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2023 Journal Article Comprehensive peptide cyclization examination yields optimized APP scaffolds with improved affinity toward Mint2Bartling, Christian R. O., Alexopoulou, Flora, Kuschert, Sarah, Chin, Yanni K.-Y., Jia, Xinying, Sereikaite, Vita, Özcelik, Dennis, Jensen, Thomas M., Jain, Palash, Nygaard, Mads M., Harpsøe, Kasper, Gloriam, David E., Mobli, Mehdi and Strømgaard, Kristian (2023). Comprehensive peptide cyclization examination yields optimized APP scaffolds with improved affinity toward Mint2. Journal of Medicinal Chemistry, 66 (4), 3045-3057. doi: 10.1021/acs.jmedchem.2c02017 |
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2023 Journal Article ScrepYard: an online resource for disulfide-stabilised tandem repeat peptidesLiu, Junyu, Maxwell, Michael, Cuddihy, Thom, Crawford, Theo, Bassetti, Madeline, Hyde, Cameron, Peigneur, Steve, Tytgat, Jan, Undheim, Eivind A.B. and Mobli, Mehdi (2023). ScrepYard: an online resource for disulfide-stabilised tandem repeat peptides. Protein Science, 32 (2) e4566, 1-12. doi: 10.1002/pro.4566 |
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2023 Journal Article Solution structure of the N-terminal extension domain of a Schistosoma japonicum asparaginyl-tRNA synthetasePeck, Yoshimi, Pickering, Darren, Mobli, Mehdi, Liddell, Michael J., Wilson, David T., Ruscher, Roland, Ryan, Stephanie, Buitrago, Geraldine, McHugh, Connor, Love, Nicholas C., Pinlac, Theresa, Haertlein, Michael, Kron, Michael A., Loukas, Alex and Daly, Norelle L. (2023). Solution structure of the N-terminal extension domain of a Schistosoma japonicum asparaginyl-tRNA synthetase. Journal of Biomolecular Structure and Dynamics, 42 (15), 1-11. doi: 10.1080/07391102.2023.2241918 |
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2022 Journal Article Methyl probes in proteins for determining ligand binding mode in weak protein–ligand complexesMohanty, Biswaranjan, Orts, Julien, Wang, Geqing, Nebl, Stefan, Alwan, Wesam S., Doak, Bradley C., Williams, Martin L., Heras, Begoña, Mobli, Mehdi and Scanlon, Martin J. (2022). Methyl probes in proteins for determining ligand binding mode in weak protein–ligand complexes. Scientific Reports, 12 (1) 11231, 1-10. doi: 10.1038/s41598-022-13561-y |
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2022 Journal Article Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteinsHealy, Michael D., Sacharz, Joanna, McNally, Kerrie E., McConville, Calum, Tillu, Vikas A., Hall, Ryan J., Chilton, Molly, Cullen, Peter J., Mobli, Mehdi, Ghai, Rajesh, Stroud, David A. and Collins, Brett M. (2022). Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins. Structure, 30 (12), 1590-1602.e6. doi: 10.1016/j.str.2022.10.001 |
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2022 Journal Article The transmembrane adaptor SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputsLiu, Liping, Lucas, Richard M., Nanson, Jeffrey D., Li, Yan, Whitfield, Jason, Curson, James E. B., Tuladhar, Neeraj, Alexandrov, Kirill, Mobli, Mehdi, Sweet, Matthew J., Kobe, Bostjan, Stow, Jennifer and Luo, Lin (2022). The transmembrane adaptor SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs. Journal of Biological Chemistry, 298 (5) 101857, 101857. doi: 10.1016/j.jbc.2022.101857 |
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2021 Journal Article NUScon: a community-driven platform for quantitative evaluation of nonuniform sampling in NMRPustovalova, Yulia, Delaglio, Frank, Craft, D. Levi, Arthanari, Haribabu, Bax, Ad, Billeter, Martin, Bostock, Mark J., Dashti, Hesam, Hansen, D. Flemming, Hyberts, Sven G., Johnson, Bruce A., Kazimierczuk, Krzysztof, Lu, Hengfa, Maciejewski, Mark, Miljenović, Tomas M., Mobli, Mehdi, Nietlispach, Daniel, Orekhov, Vladislav, Powers, Robert, Qu, Xiaobo, Robson, Scott Anthony, Rovnyak, David, Wagner, Gerhard, Ying, Jinfa, Zambrello, Matthew, Hoch, Jeffrey C., Donoho, David L. and Schuyler, Adam D. (2021). NUScon: a community-driven platform for quantitative evaluation of nonuniform sampling in NMR. Magnetic Resonance, 2 (2), 843-861. doi: 10.5194/mr-2-843-2021 |
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2021 Journal Article Structural basis for the binding of the cancer targeting scorpion toxin, ClTx, to the vascular endothelia growth factor receptor neuropilin-1Sharma, Gagan, Braga, Carolyne B., Chen, Kai-En, Jia, Xinying, Ramanujam, Venkatraman, Collins, Brett M., Rittner, Roberto and Mobli, Mehdi (2021). Structural basis for the binding of the cancer targeting scorpion toxin, ClTx, to the vascular endothelia growth factor receptor neuropilin-1. Current Research in Structural Biology, 3, 179-186. doi: 10.1016/j.crstbi.2021.07.003 |
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2021 Journal Article SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degenerationFigley, Matthew D., Gu, Weixi, Nanson, Jeffrey D., Shi, Yun, Sasaki, Yo, Cunnea, Katie, Malde, Alpeshkumar K., Jia, Xinying, Luo, Zhenyao, Saikot, Forhad K., Mosaiab, Tamim, Masic, Veronika, Holt, Stephanie, Hartley-Tassell, Lauren, McGuinness, Helen Y., Manik, Mohammad K., Bosanac, Todd, Landsberg, Michael J., Kerry, Philip S., Mobli, Mehdi, Hughes, Robert O., Milbrandt, Jeffrey, Kobe, Bostjan, DiAntonio, Aaron and Ve, Thomas (2021). SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration. Neuron, 109 (7), 1-19. doi: 10.1016/j.neuron.2021.02.009 |
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2020 Journal Article Multi-species transcriptomics reveals evolutionary diversity in the mechanisms regulating shrimp tail muscle excitation-contraction couplingHuerlimann, Roger, Maes, Gregory E., Maxwell, Michael J., Mobli, Mehdi, Launikonis, Bradley S., Jerry, Dean R. and Wade, Nicholas M. (2020). Multi-species transcriptomics reveals evolutionary diversity in the mechanisms regulating shrimp tail muscle excitation-contraction coupling. Gene, 752 144765, 144765. doi: 10.1016/j.gene.2020.144765 |
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2020 Journal Article Recombinant production, bioconjugation and membrane binding studies ofPn3a, a selective Nav1.7 inhibitorSharma, Gagan, Deuis, Jennifer R., Jia, Xinying, Mueller, Alexander, Vetter, Irina and Mobli, Mehdi (2020). Recombinant production, bioconjugation and membrane binding studies ofPn3a, a selective Nav1.7 inhibitor. Biochemical Pharmacology, 181 114148, 114148. doi: 10.1016/j.bcp.2020.114148 |
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2020 Journal Article An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteriaElliott, Alysha G., Huang, Johnny X., Neve, Søren, Zuegg, Johannes, Edwards, Ingrid A., Cain, Amy K., Boinett, Christine J., Barquist, Lars, Lundberg, Carina Vingsbo, Steen, Jason, Butler, Mark S., Mobli, Mehdi, Porter, Kaela M., Blaskovich, Mark A. T., Lociuro, Sergio, Strandh, Magnus and Cooper, Matthew A. (2020). An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria. Nature Communications, 11 (1) 3184, 3184. doi: 10.1038/s41467-020-16950-x |
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2020 Journal Article Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding genePineda, Sandy S., Chin, Yanni K.-Y., Undheim, Eivind A. B., Senff, Sebastian, Mobli, Mehdi, Dauly, Claire, Escoubas, Pierre, Nicholson, Graham M., Kaas, Quentin, Guo, Shaodong, Herzig, Volker, Mattick, John S. and King, Glenn F. (2020). Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene. Proceedings of the National Academy of Sciences, 117 (21) A41, 201914536-11408. doi: 10.1073/pnas.1914536117 |
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2020 Journal Article Mapping the molecular surface of the analgesic NaV1.7-selective peptide Pn3a reveals residues essential for membrane and channel interactionsMueller, Alexander, Dekan, Zoltan, Kaas, Quentin, Agwa, Akello J., Starobova, Hana, Alewood, Paul F., Schroeder, Christina I., Mobli, Mehdi, Deuis, Jennifer R. and Vetter, Irina (2020). Mapping the molecular surface of the analgesic NaV1.7-selective peptide Pn3a reveals residues essential for membrane and channel interactions. ACS Pharmacology and Translational Science. doi: 10.1021/acsptsci.0c00002 |
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2020 Journal Article Residual dipolar couplings for resolving cysteine bridges in disulfide-rich peptidesRamanujam, Venkatraman, Shen, Yang, Ying, Jinfa and Mobli, Mehdi (2020). Residual dipolar couplings for resolving cysteine bridges in disulfide-rich peptides. Frontiers in Chemistry, 7 889, 1-13. doi: 10.3389/fchem.2019.00889 |
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2019 Journal Article Structural and functional characterisation of a novel peptide from the Australian sea anemone Actinia tenebrosaElnahriry, Khaled A., Wai, Dorothy C.C., Krishnarjuna, Bankala, Badawy, Noha N., Chittoor, Balasubramanyam, MacRaild, Christopher A., Williams-Noonan, Billy J., Surm, Joachim M., Chalmers, David K., Zhang, Alan H., Peigneur, Steve, Mobli, Mehdi, Tytgat, Jan, Prentis, Peter and Norton, Raymond S. (2019). Structural and functional characterisation of a novel peptide from the Australian sea anemone Actinia tenebrosa. Toxicon, 168, 104-112. doi: 10.1016/j.toxicon.2019.07.002 |
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2019 Journal Article A new vector coupling ligation-independent cloning with sortase a fusion for efficient cloning and one-step purification of tag-free recombinant proteinsJia, Xinying, Crawford, Theo, Zhang, Alan H. and Mobli, Mehdi (2019). A new vector coupling ligation-independent cloning with sortase a fusion for efficient cloning and one-step purification of tag-free recombinant proteins. Protein Expression and Purification, 161, 1-7. doi: 10.1016/j.pep.2019.04.004 |
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2019 Journal Article Elucidating the lipid binding properties of membrane-active peptides using cyclised nanodiscsZhang, Alan H., Edwards, Ingrid A., Mishra, Biswa P., Sharma, Gagan, Healy, Michael D., Elliott, Alysha, Blaskovich, Mark A. T., Cooper, Matthew A., Collins, Brett M., Jia, Xinying and Mobli, Mehdi (2019). Elucidating the lipid binding properties of membrane-active peptides using cyclised nanodiscs. Frontiers in Chemistry, 7 (MAR) 238, 238. doi: 10.3389/fchem.2019.00238 |
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2019 Journal Article Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificitiesChandra, Mintu, Chin, Yanni K.-Y., Mas, Caroline, Feathers, J. Ryan, Paul, Blessy, Datta, Sanchari, Chen, Kai-En, Jia, Xinying, Yang, Zhe, Norwood, Suzanne J., Mohanty, Biswaranjan, Bugarcic, Andrea, Teasdale, Rohan D., Henne, W. Mike, Mobli, Mehdi and Collins, Brett M. (2019). Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities. Nature Communications, 10 (1) 1528, 1528. doi: 10.1038/s41467-019-09355-y |
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2019 Journal Article Optimizing the transformation of HYSCORE data using the maximum entropy algorithmMotygullina, Alina E., Mobli, Mehdi and Harmer, Jeffrey R. (2019). Optimizing the transformation of HYSCORE data using the maximum entropy algorithm. Journal of Magnetic Resonance, 301, 30-39. doi: 10.1016/j.jmr.2019.02.002 |
