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2026 Journal Article Alpha-particle therapy with an actinium-225 labeled bivalent inhibitor of prostate-specific membrane antigen is therapeutically efficacious in a mouse model of prostate cancerMorgan, Katherine A., Grieve, Melyssa L., Akhter, Dewan T., Lange, Jaclyn L., Harris, Matthew J., Thurecht, Kristofer J., Paterson, Brett M. and Donnelly, Paul S. (2026). Alpha-Particle Therapy with an Actinium-225 Labeled Bivalent Inhibitor of Prostate-Specific Membrane Antigen is Therapeutically Efficacious in a Mouse Model of Prostate Cancer. Journal of Medicinal Chemistry acs.jmedchem.6c01378. doi: 10.1021/acs.jmedchem.6c01378 |
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2026 Journal Article Affinity-Tuned Albumin Hitchhiking Extends the Bioorthogonal Capture Window in Pretargeting RadiotheranosticsHe, Xie, Fletcher, Nicholas L., Ediriweera, Gayathri R., Zhu, Yifei, Humphries, James, Howard, Christopher B., Wang, Jiazheng, Bell, Craig A., Kempe, Kristian and Thurecht, Kristofer J. (2026). Affinity-Tuned Albumin Hitchhiking Extends the Bioorthogonal Capture Window in Pretargeting Radiotheranostics. Advanced Healthcare Materials e71385, e71385-e71385. doi: 10.1002/adhm.71385 |
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2026 Journal Article A modular, accessible, and low‐cost photoreactor with precision light and temperature control for small‐scale reactionsVermeijlen, Irma G., Anderson, Will, Ediriweera, Gayathri R., Fletcher, Nicholas L., Bell, Craig A. and Thurecht, Kristofer J. (2026). A modular, accessible, and low‐cost photoreactor with precision light and temperature control for small‐scale reactions. Chemistry–Methods, 6 (6) e70122, 1-11. doi: 10.1002/cmtd.70122 |
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2026 Journal Article Cell-Mimetic Antifouling Poly(ethylene glycol) Interface Enables Selective Capture and Viable Release of Circulating Tumor CellsLi, Mengqi, Pan, Haoyuan, Zuo, Liping, Howard, Christopher B., Thurecht, Kristofer J., Yu, Qun, Gao, Zhiliang, Cui, Jiwei and Hao, Jingcheng (2026). Cell-Mimetic Antifouling Poly(ethylene glycol) Interface Enables Selective Capture and Viable Release of Circulating Tumor Cells. The Journal of Physical Chemistry B, 130 (22) acs.jpcb.6c01974, 5811-5818. doi: 10.1021/acs.jpcb.6c01974 |
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2026 Journal Article Assessing Value for Money in Theranostic Nuclear Medicine: A Systematic ReviewWang, Yufan, Wood, James L., Thurecht, Kristofer J., Yeoh, Su Yu and Tuffaha, Haitham (2026). Assessing Value for Money in Theranostic Nuclear Medicine: A Systematic Review. Journal of Nuclear Medicine, jnumed.125.271469-jnumed.125.271469. doi: 10.2967/jnumed.125.271469 |
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2026 Journal Article Utilizing biorecognition to prime tumors for enhanced nanomedicine delivery of alpha therapiesFletcher, Nicholas L., Chu, Weijing, Huda, Pie, Prior, Amber, S., Gayathri, Humphries, James, Howard, Christopher, Wood, James L., Zhang, Xiaoyan, Silva, Marina Silveira E., Lum, Benedict, Lim, Malcolm, Simpson, Fiona and Thurecht, Kristofer J. (2026). Utilizing biorecognition to prime tumors for enhanced nanomedicine delivery of alpha therapies. Journal of Controlled Release, 392 114708, 114708. doi: 10.1016/j.jconrel.2026.114708 |
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2026 Journal Article Poly(2-oxazoline) and poly(2-oxazine)-based nanomedicines: advancements, opportunities and challengesHumphries, James, Warne, Nicole M., Feeney, Orlagh M., Thurecht, Kristofer J. and Kempe, Kristian (2026). Poly(2-oxazoline) and poly(2-oxazine)-based nanomedicines: advancements, opportunities and challenges. Journal of Controlled Release, 394 114838. doi: 10.1016/j.jconrel.2026.114838 |
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2026 Journal Article Engineered protein corona by bispecific antibody endows liposome with enhanced tumor targeting ability and mitigated accelerated blood clearance effectWei, Xiaoli, Ding, Tianhao, Xi, Meili, Thurecht, Kristofer J., Howard, Christopher B., Cui, Jiwei, Zhan, Changyou and Zhang, Zui (2026). Engineered protein corona by bispecific antibody endows liposome with enhanced tumor targeting ability and mitigated accelerated blood clearance effect. Nano Today, 66 102923, 102923. doi: 10.1016/j.nantod.2025.102923 |
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2026 Journal Article Trans-endothelial trafficking in zebrafish: nanobio interactions of polyethylene glycol-based nanoparticles in live vasculatureLim, Ye-Wheen, Bell, Craig A., Fletcher, Nicholas L., Condon, Nicholas D., Akhter, Dewan T., Rae, James, Ferguson, Charles, Martel, Nick, Humphries, James, Lo, Harriet P., Wu, Yeping, Houston, Zachary H., Lagendijk, Anne K., Hall, Thomas E., Thurecht, Kristofer J. and Parton, Robert G. (2026). Trans-endothelial trafficking in zebrafish: nanobio interactions of polyethylene glycol-based nanoparticles in live vasculature. ACS Nano, 20 (3), 3132-3155. doi: 10.1021/acsnano.5c21042 |
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2026 Journal Article Synthesis and Evaluation of D8W, an Octadentate Desferrioxamine Analogue with Enhanced Water Solubility Designed for 89 Zr-ImmunoPET ImagingWood, James L., Ghosh, Saikat, Rosser, Callum A., Feeney, Samuel V., Brown, Christopher J. M., Fletcher, Nicholas L., Wheatcroft, Michael P., Thurecht, Kristofer J. and Codd, Rachel (2026). Synthesis and Evaluation of D8W, an Octadentate Desferrioxamine Analogue with Enhanced Water Solubility Designed for 89 Zr-ImmunoPET Imaging. Molecular Pharmaceutics, 23 (3) acs.molpharmaceut.5c01947, 1-14. doi: 10.1021/acs.molpharmaceut.5c01947 |
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2026 Journal Article Pretargeted polymeric systems for conducting chemo-radiotherapy on glioblastoma: an evaluation of the impact of nanomedicine structure on bioorthogonal chemistry in vivoChu, Weijing, Ediriweera, Gayathri R., Prior, Amber, Huda, Pie, Lum, Benedict, Howard, Christopher B., Fletcher, Nicholas L., Bernhardt, Paul V. and Thurecht, Kristofer J. (2026). Pretargeted polymeric systems for conducting chemo-radiotherapy on glioblastoma: an evaluation of the impact of nanomedicine structure on bioorthogonal chemistry in vivo. Biomacromolecules, 27 (1), 205-216. doi: 10.1021/acs.biomac.5c01157 |
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2025 Journal Article A modular encapsulation system for precision delivery of proteins, nucleic acids, and small moleculesLuong, Thai D., Martel, Nick, Rae, James, Lo, Harriet P., Lim, Ye-Wheen, Wu, Yeping, McMahon, Kerrie-Ann, Sun, Haolan, Fletcher, Nicholas L., Thurecht, Kristofer J., Johnston, Angus P. R., Ariotti, Nicholas, Hall, Thomas E. and Parton, Robert G. (2025). A modular encapsulation system for precision delivery of proteins, nucleic acids, and small molecules. ACS Nano, 19 (50), 42079-42096. doi: 10.1021/acsnano.5c11452 |
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2025 Journal Article Preclinical evaluation of [212Pb]Pb-ADVC001: a prostate-specific membrane antigen–targeted α-therapy for prostate cancerLiu, Feifei, Monterosso, Melissa E., Boucher, Didier, Shakti, Stelle, Li, Kwong Ching, Kim, Chanwoo, Prior, Amber, Sydes, Abby, Soderholm, Amelia T., Fletcher, Nicholas, Akhter, Dewan, Thurecht, Kristofer, Tieu, William, Kuan, Kevin, Horsfall, Aimee, Kumar, Saawan, Koehbach, Johannes, Hammond, Edward, Karmann, Anna, Rose, Stephen, Li, Gary, Puttick, Simon and Kryza, Thomas (2025). Preclinical evaluation of [212Pb]Pb-ADVC001: a prostate-specific membrane antigen–targeted α-therapy for prostate cancer. Journal of Nuclear Medicine, 66 (11), 1-11. doi: 10.2967/jnumed.125.269707 |
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2025 Journal Article The evolution of nanomedicine: the rise of next-generation nanomaterials in cancer nanomedicineForgham, Helen, Chang, Yixin, Wang, Yao, Zhu, Jiayuan, Liu, Liwei, Biggs, Heather, Kakinen, Aleksandr, Jiang, Yuhao, You, Xinru, Thurecht, Kristofer J., Ma, Shaohua, Ju, Lining Arnold, Tao, Wei, Davis, Thomas P., Wong, Joyce Y. and Qiao, Ruirui (2025). The evolution of nanomedicine: the rise of next-generation nanomaterials in cancer nanomedicine. Science Advances, 11 (43) eadx1576, 1-18. doi: 10.1126/sciadv.adx1576 |
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2025 Journal Article Development of a novel engineered antibody format for PSMA-targeted radionuclide therapyFletcher, Nicholas L., Houston, Zachary H., Chandler, Peter G., Yan, Eddie, Holgate, Rob, Wheatcroft, Michael and Thurecht, Kristofer J. (2025). Development of a novel engineered antibody format for PSMA-targeted radionuclide therapy. Molecular Pharmaceutics, 22 (7), 3666-3678. doi: 10.1021/acs.molpharmaceut.4c01193 |
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2025 Journal Article Targeted mRNA delivery with bispecific antibodies that tether LNPs to cell-surface markersDietmair, Bettina, Humphries, James, Mercer, Timothy R., Thurecht, Kristofer J., Howard, Christopher B. and Cheetham, Seth W. (2025). Targeted mRNA delivery with bispecific antibodies that tether LNPs to cell-surface markers. Molecular Therapy Nucleic Acids, 36 (2) 102520, 1-7. doi: 10.1016/j.omtn.2025.102520 |
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2025 Journal Article Immune-modulating nanomedicines for enhanced drug delivery to non-small-cell lung cancerLiu, Feifei, Howard, Christopher B., Huda, Pie, Fletcher, Nicholas L., Bell, Craig A., Blakey, Idriss, Agrez, Michael and Thurecht, Kristofer J. (2025). Immune-modulating nanomedicines for enhanced drug delivery to non-small-cell lung cancer. Biomaterials, 317 123089, 1-14. doi: 10.1016/j.biomaterials.2025.123089 |
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2025 Journal Article Receptor CDCP1 is a potential target for personalized imaging and treatment of poor outcome HER2+, triple negative and metastatic ER+/HER2- breast cancersGough, Madeline, Kwah, Kayden KX., Khan, Tashbib, Ghosh, Saikat, Sun, Biao, Lee, Catherine YJ., Sokolowski, Kamil A., Tse, Brian WC., Wickramasuriya, Lashith, Ferguson, Kaltin, Rogers, Rebecca, Goh, Justin B., Fletcher, Nicholas L., Houston, Zachary H., Thurecht, Kristofer J., Bray, Laura J., Liu, Cheng, Pyke, Christopher, Lim, Elgene, Snell, Cameron E., He, Yaowu, Hooper, John D. and Kryza, Thomas (2025). Receptor CDCP1 is a potential target for personalized imaging and treatment of poor outcome HER2+, triple negative and metastatic ER+/HER2- breast cancers. Clinical Cancer Research, 31 (8), 1504-1519. doi: 10.1158/1078-0432.ccr-24-2865 |
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2025 Journal Article Harnessing nanoparticles and bioorthogonal chemistries for improving precision of nuclear medicineEdiriweera, Gayathri R., Li, Mengdie, Fletcher, Nicholas L., Houston, Zachary H., Ahamed, Muneer, Blakey, Idriss and Thurecht, Kristofer J. (2025). Harnessing nanoparticles and bioorthogonal chemistries for improving precision of nuclear medicine. Biomaterials Science, 13 (9), 2297-2319. doi: 10.1039/d4bm01387e |
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2025 Journal Article Lipid nanoparticles and transcranial focused ultrasound enhance the delivery of SOD1 antisense oligonucleotides to the murine brain for ALS therapyEdiriweera, Gayathri R., Sivaram, Amal J., Cowin, Gary, Brown, Mikayla L., McAlary, Luke, Lum, Jeremy S., Fletcher, Nicholas L., Robinson, Liam, Simpson, Joshua D., Chen, Liyu, Wasielewska, Joanna M., Byrne, Ella, Finnie, John W., Manavis, Jim, White, Anthony R., Yerbury, Justin J., Thurecht, Kristofer J. and Vine, Kara L. (2025). Lipid nanoparticles and transcranial focused ultrasound enhance the delivery of SOD1 antisense oligonucleotides to the murine brain for ALS therapy. Journal of Controlled Release, 378, 221-235. doi: 10.1016/j.jconrel.2024.11.074 |
