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2025

Journal Article

Novel psychedelic interventions for post-traumatic stress disorder and their promise for precision medicine

Dodds, Charles, Dawson, Rachelle, Lim, Alexander, Tye, Susannah and Nasrallah, Fatima (2025). Novel psychedelic interventions for post-traumatic stress disorder and their promise for precision medicine. Therapeutic Advances in Psychopharmacology, 15 20451253251396255, 20451253251396255-15. doi: 10.1177/20451253251396255

Novel psychedelic interventions for post-traumatic stress disorder and their promise for precision medicine

2025

Journal Article

Melatonin in bipolar disorder

Macpherson, Heather K., Varela, Roger B., Truong, Trang T.T., Walder, Ken, Berk, Michael and Tye, Susannah J. (2025). Melatonin in bipolar disorder. Journal of Affective Disorders, 398 120871, 120871. doi: 10.1016/j.jad.2025.120871

Melatonin in bipolar disorder

2025

Journal Article

Of mice, molecules and mental health: establishment of the consortium for preclinical psychiatric research to find solutions to the translational gap

Consortium for Preclinical Psychiatric Research, Hill, Rachel A., Bastawy, Eslam M., Berk, Michael, Brown, Robyn M., Burne, Thomas H., Chesworth, Rose, Clark, Scott R., Clemens, Kelly J., Cui, Xiaoying, Dunn, Ariel L., Eratne, Dhamidhu, Foldi, Claire J., Gatt, Justine M., Gubert, Carolina, Gurvich, Caroline, Hannan, Anthony J., Harms, Lauren, Hill-Yardin, Elisa L., Jaehne, Emily J., Jawahar, Magdalene C., Jones, Nigel C., Kang, Matthew JY, Karl, Tim, Kesby, James P., Kim, Jee Hyun, Lawrence, Andrew J., Cruickshank, Heather, Manning, Elizabeth E. ... Sundram, Suresh (2025). Of mice, molecules and mental health: establishment of the consortium for preclinical psychiatric research to find solutions to the translational gap. Molecular Psychiatry, 1-4. doi: 10.1038/s41380-025-03361-x

Of mice, molecules and mental health: establishment of the consortium for preclinical psychiatric research to find solutions to the translational gap

2025

Journal Article

Fueling the future: brain bioenergetics as a driver of neurodevelopment and mental health trajectories

Tye, Susannah J. and Cullen, Kathryn R. (2025). Fueling the future: brain bioenergetics as a driver of neurodevelopment and mental health trajectories. Neuropsychopharmacology, 51 (1), 334-336. doi: 10.1038/s41386-025-02230-z

Fueling the future: brain bioenergetics as a driver of neurodevelopment and mental health trajectories

2025

Conference Publication

Immunometabolic Dysfunction and Dopaminergic Impairment in an Animal Model of Treatment-Resistant Anhedonia: Implications for Bipolar Disorder

Varela, Roger, Macpherson, Heather, Houghton, Tristan, Yates, Clarissa, Yates, Nathanael, Daygon, Dara and Tye, Susannah (2025). Immunometabolic Dysfunction and Dopaminergic Impairment in an Animal Model of Treatment-Resistant Anhedonia: Implications for Bipolar Disorder. HOBOKEN: WILEY.

Immunometabolic Dysfunction and Dopaminergic Impairment in an Animal Model of Treatment-Resistant Anhedonia: Implications for Bipolar Disorder

2025

Conference Publication

Unpredictable Circadian Disturbance Induces Bipolar-Like Behavioural and Immunometabolic Dysregulation in Rats

Macpherson, Heather, Varela, Roger, McCullough, Sebastian, Houghton, Tristan, Chawla, Isha, Wang, Ning, Daygon, Venea, Cui, Xiaoying and Tye, Susannah (2025). Unpredictable Circadian Disturbance Induces Bipolar-Like Behavioural and Immunometabolic Dysregulation in Rats. HOBOKEN: WILEY.

Unpredictable Circadian Disturbance Induces Bipolar-Like Behavioural and Immunometabolic Dysregulation in Rats

2025

Conference Publication

Exploring the Role of Antidepressants on Mitochondrial Energetics and Risk of Antidepressant Induced Mania

Resendez, Manuel Gardea, Coombes, Brandon, Veldic, Marin, Tye, Susannah, Romo-Nava, Francisco, Ozerdem, Aysegul, Prieto, Miguel, Cuellar-Barboza, Alfredo, Nunez, Nicolas, Miola, Alessandro, McElroy, Susan, Biernacka, Joanna, Morava, Eva, Kozicz, Tamas and Frye, Mark (2025). Exploring the Role of Antidepressants on Mitochondrial Energetics and Risk of Antidepressant Induced Mania. HOBOKEN: WILEY.

Exploring the Role of Antidepressants on Mitochondrial Energetics and Risk of Antidepressant Induced Mania

2025

Conference Publication

Bioenergetic Dysregulation in Peripheral Immune Cells: Links to Anhedonia and Fatigue in Depressed Young Adults

Varela, Roger, Cullen, Kathryn, Morath, Brooke and Tye, Susannah (2025). Bioenergetic Dysregulation in Peripheral Immune Cells: Links to Anhedonia and Fatigue in Depressed Young Adults. HOBOKEN: WILEY.

Bioenergetic Dysregulation in Peripheral Immune Cells: Links to Anhedonia and Fatigue in Depressed Young Adults

2025

Conference Publication

Melatonin Mitigates IL-6-Induced Hyperdopaminergia, Oxidative Stress, and Metabolic Dysfunction: Implications for Dopaminergic Dysregulation in Bipolar Disorder

Macpherson, Heather, Varela, Roger, Daygon, Venea, Kesby, James, Cui, Xiaoying and Tye, Susannah (2025). Melatonin Mitigates IL-6-Induced Hyperdopaminergia, Oxidative Stress, and Metabolic Dysfunction: Implications for Dopaminergic Dysregulation in Bipolar Disorder. HOBOKEN: WILEY.

Melatonin Mitigates IL-6-Induced Hyperdopaminergia, Oxidative Stress, and Metabolic Dysfunction: Implications for Dopaminergic Dysregulation in Bipolar Disorder

2025

Journal Article

Inflammation and metabolic dysfunction underly anhedonia-like behavior in antidepressant resistant male rats

Varela, Roger B., Macpherson, Heather, Walker, Adam J., Houghton, Tristan, Yates, Clarissa, Yates, Nathanael J., Daygon, Dara and Tye, Susannah J. (2025). Inflammation and metabolic dysfunction underly anhedonia-like behavior in antidepressant resistant male rats. Brain, Behavior, and Immunity, 127, 170-182. doi: 10.1016/j.bbi.2025.03.001

Inflammation and metabolic dysfunction underly anhedonia-like behavior in antidepressant resistant male rats

2024

Conference Publication

Inflammation in combination with metabolic deficits underly Anhedonia-like behavior in treatment resistant male rats

Varela, Roger, Macpherson, Heather, Houghton, Tristan, Yates, Clarissa, Yates, Nathanael, Daygon, Dara and Tye, Susannah (2024). Inflammation in combination with metabolic deficits underly Anhedonia-like behavior in treatment resistant male rats. ACNP 63rd Annual Meeting: Poster Abstracts P609-P914, Phoenix, AZ, United States, 8 - 11 December 2024. London, United Kingdom: Nature Publishing Group.

Inflammation in combination with metabolic deficits underly Anhedonia-like behavior in treatment resistant male rats

2024

Journal Article

The Wnt signaling pathway in major depressive disorder: A systematic review of human studies

Sanchez-Ruiz, Jorge A., Treviño-Alvarez, Andres M., Zambrano-Lucio, Miguel, Lozano Díaz, Sofía T., Wang, Ning, Biernacka, Joanna M., Tye, Susannah J. and Cuellar-Barboza, Alfredo B. (2024). The Wnt signaling pathway in major depressive disorder: A systematic review of human studies. Psychiatry Research, 339 115983, 1-15. doi: 10.1016/j.psychres.2024.115983

The Wnt signaling pathway in major depressive disorder: A systematic review of human studies

2024

Journal Article

Anti‐manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine

Varela, Roger B., Boschen, Suelen L., Yates, Nathanael, Houghton, Tristan, Blaha, Charles D., Lee, Kendall H., Bennet, Kevin E., Kouzani, Abbas Z., Berk, Michael, Quevedo, João, Valvassori, Samira S. and Tye, Susannah J. (2024). Anti‐manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine. Bipolar Disorders, 26 (4), 376-387. doi: 10.1111/bdi.13423

Anti‐manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine

2024

Journal Article

SmartStim: An Artificial Intelligence Enabled Deep Brain Stimulation Device

Corva, Dean M., Parke, Brenna, West, Alyssa, Doeven, Egan H., Adams, Scott D., Tye, Susannah J., Hashemi, Parastoo, Berk, Michael and Kouzani, Abbas Z. (2024). SmartStim: An Artificial Intelligence Enabled Deep Brain Stimulation Device. IEEE Transactions on Medical Robotics and Bionics, PP (99), 674-684. doi: 10.1109/tmrb.2024.3381341

SmartStim: An Artificial Intelligence Enabled Deep Brain Stimulation Device

2024

Journal Article

Clinical outcomes in the biomarkers of ketamine (Bio-K) study of open-label IV ketamine for refractory depression

Parikh, Sagar V., Vande Voort, Jennifer L., Yocum, Anastasia K., Achtyes, Eric, Goes, Fernando S., Nykamp, Louis, Singh, Balwinder, Lopez-Vives, Daniela, Sera, Cortney E., Maixner, Daniel, Tarnal, Vijay, Severe, Jennifer, Bartek, Steven, Tye, Susannah J., Rico, Jose, Stoppel, Cynthia J., Becerra, Alexis, Smart, LeAnn, Miller, Christina R., Frye, Mark A., Greden, John F. and Bobo, William V. (2024). Clinical outcomes in the biomarkers of ketamine (Bio-K) study of open-label IV ketamine for refractory depression. Journal of Affective Disorders, 348, 143-151. doi: 10.1016/j.jad.2023.12.033

Clinical outcomes in the biomarkers of ketamine (Bio-K) study of open-label IV ketamine for refractory depression

2024

Journal Article

Pharmacogenomic overlap between antidepressant treatment response in major depression & antidepressant associated treatment emergent mania in bipolar disorder

Nuñez, Nicolas A., Coombes, Brandon J., Beaupre, Lindsay Melhuish, Ozerdem, Aysegul, Resendez, Manuel Gardea, Romo-Nava, Francisco, Bond, David J., Veldic, Marin, Singh, Balwinder, Moore, Katherine M., Betcher, Hannah K., Kung, Simon, Prieto, Miguel L., Fuentes, Manuel, Ercis, Mete, Miola, Alessandro, Sanchez Ruiz, Jorge A., Jenkins, Gregory, Batzler, Anthony, Leung, Jonathan G., Cuellar-Barboza, Alfredo, Tye, Susannah J., McElroy, Susan L., Biernacka, Joanna M. and Frye, Mark A. (2024). Pharmacogenomic overlap between antidepressant treatment response in major depression & antidepressant associated treatment emergent mania in bipolar disorder. Translational Psychiatry, 14 (1) 93, 93. doi: 10.1038/s41398-024-02798-y

Pharmacogenomic overlap between antidepressant treatment response in major depression & antidepressant associated treatment emergent mania in bipolar disorder

2024

Journal Article

SmartFSCV: An artificial intelligence enabled miniaturised FSCV device targeting serotonin

Corva, Dean M., Doeven, Egan H., Parke, Brenna, Adams, Scott D., Tye, Susannah J., Hashemi, Parastoo, Berk, Michael and Kouzani, Abbas Z. (2024). SmartFSCV: An artificial intelligence enabled miniaturised FSCV device targeting serotonin. IEEE Open Journal of Engineering in Medicine and Biology, 5 (99), 75-85. doi: 10.1109/OJEMB.2024.3356177

SmartFSCV: An artificial intelligence enabled miniaturised FSCV device targeting serotonin

2023

Conference Publication

Circuit-Based Manipulation of Striatal Dopamine: A State-Dependent and Mood Stabilizing Approach

Tye, Susannah (2023). Circuit-Based Manipulation of Striatal Dopamine: A State-Dependent and Mood Stabilizing Approach. 62nd Annual Meeting of the American-College-of-Neuropsychopharmacology (ACNP), Tampa Fl, Dec 03-06, 2023. LONDON: SPRINGERNATURE.

Circuit-Based Manipulation of Striatal Dopamine: A State-Dependent and Mood Stabilizing Approach

2023

Journal Article

Oxycodone-induced dopaminergic and respiratory effects are modulated by deep brain stimulation

Yuen, Jason, Goyal, Abhinav, Rusheen, Aaron E., Kouzani, Abbas Z., Berk, Michael, Kim, Jee Hyun, Tye, Susannah J., Abulseoud, Osama A., Oesterle, Tyler S., Blaha, Charles D., Bennet, Kevin E., Lee, Kendall H., Oh, Yoonbae and Shin, Hojin (2023). Oxycodone-induced dopaminergic and respiratory effects are modulated by deep brain stimulation. Frontiers in Pharmacology, 14 1199655. doi: 10.3389/fphar.2023.1199655

Oxycodone-induced dopaminergic and respiratory effects are modulated by deep brain stimulation

2023

Conference Publication

Critical Role of Insulin as an Immunomodulatory Target in Treatment Resistant Depression

Tye, Susannah, Price, Joshua, Walker, Adam, Sutor, Shari, Erhardt, Sophie, Schwieler, Lilly, Cullen, Kathryn, Voort, Jennifer Vande, Frye, Mark, Bobo, William and Shiroma, Paulo (2023). Critical Role of Insulin as an Immunomodulatory Target in Treatment Resistant Depression. 78th Annual Meeting of the Society of Biological Psychiatry, San Diego, CA United States, 27-29 April 2023. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.biopsych.2023.02.076

Critical Role of Insulin as an Immunomodulatory Target in Treatment Resistant Depression