Overview
Background
The aim of my research is to determine the underlying molecular interractions that occur between pathogens and their host and to use this information to develop novel avenues for therapeutic intervention.
Dr Kerr received his PhD from The University of Queensland in 2006, working with Associate Professor Rohan D. Teasdale on membrane trafficking. In 2011 he was awarded an Alexander von Humboldt fellowship to extend his skills into the host-pathogen arena at the Max-Planck Institute for Infection Biology. In 2013 he was awarded an ARC DECRA fellowship to return to the UQ Institute for Molecular Bioscience where he is working with Rohan again to exmaine how pathogens exploit mammalian endocytic pathways during infection.
Availability
- Dr Markus Kerr is:
- Available for supervision
Fields of research
Research interests
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Host-Pathogen Interactions
Host-pathogen interactions are the interface of infectious diseases. By studying these processes we not only gain valuable fundamental insight into both organisms involved, we also identify possible avenues for therapeutic intervention. My current focus is upon how intracellular pathogens like Chlamydia and Salmonella manipulate the cell to generate their replicative niche.
Works
Search Professor Markus Kerr’s works on UQ eSpace
2018
Journal Article
Sorting Nexin 27 (SNX27) regulates the trafficking and activity of the glutamine transporter ASCT2
Yang, Zhe, Follett, Jordan, Kerr, Markus C., Clairfeuille, Thomas, Chandra, Mintu, Collins, Brett M. and Teasdale, Rohan D. (2018). Sorting Nexin 27 (SNX27) regulates the trafficking and activity of the glutamine transporter ASCT2. Journal of Biological Chemistry, 293 (18), 6802-6811. doi: 10.1074/jbc.RA117.000735
2017
Journal Article
Salmonella effector SopD2 interferes with Rab34 function
Teo, Wei Xuan, Yang, Zhe, Kerr, Markus Charles, Luo, Lin, Guo, Zhong, Alexandrov, Kirill, Stow, Jenny Lea and Teasdale, Rohan David (2017). Salmonella effector SopD2 interferes with Rab34 function. Cell Biology International, 41 (4), 433-446. doi: 10.1002/cbin.10739
2017
Journal Article
Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis
Kerr, Markus C., Gomez, Guillermo A., Ferguson, Charles, Tanzer, Maria C., Murphy, James M., Yap, Alpha S., Parton, Robert G., Huston, Wilhelmina M. and Teasdale, Rohan D. (2017). Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis. Nature Communications, 8 (1) 14729, 14729. doi: 10.1038/ncomms14729
2017
Journal Article
Structural basis for the hijacking of endosomal sorting nexin proteins by Chlamydia trachomatis
Paul, Blessy, Kim, Hyun Sung, Kerr, Markus C., Huston, Wilhelmina M., Teasdale, Rohan D. and Collins, Brett M. (2017). Structural basis for the hijacking of endosomal sorting nexin proteins by Chlamydia trachomatis. eLife, 6 (e22311) e22311, 1-23. doi: 10.7554/eLife.22311
2016
Journal Article
A molecular code for endosomal recycling of phosphorylated cargos by the SNX27–retromer complex
Clairfeuille, Thomas, Mas, Caroline, Chan, Audrey S. M., Yang, Zhe, Tello-Lafoz, Maria, Chandra, Mintu, Wigagdo, Jocelyn, Kerr, Markus, Blessy, Paul, Merida, Isabel, Teasdale, Rohan D., Pavlos, Nathan J., Anggono, Victor and Collins, Brett (2016). A molecular code for endosomal recycling of phosphorylated cargos by the SNX27–retromer complex. Nature Structural and Molecular Biology, 23 (10), 921-932. doi: 10.1038/nsmb.3290
2016
Journal Article
MTMR4 is required for the stability of the salmonella-containing vacuole
Teo, Wei X., Kerr, Markus C. and Teasdale, Rohan D. (2016). MTMR4 is required for the stability of the salmonella-containing vacuole. Frontiers in Cellular and Infection Microbiology, 6 (91) 91, 1-11. doi: 10.3389/fcimb.2016.00091
2016
Journal Article
Sortilin is associated with the chlamydial inclusion and is modulated during infection
Teo, Wei Xuan, Kerr, Markus Charles, Huston, Wilhelmina May and Teasdale, Rohan David (2016). Sortilin is associated with the chlamydial inclusion and is modulated during infection. Biology Open, 5 (4), 429-435. doi: 10.1242/bio.016485
2014
Journal Article
Chlamydia infection depends on a functional MdM2-p53 axis
Gonzalez, Erik, Rother, Marion, Kerr, Markus C., Al-Zeer, Munir A., Abu-Lubad, Mohammad, Kessler, Mirjana, Brinkmann, Volker, Loewer, Alexander and Meyer, Thomas F. (2014). Chlamydia infection depends on a functional MdM2-p53 axis. Nature Communications, 5 (1) 5201, 5201. doi: 10.1038/ncomms6201
2014
Journal Article
Chlamydia trachomatis remodels stable microtubules to coordinate Golgi stack recruitment to the chlamydial inclusion surface
Al-Zeer, Munir A., Al-Youndes, Hesham M., Kerr, Markus, Abu-Lubad, Mohammad, Gonzalez, Erik, Brinkmann, Volker and Meyer, Thomas F. (2014). Chlamydia trachomatis remodels stable microtubules to coordinate Golgi stack recruitment to the chlamydial inclusion surface. Molecular Microbiology, 94 (6), 1285-1297. doi: 10.1111/mmi.12829
2014
Journal Article
Live imaging of endosome dynamics
Kerr, Markus and Teasdale, Rohan D. (2014). Live imaging of endosome dynamics. Seminars in Cell and Developmental Biology, 31, 11-19. doi: 10.1016/j.semcdb.2014.03.027
2014
Book Chapter
Cancer insights through macropinocytosis: a role for sorting nexins?
Wang, Jack T. H., Kerr, Markus and Teasdale, Rohan D. (2014). Cancer insights through macropinocytosis: a role for sorting nexins?. The research and biology of Cancer I. (pp. 1-23) edited by iConcept Press. Hong Kong, China: iConcept Press.
2013
Journal Article
Patched1 is required in neural crest cells for the prevention of orofacial clefts
Metzis, Vicki, Courtney, Andrew D., Kerr, Markus C., Ferguson, Charles, Rondón Galeano, Maria C., Parton, Robert G., Wainwright, Brandon J. and Wicking, Carol (2013). Patched1 is required in neural crest cells for the prevention of orofacial clefts. Human Molecular Genetics, Advance Access (24) ddt353, 1-10. doi: 10.1093/hmg/ddt353
2012
Journal Article
A novel type III endosome transmembrane protein, TEMP
Aturaliya, Rajith, Kerr, Markus and Teasdale, Rohan D. (2012). A novel type III endosome transmembrane protein, TEMP. Cells, 1 (4), 1029-1044. doi: 10.3390/cells1041029
2012
Book Chapter
The phosphoinositides: key regulators of Salmonella containing vacuole (SCV) trafficking and identity
Kerr, M. C., Castro, N. A., Karunaratne, S. and Teasdale, R. D. (2012). The phosphoinositides: key regulators of Salmonella containing vacuole (SCV) trafficking and identity. Salmonella - distribution, adaptation, control measures and molecular technologies. (pp. 251-264) edited by Bassam A. Annous and Joshua B. Gurtler. Rijeka, Croatia: InTech. doi: 10.5772/30761
2011
Journal Article
VPS26A and VPS26B subunits define distinct Retromer complexes
Bugarcic, Andrea, Yang, Zhe, Kerr, Markus C., Griffith, John Griffin, Collins, Brett M. and Teasdale, Rohan D. (2011). VPS26A and VPS26B subunits define distinct Retromer complexes. Traffic, 12 (12), 1759-1773. doi: 10.1111/j.1600-0854.2011.01284.x
2011
Journal Article
Identification and characterization of a new family of cell penetrating peptides: Cyclic cell penetrating peptides
Cascales, Laura, Henriques, Sónia T., Kerr, Markus C., Huang, Yen-Hua, Sweet, Matthew J., Daly, Norelle L. and Craik, David J. (2011). Identification and characterization of a new family of cell penetrating peptides: Cyclic cell penetrating peptides. Journal of Biological Chemistry, Epub ahead of print (42), 36932-36943. doi: 10.1074/jbc.M111.264424
2010
Journal Article
The SNX-PX-BAR family in macropinocytosis: The regulation of macropinosome formation by SNX-PX-BAR proteins
Wang, Jth, Kerr, MC, Karunaratne, S, Jeanes, A, Yap, AS and Teasdale, RD (2010). The SNX-PX-BAR family in macropinocytosis: The regulation of macropinosome formation by SNX-PX-BAR proteins. PLoS One, 5 (10) e13763, e13763-1-e13763-13. doi: 10.1371/journal.pone.0013763
2010
Journal Article
Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella
Kerr, Markus C., Wang, Jack T. H., Castro, Natalie A., Hamilton, Nicholas A., Town, Liam, Brown, Darren L., Meunier, Frederic A., Brown, Nat F., Stow, Jennifer L. and Teasdale, Rohan D. (2010). Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella. EMBO Journal, 29 (8), 1331-1347. doi: 10.1038/emboj.2010.28
2009
Journal Article
Trafficking, development and hedgehog
Simpson, Fiona, Kerr, Markus C. and Wicking, Carol (2009). Trafficking, development and hedgehog. Mechanisms of Development, 126 (5 - 6), 279-288. doi: 10.1016/j.mod.2009.01.007
2009
Journal Article
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line
Suzuki, H, Forrest, ARR, van Nimwegen, E, Daub, CO, Balwierz, PJ, Irvine, KM, Lassmann, T, Ravasi, T, Hasegawa, Y, de Hoon, MJL, Katayama, S, Schroder, K, Carninci, P, Tomaru, Y, Kanamori-Katayama, M, Kubosaki, A, Akalin, A, Ando, Y, Arner, E, Asada, M, Asahara, H, Bailey, T, Bajic, VB, Bauer, D, Beckhouse, AG, Bertin, N, Bjorkegren, J, Brombacher, F, Bulger, E ... Riken Omics Science Center (2009). The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nature Genetics, 41 (5), 553-562. doi: 10.1038/ng.375
Funding
Past funding
Supervision
Availability
- Dr Markus Kerr is:
- Available for supervision
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Supervision history
Completed supervision
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2016
Doctor Philosophy
Examining the contribution of Host Cell Membrane Trafficking Pathways to Intracellular Infection Biology
Associate Advisor
Other advisors: Associate Professor Rohan Teasdale
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2010
Doctor Philosophy
Investigating macropinocytosis: The role of sorting nexins in macropinosome biogenesis
Associate Advisor
Other advisors: Associate Professor Rohan Teasdale
Media
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