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2020

Journal Article

The peripheral immune system and amyotrophic lateral sclerosis

McCombe, Pamela A., Lee, John D., Woodruff, Trent M. and Henderson, Robert D. (2020). The peripheral immune system and amyotrophic lateral sclerosis. Frontiers in Neurology, 11 279, 279. doi: 10.3389/fneur.2020.00279

The peripheral immune system and amyotrophic lateral sclerosis

2020

Journal Article

The potential interplay between energy metabolism and innate complement activation in amyotrophic lateral sclerosis

McDonald, Tanya S., McCombe, Pamela A., Woodruff, Trent M. and Lee, John D. (2020). The potential interplay between energy metabolism and innate complement activation in amyotrophic lateral sclerosis. The FASEB Journal, 34 (6) fj.201901781, 7225-7233. doi: 10.1096/fj.201901781

The potential interplay between energy metabolism and innate complement activation in amyotrophic lateral sclerosis

2020

Conference Publication

Postpartum Relapse After First On-Study Pregnancy in RRMS Patients Treated With Alemtuzumab in the Phase 2 and 3 Clinical Development Program Over 8 Years

Celius, Elisabeth G., Oh, Jiwon, Achiron, Anat, Compston, D Alastair S., Devonshire, Virginia, Hellwig, Kerstin, Hutton, George J., McCombe, Pamela, Moore, Marie, Simm, Renata Faria, Sousa, Livia, Vincent, Stephen G., Chung, Luke, Daizadeh, Nadia, Mitchell, Colin and Rog, David (2020). Postpartum Relapse After First On-Study Pregnancy in RRMS Patients Treated With Alemtuzumab in the Phase 2 and 3 Clinical Development Program Over 8 Years. 2020 AAN Science Highlights, Online, 14 April 2020. Philadelphia, PA United States: Wolters Kluwer. doi: 10.1212/wnl.94.15_supplement.169

Postpartum Relapse After First On-Study Pregnancy in RRMS Patients Treated With Alemtuzumab in the Phase 2 and 3 Clinical Development Program Over 8 Years

2020

Conference Publication

Predicting Long-Term Sustained Disability Progression in Multiple Sclerosis

Sharmin, Sifat, Bovis, Francesca, Malpas, Charles, Horakova, Dana, Havrdova, Eva, Ayuso, Guillermo Izquierdo, Eichau, Sara, Trojano, Maria, Prat, Alexandre, Girard, Marc, Duquette, Pierre, Onofrj, Marco, Lugaresi, Alessandra, Grand'Maison, Francois, Grammond, Pierre, Sola, Patrizia, Ferraro, Diana, Terzi, Murat, Hupperts, R. M. M., Alroughani, Raed, Boz, Cavit, Shaygannejad, Vijay, Van Pesch, Vincent, Kappos, Ludwig, Lechner-Scott, Jeannette, Bergamaschi, Roberto, Turkoglu, Recai, Solaro, Claudio, Ramo-Tello, Cristina ... Kalincik, Tomas (2020). Predicting Long-Term Sustained Disability Progression in Multiple Sclerosis. Annual Meeting of the American Academy of Neurology, Toronto, Canada, 25 April-1 May 2020. Philadelphia, PA, United States: Lippincott Williams & Wilkins.

Predicting Long-Term Sustained Disability Progression in Multiple Sclerosis

2020

Conference Publication

Cladribine: a multicentre LOng-term efficacy Biomarker Australian Study (CLOBAS)

Maltby, Vicki, Lydon, Amanda, Monif, Mastura, Kilpatrick, Trevor, Butzkueven, Helmut, Taylor, Bruce, McCombe, Pamela, Hodgkinson, Suzanne, Fabis-Pedrini, Marzena, Kermode, Allan, Barnett, Michael, Kalincik, Tomas and Lechner-Scott, Jeannette (2020). Cladribine: a multicentre LOng-term efficacy Biomarker Australian Study (CLOBAS). 2020 AAN Science Highlights, Online, 14 April 2020. Philadelphia, PA United States: Wolters Kluwer. doi: 10.1212/wnl.94.15_supplement.5285

Cladribine: a multicentre LOng-term efficacy Biomarker Australian Study (CLOBAS)

2020

Conference Publication

Determinants of Therapeutic Lag in Multiple Sclerosis

Roos, Izanne, Leray, Emmanuelle, Frascoli, Federico, Casey, Romain, Horakova, Dana, Havrdova, Eva, Trojano, Maria, Ayuso, Guillermo Izquierdo, Madueno, Sara Eichau, Patti, Francesco, Prat, Alexandre, Girard, Marc, Duquette, Pierre, Onofrj, Marco, Lugaresi, Alessandra, Grammond, Pierre, Ozakbas, Serkan, Sola, Patrizia, Ferraro, Diana, Bergamaschi, Roberto, Cartechini, Elisabetta, Sa, Maria Jose, Boz, Cavit, Grand-Maison, Francois, Lechner-Scott, Jeannette, Terzi, Murat, Granella, Franco, Alroughani, Raed, Iuliano, Gerardo ... Kalincik, Tomas (2020). Determinants of Therapeutic Lag in Multiple Sclerosis. Annual Meeting of the American Academy of Neurology, Toronto, Canada, 25 April-1 May 2020. Philadelphia, PA, United States: Lippincott Williams & Wilkins.

Determinants of Therapeutic Lag in Multiple Sclerosis

2020

Conference Publication

Real world safety of Alemtuzumab in the treatment of Multiple Sclerosis – Australian cohort study

Corbett, Joel, Blum, Stefan, Boggild, Mike, Broadley, Simon and McCombe, Pamela (2020). Real world safety of Alemtuzumab in the treatment of Multiple Sclerosis – Australian cohort study. 2020 AAN Science Highlights, Online, 14 April 2020. Philadelphia, PA United States: Wolters Kluwer. doi: 10.1212/wnl.94.15_supplement.1499

Real world safety of Alemtuzumab in the treatment of Multiple Sclerosis – Australian cohort study

2020

Conference Publication

Immunotherapies Improve Long-Term Disability Outcomes in Relapsing-Remitting Multiple Sclerosis

Kalincik, Tomas, Diouf, Ibrahima, Malpas, Charles, Horakova, Dana, Havrdova, Eva, Trojano, Maria, Ayuso, Guillermo Izquierdo, Eichau, Sara, Onofrj, Marco, Lugaresi, Alessandra, Prat, Alexandre, Girard, Marc, Duquette, Pierre, Grammond, Pierre, Grand'Maison, Francois, Sola, Patrizia, Ferraro, Diana, Shaygannejad, Vahid, Alroughani, Raed, Hupperts, R. M. M., Terzi, Murat, Boz, Cavit, Lechner-Scott, Jeannette, Cartechini, Elisabetta, Van Pesch, Vincent, Iuliano, Gerardo, Granella, Franco, Bergamaschi, Roberto, Fernandez Bolanos, Ricardo ... Butzkueven, Helmut (2020). Immunotherapies Improve Long-Term Disability Outcomes in Relapsing-Remitting Multiple Sclerosis. Annual Meeting of the American Academy of Neurology, Toronto, Canada, 25 April-1 May 2020. Philadelphia, PA, United States: Lippincott Williams & Wilkins.

Immunotherapies Improve Long-Term Disability Outcomes in Relapsing-Remitting Multiple Sclerosis

2020

Conference Publication

Low dose Rituximab in the treatment of myasthenia gravis

Chan, Fiona, Swayne, Andrew, Gillis, David, Wong, Richard, Walsh, Michael, Henderson, Robert, McCombe, Pamela and Blum, Stefan (2020). Low dose Rituximab in the treatment of myasthenia gravis. 18th Biennial Clinical Neurophysiology Workshop of the Australian and New Zealand Association of Neurologists, Gold Coast, QLD, Australia, 29 September–2 October 2019. E Park, Shannon, Ireland: Elsevier . doi: 10.1016/j.clinph.2019.11.034

Low dose Rituximab in the treatment of myasthenia gravis

2020

Conference Publication

Determinants of Therapeutic Lag in Relapsing Multiple Sclerosis

Roos, I., Frascoli, F., Horakova, D., Havrdova, E. Kubala, Trojano, M., Izquierdo, G., Eichau, S., Patti, F., Prat, A., Girard, M., Duquette, P., Onofrj, M., Lugaresi, A., Grammond, P., Ozakbas, S., Sola, P., Ferraro, D., Bergamaschi, R., Cartechini, E., Sa, M. Jose, Boz, C., Grand'Maison, F., Lechner-Scott, J., Terzi, M., Granella, F., Alroughani, R., Iuliano, G., Hupperts, R., Spitaleri, D. ... Kalincik, T. (2020). Determinants of Therapeutic Lag in Relapsing Multiple Sclerosis. Conference of MS Research Australia, Melbourne, Australia, 31 October-1 November 2019. London, United Kingdom: Sage Publications.

Determinants of Therapeutic Lag in Relapsing Multiple Sclerosis

2020

Journal Article

Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis

Nabais, Marta F., Lin, Tian, Benyamin, Beben, Williams, Kelly L., Garton, Fleur C., Vinkhuyzen, Anna A. E., Zhang, Futao, Vallerga, Costanza L., Restuadi, Restuadi, Freydenzon, Anna, Zwamborn, Ramona A. J., Hop, Paul J., Robinson, Matthew R., Gratten, Jacob, Visscher, Peter M., Hannon, Eilis, Mill, Jonathan, Brown, Matthew A., Laing, Nigel G., Mather, Karen A., Sachdev, Perminder S., Ngo, Shyuan T., Steyn, Frederik J., Wallace, Leanne, Henders, Anjali K., Needham, Merrilee, Veldink, Jan H., Mathers, Susan, Nicholson, Garth ... Wray, Naomi R. (2020). Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis. npj Genomic Medicine, 5 (1) 10, 1-9. doi: 10.1038/s41525-020-0118-3

Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis

2020

Journal Article

Plasma from some patients with amyotrophic lateral sclerosis exhibits elevated formaldehyde levels

Lee, Aven, Arachchige, Buddhika Jayakody, Reed, Sarah, Henderson, Robert, Aylward, James and McCombe, Pamela Ann (2020). Plasma from some patients with amyotrophic lateral sclerosis exhibits elevated formaldehyde levels. Journal of the Neurological Sciences, 409 116589, 116589. doi: 10.1016/j.jns.2019.116589

Plasma from some patients with amyotrophic lateral sclerosis exhibits elevated formaldehyde levels

2020

Journal Article

Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosis

McGill, Raquel B., Steyn, Frederik J., Ngo, Shyuan T., Thorpe, Kathryn A., Heggie, Susan, Ruitenberg, Marc J., Henderson, Robert D., McCombe, Pamela A. and Woodruff, Trent M. (2020). Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosis. Brain Communications, 2 (1) fcaa013, fcaa013. doi: 10.1093/braincomms/fcaa013

Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosis

2020

Journal Article

Cylindrical spirals in two families: clinical and genetic investigations

Beecroft, Sarah J., Olive, Montse, Gonzalez Quereda, Lidia, Gallano, Pia, Ojanguren, Isabel, McLean, Catriona, McCombe, Pamela, Laing, Nigel G. and Ravenscroft, Gianina (2020). Cylindrical spirals in two families: clinical and genetic investigations. Neuromuscular Disorders, 30 (2), 151-158. doi: 10.1016/j.nmd.2019.12.006

Cylindrical spirals in two families: clinical and genetic investigations

2020

Journal Article

Clinical and therapeutic predictors of disease outcomes in AQP4-IgG+ neuromyelitis optica spectrum disorder

Kunchok, Amy, Malpas, Charles, Nytrova, Petra, Havrdova, Eva Kubala, Alroughani, Raed, Terzi, Murat, Yamout, Bassem, Hor, Jyh Yung, Karabudak, Rana, Boz, Cavit, Ozakbas, Serkan, Olascoaga, Javier, Simo, Magdolna, Granella, Franco, Patti, Francesco, McCombe, Pamela, Csepany, Tunde, Singhal, Bhim, Bergamaschi, Roberto, Fragoso, Yara, Al-Harbi, Talal, Turkoglu, Recai, Lechner-Scott, Jeannette, Laureys, Guy, Oreja-Guevara, Celia, Pucci, Eugenio, Sola, Patrizia, Ferraro, Diana, Altintas, Ayse ... Kalincik, Tomas (2020). Clinical and therapeutic predictors of disease outcomes in AQP4-IgG+ neuromyelitis optica spectrum disorder. Multiple Sclerosis and Related Disorders, 38 101868, 1-8. doi: 10.1016/j.msard.2019.101868

Clinical and therapeutic predictors of disease outcomes in AQP4-IgG+ neuromyelitis optica spectrum disorder

2020

Journal Article

The clinical profile of NMOSD in Australia and New Zealand

Bukhari, Wajih, Clarke, Laura, O’Gorman, Cullen, Khalilidehkordi, Elham, Arnett, Simon, Prain, Kerri M., Woodhall, Mark, Silvestrini, Roger, Bundell, Christine S., Ramanathan, Sudarshini, Abernethy, David, Bhuta, Sandeep, Blum, Stefan, Boggild, Mike, Boundy, Karyn, Brew, Bruce J., Brownlee, Wallace, Butzkueven, Helmut, Carroll, William M., Chen, Celia, Coulthard, Alan, Dale, Russell C., Das, Chandi, Dear, Keith, Fabis-Pedrini, Marzena J., Fulcher, David, Gillis, David, Hawke, Simon, Heard, Robert ... Broadley, Simon A. (2020). The clinical profile of NMOSD in Australia and New Zealand. Journal of Neurology, 267 (5), 1431-1443. doi: 10.1007/s00415-020-09716-4

The clinical profile of NMOSD in Australia and New Zealand

2020

Conference Publication

Alemtuzumab Improves Clinical and MRI Disease Activity Outcomes, Including Slowing of Brain Volume Loss, in RRMS Patients Over 8 Years: CARE-MS I Follow-up (TOPAZ Study)

Hartung, H-P, Comi, G., Arnold, D. L., Boyko, A. N., Havrdova, E. K., Inshasi, J. S., McCombe, P., Nakamura, K., Oreja-Guevara, C., Pelletier, D., Pozzilli, C., Selmaj, K. W., Scott, T. F., Chung, L., Daizadeh, N., Afsar, S. and Van Wijmeersch, B. (2020). Alemtuzumab Improves Clinical and MRI Disease Activity Outcomes, Including Slowing of Brain Volume Loss, in RRMS Patients Over 8 Years: CARE-MS I Follow-up (TOPAZ Study). In: Conference of the Pan Asian Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS), Singapore, Singapore, (NP60-NP61). 13-15 November 2019.

Alemtuzumab Improves Clinical and MRI Disease Activity Outcomes, Including Slowing of Brain Volume Loss, in RRMS Patients Over 8 Years: CARE-MS I Follow-up (TOPAZ Study)

2020

Book Chapter

Sexual dimorphism in the immune system

McCombe, Pamela A. and Greer, Judith M. (2020). Sexual dimorphism in the immune system. The autoimmune diseases. (pp. 419-428) edited by Noel R. Rose and Ian R. Mackay. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-812102-3.00024-5

Sexual dimorphism in the immune system

2020

Conference Publication

Efficacy Outcomes in RRMS Patients Who Switched From SC IFNB-1a in CARE-MS I and II to Alemtuzumab in the Extension Studies: 7-Year Follow-up

Pelletier, D., Arnold, D. L., Bass, A. D., Boyko, A. N., Broadley, S., Comi, G., McCombe, P., Montalban, X., Pozzilli, C., Rovira, A., Selmaj, K. W., Singer, B. A., Vermersch, P., Chung, L., Poole, E. and Wray, S. (2020). Efficacy Outcomes in RRMS Patients Who Switched From SC IFNB-1a in CARE-MS I and II to Alemtuzumab in the Extension Studies: 7-Year Follow-up. Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) Forum, West Palm Beach, FL, United States, 27-29 February 2020. London, United Kingdom: Sage Publications.

Efficacy Outcomes in RRMS Patients Who Switched From SC IFNB-1a in CARE-MS I and II to Alemtuzumab in the Extension Studies: 7-Year Follow-up

2020

Conference Publication

Postpartum Relapse After First On-Study Pregnancy in RRMS Patients Treated With Alemtuzumab in the Phase 2 and 3 Clinical Development Program Over 8 Years

Celius, Elisabeth G., Oh, Jiwon, Achiron, Anat, Compston, D. Alastair S., Devonshire, Virginia, Hellwig, Kerstin, Hutton, George J., McCombe, Pamela, Moore, Marie, Simm, Renata Faria, Sousa, Livia, Vincent, Stephen G., Chung, Luke, Daizadeh, Nadia, Mitchell, Colin and Rog, David (2020). Postpartum Relapse After First On-Study Pregnancy in RRMS Patients Treated With Alemtuzumab in the Phase 2 and 3 Clinical Development Program Over 8 Years. Annual Meeting of the American Academy of Neurology, Toronto, Canada, 25 April - 1 May 2020. Philadelphia, PA United States: Lippincott Williams & Wilkins.

Postpartum Relapse After First On-Study Pregnancy in RRMS Patients Treated With Alemtuzumab in the Phase 2 and 3 Clinical Development Program Over 8 Years