Dr

M. Zeeshan Chaudhry

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Background

Zeeshan Chaudhry is an emerging expert in T cell biology filed. His research integrates molecular immunology, virology and systems biology approaches to define the transcriptional regulation of immune cells, particularly CD8⁺ T cells and innate lymphoid cells, including NK cells and ILCs. He aims to uncover the molecular mechanisms that guide the development of long-lived memory T cells, which are critical for durable protective immunity. A key interest of his work is how stem-like progenitors of these cells can be manipulated to combat chronic diseases.

Dr. Chaudhry received his doctoral training at the Helmholtz Centre for Infection Research in Germany, where he investigated viral immune evasion strategies. His research has been published in leading journals such as Nature Immunology, Immunity, Science Immunology and PNAS.

Availability

Dr M. Zeeshan Chaudhry is:
Available for supervision
Media expert

Qualifications

  • Doctor of Philosophy of Natural Sciences, Medizinische Hochschule Hannover

Research interests

  • Transcriptional Regulation of T cells

  • Immune cell Progenitor regulation

Search Professor M. Zeeshan Chaudhry’s works on UQ eSpace

24 works between 2016 and 2026
All (24) Journal Article (23) Book Chapter (1)

1 - 20 of 24 works

Featured

2024

Journal Article

NFAT signaling is indispensable for persistent memory responses of MCMV-specific CD8+ T cells

Chaudhry, M. Zeeshan, Borkner, Lisa, Kulkarni, Upasana, Berberich-Siebelt, Friederike and Cicin-Sain, Luka (2024). NFAT signaling is indispensable for persistent memory responses of MCMV-specific CD8+ T cells. PLoS Pathogens, 20 (2 February) e1012025. doi: 10.1371/journal.ppat.1012025

NFAT signaling is indispensable for persistent memory responses of MCMV-specific CD8+ T cells

Featured

2022

Journal Article

Rapid SARS-CoV-2 adaptation to available cellular proteases

Chaudhry, M. Zeeshan, Eschke, Kathrin, Hoffmann, Markus, Grashoff, Martina, Abassi, Leila, Kim, Yeonsu, Brunotte, Linda, Ludwig, Stephan, Kröger, Andrea, Klawonn, Frank, Pöhlmann, Stefan H. and Cicin-Sain, Luka (2022). Rapid SARS-CoV-2 adaptation to available cellular proteases. Journal of Virology, 96 (5) e0218621, 1-17. doi: 10.1128/jvi.02186-21

Rapid SARS-CoV-2 adaptation to available cellular proteases

Featured

2020

Journal Article

Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells

Zeeshan Chaudhry, M., Casalegno-Garduno, Rosaely, Sitnik, Katarzyna M., Kasmapour, Bahram, Pulm, Ann-Kathrin, Brizic, Ilija, Eiz-Vesper, Britta, Moosmann, Andreas, Jonjic, Stipan, Mocarski, Edward S. and Cicin-Sain, Luka (2020). Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells. Proceedings of the National Academy of Sciences of the United States of America, 117 (23), 12961-12968. doi: 10.1073/pnas.1914667117

Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells

2026

Journal Article

Author Correction: Peyer’s patch M cells organize an epithelial niche that sustains group 3 innate lymphoid cells and IL-22

Cao, Wang H. J., You, Yue, Wang, Nancy, Chaudhry, M. Zeeshan, Yu, Huiyang, Bell, Peter T., Noye, Ellesandra C., Denman, Renae, Lee, Byungchul, Waddington, Abbey, Ye, Junpeng, Schreuder, Jaring, Huang, Qiutong, Tellier, Julie, Curio, Sophie, Santiago, James, Amann-Zalcenstein, Daniela, Jacquelot, Nicolas, Hickey, Peter, Nutt, Stephen L., Seillet, Cyril, Hansbro, Philip M., Wimmer, Verena C., Strugnell, Richard A., Tuong, Zewen Kelvin, Ritchie, Matthew E. and Belz, Gabrielle T. (2026). Author Correction: Peyer’s patch M cells organize an epithelial niche that sustains group 3 innate lymphoid cells and IL-22. Nature Immunology, 27 (10), 2173-2173. doi: 10.1038/s41590-026-02669-2

Author Correction: Peyer’s patch M cells organize an epithelial niche that sustains group 3 innate lymphoid cells and IL-22

2026

Journal Article

Peyer’s patch M cells organize an epithelial niche that sustains group 3 innate lymphoid cells and IL-22

Cao, Wang H. J., You, Yue, Wang, Nancy, Chaudhry, M. Zeeshan, Yu, Huiyang, Bell, Peter T., Noye, Ellesandra C., Denman, Renae, Lee, Byungchul, Waddington, Abbey, Ye, Junpeng, Schreuder, Jaring, Huang, Qiutong, Tellier, Julie, Curio, Sophie, Santiago, James, Amann-Zalcenstein, Daniela, Jacquelot, Nicolas, Hickey, Peter, Nutt, Stephen L., Seillet, Cyril, Hansbro, Philip M., Wimmer, Verena C., Strugnell, Richard A., Tuong, Zewen Kelvin, Richie, Matthew E. and Belz, Gabrielle T. (2026). Peyer’s patch M cells organize an epithelial niche that sustains group 3 innate lymphoid cells and IL-22. Nature Immunology, 27 (9), 1829-1841. doi: 10.1038/s41590-026-02606-3

Peyer’s patch M cells organize an epithelial niche that sustains group 3 innate lymphoid cells and IL-22

2026

Journal Article

<scp> <i>ICB</i> </scp> Special Feature: Highlights of 2025

Chaudhry, M. Zeeshan (2026). ICB Special Feature: Highlights of 2025. Immunology & Cell Biology, 104 (8) imcb.70149, 768-770. doi: 10.1111/imcb.70149

<scp> <i>ICB</i> </scp> Special Feature: Highlights of 2025

2026

Journal Article

The GFI1-FOXO1 axis regulates NK cell maturation and function

Huang, Qiutong, Chaudhry, M. Zeeshan, Dight, James, Alim, Louisa, Yu, Huiyang, Denman, Renae, Man, Hiu On, Schreuder, Jaring, Garnham, Alexandra L., Tuong, Zewen K., Souza-Fonseca-Guimaraes, Fernando, Jacquelot, Nicolas and Belz, Gabrielle T. (2026). The GFI1-FOXO1 axis regulates NK cell maturation and function. Nature Communications, 17 (1) 5593, 1. doi: 10.1038/s41467-026-72022-6

The GFI1-FOXO1 axis regulates NK cell maturation and function

2026

Journal Article

One cell, many fates: transcriptional networks governing CD8<SUP>+</SUP> T cell differentiation

Chaudhry, M. Zeeshan and Belz, Gabrielle T. (2026). One cell, many fates: transcriptional networks governing CD8+ T cell differentiation. Immunology and Cell Biology, 104 (5) imcb.70106, 436-438. doi: 10.1111/imcb.70106

One cell, many fates: transcriptional networks governing CD8<SUP>+</SUP> T cell differentiation

2026

Journal Article

Transcriptional programming governs the transition from shared progenitors to divergent CD8+ T cell fates

Chaudhry, M Zeeshan and Belz, Gabrielle T (2026). Transcriptional programming governs the transition from shared progenitors to divergent CD8+ T cell fates. Immunology and Cell Biology, 104 (4) imcb.70101, 396-399. doi: 10.1111/imcb.70101

Transcriptional programming governs the transition from shared progenitors to divergent CD8+ T cell fates

2025

Journal Article

GFI1-driven transcriptional and epigenetic programs maintain CD8+ T cell stemness and persistence

Chaudhry, M. Zeeshan, Chen, Evelyn, Man, Hiu On, Jones, Aneesha, Denman, Renae, Yu, Huiyang, Huang, Qiutong, Ilich, Adrian, Schreuder, Jaring, Navarro, Severine, Tuong, Zewen K. and Belz, Gabrielle T. (2025). GFI1-driven transcriptional and epigenetic programs maintain CD8+ T cell stemness and persistence. Nature Immunology, 26 (6) 1418, 894-907. doi: 10.1038/s41590-025-02151-5

GFI1-driven transcriptional and epigenetic programs maintain CD8+ T cell stemness and persistence

2025

Journal Article

Distinctive CD8+ T&nbsp;cell activation by antigen-presenting plasmacytoid dendritic cells compared to conventional dendritic cells

van der Sluis, Renée M., García-Rodríguez, Juan L., Nielsen, Ian Helstrup, Gris-Oliver, Albert, Becker, Jennifer, Costa, Bibiana, Chaudhry, M. Zeeshan, Werner, Marvin, Laustsen, Anders, Pedersen, Jesper G., Gammelgaard, Kristine R., Mogensen, Trine H., Kalinke, Ulrich, Cicin-Sain, Luka, Bak, Rasmus O., Kristensen, Lasse S. and Jakobsen, Martin R. (2025). Distinctive CD8+ T&nbsp;cell activation by antigen-presenting plasmacytoid dendritic cells compared to conventional dendritic cells. Cell Reports, 44 (3) 115413, 115413. doi: 10.1016/j.celrep.2025.115413

Distinctive CD8+ T&nbsp;cell activation by antigen-presenting plasmacytoid dendritic cells compared to conventional dendritic cells

2024

Journal Article

Chameleon impersonation of NK cells and ILC1s

Chaudhry, M. Zeeshan and Belz, Gabrielle T. (2024). Chameleon impersonation of NK cells and ILC1s. Nature Immunology, 25 (8), 1313-1315. doi: 10.1038/s41590-024-01886-x

Chameleon impersonation of NK cells and ILC1s

2024

Journal Article

A single-dose MCMV-based vaccine elicits long-lasting immune protection in mice against distinct SARS-CoV-2 variants

Metzdorf, Kristin, Jacobsen, Henning, Kim, Yeonsu, Teixeira Alves, Luiz Gustavo, Kulkarni, Upasana, Brdovčak, Maja Cokarić, Materljan, Jelena, Eschke, Kathrin, Chaudhry, M. Zeeshan, Hoffmann, Markus, Bertoglio, Federico, Ruschig, Maximilian, Hust, Michael, Šustić, Marko, Krmpotić, Astrid, Jonjić, Stipan, Widera, Marek, Ciesek, Sandra, Pöhlmann, Stefan, Landthaler, Markus and Čičin-Šain, Luka (2024). A single-dose MCMV-based vaccine elicits long-lasting immune protection in mice against distinct SARS-CoV-2 variants. Frontiers in Immunology, 15 1383086, 1-18. doi: 10.3389/fimmu.2024.1383086

A single-dose MCMV-based vaccine elicits long-lasting immune protection in mice against distinct SARS-CoV-2 variants

2024

Journal Article

GFI1B specifies developmental potential of innate lymphoid cell progenitors in the lungs

Huang, Qiutong, Cao, Wang H.J., Curio, Sophie, Yu, Huiyang, Denman, Renae, Chen, Evelyn, Schreuder, Jaring, Dight, James, Chaudhry, M., Jacquelot, Nicolas, Wimmer, Verena C., Seillet, Cyril, Möröy, Tarik and Belz, Gabrielle T. (2024). GFI1B specifies developmental potential of innate lymphoid cell progenitors in the lungs. Science Immunology, 9 (95) eadj2654, eadj2654. doi: 10.1126/sciimmunol.adj2654

GFI1B specifies developmental potential of innate lymphoid cell progenitors in the lungs

2024

Journal Article

Decidual-tissue-resident memory T cells protect against nonprimary human cytomegalovirus infection at the maternal-fetal interface

Alfi, Or, Cohen, Mevaseret, Bar-On, Shikma, Hashimshony, Tamar, Levitt, Lorinne, Raz, Yael, Blecher, Yair, Chaudhry, M. Zeeshan, Cicin-Sain, Luka, Ben-El, Rina, Oiknine-Djian, Esther, Lahav, Tamar, Vorontsov, Olesya, Cohen, Adiel, Zakay-Rones, Zichria, Daniel, Leonor, Berger, Michael, Mandel-Gutfreund, Yael, Panet, Amos and Wolf, Dana G. (2024). Decidual-tissue-resident memory T cells protect against nonprimary human cytomegalovirus infection at the maternal-fetal interface. Cell Reports, 43 (2) 113698. doi: 10.1016/j.celrep.2024.113698

Decidual-tissue-resident memory T cells protect against nonprimary human cytomegalovirus infection at the maternal-fetal interface

2022

Journal Article

ORFeome phage display reveals a major immunogenic epitope on the S2 subdomain of SARS-CoV-2 spike protein

Ballmann, Rico, Hotop, Sven-Kevin, Bertoglio, Federico, Steinke, Stephan, Heine, Philip Alexander, Chaudhry, M. Zeeshan, Jahn, Dieter, Pucker, Boas, Baldanti, Fausto, Piralla, Antonio, Schubert, Maren, Čičin-Šain, Luka, Brönstrup, Mark, Hust, Michael and Dübel, Stefan (2022). ORFeome phage display reveals a major immunogenic epitope on the S2 subdomain of SARS-CoV-2 spike protein. Viruses, 14 (6) 1326, 1-13. doi: 10.3390/v14061326

ORFeome phage display reveals a major immunogenic epitope on the S2 subdomain of SARS-CoV-2 spike protein

2022

Journal Article

MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination

Kim, Yeonsu, Zheng, Xiaoyan, Eschke, Kathrin, Chaudhry, M. Zeeshan, Bertoglio, Federico, Tomić, Adriana, Krmpotić, Astrid, Hoffmann, Markus, Bar-On, Yotam, Boehme, Julia, Bruder, Dunja, Ebensen, Thomas, Brunotte, Linda, Ludwig, Stephan, Messerle, Martin, Guzman, Carlos, Mandelboim, Ofer, Hust, Michael, Pöhlmann, Stefan, Jonjić, Stipan and Čičin-Šain, Luka (2022). MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination. Cellular and Molecular Immunology, 19 (2), 234-244. doi: 10.1038/s41423-021-00814-5

MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination

2021

Journal Article

Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection

Flommersfeld, Sophie, Böttcher, Jan P., Ersching, Jonatan, Flossdorf, Michael, Meiser, Philippa, Pachmayr, Ludwig O., Leube, Justin, Hensel, Inge, Jarosch, Sebastian, Zhang, Qin, Chaudhry, M. Zeeshan, Andrae, Immanuel, Schiemann, Matthias, Busch, Dirk.H., Cicin-Sain, Luka, Sun, Joseph C., Gasteiger, Georg, Victora, Gabriel D., Höfer, Thomas, Buchholz, Veit R. and Grassmann, Simon (2021). Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection. Immunity, 54 (10), 2288-2304.e7. doi: 10.1016/j.immuni.2021.08.002

Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection

2021

Journal Article

Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy

Müller, Thomas R., Jarosch, Sebastian, Hammel, Monika, Leube, Justin, Grassmann, Simon, Bernard, Bettina, Effenberger, Manuel, Andrä, Immanuel, Chaudhry, M. Zeeshan, Käuferle, Theresa, Malo, Antje, Cicin-Sain, Luka, Steinberger, Peter, Feuchtinger, Tobias, Protzer, Ulrike, Schumann, Kathrin, Neuenhahn, Michael, Schober, Kilian and Busch, Dirk H. (2021). Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy. Cell Reports Medicine, 2 (8) 100374, 100374. doi: 10.1016/j.xcrm.2021.100374

Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy

2021

Journal Article

A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients binds to the ACE2-RBD interface and is tolerant to most known RBD mutations

Bertoglio, Federico, Fühner, Viola, Ruschig, Maximilian, Heine, Philip Alexander, Abassi, Leila, Klünemann, Thomas, Rand, Ulfert, Meier, Doris, Langreder, Nora, Steinke, Stephan, Ballmann, Rico, Schneider, Kai-Thomas, Roth, Kristian Daniel Ralph, Kuhn, Philipp, Riese, Peggy, Schäckermann, Dorina, Korn, Janin, Koch, Allan, Chaudhry, M Zeeshan, Eschke, Kathrin, Kim, Yeonsu, Zock-Emmenthal, Susanne, Becker, Marlies, Scholz, Margitta, Moreira, Gustavo Marçal Schmidt Garcia, Wenzel, Esther Veronika, Russo, Giulio, Garritsen, Hendrikus S P, Casu, Sebastian ... Hust, Michael (2021). A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients binds to the ACE2-RBD interface and is tolerant to most known RBD mutations. Cell Reports, 36 (4) 109433, 1-23. doi: 10.1016/j.celrep.2021.109433

A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients binds to the ACE2-RBD interface and is tolerant to most known RBD mutations

Availability

Dr M. Zeeshan Chaudhry is:
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Supervision history

Current supervision

Completed supervision

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