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2026 Journal Article The nanobody Nb.C1 potentiates human acid-sensing ion channel 1a and 1bGolder, Mimi, Butcher, Neville J., Naughton, Jennifer D., Liu, Junyu, Crawford, Theo, Rash, Lachlan D., Mobli, Mehdi and Cristofori-Armstrong, Ben (2026). The nanobody Nb.C1 potentiates human acid-sensing ion channel 1a and 1b. European Journal of Pharmacology, 1022 178850, 178850-1022. doi: 10.1016/j.ejphar.2026.178850 |
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2026 Journal Article The Isolated Thumb Domain of Acid‐Sensing Ion Channels Forms a Minimal Folding Unit Enabling Ligand Binding StudiesMishra, Biswa P., Cristofori‐Armstrong, Ben, Budusan, Elena, Golder, Mimi, Butcher, Neville J., Liu, Junyu, Crawford, Theo, Chin, Yanni K.‐Y., Pereira Schmidt, Anneka, Jia, Xinying, Smallwood, Taylor B., Clark, Richard J., Wurm, Jan P., Rash, Lachlan D. and Mobli, Mehdi (2026). The Isolated Thumb Domain of Acid‐Sensing Ion Channels Forms a Minimal Folding Unit Enabling Ligand Binding Studies. Angewandte Chemie International Edition e23977, 1-12. doi: 10.1002/anie.202523977 |
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2026 Journal Article A single stable topological stereoisomer of a two disulfide conotoxin mimetic demonstrates full potency on the human norepinephrine transporterWilhelm, Patrick, Whish, Lachlan, Mohammadi, Sarasa, Bongers, Meg, Brust, Andreas, Andersson, Asa, Ragnarsson, Lotten, Mobli, Mehdi, Lewis, Richard, Macdonald, Christie and Alewood, Paul (2026). A single stable topological stereoisomer of a two disulfide conotoxin mimetic demonstrates full potency on the human norepinephrine transporter. Australian Journal of Chemistry, 79 (3) CH25185. doi: 10.1071/ch25185 |
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2025 Journal Article Optimization of production and enzymatic efficiency for self‐cyclizing nanodisc proteinsNaughton, Jennifer D., Xie, Donghong, Zhu, Yifei, Cristofori‐Armstrong, Ben, Chin, Yanni K.‐Y., Jia, Xinying, Crawford, Theo and Mobli, Mehdi (2025). Optimization of production and enzymatic efficiency for self‐cyclizing nanodisc proteins. Protein Science, 35 (1) e70429, e70429. doi: 10.1002/pro.70429 |
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2025 Journal Article The Arabidopsis TIRome informs the design of artificial TIR (Toll/interleukin-1 receptor) domain proteinsBayless, Adam M., Song, Lijiang, Sorbello, Mitchell, Ogden, Sam C., Todd, Tyler S., Flint, Alice, Maruta, Natsumi, Tulu, Jedidiah, Drenichev, Mikhail, Ntoukakis, Vardis, Ve, Thomas, Mobli, Mehdi, Wan, Li, Liu, Qingli, Dangl, Jeffery L., Kobe, Bostjan, Grant, Murray and Nishimura, Marc T. (2025). The Arabidopsis TIRome informs the design of artificial TIR (Toll/interleukin-1 receptor) domain proteins. Proceedings of the National Academy of Sciences, 122 (37) e2505893122, 1-12. doi: 10.1073/pnas.2505893122 |
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2025 Journal Article Topological isomers of a potent wound healing peptide: structural insights and implications for bioactivityRaffaelli, Tiziano, Wilson, David T., Mobli, Mehdi, Smout, Michael J., Zhao, Guangzu, Takjoo, Rozita, Bansal, Paramjit S., Yu, Rilei, Zhang, Zixuan, Loukas, Alex and Daly, Norelle L. (2025). Topological isomers of a potent wound healing peptide: structural insights and implications for bioactivity. Journal of Biological Chemistry, 301 (7) 110340, 110340. doi: 10.1016/j.jbc.2025.110340 |
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2025 Journal Article Streamlined postprocessing of NMR structures with the molecular restrainer: a universal tool for high-quality protein–ligand models and non-standard amino acid residuesMareš, Jiří, Tarang, Guneet Singh, Marin, Dmitriy, Mobli, Mehdi, Redon, Stephane and Orts, Julien (2025). Streamlined postprocessing of NMR structures with the molecular restrainer: a universal tool for high-quality protein–ligand models and non-standard amino acid residues. International Journal of Molecular Sciences, 26 (11) 5091, 1-12. doi: 10.3390/ijms26115091 |
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2025 Journal Article An enzymatic dual-oxa Diels–Alder reaction constructs the oxygen-bridged tricyclic acetal unit of (–)-anthrabenzoxocinoneYan, Xiaoli, Jia, Xinying, Luo, Zhenyao, Ji, Shunjia, Zhang, Meng-Jie, Zhang, Hui, Yu, Mingjia, Orts, Julien, Jiang, Kai, Lin, Zhi, Deng, Zixin, Kong, Xu-Dong, Kobe, Bostjan, Zhao, Yi-Lei, Mobli, Mehdi and Qu, Xudong (2025). An enzymatic dual-oxa Diels–Alder reaction constructs the oxygen-bridged tricyclic acetal unit of (–)-anthrabenzoxocinone. Nature Chemistry, 17 (7) e2321722121, 1058-1066. doi: 10.1038/s41557-025-01804-0 |
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2025 Journal Article Refining the NaV1.7 pharmacophore of a class of venom-derived peptide inhibitors via a combination of in silico screening and rational engineeringSharma, Gagan, Deuis, Jennifer R., Jia, Xinying, Crawford, Theo, Rahnama, Sassan, Undheim, Eivind A. B., Vetter, Irina, Chin, Yanni K.Y. and Mobli, Mehdi (2025). Refining the NaV1.7 pharmacophore of a class of venom-derived peptide inhibitors via a combination of in silico screening and rational engineering. Febs Letters, 599 (12), 1717-1732. doi: 10.1002/1873-3468.70036 |
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2024 Journal Article o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2Rahaman, Md. Habibur, Thygesen, Sara J., Maxwell, Michael J., Kim, Hyoyoung, Mudai, Prerna, Nanson, Jeffrey D., Jia, Xinying, Vajjhala, Parimala R., Hedger, Andrew, Vetter, Irina, Haselhorst, Thomas, Robertson, Avril A. B., Dymock, Brian, Ve, Thomas, Mobli, Mehdi, Stacey, Katryn J. and Kobe, Bostjan (2024). o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2. Journal of Enzyme Inhibition and Medicinal Chemistry, 39 (1) 2313055, 2313055. doi: 10.1080/14756366.2024.2313055 |
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2024 Journal Article Structural basis of the bivalency of the TRPV1 agonist DkTxRamanujam, Venkatraman, Crawford, Theo, Cristofori‐Armstrong, Ben, Deuis, Jennifer R., Jia, Xinying, Maxwell, Michael J., Jami, Sina, Ma, Linlin, Vetter, Irina and Mobli, Mehdi (2024). Structural basis of the bivalency of the TRPV1 agonist DkTx. Angewandte Chemie, 136 (3), 1-8. doi: 10.1002/ange.202314621 |
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2024 Journal Article Structural basis of the bivalency of the TRPV1 agonist DkTxRamanujam, Venkatraman, Crawford, Theo, Cristofori-Armstrong, Ben, Deuis, Jennifer, Jia, Xinying, Maxwell, Michael, Jami, Sina, Ma, Linlin, Vetter, Irina and Mobli, Mehdi (2024). Structural basis of the bivalency of the TRPV1 agonist DkTx. Angewandte Chemie International Edition, 63 (3) e202314621, 1-8. doi: 10.1002/anie.202314621 |
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2023 Journal Article Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisationJia, Xinying, Chin, Yanni K.-Y., Zhang, Alan H., Crawford, Theo, Zhu, Yifei, Fletcher, Nicholas L., Zhou, Zihan, Hamilton, Brett R., Stroet, Martin, Thurecht, Kristofer J. and Mobli, Mehdi (2023). Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisation. Communications Chemistry, 6 (1) 48, 1-10. doi: 10.1038/s42004-023-00841-5 |
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2023 Journal Article Structural conformation and activity of spider-derived inhibitory cystine knot peptide Pn3a are modulated by pHTran, Poanna, Crawford, Theo, Ragnarsson, Lotten, Deuis, Jennifer R., Mobli, Mehdi, Sharpe, Simon J., Schroeder, Christina I. and Vetter, Irina (2023). Structural conformation and activity of spider-derived inhibitory cystine knot peptide Pn3a are modulated by pH. ACS Omega, 8 (29), 26276-26286. doi: 10.1021/acsomega.3c02664 |
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2023 Journal Article Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 functionJami, Sina, Deuis, Jennifer R., Klasfauseweh, Tabea, Cheng, Xiaoyang, Kurdyukov, Sergey, Chung, Felicity, Okorokov, Andrei L., Li, Shengnan, Zhang, Jiangtao, Cristofori-Armstrong, Ben, Israel, Mathilde R., Ju, Robert J., Robinson, Samuel D., Zhao, Peng, Ragnarsson, Lotten, Andersson, Åsa, Tran, Poanna, Schendel, Vanessa, McMahon, Kirsten L., Tran, Hue N. T., Chin, Yanni K.-Y., Zhu, Yifei, Liu, Junyu, Crawford, Theo, Purushothamvasan, Saipriyaa, Habib, Abdella M., Andersson, David A., Rash, Lachlan D., Wood, John N. ... Vetter, Irina (2023). Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function. Nature Communications, 14 (1) 2442. doi: 10.1038/s41467-023-37963-2 |
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2023 Journal Article Designing antimicrobial peptides using deep learning and molecular dynamic simulationsCao, Qiushi, Ge, Cheng, Wang, Xuejie, Harvey, Peta J., Zhang, Zixuan, Ma, Yuan, Wang, Xianghong, Jia, Xinying, Mobli, Mehdi, Craik, David J., Jiang, Tao, Yang, Jinbo, Wei, Zhiqiang, Wang, Yan, Chang, Shan and Yu, Rilei (2023). Designing antimicrobial peptides using deep learning and molecular dynamic simulations. Briefings in Bioinformatics, 24 (2) bbad058, 1-13. doi: 10.1093/bib/bbad058 |
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2023 Journal Article Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMRKuschert, Sarah, Stroet, Martin, Chin, Yanni Ka-Yan, Conibear, Anne Claire, Jia, Xinying, Lee, Thomas, Bartling, Christian Reinhard Otto, Strømgaard, Kristian, Güntert, Peter, Rosengren, Karl Johan, Mark, Alan Edward and Mobli, Mehdi (2023). Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR. Magnetic Resonance, 4 (1), 57-72. doi: 10.5194/mr-4-57-2023 |
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2023 Journal Article A bivalent remipede toxin promotes calcium release via ryanodine receptor activationMaxwell, Michael J., Thekkedam, Chris, Lamboley, Cedric, Chin, Yanni K.-Y., Crawford, Theo, Smith, Jennifer J., Liu, Junyu, Jia, Xinying, Vetter, Irina, Laver, Derek R., Launikonis, Bradley S., Dulhunty, Angela, Undheim, Eivind A. B. and Mobli, Mehdi (2023). A bivalent remipede toxin promotes calcium release via ryanodine receptor activation. Nature Communications, 14 (1) 1036, 1-13. doi: 10.1038/s41467-023-36579-w |
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2023 Journal Article Comprehensive peptide cyclization examination yields optimized APP scaffolds with improved affinity toward Mint2Bartling, Christian R. O., Alexopoulou, Flora, Kuschert, Sarah, Chin, Yanni K.-Y., Jia, Xinying, Sereikaite, Vita, Özcelik, Dennis, Jensen, Thomas M., Jain, Palash, Nygaard, Mads M., Harpsøe, Kasper, Gloriam, David E., Mobli, Mehdi and Strømgaard, Kristian (2023). Comprehensive peptide cyclization examination yields optimized APP scaffolds with improved affinity toward Mint2. Journal of Medicinal Chemistry, 66 (4), 3045-3057. doi: 10.1021/acs.jmedchem.2c02017 |
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2023 Journal Article ScrepYard: an online resource for disulfide-stabilised tandem repeat peptidesLiu, Junyu, Maxwell, Michael, Cuddihy, Thom, Crawford, Theo, Bassetti, Madeline, Hyde, Cameron, Peigneur, Steve, Tytgat, Jan, Undheim, Eivind A.B. and Mobli, Mehdi (2023). ScrepYard: an online resource for disulfide-stabilised tandem repeat peptides. Protein Science, 32 (2) e4566, 1-12. doi: 10.1002/pro.4566 |
