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2015 Journal Article Facile synthesis of mono- and bis-methylated Fmoc-Dap, -Dab and -Orn amino acidsLindahl, Fredrik, Hoang, Huy N., Fairlie, David P. and Cooper, Matthew A. (2015). Facile synthesis of mono- and bis-methylated Fmoc-Dap, -Dab and -Orn amino acids. Chemical Communications, 51 (21), 4496-4498. doi: 10.1039/c4cc09780g |
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2015 Journal Article Peptide inhibitors of the Escherichia coli DsbA oxidative machinery essential for bacterial virulenceDuprez, Wilko, Premkumar, Lakshmanane, Halili, Maria A., Lindahl, Fredrik, Reid, Robert C., Fairlie, David P. and Martin, Jennifer L. (2015). Peptide inhibitors of the Escherichia coli DsbA oxidative machinery essential for bacterial virulence. Journal of Medicinal Chemistry, 58 (2), 577-587. doi: 10.1021/jm500955s |
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2015 Journal Article Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme systemHalili, Maria A., Bachu, Prabhakar, Lindahl, Fredrik, Bechara, Cherine, Mohanty, Biswaranjan, Reid, Robert C., Scanlon, Martin, Robinson, Carol V., Fairlie, David P. and Martin, Jennifer L. (2015). Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system. ACS Chemical Biology, 10 (4), 957-964. doi: 10.1021/cb500988r |
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2015 Conference Publication Tetramer identification of functional mouse mucosal associated invariant T (MAIT) cellsSakala, Isaac G., Kjer-Nielsen, Lars, Eickhoff, Christopher S., Wang, Xiaoli, Liu, Ligong, Fairlie, David P., Rossjohn, Jamie, McCluskey, James, Hoft, Daniel F. and Hansen, Ted H. (2015). Tetramer identification of functional mouse mucosal associated invariant T (MAIT) cells. 8th International Workshop on Antigen Processing and Presentation, Philadelphia Pa, Jun 10-13, 2014. Oxford United Kingdom: Pergamon Press. |
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2015 Conference Publication Targeting Host Complement C3a/C5a Receptors to Control of Acute Graft-Versus-Host Disease in MiceHung Nguyen, Heinrichs, Jessica Lauren, Fu, Jianing, Wu, Yongxia, Bastian, David, Schutt, Steven, Daenthanasanmak, Anusara, Dany, Mohammmed, Liu, Chen, Fairlie, David, Tomlinson, Stephen and Yu, Xue-Zhong (2015). Targeting Host Complement C3a/C5a Receptors to Control of Acute Graft-Versus-Host Disease in Mice. 57th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, United States, 5-8 December 2015. Washington, DC, United States: American Society of Hematology. |
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2015 Journal Article Toward peptide-based inhibitors as therapies for Parkinson's diseaseMason, Jody M. and Fairlie, David P. (2015). Toward peptide-based inhibitors as therapies for Parkinson's disease. Future Medicinal Chemistry, 7 (16), 2103-2105. doi: 10.4155/fmc.15.139 |
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2015 Conference Publication Cyclic penta- and hexa leucine peptides without N-methylation are orally absorbedKok, Woan Mei, Hill, Timothy A., Lohman, Rink-Jan, Hoang, Huy N., Nielsen, Daniel S., Scully, Conor G., Schroeder, Christina I., Colless, Barbara, Bernhardt, Paul V., Edmonds, David, Griffith, David, Rotter, Charles, Ruggeri, Roger, Price, David, Liras, Spiros, Craik, David and Fairlie, David (2015). Cyclic penta- and hexa leucine peptides without N-methylation are orally absorbed. American Chemical Society Meeting, x, 2015. Washington, DC United States: American Chemical Society. |
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2015 Other Outputs Reactivity of commercially available Fmoc amino acids: supplementary informationLindahl, Fredrik, Hoang, Huy Ngoc, Fairlie, David P. and Cooper, Matthew A. (2015). Reactivity of commercially available Fmoc amino acids: supplementary information. The Royal Society of Chemistry. (Dataset) |
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2015 Book Chapter Helix-constrained nociceptin peptides are potent agonists and antagonists of ORL-1 and nociceptionLohman, Rink-Jan, Harrison, Rosemary S., Ruiz-Gomez, Gloria, Hoang, Huy Ngoc, Shepherd, Nicholas E., Chow, Shiao, Hill, Timothy A., Madala, Praveen K. and Fairlie, David P. (2015). Helix-constrained nociceptin peptides are potent agonists and antagonists of ORL-1 and nociception. Nociceptin opioid. (pp. 1-55) edited by Gerald Litwack. Maryland Heights, MO, United States: Academic Press. doi: 10.1016/bs.vh.2014.10.001 |
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2015 Conference Publication Downsizing Proteins Without Losing Potency or FunctionFairlie, David P. , Yau, Mei-Kwan , Hamidon, Johan K. , Singh, Ranee , Lim, Junxian , Suen, Jacky Y. , Rowley, Jessica A. , Lohman, Rink-Jan , Stoermer, Martin J. , Iyer, Abishek and Reid, Robert C. (2015). Downsizing Proteins Without Losing Potency or Function. American Peptide Symposium 2015, Orlando , Florida, United States, 20-25 June 2015. American Peptide Society. doi: 10.17952/24APS.2015.016 |
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2014 Journal Article Rational design and synthesis of orally bioavailable peptides guided by NMR amide temperature coefficientsWang, Conan K., Northfield, Susan E., Colless, Barbara, Chaousis, Stephanie, Hamernig, Ingrid, Lohman, Rink-Jan, Nielsen, Daniel S., Schroeder, Christina I., Liras, Spiros, Price, David, A., Fairlie, David and Craik, David J. (2014). Rational design and synthesis of orally bioavailable peptides guided by NMR amide temperature coefficients. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 111 (49), 17504-17509. doi: 10.1073/pnas.1417611111 |
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2014 Journal Article Potent heterocyclic ligands for human complement C3a receptorReid, Robert C., Yau, Mei-Kwan, Singh, Ranee, Hamidon, Johan K., Lim, Junxian, Stoermer, Martin J. and Fairlie, David P. (2014). Potent heterocyclic ligands for human complement C3a receptor. Journal of Medicinal Chemistry, 57 (20), 8459-8470. doi: 10.1021/jm500956p |
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2014 Journal Article Helical cyclic pentapeptides constrain HIV-1 Rev peptide for enhanced RNA bindingHarrison, Rosemary S., Shepherd, Nicholas E., Hoang, Huy N., Beyer, Renee L., Ruiz-Gomez, Gloria, Kelso, Michael J., Mei Kok, W., Hill, Timothy A., Abbenante, Giovanni and Fairlie, David P. (2014). Helical cyclic pentapeptides constrain HIV-1 Rev peptide for enhanced RNA binding. Tetrahedron, 70 (42), 7645-7650. doi: 10.1016/j.tet.2014.07.096 |
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2014 Journal Article Cyclic penta- and hexaleucine peptides without N-methylation are orally absorbedHill, Timothy A., Lohman, Rink-Jan, Hoang, Huy N., Nielsen, Daniel S., Scully, Conor C. G., Kok, W. Mei, Liu, Ligong, Lucke, Andrew J., Stoermer, Martin J., Schroeder, Christina I., Chaousis, Stephanie, Colless, Barbara, Bernhardt, Paul V., Edmonds, David J., Griffith, David A., Rotter, Charles J., Ruggeri, Roger B., Price, David A., Liras, Spiros, Craik, David J. and Fairlie, David P. (2014). Cyclic penta- and hexaleucine peptides without N-methylation are orally absorbed. ACS Medicinal Chemistry Letters, 5 (10), 1148-1151. doi: 10.1021/ml5002823 |
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2014 Journal Article Fixierung cyclischer Peptide: Mimetika von ProteinstrukturmotivenHill, Timothy A., Shepherd, Nicholas E., Diness, Frederik and Fairlie, David P. (2014). Fixierung cyclischer Peptide: Mimetika von Proteinstrukturmotiven. Angewandte Chemie, 126 (48), 13234-13257. doi: 10.1002/ange.201401058 |
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2014 Journal Article A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cellsEckle, Sidonia B.G., Birkinshaw, Richard W., Kostenko, Lyudmila, Corbett, Alexandra J., McWilliam, Hamish E. G., Reantragoon, Rangsima, Chen, Zhenjun, Gherardin, Nicholas A., Beddoe, Travis, Liu, Ligong, Patel, Onisha, Meehan, Bronwyn, Fairlie, David P., Villadangos, Jose A., Godfrey, Dale I., Kjer-Nielsen, Lars, McCluskey, James and Rossjohn, Jamie (2014). A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells. Journal of Experimental Medicine, 211 (8), 1585-1600. doi: 10.1084/jem.20140484 |
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2014 Journal Article Crystal Structure of the Dithiol Oxidase DsbA Enzyme from Proteus Mirabilis Bound Non-covalently to an Active Site Peptide Ligand.Kurth, Fabian, Duprez, Wilko, Premkumar, Lakshmanane, Schembri, Mark A., Fairlie, David P. and Martin, Jennifer L. (2014). Crystal Structure of the Dithiol Oxidase DsbA Enzyme from Proteus Mirabilis Bound Non-covalently to an Active Site Peptide Ligand.. Journal of Biological Chemistry, 289 (28), 19810-19822. doi: 10.1074/jbc.M114.552380 |
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2014 Journal Article Comparative α-Helicity of Cyclic Pentapeptides in Waterde Araujo, Aline D., Hoang, Huy N., Kok, W. Mei, Diness, Frederik, Gupta, Praveer, Hill, Timothy A., Driver, Russell W., Price, David A., Liras, Spiros and Fairlie, David P. (2014). Comparative α-Helicity of Cyclic Pentapeptides in Water. Angewandte Chemie International Edition, 53 (27), 6965-6969. doi: 10.1002/anie.201310245/abstract |
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2014 Conference Publication Tetramer identification of functional mouse mucosal associated invariant T cellsSakala, Isaac, Kjer-Nielsen, Lars, Eickhoff, Christopher, Wang, Xiaoli, Liu, Ligong, Fairlie, David, Rossjohn, Jamie, Hoft, Daniel and Hansen, Ted (2014). Tetramer identification of functional mouse mucosal associated invariant T cells. BETHESDA: AMER ASSOC IMMUNOLOGISTS. |
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2014 Journal Article C5aR and C5L2 act in concert to balance immunometabolism in adipose tissuePoursharifi, Pegah, Lapointe, Marc, Fisette, Alexandre, Lu, Huiling, Roy, Christian, Munkonda, Mercedes Nancy, Fairlie, David P. and Cianflone, Katherine (2014). C5aR and C5L2 act in concert to balance immunometabolism in adipose tissue. Molecular and Cellular Endocrinology, 382 (1), 325-333. doi: 10.1016/j.mce.2013.10.019 |
