Skip to menu Skip to content Skip to footer

2011

Journal Article

Histone deacetylase inhibitors and periodontal bone loss

Cantley, M. D., Bartold, P. M., Marino, V., Fairlie, D. P., Le, G. T., Lucke, A. J. and Haynes, D. R. (2011). Histone deacetylase inhibitors and periodontal bone loss. Journal of Periodontal Research, 46 (6), 697-703. doi: 10.1111/j.1600-0765.2011.01392.x

Histone deacetylase inhibitors and periodontal bone loss

2011

Journal Article

Inhibitors of histone deacetylases in class I and class II suppress human osteoclasts in vitro

Cantley, M. D., Fairlie, D. P., Bartold, P. M., Rainsford, K. D., Le, G. T., Lucke, A. J., Holding, C. A. and Haynes, D. R. (2011). Inhibitors of histone deacetylases in class I and class II suppress human osteoclasts in vitro. Journal of Cellular Physiology, 226 (12), 3233-3241. doi: 10.1002/jcp.22684

Inhibitors of histone deacetylases in class I and class II suppress human osteoclasts in vitro

2011

Journal Article

Protein a-turns recreated in structurally stable small molecules

Hoang, Huy N., Driver, Russell W., Beyer, Renée L., Malde, Alpeshkumar K., Le, Giang T., Abbenante, Giovanni, Mark, Alan E. and Fairlie, David P. (2011). Protein a-turns recreated in structurally stable small molecules. Angewandte Chemie International Edition, 123 (47), 11303-11307. doi: 10.1002/ange.201105119

Protein a-turns recreated in structurally stable small molecules

2011

Journal Article

Inhibition of inflammation and fibrosis by a complement C5a receptor antagonist in DOCA-salt hypertensive rats

Iyer, Abishek, Woodruff, Trent M., Wu, Mike C. L., Stylianou, Con, Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and Brown, Lindsay (2011). Inhibition of inflammation and fibrosis by a complement C5a receptor antagonist in DOCA-salt hypertensive rats. Journal of Cardiovascular Pharmacology, 58 (5), 479-486. doi: 10.1097/FJC.0b013e31822a7a09

Inhibition of inflammation and fibrosis by a complement C5a receptor antagonist in DOCA-salt hypertensive rats

2011

Conference Publication

Inhibiting Histone Deacetylases Expressed in Human Periodontal Tissues Prevents Bone Loss in An Animal Model of Periodontal Disease

Cantley, M. D., Fairlie, D. P., Bartold, P., Marino, V. and Haynes, D. R. (2011). Inhibiting Histone Deacetylases Expressed in Human Periodontal Tissues Prevents Bone Loss in An Animal Model of Periodontal Disease. IOF Regionals 2nd Asia-Pacific Osteoporosis and Bone Meeting / ANZBMS Annual Scientific Meeting held with the JSBMR, Gold Coast Australia, Sep 04-08, 2011. LONDON: SPRINGER LONDON LTD.

Inhibiting Histone Deacetylases Expressed in Human Periodontal Tissues Prevents Bone Loss in An Animal Model of Periodontal Disease

2011

Journal Article

Histone deacetylases as regulators of inflammation and immunity

Shakespear, Melanie R., Halili, Maria A., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2011). Histone deacetylases as regulators of inflammation and immunity. Trends in Immunology, 32 (7), 335-343. doi: 10.1016/j.it.2011.04.001

Histone deacetylases as regulators of inflammation and immunity

2011

Journal Article

Structure, function and pathophysiology of protease activated receptors

Adams, Mark N., Ramachandran, Rithwik, Yau, Mei-Kwan, Suen, Jacky Y., Fairlie, David P., Hollenberg, Morley D. and Hooper, John D. (2011). Structure, function and pathophysiology of protease activated receptors. Pharmacology and Therapeutics, 120 (3), 248-282. doi: 10.1016/j.pharmthera.2011.01.003

Structure, function and pathophysiology of protease activated receptors

2011

Journal Article

Ex Vivo activity of histone deacetylase inhibitors against multidrug-resistant clinical isolates of Plasmodium falciparum and P. vivax

Marfurt, Jutta, Chalfein, Ferryanto, Prayoga, Pak, Wabiser, Frans, Kenangalem, Enny, Piera, Kim A., Fairlie, David P., Tjitra, Emiliana, Anstey, Nicholas M., Andrews, Kathy T. and Price, Rick N. (2011). Ex Vivo activity of histone deacetylase inhibitors against multidrug-resistant clinical isolates of Plasmodium falciparum and P. vivax. Antimicrobial agents and chemotherapy, 55 (3), 961-966. doi: 10.1128/AAC.01220-10

Ex Vivo activity of histone deacetylase inhibitors against multidrug-resistant clinical isolates of Plasmodium falciparum and P. vivax

2011

Journal Article

Amyloid formation from an α-helical peptide bundle is seeded by 310-helix aggregates

Singh, Yogendra, Sharpe, Philip C., Hoang, Huy N., Lucke, Andrew J., McDowall, Alasdair W., Bottomley, Stephen P. and Fairlie, David P. (2011). Amyloid formation from an α-helical peptide bundle is seeded by 310-helix aggregates. Chemistry: A European Journal, 17 (1), 151-160. doi: 10.1002/chem.201002500

Amyloid formation from an α-helical peptide bundle is seeded by 310-helix aggregates

2011

Conference Publication

Towards orally bioavailable peptides and peptidomimetics

Fairlie, David P., Stoermer, Martin, Lucke, Andrew, Lohman, Rink-Jan, Liu, Ligong and Ruiz-Gomez, Gloria (2011). Towards orally bioavailable peptides and peptidomimetics. 241st National Meeting and Exposition of the American-Chemical-Society (ACS), Anaheim, CA, United States, 27-31 March 2011. Washington, DC, United States: American Chemical Society.

Towards orally bioavailable peptides and peptidomimetics

2011

Conference Publication

Novel agonists and antagonists for protease activated receptor 2

Yau, Annika M., Liu, Ligong, Reid, Robert C., Barry, Grant D., Suen, Jacky Y., Lohman, Rink-Jan, Le, Giang T., Cotterell, Adam and Fairlie, David P. (2011). Novel agonists and antagonists for protease activated receptor 2. National Meeting of the American Chemical Society (242nd, ACS, 2011), Denver, CO, U.S.A., 28 August-1 September 2011. WASHINGTON: AMER CHEMICAL SOC.

Novel agonists and antagonists for protease activated receptor 2

2011

Book Chapter

Recent advances in β-Strand mimetics

Loughlin, Wendy A. and Fairlie, David P. (2011). Recent advances in β-Strand mimetics. Amino acids, peptides and proteins in organic chemistry: protection reactions, medicinal chemistry, combinatorial synthesis. (pp. 129-147) edited by Andrew B. Hughes. Somerset, NJ, United States: Wiley-VCH. doi: 10.1002/9783527631827.ch3

Recent advances in β-Strand mimetics

2010

Journal Article

Inhibitors selective for HDAC6 in enzymes and cells

Gupta, Praveer K., Reid, Robert C., Liu, Ligong, Lucke, Andrew J., Broomfield, Steve A., Andrews, Melanie R., Sweet, Matthew J. and Fairlie, David P. (2010). Inhibitors selective for HDAC6 in enzymes and cells. Bioorganic & Medicinal Chemistry Letters, 20 (23), 7067-7070. doi: 10.1016/j.bmcl.2010.09.100

Inhibitors selective for HDAC6 in enzymes and cells

2010

Journal Article

Antimalarial histone deacetylase inhibitors containing cinnamate or NSAID components

Wheatley, Nicole C., Andrews, Katherine T., Tran, Truc L., Lucke, Andrew J., Reid, Robert C. and Fairlie, David P. (2010). Antimalarial histone deacetylase inhibitors containing cinnamate or NSAID components. Bioorganic & Medicinal Chemistry Letters, 20 (23), 7080-7084. doi: 10.1016/j.bmcl.2010.09.096

Antimalarial histone deacetylase inhibitors containing cinnamate or NSAID components

2010

Journal Article

Novel helix-constrained nociceptin derivatives are potent agonists and antagonists of ERK phosphorylation and thermal analgesia in mice

Harrison, Rosemary S., Ruiz-Gomez, Gloria, Hill, Timothy A., Chow, Shiao Y., Shepherd, Nicholas E., Lohman, Rink-Jan, Abbenante, Giovanni, Hoang, Huy N. and Fairlie, David P. (2010). Novel helix-constrained nociceptin derivatives are potent agonists and antagonists of ERK phosphorylation and thermal analgesia in mice. Journal of Medicinal Chemistry, 53 (23), 8400-8408. doi: 10.1021/jm101139f

Novel helix-constrained nociceptin derivatives are potent agonists and antagonists of ERK phosphorylation and thermal analgesia in mice

2010

Journal Article

Profiling gene expression induced by protease-activated receptor 2 (PAR2) activation in human kidney cells

Suen, JY, Gardiner, B, Grimmond, S and Fairlie, DP (2010). Profiling gene expression induced by protease-activated receptor 2 (PAR2) activation in human kidney cells. PLoS One, 5 (11) e13809, e13809-1-e13809-14. doi: 10.1371/journal.pone.0013809

Profiling gene expression induced by protease-activated receptor 2 (PAR2) activation in human kidney cells

2010

Journal Article

Selective Hexapeptide Agonists and Antagonists for Human Complement C3a Receptor (Journal of Medicinal Chemistry (2010) 53 (4938)

Scully, Conor C. G., Blakeney, Jade S., Singh, Ranee, Hoang, Huy N., Abbenante, Giovanni, Reid, Robert C. and Fairlie, David P. (2010). Selective Hexapeptide Agonists and Antagonists for Human Complement C3a Receptor (Journal of Medicinal Chemistry (2010) 53 (4938). Journal of Medicinal Chemistry, 53 (22), 8208-8208. doi: 10.1021/jm1013314

Selective Hexapeptide Agonists and Antagonists for Human Complement C3a Receptor (Journal of Medicinal Chemistry (2010) 53 (4938)

2010

Journal Article

Novel agonists and antagonists for human protease activated receptor 2

Barry, Grant D., Suen, Jacky Y., Le, Giang T., Cotterell, Adam, Reid, Robert C. and Fairlie, David P. (2010). Novel agonists and antagonists for human protease activated receptor 2. Journal of Medicinal Chemistry, 53 (20), 7428-7440. doi: 10.1021/jm100984y

Novel agonists and antagonists for human protease activated receptor 2

2010

Conference Publication

Modelling of the C5a receptor by iterative mutation

Holt, J. R., Monk, P. N., Fairlie, D. P. and Madala, P. Kumar (2010). Modelling of the C5a receptor by iterative mutation. 23rd International National Complement Workshop, New York Ny, Aug 01-05, 2010. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/j.molimm.2010.05.061

Modelling of the C5a receptor by iterative mutation

2010

Journal Article

Selective hexapeptide agonists and antagonists for human complement C3a receptor

Scully, Conor C. G., Blakeney, Jade S., Singh, Ranee, Hoang, Huy N., Abbenante, Giovanni, Reid, Robert C. and Fairlie, David P. (2010). Selective hexapeptide agonists and antagonists for human complement C3a receptor. Journal of Medicinal Chemistry, 53 (13), 4938-4948. doi: 10.1021/jm1003705

Selective hexapeptide agonists and antagonists for human complement C3a receptor