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2010

Journal Article

Update 1 of: Proteases universally recognize beta strands in their active sites

Madala, Praveen K., Tyndall, Joel D. A., Nall, Tessa and Fairlie, David P. (2010). Update 1 of: Proteases universally recognize beta strands in their active sites. Chemical Reviews, 110 (4), 1-33. doi: 10.1021/cr900368a

Update 1 of: Proteases universally recognize beta strands in their active sites

2010

Journal Article

Update 1 of: Beta-strand mimetics

Loughlin, Wendy A., Tyndall, Joel D. A., Glenn, Matthew P., Hill, Timothy A. and Fairlie, David P. (2010). Update 1 of: Beta-strand mimetics. Chemical Reviews, 110 (6), 1-38. doi: 10.1021/cr900395y

Update 1 of: Beta-strand mimetics

2010

Journal Article

Update 1 of: beta-strand mimetics

Loughlin, Wendy A., Tyndall, Joel D. A., Glenn, Matthew P., Hill, Timothy A. and Fairlie, David P. (2010). Update 1 of: beta-strand mimetics. Chemical Reviews, 110 (6), PR32-PR69. doi: 10.1021/cr040648k

Update 1 of: beta-strand mimetics

2010

Journal Article

Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS

Halili, Maria A., Andrews, Melanie R., Labzin, Larisa I., Schroder, Kate, Matthias, Gabriele, Cao, Chun, Lovelace, Erica, Reid, Robert C., Le, Giang T., Hume, David A., Irvine, Katharine M., Matthias, Patrick, Fairlie, David P. and Sweet, Matthew J. (2010). Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. Journal of Leukocyte Biology, 87 (6), 1103-1114. doi: 10.1189/jlb.0509363

Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS

2010

Journal Article

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

Harrison, Rosemary S., Shepherd, Nicholas E., Hoang, Huy N., Ruiz-Goméz, Gloria, Hill, Timothy A., Driver, Russell W., Desai, Vishal S., Young, Paul R., Abbenante, Giovanni and Fairlie, David P. (2010). Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency. Proceedings of the National Academy of Sciences of the United States of America, 107 (26), 11686-11691. doi: 10.1073/pnas.1002498107

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

2010

Journal Article

Update 1 of: Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure

Ruiz-Gomez, Gloria, Tyndall, Joel D. A., Pfeiffer, Bernhard, Abbenante, Giovanni and Fairlie, David (2010). Update 1 of: Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure. Chemical Reviews, 110 (6), 1-41. doi: 10.1021/cr900344w

Update 1 of: Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure

2010

Journal Article

Update 1 of: Over One Hundred Petide-Activated G Protein-Coupled Receptors Recognized Ligands with Turn Structure

Ruiz-Gomez, Gloria, Tyndall, Joel D. A., Pfeiffer, Bernhard, Abbenante, Giovanni and Fairlie, David P. (2010). Update 1 of: Over One Hundred Petide-Activated G Protein-Coupled Receptors Recognized Ligands with Turn Structure. Chemical Reviews, 110 (4), PR1-PR41.

Update 1 of: Over One Hundred Petide-Activated G Protein-Coupled Receptors Recognized Ligands with Turn Structure

2010

Journal Article

Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats

Iyer, Abishek, Fenning, Andrew, Lim, Junxian, Le, Giang T, Reid, Robert C, Halili, Maria A, Fairlie, David P and Brown, Lindsay (2010). Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats. British Journal of Pharmacology, 159 (7), 1408-1417. doi: 10.1111/j.1476-5381.2010.00637.x

Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats

2010

Journal Article

Noncovalent tripeptidyl benzyl- And cyclohexyl-amine inhibitors of the cysteine protease caspase-1

Loser, Reik, Abbenante, Giovanni, Madala, Praveen K., Halili, Maria, Le, Giang T. and Fairlie, David P. (2010). Noncovalent tripeptidyl benzyl- And cyclohexyl-amine inhibitors of the cysteine protease caspase-1. Journal of Medicinal Chemistry, 53 (6), 2651-2655. doi: 10.1021/jm901790w

Noncovalent tripeptidyl benzyl- And cyclohexyl-amine inhibitors of the cysteine protease caspase-1

2010

Journal Article

Inflammatory lipid mediators in adipocyte function and obesity

Iyer, Abishek, Fairlie, David P., Prins, Johannes B., Hammock, Bruce D. and Brown, Lindsay (2010). Inflammatory lipid mediators in adipocyte function and obesity. Nature Reviews Endocrinology, 6 (2), 71-82. doi: 10.1038/nrendo.2009.264

Inflammatory lipid mediators in adipocyte function and obesity

2010

Conference Publication

A Novel Protease-Activated Receptor-2 Antagonist Targeting Inflammation and Proliferation in Human Renal Tubular Epithelial Cells

Vesey David A., Suen, Jacky Yung, Johnson, David W. and Fairlie, David (2010). A Novel Protease-Activated Receptor-2 Antagonist Targeting Inflammation and Proliferation in Human Renal Tubular Epithelial Cells. Kidney Week, American society of Nephrology, Denver Colorado USA, November 16 - 21. Journal of the American Society of Nephrology:

A Novel Protease-Activated Receptor-2 Antagonist Targeting Inflammation and Proliferation in Human Renal Tubular Epithelial Cells

2010

Conference Publication

Potent inhibitors of West Nile Virus NS2B/NS3 protease

Chappell, K. J., Fairlie, D. P., Gan, C. H., Gupta, P. K., Hu, S., Jensen, C. M., Liebscher, S., Martin, J. L., Robin, G., Stoermer M. J., Xu, W. and Young, P. R. (2010). Potent inhibitors of West Nile Virus NS2B/NS3 protease. 6th General Meeting of the International Proteolysis Society, Gold Coast, QLD, Australia, 26-30 October 2009. Berlin, Germany: Walter De Gruyter.

Potent inhibitors of West Nile Virus NS2B/NS3 protease

2010

Conference Publication

Protease-activated receptor-2 and renal carcinogenesis

Vesey, D., Rajandram, R., Blakeney, J., Suen, J., Johnson, D., Fairlie, D. and Gobe, G. (2010). Protease-activated receptor-2 and renal carcinogenesis. 46th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Perth Convention and Exhibition Centre, Perth, Western Australia, 12-15 September 2010. Richmond, Vic., Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1797.2010.01377_1.x

Protease-activated receptor-2 and renal carcinogenesis

2010

Conference Publication

Sneaking up on West Nile Virus NS2B/NS3 protease subcellular activity utilising dye-quenched substrates

Liebscher, Susan, Chappell, K. J., Stoermer, Martin J., Watterson, Daniel, Webb, Richard I., Khromykh, Alexander A., Fairlie, David P. and Young, Paul R. (2010). Sneaking up on West Nile Virus NS2B/NS3 protease subcellular activity utilising dye-quenched substrates. PlusStrand 2010: The Ninth International Symposium on Positive-Strand RNA Viruses, Atlanta, GA, U.S.A., 17-21 May 2010.

Sneaking up on West Nile Virus NS2B/NS3 protease subcellular activity utilising dye-quenched substrates

2009

Journal Article

In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses

Kampmann, T., Yennamalli, R., Campbell, P., Stoermer, M. J., Fairlie, D. P., Kobe, B. and Young, P. R. (2009). In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses. Antiviral Research, 84 (3), 234-241. doi: 10.1016/j.antiviral.2009.09.007

In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses

2009

Journal Article

Left- and right-handed alpha-helical turns in homo- and hetero-chiral helical scaffolds

Shepherd, N. E., Hoang, H. N., Abbenante, G and Fairlie, D. P. (2009). Left- and right-handed alpha-helical turns in homo- and hetero-chiral helical scaffolds. Journal of the American Chemical Society, 131 (43), 15877-15886. doi: 10.1021/ja9065283

Left- and right-handed alpha-helical turns in homo- and hetero-chiral helical scaffolds

2009

Journal Article

Structure-activity relationships for substrate-based inhibitors of human complement factor B

Ruiz-Gomez, G, Lim, J, Halili, M. A., Le, G. T., Madala, P. K., Abbenante, G and Fairlie, D. P. (2009). Structure-activity relationships for substrate-based inhibitors of human complement factor B. JOURNAL OF MEDICINAL CHEMISTRY, 52 (19), 6042-6052. doi: 10.1021/jm900781m

Structure-activity relationships for substrate-based inhibitors of human complement factor B

2009

Journal Article

Base-sensitivity of arginine alpha-ketoamide inhibitors of serine proteases

Stoermer, Martin J., Leung, Donmienne, Young, Paul R. and Fairlie, David P. (2009). Base-sensitivity of arginine alpha-ketoamide inhibitors of serine proteases. Australian Journal of Chemistry, 62 (9), 988-992. doi: 10.1071/CH09150

Base-sensitivity of arginine alpha-ketoamide inhibitors of serine proteases

2009

Journal Article

A cyclic beta-strand tripeptide with an alpha-helix like CD spectrum

Driver, Russell W., Hoang, Huy N., Abbenante, Giovanni and Fairlie, David P. (2009). A cyclic beta-strand tripeptide with an alpha-helix like CD spectrum. Organic Letters, 11 (14), 3092-3095. doi: 10.1021/ol901181b

A cyclic beta-strand tripeptide with an alpha-helix like CD spectrum

2009

Conference Publication

Inhibition of both class I and class II histone deacetylases is required to effectively inhibit osteoclast bone resorption in vivo and in vitro

Cantley, M. D., Fairlie, D. P., Bartold, M. P., Rainsford, K. D. and Haynes, D. R. (2009). Inhibition of both class I and class II histone deacetylases is required to effectively inhibit osteoclast bone resorption in vivo and in vitro. 2nd Joint Meeting of the International-Bone-and-Mineral-Society/Australian-New-Zealand-Bone-and-Mineral-Society, Sydney Australia, Mar 21-25, 2009. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.bone.2009.01.292

Inhibition of both class I and class II histone deacetylases is required to effectively inhibit osteoclast bone resorption in vivo and in vitro