Overview
Background
Eoin O'Sullivan, MD, PhD is a Consultant Nephrologist (Senior Staff Specialist) at Metro North, and Lecturer at the Institute for Molecular Bioscience, University of Queensland and Associate at QIMR Berghofer. He has a diverse academic background, with degrees in medicine from University College Cork, Ireland , and a PhD from the University of Edinburgh, UK, where he specialized in the biology of senescence in kidney injury. Dr. O'Sullivan also holds multiple certifications in nephrology and a Masters in medical education.
His research focuses on kidney fibrosis and cellular senescence, with over 52 publications and 10 patent applications. His work has been cited more than 15,000 times, and he has contributed to major advancements in therapeutic strategies for chronic kidney disease. He collaborates extensively with industry partners to develop anti-fibrotic therapies, with several of his discoveries leading to potential new drug targets.
In addition to his research, Dr. O'Sullivan is actively involved in medical education and mentorship, involved with ANZSN Educational an scientific comittees, with national level educational experiences both in Australia and in UK.
Current Research focus:
Theme 1. Senescence
Using single cell RNA-Seq techniques to discover therapeutic targets for people living with Kidney Disease.
Theme 2: Translational Data analysis
Machine learning and AI approaches to clinical data interpretation, prognosis, decision support.
Availability
- Dr Eoin O'Sullivan is:
- Available for supervision
Research interests
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Senescence
Understanding cellular senescence as a biomarkers and therapeutic target for chronic disease outcomes, in particular renal fibrosis/CKD
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single cell RNA-Seq
novel translational approaches to using single cell RNA-Seq, in particular to uncover targets and biomarkers in CKD
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Machine learning and AI
analysis of large volumes of public data ( ECG, clinical parameters, text ) with international collaborations - looking for translational pathways for novel algorithms - in particular focused on Renal and cardiological outcomes,
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Renal Vasculitis
translational focus on clinical data, access to patient data, samples, network of collaborators
Research impacts
Complete list of published works: https://orcid.org/0000-0002-7709-6595
My senescence research program to date has created new knowledge in the field of kidney fibrosis and senescence, documented across multiple publications demonstrating international and cross disciplinary reach attracting over 2,500 citations from 74 countries across 6 continents including major institutions such as University of Oxford, Cambridge, Harvard, Mayo clinic, Johns Hopkins, and several Australian universities. My publications are in the top 10% cited worldwide and appear in the top 10% of journals. Research areas citing this work include cellular biology, computational biology, clinical medicine, and pharmacology (Scival 13/1/24). this program alone places me on the 86th citation percentile for researchers (WOS 6/3/23) Several of these papers are in the top 1% of citations for their ESI subject area (Scival)
Works
Search Professor Eoin O'Sullivan’s works on UQ eSpace
2025
Journal Article
Higher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial
Abani, O., Abbas, A., Abbas, F., Abbas, J., Abbas, K., Abbas, M., Abbasi, S., Abbass, H., Abbott, A., Abdallah, N., Abdelaziz, A., Abdelfattah, M., Abdelqader, B., Abdul, A., Abdul, B., Abdul, S., Abdul Rasheed, A., Abdulakeem, A., Abdul-Kadir, R., Abdullah, A., Abdulmumeen, A., Abdul-Raheem, R., Abdulshukkoor, N., Abdusamad, K., Abed El Khaleq, Y., Abedalla, M., Abeer Ul Amna, A., Abel, L., Abernethy, K. ... Zuriaga-Alvaro, A. (2025). Higher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial. eClinicalMedicine, 81 103080, 103080. doi: 10.1016/j.eclinm.2025.103080
2024
Journal Article
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ
Kiourtis, Christos, Terradas-Terradas, Maria, Gee, Lucy M., May, Stephanie, Georgakopoulou, Anastasia, Collins, Amy L., O’Sullivan, Eoin D., Baird, David P., Hassan, Mohsin, Shaw, Robin, Tan, Ee Hong, Müller, Miryam, Engelmann, Cornelius, Andreola, Fausto, Hsieh, Ya-Ching, Reed, Lee H., Borthwick, Lee A., Nixon, Colin, Clark, William, Hanson, Peter S., Sumpton, David, Mackay, Gillian, Suzuki, Toshiyasu, Najumudeen, Arafath K., Inman, Gareth J., Campbell, Andrew, Barry, Simon T., Quaglia, Alberto, Morris, Christopher M. ... Bird, Thomas G. (2024). Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ. Nature Cell Biology, 26 (12) eaan1230, 2075-2083. doi: 10.1038/s41556-024-01543-3
2024
Journal Article
A comparison of the diagnostic ability of large language models in challenging clinical cases
Khan, Maria Palwasha and O'Sullivan, Eoin Daniel (2024). A comparison of the diagnostic ability of large language models in challenging clinical cases. Frontiers in Artificial Intelligence, 7 1379297, 1379297. doi: 10.3389/frai.2024.1379297
2024
Journal Article
Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial
Faust, Saul N, Haynes, Richard, Jones, Christine E, Staplin, Natalie, Whittaker, Elizabeth, Jaki, Thomas, Juszczak, Ed, Spata, Enti, Wan, Mandy, Bamford, Alasdair, Dimitri, Paul, Finn, Adam, Furness, John, Ramanan, Athimalaipet V, Gale, Christopher, Cathie, Katrina, Drysdale, Simon, Bernatoniene, Jolanta, Murray, Clare, Roehr, Charles C, Fleming, Paul, Riordan, Andrew, Bandi, Srini, Jyothish, Deepthi, Evans, Jennifer, Emonts, Marieke, Kelly, Dominic, Pathan, Nazima, Davies, Patrick ... Zuriaga-Alvaro, A. (2024). Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet Child and Adolescent Health, 8 (3), 190-200. doi: 10.1016/S2352-4642(23)00316-4
2024
Journal Article
Avacopan as an additional therapeutic intervention to promote renal recovery in severe ANCA-associated vasculitis: A case report
Atrens, Aleks D., Hutton, Holly, O'Sullivan, Eoin, Moore, John and Madhan, Krishan (2024). Avacopan as an additional therapeutic intervention to promote renal recovery in severe ANCA-associated vasculitis: A case report. Nephrology, 29 (2), 105-107. doi: 10.1111/nep.14253
2024
Book Chapter
Nephron Senescence and Mechanisms
Healy, Helen, Kassianos, Andrew J., Ng, Monica S. Y. and O’Sullivan, Eoin D. (2024). Nephron Senescence and Mechanisms. Kidney Disease in the Elderly. (pp. 25-41) Cham, Switzerland: Springer. doi: 10.1007/978-3-031-68460-9_3
2023
Journal Article
Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Abani, O., Abbas, A., Abbas, F., Abbas, J., Abbas, K., Abbas, M., Abbasi, S., Abbass, H., Abbott, A., Abdallah, N., Abdelaziz, A., Abdelfattah, M., Abdelqader, B., Abdul, A., Abdul, B., Abdul, S., Abdul Rasheed, A., Abdulakeem, A., Abdul-Kadir, R., Abdullah, A., Abdulmumeen, A., Abdul-Raheem, R., Abdulshukkoor, N., Abdusamad, K., Abed El Khaleq, Y., Abedalla, M., Abeer Ul Amna, A., Abel, L., Abernethy, K. ... Zuriaga-Alvaro, A. (2023). Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet Diabetes and Endocrinology, 11 (12), 905-914. doi: 10.1016/S2213-8587(23)00253-X
2023
Journal Article
Do early relapses predict the risk of long-term relapsing disease in an adult and paediatric cohort with MOGAD?
Chen, Bo, Gomez-Figueroa, Enrique, Redenbaugh, Vyanka, Francis, Anna, Satukijchai, Chanjira, Wu, Yan, Messina, Silvia, Sa, Mario, Woodhall, Mark, Robertson, Neil P., Lim, Ming, Wassmer, Evangeline, Kneen, Rachel, Huda, Saif, Blain, Camilla, Halfpenny, Christopher, Hemingway, Cheryl, O'Sullivan, Eoin, Hobart, Jeremy, Fisniku, Leonora K., Martin, Roswell J., Dobson, Ruth, Cooper, Sarah A., Williams, Victoria, Waters, Patrick, Chen, John J., Pittock, Sean J., Ramdas, Sithara, Leite, Maria Isabel ... Palace, Jacqueline (2023). Do early relapses predict the risk of long-term relapsing disease in an adult and paediatric cohort with MOGAD?. Annals of Neurology, 94 (3), 508-517. doi: 10.1002/ana.26731
2023
Conference Publication
A family of flare- a case of lupus nephritis associated with SPENDCI syndrome with a sister having similar syndrome
Pagnis, Rachna, Hepburn, Kirsten, O'Sullivan, Eoin and Puri, Priyanka (2023). A family of flare- a case of lupus nephritis associated with SPENDCI syndrome with a sister having similar syndrome. 58th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Christchurch, New Zealand, 4–6 September 2023. Richmond, VIC, Australia: John Wiley & Sons.
2023
Conference Publication
Discovery And Validation Of Novel Renal Epithelial Senescence Associated Biomarkers
Baird, David, Reck, Maximilian, Campbell, Ross, O'Sullivan, Eoin, Docherty, Marie-Helena, Cairns, Carolynn, Carvalho, Cyril, Vermeren, Matthieu, Hughes, Jeremy, Mark, Patrick, Denby, Laura, Conway, Bryan, Mylonas, Katie and Ferenbach, David (2023). Discovery And Validation Of Novel Renal Epithelial Senescence Associated Biomarkers. 60th ERA Congress, Milan, Italy, 15-18 June 2023. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ndt/gfad063c_4455
2023
Journal Article
Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis
O'Sullivan, Eoin D., Mylonas, Katie J., Xin, Cuiyan, Baird, David P., Carvalho, Cyril, Docherty, Marie-Helena, Campbell, Ross, Matchett, Kylie P., Waddell, Scott H., Walker, Alexander D., Gallagher, Kevin M., Jia, Siyang, Leung, Steve, Laird, Alexander, Wilflingseder, Julia, Willi, Michaela, Reck, Maximilian, Finnie, Sarah, Pisco, Angela, Gordon-Keylock, Sabrina, Medvinsky, Alexander, Boulter, Luke, Henderson, Neil C., Kirschner, Kristina, Chandra, Tamir, Conway, Bryan R., Hughes, Jeremy, Denby, Laura, Bonventre, Joseph V. and Ferenbach, David A. (2023). Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis. Science Translational Medicine, 15 (698) abn0736, eabn0736. doi: 10.1126/scitranslmed.abn0736
2022
Journal Article
Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis
O'Sullivan, Eoin D., Mylonas, Katie J., Bell, Rachel, Carvalho, Cyril, Baird, David P., Cairns, Carolynn, Gallagher, Kevin M., Campbell, Ross, Docherty, Marie, Laird, Alexander, Henderson, Neil C., Chandra, Tamir, Kirschner, Kristina, Conway, Bryan, Dihazi, Gry H., Zeisberg, Michael, Hughes, Jeremy, Denby, Laura, Dihazi, Hassan and Ferenbach, David A. (2022). Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis. JCI Insight, 7 (22) e154124. doi: 10.1172/jci.insight.154124
2022
Journal Article
Cognitive bias is a crucial factor in nurses' decision making
O'sullivan, Eoin D. (2022). Cognitive bias is a crucial factor in nurses' decision making. Evidence-Based Nursing, 26 (1), 37-37. doi: 10.1136/ebnurs-2022-103585
2022
Journal Article
Covid-19: the government's gaslighting has left vulnerable patients feeling forgotten
O'Sullivan, Eoin D. (2022). Covid-19: the government's gaslighting has left vulnerable patients feeling forgotten. The BMJ (378) o2033. doi: 10.1136/bmj.o2033
2022
Journal Article
Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Abani, Obbina, Abbas, Ali, Abbas, Fatima, Abbas, Mustafa, Abbasi, Sadia, Abbass, Hakam, Abbott, Alfie, Abdallah, Nabeel, Abdelaziz, Ashraf, Abdelfattah, Mohamed, Abdelqader, Bushra, Abdul, Basir, Abdul Rasheed, Althaf, Abdulakeem, Ajibode, Abdul-Kadir, Rezan, Abdullah, Abdullah, Abdulmumeen, Abdulfatahi, Abdul-Raheem, Rasheed, Abdulshukkoor, Niyaz, Abdusamad, Kula, Abed El Khaleq, Yazeed, Abedalla, Mai, Ul-Amna, Abeer, Abernethy, Katrina, Aboaba, Adebanke, Abo-Leyah, Hani, Abou-Haggar, Ahmed, Abouibrahim, Mahmoud, Abraham, Miriam ... RECOVERY Collaborative Group (2022). Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 399 (10325), 665-676. doi: 10.1016/S0140-6736(22)00163-5
2022
Journal Article
Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Abani, Obbina, Abbas, Ali, Abbas, Fatima, Abbas, Mustafa, Abbasi, Sadia, Abbass, Hakam, Abbott, Alfie, Abdallah, Nabeel, Abdelaziz, Ashraf, Abdelfattah, Mohamed, Abdelqader, Bushra, Abdul, Basir, Abdul Rasheed, Althaf, Abdulakeem, Ajibode, Abdul-Kadir, Rezan, Abdullah, Abdullah, Abdulmumeen, Abdulfatahi, Abdul-Raheem, Rasheed, Abdulshukkoor, Niyaz, Abdusamad, Kula, Abed El Khaleq, Yazeed, Abedalla, Mai, Abeer Ul Amna, Abeer Ul Amna, Abernethy, Katrina, Aboaba, Adebanke, Abo-Leyah, Hani, Abou-Haggar, Ahmed, Abouibrahim, Mahmoud, Abraham, Miriam ... RECOVERY Collaborative Group (2022). Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 399 (10320), 143-151. doi: 10.1016/S0140-6736(21)01825-0
2021
Journal Article
Aging modulates the effects of ischemic injury upon mesenchymal cells within the renal interstitium and microvasculature
Shaw, Isaac W., O'Sullivan, Eoin D., Pisco, Angela O., Borthwick, Gary, Gallagher, Kevin M., Péault, Bruno, Hughes, Jeremy and Ferenbach, David A. (2021). Aging modulates the effects of ischemic injury upon mesenchymal cells within the renal interstitium and microvasculature. Stem Cells Translational Medicine, 10 (8), 1232-1248. doi: 10.1002/sctm.20-0392
2021
Journal Article
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial
Abani, Obbina, Abbas, Ali, Abbas, Fatima, Abbas, Mustafa, Abbasi, Sadia, Abbass, Hakam, Abbott, Alfie, Abdallah, Nabeel, Abdelaziz, Ashraf, Abdelfattah, Mohamed, Abdelqader, Bushra, Abdo, David, Abdul, Basir, Abdul Rasheed, Althaf, Abdulakeem, Ajibode, Abdul-Kadir, Rezan, Abdulle, Amina, Abdulmumeen, Abdulfatahi, Abdul-Raheem, Rasheed, Abdulshukkoor, Niyaz, Abdusamad, Kula, Abed El Khaleq, Yazeed, Abedalla, Mai, Abeer Ul Amna, Abeer Ul Amna, Abernethy, Katrina, Aboaba, Adebanke, Abo-Leyah, Hani, Abou-Haggar, Ahmed, Abouibrahim, Mahmoud ... RECOVERY Collaborative Group (2021). Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. The Lancet, 397 (10289), 2049-2059. doi: 10.1016/S0140-6736(21)00897-7
2021
Journal Article
Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair
Mylonas, Katie J., O’Sullivan, Eoin D., Humphries, Duncan, Baird, David P., Docherty, Marie-Helena, Neely, Sarah A., Krimpenfort, Paul J., Melk, Anette, Schmitt, Roland, Ferreira-Gonzalez, Sofia, Forbes, Stuart J., Hughes, Jeremy and Ferenbach, David A. (2021). Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair. Science Translational Medicine, 13 (594) eabb0203. doi: 10.1126/scitranslmed.abb0203
2021
Journal Article
Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Abani, Obbina, Abbas, Ali, Abbas, Fatima, Abbas, Mustafa, Abbasi, Sadia, Abbass, Hakam, Abbott, Alfie, Abdallah, Nabeel, Abdelaziz, Ashraf, Abdelfattah, Mohamed, Abdelqader, Bushra, Abdul, Basir, Abdul Rasheed, Althaf, Abdulakeem, Ajibode, Abdul-Kadir, Rezan, Abdulmumeen, Abdulfatahi, Abdul-Raheem, Rasheed, Abdulshukkoor, Niyaz, Abdusamad, Kula, Abed El Khaleq, Yazeed, Abedalla, Mai, Abeer Ul Amna, Abeer, Abernethy, Katrina, Aboaba, Adebanke, Abo-Leyah, Hani, Abou-Haggar, Ahmed, Abouibrahim, Mahmoud, Abraham, Miriam, Abraham, Tizzy ... RECOVERY Collaborative Group (2021). Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 397 (10285), 1637-1645. doi: 10.1016/S0140-6736(21)00676-0
Supervision
Availability
- Dr Eoin O'Sullivan is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
The IVCare adaptive platform trial: Towards zero bloodstream infections in IV catheters
Associate Advisor
Other advisors: Dr Jessica Schults, Professor Claire Rickard
Media
Enquiries
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