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2014 Journal Article Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small moleculesTrenholme, Katharine, Marek, Linda, Duffy, Sandra, Pradel, Gabriele, Fisher, Gillian, Hansen, Finn K., Skinner-Adams, Tina S., Butterworth, Alice, Ngwa, Che Julius, Moecking, Jonas, Goodman, Christopher D., McFadden, Geoffrey I., Sumanadasa, Subathdrage D. M., Fairlie, David P., Avery, Vicky M., Kurz, Thomas and Andrews, Katherine T. (2014). Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules. Antimicrobial Agents and Chemotherapy, 58 (7), 3666-3678. doi: 10.1128/AAC.02721-13 |
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2014 Journal Article Biased signalling and proteinase-activated receptors (PARs): Targeting inflammatory diseaseHollenberg, M. D., Mihara, K., Polley, D., Suen, J. Y., Han, A., Fairlie, D. P. and Ramachandran, R. (2014). Biased signalling and proteinase-activated receptors (PARs): Targeting inflammatory disease. British Journal of Pharmacology, 171 (5), 1180-1194. doi: 10.1111/bph.12544 |
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2014 Conference Publication Characterization of the alpha-proteobacteria Wolbachia pipientis protein disulphide machinery reveals a regulatory mechanism absent in gamma-proteobacteriaWalden, Patricia M., Halili, Maria A., Archbold, Julia K., Lindahl, Fredrik, Fairlie, David P., Inaba, Kenji and Martin, Jennifer L. (2014). Characterization of the alpha-proteobacteria Wolbachia pipientis protein disulphide machinery reveals a regulatory mechanism absent in gamma-proteobacteria. 28th Annual Symposium of the Protein-Society, San Diego, California, 27-30 July 2014. Hoboken, NJ, United States : Wiley-Blackwell. |
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2013 Journal Article The alpha-proteobacteria Wolbachia pipientis protein disulfide machinery has a regulatory mechanism absent in gamma-proteobacteriaWalden, Patricia, Halili, Maria, Julia Archbold, Fredrik Lindahl, Fairlie, David P., Inaba, Kenji and Martin, Jennifer L. (2013). The alpha-proteobacteria Wolbachia pipientis protein disulfide machinery has a regulatory mechanism absent in gamma-proteobacteria. PloS One, 8 (11) e81440, e81440.1-e81440.9. doi: 10.1371/journal.pone.0081440 |
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2013 Journal Article Comparative sequence, structure and redox analyses of Klebsiella pneumoniae DsbA show that anti-virulence target DsbA enzymes fall into distinct classesKurth, Fabian, Rimmer, Kieran, Premkumar, Lakshmanane, Mohanty, Biswaranjan, Duprez, Wilko, Halili, Maria A., Shouldice, Stephen R., Heras, Begoña, Fairlie, David P., Scanlon, Martin J. and Martin, Jennifer L. (2013). Comparative sequence, structure and redox analyses of Klebsiella pneumoniae DsbA show that anti-virulence target DsbA enzymes fall into distinct classes. PloS One, 8 (11) e80210, e80210.1-e80210.15. doi: 10.1371/journal.pone.0080210 |
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2013 Journal Article An mRNA atlas of G protein-coupled receptor expression during primary human monocyte/macrophage differentiation and lipopolysaccharide-mediated activation identifies targetable candidate regulators of inflammationHohenhaus, Daniel M., Schaale, Kolja, Le Cao, Kim-Anh, Seow, Vernon, Iyer, Abishek, Fairlie, David P. and Sweet, Matthew J. (2013). An mRNA atlas of G protein-coupled receptor expression during primary human monocyte/macrophage differentiation and lipopolysaccharide-mediated activation identifies targetable candidate regulators of inflammation. Immunobiology, 218 (11), 1345-1353. doi: 10.1016/j.imbio.2013.07.001 |
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2013 Journal Article Toward drugs for protease-activated receptor 2 (PAR2)Yau, Mei-Kwan, Liu, L.igong and Fairlie, David P. (2013). Toward drugs for protease-activated receptor 2 (PAR2). Journal of Medicinal Chemistry, 56 (19), 7477-7497. doi: 10.1021/jm400638v |
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2013 Journal Article Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cellsReantragoon, Rangsima, Corbett, Alexandra J., Sakala, Isaac G., Gherardin, Nicholas A., Furness, John B., Chen, Zhenjun, Eckle, Sidonia B. G., Uldrich, Adam P., Birkinshaw, Richard W., Patel, Onisha, Kostenko, Lyudmila, Meehan, Bronwyn, Kedzierska, Katherine, Liu, Ligong, Fairlie, David P., Hansen, Ted H., Godfrey, Dale I., Rossjohn, Jamie, McCluskey, James and Kjer-Nielsen, Lars (2013). Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells. Journal of Experimental Medicine, 210 (11), 2305-2320. doi: 10.1084/jem.20130958 |
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2013 Journal Article Inflammatory Responses Induced by Lipopolysaccharide Are Amplified in Primary Human Monocytes but Suppressed in Macrophages by Complement Protein C5aSeow, Vernon, Lim, Junxian, Iyer, Abishek, Suen, Jacky Y., Ariffin, Juliana K., Hohenhaus, Daniel M., Sweet, Matthew J. and Fairlie, David P. (2013). Inflammatory Responses Induced by Lipopolysaccharide Are Amplified in Primary Human Monocytes but Suppressed in Macrophages by Complement Protein C5a. Journal of Immunology, 191 (8), 4308-4316. doi: 10.4049/jimmunol.1301355 |
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2013 Journal Article Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidasesPremkumar, Lakshmanane, Heras, Begoña, Duprez, Wilko, Walden, Patricia, Halili, Maria, Kurth, Fabian, Fairlie, David P. and Martin, Jennifer L. (2013). Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidases. Acta Crystallographica Section D: Biological Crystallography, 69 (10), 1981-1994. doi: 10.1107/S0907444913017800 |
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2013 Journal Article C5a, but not C5a-des Arg, induces upregulation of heteromer formation between complement C5a receptors C5aR and C5L2Croker, Daniel E., Halai, Reena, Fairlie, David P. and Cooper, Matthew A. (2013). C5a, but not C5a-des Arg, induces upregulation of heteromer formation between complement C5a receptors C5aR and C5L2. Immunology and Cell Biology, 91 (10), 625-633. doi: 10.1038/icb.2013.48 |
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2013 Conference Publication Novel inhibitors of DENV NS2B/NS3pro proteaseChow, Shiao Yun, Stoermer, Martin J., Chappell, Keith J., Young, Paul R. and Fairlie, David P. (2013). Novel inhibitors of DENV NS2B/NS3pro protease. 246th National Meeting of the American-Chemical-Society (ACS), Indianapolis in, Sep 08-12, 2013. WASHINGTON: AMER CHEMICAL SOC. |
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2013 Journal Article An interaction between the methyltransferase and RNA dependent RNA polymerase domains of the West Nile virus NS5 proteinTan, Cindy S. E., Hobson-Peters, Jody M., Stoermer, Martin J., Fairlie, David P., Khromykh, Alexander A. and Hall, Roy A. (2013). An interaction between the methyltransferase and RNA dependent RNA polymerase domains of the West Nile virus NS5 protein. Journal of General Virology, 94 (Pt. 9), 1961-1971. doi: 10.1099/vir.0.054395-0 |
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2013 Journal Article Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonismLim, Junxian, Iyer, Abishek, Liu, Ligong, Suen, Jacky Y., Lohman, Rink-Jan, Seow, Vernon, Yau, Mei-Kwan, Brown, Lindsay and Fairlie, David P. (2013). Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism. The FASEB Journal, 27 (12), 4757-4767. doi: 10.1096/fj.13-232702 |
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2013 Journal Article Recognition of vitamin B metabolites by mucosal-associated invariant T cellsPatel, Onisha, Kjer-Nielsen, Lars, Le Nours, Jerome, Eckle, Sidonia B. G., Birkinshaw, Richard, Beddoe, Travis, Corbett, Alexandra J., Liu, Ligong, Miles, John J., Meehan, Bronwyn, Reantragoon, Rangsima, Sandoval-Romero, Maria L., Sullivan, Lucy C., Brooks, Andrew G., Chen, Zhenjun, Fairlie, David P., McCluskey, James and Rossjohn, Jamie (2013). Recognition of vitamin B metabolites by mucosal-associated invariant T cells. Nature Communications, 4 (1) 2142, 2142.1-2142.8. doi: 10.1038/ncomms3142 |
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2013 Journal Article Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophagesShakespear, Melanie R., Hohenhaus, Daniel M., Kelly, Greg M., Kamal, Nabilah A., Gupta, Praveer, Labzin, Larisa I., Schroder, Kate, Garceau, Valerie, Barbero, Sheila, Iyer, Abishek, Hume, David A., Reid, Robert C., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2013). Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages. Journal of Biological Chemistry, 288 (35), 25362-25374. doi: 10.1074/jbc.M113.496281 |
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2013 Journal Article Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffoldsNgoei, Kevin R. W., Ng, Dominic C. H., Gooley, Paul R., Fairlie, David P., Stoermer, Martin J. and Bogoyevitch, Marie A. (2013). Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1834 (6), 1077-1088. doi: 10.1016/j.bbapap.2013.02.001 |
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2013 Journal Article How MAIT cells control the growth of intracellular mycobacteria (P4381)Sakala, Isaac, Yankelevich, Wei-Jen, Kjer-Nielsen, Lars, Fairlie, David, Rossjohn, Jamie, McCluskey, James, Hoft, Daniel and Hansen, Ted (2013). How MAIT cells control the growth of intracellular mycobacteria (P4381). The Journal of Immunology, 190 (1_Supplement), 183.26-183.26. doi: 10.4049/jimmunol.190.supp.183.26 |
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2013 Journal Article PAR2-induced inflammatory responses in human kidney tubular epithelial cellsVesey, David A., Suen, Jacky Y., Seow, Vernon, Lohman, Rink-Jan, Liu, Ligong, Gobe, Glenda C., Johnson, David W. and Fairlie, David P. (2013). PAR2-induced inflammatory responses in human kidney tubular epithelial cells. American Journal of Physiology - Renal Physiology, 304 (6), F737-F750. doi: 10.1152/ajprenal.00540.2012 |
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2013 Journal Article Truncated and Helix-Constrained Peptides with High Affinity and Specificity for the cFos Coiled-Coil of AP-1Rao, Tara, Ruiz-Gomez, Gloria, Hill, Timothy A., Hoang, Huy N., Fairlie, David P. and Mason, Jody M. (2013). Truncated and Helix-Constrained Peptides with High Affinity and Specificity for the cFos Coiled-Coil of AP-1. PLoS One, 8 (3) e59415, e59415.1-e59415.12. doi: 10.1371/journal.pone.0059415 |
