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2015 Journal Article Nutrient and immune sensing are obligate pathways in metabolism, immunity and diseaseIyer, Abishek, Brown, Lindsay, Whitehead, Jonathan P., Prins, Johannes B. and Fairlie, David P. (2015). Nutrient and immune sensing are obligate pathways in metabolism, immunity and disease. The FASEB Journal. doi: 10.1096/fj.15-271155 |
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2015 Journal Article Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin MetabolitesSakala, Isaac G., Kjer-Nielsen, Lars, Eickhoff, Christopher S., Wang, Xiaoli, Blazevic, Azra, Liu, Ligong, Fairlie, David P., Rossjohn, Jamie, McCluskey, James, Fremont, David H., Hansen, Ted H. and Hoft, Daniel F. (2015). Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites. The Journal of Immunology, 195 (2), 587-601. doi: 10.4049/jimmunol.1402545 |
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2015 Journal Article Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramersRahimpour, Azad, Koay, Hui Fern, Enders, Anselm, Clanchy, Rhiannon, Eckle, Sidonia B. G., Meehan, Bronwyn, Chen, Zhenjun, Whittle, Belinda, Liu, Ligong, Fairlie, David P., Goodnow, Chris C., McCluskey, James, Rossjohn, Jamie, Uldrich, Adam P., Pellicci, Daniel G. and Godfrey, Dale I. (2015). Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers. Journal of Experimental Medicine, 212 (7), 1095-1108. doi: 10.1084/jem.20142110 |
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2015 Journal Article Three homology models for PAR2 derived from different templates: Application to antagonist discoveryPerry, Samuel R., Xu, Weijun, Wirija, Anna, Lim, Junxian, Yau, Mei-Kwan, Stoermer, Martin J., Lucke, Andrew J. and Fairlie, David P. (2015). Three homology models for PAR2 derived from different templates: Application to antagonist discovery. Journal of Chemical Information And Modeling, 55 (6), 1181-1191. doi: 10.1021/acs.jcim.5b00087 |
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2015 Journal Article Antigen-specific MAIT cell subsets involved in TB immunity (INC2P.420)Sakala, Isaac, Kjer-Nielsen, Lars, Eickhoff, Christopher, Wang, Xiaoli, Blazevic, Azra, Liu, Ligong, Fairlie, David, Rossjohn, Jamie, McCluskey, James, Fremont, Daved, Hansen, Ted and Hoft, Daniel (2015). Antigen-specific MAIT cell subsets involved in TB immunity (INC2P.420). The Journal of Immunology, 194 (1_Supplement), 55.14-55.14. doi: 10.4049/jimmunol.194.supp.55.14 |
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2015 Conference Publication Antigen-specific MAIT cell subsets involved in TB immunitySakala, Isaac, Kjer-Nielsen, Lars, Eickhoff, Christopher, Wang, Xiaoli, Blazevic, Azra, Liu, Ligong, Fairlie, David, Rossjohn, Jamie, McCluskey, James, Fremont, Daved, Hansen, Ted and Hoft, Daniel (2015). Antigen-specific MAIT cell subsets involved in TB immunity. Annual Meeting of the American-Association-of-Immunologists (IMMUNOLOGY), New Orleans La, May 08-12, 2015. BETHESDA: AMER ASSOC IMMUNOLOGISTS. |
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2015 Journal Article Short hydrophobic peptides with cyclic constraints are potent glucagon-like peptide-1 receptor (GLP-1R) agonistsHoang, Huy N., Song, Kun, Hill, Timothy A., Derksen, David R., Edmonds, David J., Kok, W. Mei, Limberakis, Chris, Liras, Spiros, Loria, Paula M., Mascitti, Vincent, Mathiowetz, Alan M., Mitchell, Justin M., Piotrowski, David W., Price, David A., Stanton, Robert V., Suen, Jacky Y., Withka, Jane M., Griffith, David A. and Fairlie, David P. (2015). Short hydrophobic peptides with cyclic constraints are potent glucagon-like peptide-1 receptor (GLP-1R) agonists. Journal of Medicinal Chemistry, 58 (9), 4080-4085. doi: 10.1021/acs.jmedchem.5b00166 |
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2015 Journal Article Comparing sixteen scoring functions for predicting biological activities of ligands for protein targetsXu, Weijun, Lucke, Andrew J. and Fairlie, David P. (2015). Comparing sixteen scoring functions for predicting biological activities of ligands for protein targets. Journal of Molecular Graphics and Modelling, 57, 76-88. doi: 10.1016/j.jmgm.2015.01.009 |
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2015 Journal Article Inhibiting histone deacetylase 1 suppresses both inflammation and bone loss in arthritisCantley, Melissa D., Fairlie, David P., Bartold, P. Mark, Marino, Victor, Gupta, Praveer K. and Haynes, David R. (2015). Inhibiting histone deacetylase 1 suppresses both inflammation and bone loss in arthritis. Rheumatology, 54 (9), 1713-1723. doi: 10.1093/rheumatology/kev022 |
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2015 Journal Article Facile synthesis of mono- and bis-methylated Fmoc-Dap, -Dab and -Orn amino acidsLindahl, Fredrik, Hoang, Huy N., Fairlie, David P. and Cooper, Matthew A. (2015). Facile synthesis of mono- and bis-methylated Fmoc-Dap, -Dab and -Orn amino acids. Chemical Communications, 51 (21), 4496-4498. doi: 10.1039/c4cc09780g |
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2015 Journal Article Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme systemHalili, Maria A., Bachu, Prabhakar, Lindahl, Fredrik, Bechara, Cherine, Mohanty, Biswaranjan, Reid, Robert C., Scanlon, Martin, Robinson, Carol V., Fairlie, David P. and Martin, Jennifer L. (2015). Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system. ACS Chemical Biology, 10 (4), 957-964. doi: 10.1021/cb500988r |
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2015 Conference Publication Tetramer identification of functional mouse mucosal associated invariant T (MAIT) cellsSakala, Isaac G., Kjer-Nielsen, Lars, Eickhoff, Christopher S., Wang, Xiaoli, Liu, Ligong, Fairlie, David P., Rossjohn, Jamie, McCluskey, James, Hoft, Daniel F. and Hansen, Ted H. (2015). Tetramer identification of functional mouse mucosal associated invariant T (MAIT) cells. 8th International Workshop on Antigen Processing and Presentation, Philadelphia Pa, Jun 10-13, 2014. Oxford United Kingdom: Pergamon Press. |
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2015 Conference Publication Targeting Host Complement C3a/C5a Receptors to Control of Acute Graft-Versus-Host Disease in MiceHung Nguyen, Heinrichs, Jessica Lauren, Fu, Jianing, Wu, Yongxia, Bastian, David, Schutt, Steven, Daenthanasanmak, Anusara, Dany, Mohammmed, Liu, Chen, Fairlie, David, Tomlinson, Stephen and Yu, Xue-Zhong (2015). Targeting Host Complement C3a/C5a Receptors to Control of Acute Graft-Versus-Host Disease in Mice. 57th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, United States, 5-8 December 2015. Washington, DC, United States: American Society of Hematology. |
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2015 Journal Article Toward peptide-based inhibitors as therapies for Parkinson's diseaseMason, Jody M. and Fairlie, David P. (2015). Toward peptide-based inhibitors as therapies for Parkinson's disease. Future Medicinal Chemistry, 7 (16), 2103-2105. doi: 10.4155/fmc.15.139 |
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2015 Conference Publication Cyclic penta- and hexa leucine peptides without N-methylation are orally absorbedKok, Woan Mei, Hill, Timothy A., Lohman, Rink-Jan, Hoang, Huy N., Nielsen, Daniel S., Scully, Conor G., Schroeder, Christina I., Colless, Barbara, Bernhardt, Paul V., Edmonds, David, Griffith, David, Rotter, Charles, Ruggeri, Roger, Price, David, Liras, Spiros, Craik, David and Fairlie, David (2015). Cyclic penta- and hexa leucine peptides without N-methylation are orally absorbed. American Chemical Society Meeting, x, 2015. Washington, DC United States: American Chemical Society. |
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2015 Other Outputs Reactivity of commercially available Fmoc amino acids: supplementary informationLindahl, Fredrik, Hoang, Huy Ngoc, Fairlie, David P. and Cooper, Matthew A. (2015). Reactivity of commercially available Fmoc amino acids: supplementary information. The Royal Society of Chemistry. (Dataset) |
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2015 Book Chapter Helix-constrained nociceptin peptides are potent agonists and antagonists of ORL-1 and nociceptionLohman, Rink-Jan, Harrison, Rosemary S., Ruiz-Gomez, Gloria, Hoang, Huy Ngoc, Shepherd, Nicholas E., Chow, Shiao, Hill, Timothy A., Madala, Praveen K. and Fairlie, David P. (2015). Helix-constrained nociceptin peptides are potent agonists and antagonists of ORL-1 and nociception. Nociceptin opioid. (pp. 1-55) edited by Gerald Litwack. Maryland Heights, MO, United States: Academic Press. doi: 10.1016/bs.vh.2014.10.001 |
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2015 Conference Publication Downsizing Proteins Without Losing Potency or FunctionFairlie, David P. , Yau, Mei-Kwan , Hamidon, Johan K. , Singh, Ranee , Lim, Junxian , Suen, Jacky Y. , Rowley, Jessica A. , Lohman, Rink-Jan , Stoermer, Martin J. , Iyer, Abishek and Reid, Robert C. (2015). Downsizing Proteins Without Losing Potency or Function. American Peptide Symposium 2015, Orlando , Florida, United States, 20-25 June 2015. American Peptide Society. doi: 10.17952/24APS.2015.016 |
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2014 Journal Article Peptide inhibitors of the Escherichia coli DsbA oxidative machinery essential for bacterial virulenceDuprez, Wilko, Premkumar, Lakshmanane, Halili, Maria A., Lindahl, Fredrik, Reid, Robert C., Fairlie, David P. and Martin, Jennifer L. (2014). Peptide inhibitors of the Escherichia coli DsbA oxidative machinery essential for bacterial virulence. Journal of Medicinal Chemistry, 58 (2), 577-587. doi: 10.1021/jm500955s |
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2014 Journal Article Rational design and synthesis of orally bioavailable peptides guided by NMR amide temperature coefficientsWang, Conan K., Northfield, Susan E., Colless, Barbara, Chaousis, Stephanie, Hamernig, Ingrid, Lohman, Rink-Jan, Nielsen, Daniel S., Schroeder, Christina I., Liras, Spiros, Price, David, A., Fairlie, David and Craik, David J. (2014). Rational design and synthesis of orally bioavailable peptides guided by NMR amide temperature coefficients. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 111 (49), 17504-17509. doi: 10.1073/pnas.1417611111 |
