Jie, Sheng, Shihong, Johanns, Jewel, Panés, Julián, Tkachev, Alexander, Kalimullina, Dilara, Petryka, Robert, Osipenko, Marina, Tsarynna, Nataliia, Bilianskyi, Leonid, Kleczkowski, Dariusz, Yurkiv, Andrii, Woynarowski, Marek, Abrahamovych, Orest, Ivanishyn, Olha, Rydzewska, Grazyna, Kierkus, Jaroslaw, Petrova, Elina, Vasilevskaya, Olga, Afanasieva, Halyna, Francesconi, Carlos, Leszczyszyn, Jaroslaw, Bunkova, Elena, Platonov, Dmitry ... for the VEGA Study Group (2023). Guselkumab plus golimumab combination therapy versus guselkumab or golimumab monotherapy in patients with ulcerative colitis (VEGA): a randomised, double-blind, controlled, phase 2, proof-of-concept trial. The Lancet Gastroenterology and Hepatology, 8 (4), 307-320. doi: 10.1016/S2468-1253(22)00427-7 |
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2023 Journal Article Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liverAlabbas, Saleh Y., Giri, Rabina, Oancea, Iulia, Davies, Julie, Schreibner, Veronika, Florin, Timothy H. and Begun, Jakob (2023). Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver. Journal of Gastroenterology and Hepatology, 38 (4), 609-618. doi: 10.1111/jgh.16102 |
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2023 Journal Article Reactive oxygen species as mediators of disease progression and therapeutic response in colorectal cancerLyons, Nicholas, Giri, Rabina, Begun, Jakob, Clark, David A, Proud, David, He, Yaowu, Hooper, John and Kryza, Thomas (2023). Reactive oxygen species as mediators of disease progression and therapeutic response in colorectal cancer. Antioxidants and Redox Signaling, 39 (1-3), 186-205. doi: 10.1089/ars.2022.0127 |
