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2008 Journal Article Potent antimalarial activity of histone deacetylase inhibitor analoguesAndrews, K. T., Tran, T. N., Lucke, A. J., Kahnberg, P., Le, G. T., Boyle, G. M., Gardiner, D. L., Skinner-Adams, T. S. and Fairlie, D. P. (2008). Potent antimalarial activity of histone deacetylase inhibitor analogues. Antimicrobial agents and chemotherapy, 52 (4), 1454-1461. doi: 10.1128/AAC.00757-07 |
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2008 Journal Article Mutagenesis of the West Nile virus NS2B cofactor domain reveals two regions essential for protease activityChappell, Keith J., Stoermer, Martin J., Fairlie, David P. and Young, Paul R. (2008). Mutagenesis of the West Nile virus NS2B cofactor domain reveals two regions essential for protease activity. Journal of General Virology, 89 (4), 1010-1014. doi: 10.1099/vir.0.83447-0 |
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2008 Journal Article A dual-purpose synthetic colloidal platform for protease mapping: substrate profiling for Dengue and West Nile virus proteasesMarcon, L., Kozak, D., Battersby, B.J., Chappell, K., Fairlie, D., Young, P.R. and Trau, M. (2008). A dual-purpose synthetic colloidal platform for protease mapping: substrate profiling for Dengue and West Nile virus proteases. Analytical Biochemistry, 2008 (376), 151-153. doi: 10.1016/j.ab.2008.01.034 |
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2008 Journal Article Crystal structures of highly constrained Substrate and Hydrolysis products bound to HIV-1 Protease. Implications for the Catalytic MechanismTyndall, Joel D. A., Pattenden, Leonard K., Reid, Robert C., Hu, Shu-Hong, Alewood, Dianne, Alewood, Paul F., Walsh, Terry, Fairlie, David P. and Martin, Jennifer L. (2008). Crystal structures of highly constrained Substrate and Hydrolysis products bound to HIV-1 Protease. Implications for the Catalytic Mechanism. Biochemistry, 47 (12), 3736-3744. doi: 10.1021/bi7023157 |
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2008 Conference Publication MEDI 256-Activation and inhibition of latent serine proteases, complement factors B and C2Fairlie, DP, Le, GT, Halili, M, Ruiz-Gomez, G and Abbenante, J (2008). MEDI 256-Activation and inhibition of latent serine proteases, complement factors B and C2. 236th National Meeting of the American Chemical Society, Philadelphia PA, 17-21 August 2008. Atlanta, GA, USA: The American Chemical Society. |
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2008 Journal Article Clean Or dirty - Just how selective do drugs need to be?Abbenante, Giovanni, Reid, Robert C. and Fairlie, David P. (2008). Clean Or dirty - Just how selective do drugs need to be?. Australian Journal of Chemistry, 61 (9), 654-660. doi: 10.1071/CH08186 |
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2008 Conference Publication COMP 264-Unraveling the mechanism of antagonism for human C5a receptor: Comparison of three structurally different antagonistsMadala, P. K., Stoermer, M., Tyndall, J. D. A., Monk, P. N., Higginbottom, A. and Fairlie, D. P. (2008). COMP 264-Unraveling the mechanism of antagonism for human C5a receptor: Comparison of three structurally different antagonists. 236th National Meeting of the American Chemical Society, Philadelphia, USA, 17-21 August, 2008. Washington, D. C., USA: American Chemical Society. |
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2008 Book Chapter Parallel synthesis af anticancer, antiinflammatory and antiviral agents derived from L- and D- amino acidsReid, Robert, C. and Fairlie, David P. (2008). Parallel synthesis af anticancer, antiinflammatory and antiviral agents derived from L- and D- amino acids. High-throughput lead optimisation in drug discovery. (pp. 177-194) edited by Tushar Kshirsagar. Boca Raton, USA: CRC Press. doi: 10.1201/9781420006964.ch7 |
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2007 Journal Article Hepta and octapeptide agonists of protease-activated receptor 2Devlin, M. G., Pfeiffer, B., Flanagan, B. M., Beyer, R., Cocks, T. M and Fairlie, D. P. (2007). Hepta and octapeptide agonists of protease-activated receptor 2. Journal of Peptide Science, 13 (12), 856-861. doi: 10.1002/psc.912 |
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2007 Journal Article A refined agonist pharmacophore for protease activated receptor 2Barry, Grant D., Suen, Jacky Y., Low, Heng Boon, Pfeiffer, Bernhard, Flanagan, Bernadine, Halili, Maria, Le, Giang T. and Fairlie, David P. (2007). A refined agonist pharmacophore for protease activated receptor 2. Bioorganic & Medicinal Chemistry Letters, 17 (20), 5552-5557. doi: 10.1016/j.bmcl.2007.08.026 |
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2007 Journal Article Profiling the enzymatic properties and inhibition of human complement factor BLe, G. T, Abbenante, G. and Fairlie, D. P (2007). Profiling the enzymatic properties and inhibition of human complement factor B. Journal of Biological Chemistry, 282 (48), 34809-34816. doi: 10.1074/jbc.M705646200 |
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2007 Other Outputs Compounds and inhibitors of phospholipasesReid, Robert C., Clark, Christopher I., Hansford, Karl, Stoermer, Martin J., McGeary, Ross P., Fairlie, David P. and Schafer, Karl (2007). Compounds and inhibitors of phospholipases. US7253194. |
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2007 Other Outputs New amino acid derivatives useful for the treatment of inflammatory disease or condition e.g. rheumatic arthritisClark, C. I., Fairlie, D. P., Hansford, K., McGeary, R. P., Reid, R. C. and Stoermer, M. J. (2007). New amino acid derivatives useful for the treatment of inflammatory disease or condition e.g. rheumatic arthritis. |
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2007 Journal Article Organic azide inhibitors of cysteine proteases (vol 128, pg 12396, 2006)Le, Giang Thanh, Abbenante, Giovanni, Madala, Praveen K., Hoang, Huy N. and Fairlie, David P. (2007). Organic azide inhibitors of cysteine proteases (vol 128, pg 12396, 2006). Journal of the American Chemical Society, 129 (30), 9532-9532. doi: 10.1021/ja076897i |
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2007 Journal Article Generation and characterization of proteolytically active and highly stable truncated and full-length recombinant West Nile virus NS3Chappell, K. J., Stoermer, M. J., Fairlie, D. P. and Young, P. R. (2007). Generation and characterization of proteolytically active and highly stable truncated and full-length recombinant West Nile virus NS3. Protein Expression and Purification, 53 (1), 87-96. doi: 10.1016/j.pep.2006.10.022 |
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2007 Journal Article Erratum: Latest developments in the treatment of inflammatory disease (Current Medicinal Chemistry (2005) vol. 12 (25) (2923-224))Fairlie, David (2007). Erratum: Latest developments in the treatment of inflammatory disease (Current Medicinal Chemistry (2005) vol. 12 (25) (2923-224)). Current Medicinal Chemistry, 14 (8) doi: 10.2174/092986707780362989 |
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2007 Journal Article Substrate specificity of recombinant dengue 2 virus NS2B-NS3 protease: Influence of natural and unnatural basic amino acids on hydrolysis of synthetic fluorescent substratesGouvea, I. E, Izidoro, M. A, Judice, W. A. S, Cezari, M. H. S, Caliendo, G., Santagada, V., dos Santos, C. N. D, Queiroz, M. H, Juliano, M. A, Young, P. R, Fairlie, D. P and Juliano, L. (2007). Substrate specificity of recombinant dengue 2 virus NS2B-NS3 protease: Influence of natural and unnatural basic amino acids on hydrolysis of synthetic fluorescent substrates. Archives of Biochemistry and Biophysics, 457 (2), 187-196. doi: 10.1016/j.abb.2006.11.005 |
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2007 Journal Article The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand bindingScola, A. M., Higginbottom, A., Partridge, L, J., Reid, R. C., Woodruff, T., Taylor, S. M., Fairlie, D. P. and Monk, P. N. (2007). The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding. Journal of Biological Chemistry, 282 (6), 3664-3671. doi: 10.1074/jbc.M609178200 |
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2007 Journal Article A new paradigm for protein kinase inhibition: blocking phosphorylation without directly targeting ATP bindingBogoyevitch, M. A and Fairlie, D. P (2007). A new paradigm for protein kinase inhibition: blocking phosphorylation without directly targeting ATP binding. Drug Discovery Today, 12 (15-16), 622-633. doi: 10.1016/j.drudis.2007.06.008 |
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2007 Journal Article Unexpected photolytic decomposition of alkyl azides under mild conditionsAbbenante, G., Le, G. and Fairlie, D. P. (2007). Unexpected photolytic decomposition of alkyl azides under mild conditions. Chemical Communications, 2007 (43), 4501-4503. doi: 10.1039/b708134k |
