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2023

Journal Article

Multi‐omic and spatial dissection of immunotherapy response groups in non‐small cell lung cancer

Monkman, James, Kim, Honesty, Mayer, Aaron, Mehdi, Ahmed, Matigian, Nicholas, Cumberbatch, Marie, Bhagat, Milan, Ladwa, Rahul, Mueller, Scott N., Adams, Mark N., O'Byrne, Ken and Kulasinghe, Arutha (2023). Multi‐omic and spatial dissection of immunotherapy response groups in non‐small cell lung cancer. Immunology, 169 (4), 487-502. doi: 10.1111/imm.13646

Multi‐omic and spatial dissection of immunotherapy response groups in non‐small cell lung cancer

2023

Journal Article

Mapping immunotherapy sensitivity with multiomic approaches

Kulasinghe, Arutha (2023). Mapping immunotherapy sensitivity with multiomic approaches. Immuno Oncology Insights, 4 (6), 235-237. doi: 10.18609/ioi.2023.031

Mapping immunotherapy sensitivity with multiomic approaches

2023

Journal Article

Liquid biopsy snapshots of key phosphoproteomic pathways in lung cancer patients for diagnosis and therapy monitoring

Ahmed, Mostak, Wuethrich, Alain, Constantin, Nicolas, Shanmugasundaram, Karthik Balaji, Mainwaring, Paul, Kulasinghe, Arutha, O’Leary, Connor, O’Byrne, Ken, Sina, Abu Ali Ibn, Carrascosa, Laura G. and Trau, Matt (2023). Liquid biopsy snapshots of key phosphoproteomic pathways in lung cancer patients for diagnosis and therapy monitoring. Analytical Chemistry, 95 (22), 8522-8532. doi: 10.1021/acs.analchem.3c00519

Liquid biopsy snapshots of key phosphoproteomic pathways in lung cancer patients for diagnosis and therapy monitoring

2023

Conference Publication

Spatial phenotyping of cytokine signatures reflecting the immunotherapy responses in head and neck cancer

Ji, HaYeun, Jhaveri, Niyati, Pratapa, Aditya, Ma, Ning, Ben Cheikh, Bassem, Monkman, James, O’Byrne, Ken, Hughes, Brett, Kulasinghe, Arutha and Braubach, Oliver (2023). Spatial phenotyping of cytokine signatures reflecting the immunotherapy responses in head and neck cancer. Immunology 2023™ Meeting, Washington, DC United States, 11-15 May 2023. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.210.supp.171.09

Spatial phenotyping of cytokine signatures reflecting the immunotherapy responses in head and neck cancer

2023

Conference Publication

Spatial phenotyping of cytokine signatures reflecting the immunotherapy responses in head and neck cancer

Ji, HaYeun, Jhaveri, Niyati, Pratapa, Aditya, Ma, Ning, Ben Cheikh, Bassem, Monkman, James, O'Byrne, Ken, Hughes, Brett, Kulasinghe, Arutha and Braubach, Oliver (2023). Spatial phenotyping of cytokine signatures reflecting the immunotherapy responses in head and neck cancer. Annual Meeting of the American-Association-of-Immunologists (AAI), Washington Dc, May 11-15, 2023. BETHESDA: AMER ASSOC IMMUNOLOGISTS.

Spatial phenotyping of cytokine signatures reflecting the immunotherapy responses in head and neck cancer

2023

Conference Publication

Immune profiling of immunotherapy and adjuvant chemotherapy pretreatment NSCLC tissues by CODEX

Monkman, James, Moradi, Afshin, O'Leary, Connor, Wu, Zhenqin, Hamel, Steven, Mason, David, Schneider, Fabian, Mansfield, James Robert, Meyer, Aaron, O'Byrne, Ken and Kulasinghe, Arutha (2023). Immune profiling of immunotherapy and adjuvant chemotherapy pretreatment NSCLC tissues by CODEX. AACR Annual Meeting 2023, Orlando, FL United States, 14-19 April 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2023-4627

Immune profiling of immunotherapy and adjuvant chemotherapy pretreatment NSCLC tissues by CODEX

2023

Conference Publication

Abstract 5647: Single cell, multiomic spatial phenotyping of immunotherapy responses in head and neck cancer

Ji, HaYeun, Jhaveri, Niyati, Ma, Ning, Cheikh, Bassem B., Pratapa, Aditya, Monkman, James, O’Byrne, Ken, Hughes, Brett, Kulasinghe, Arutha and Braubach, Oliver (2023). Abstract 5647: Single cell, multiomic spatial phenotyping of immunotherapy responses in head and neck cancer. AACR Annual Meeting 2023, Orlando, FL United States, 14-19 April 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2023-5647

Abstract 5647: Single cell, multiomic spatial phenotyping of immunotherapy responses in head and neck cancer

2023

Conference Publication

Abstract 4626: Spatial profiling of the tumor microenvironment in head and neck cancer identifies immune checkpoints and proteins involved in cell death signaling biomarkers of immunotherapy response

Sadeghirad, Habib, Liu, Ning, Monkman, James, Tan, Chin Wee, Cooper, Caroline, Caldera, Jeni, Church, Sarah, Schneider, Fabian, Mansfield, James Robert, O'Byrne, Ken, Davis, Melissa, Hughes, Brett and Kulasinghe, Arutha (2023). Abstract 4626: Spatial profiling of the tumor microenvironment in head and neck cancer identifies immune checkpoints and proteins involved in cell death signaling biomarkers of immunotherapy response. AACR Annual Meeting 2023, Orlando, FL United States, 14-19 April 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2023-4626

Abstract 4626: Spatial profiling of the tumor microenvironment in head and neck cancer identifies immune checkpoints and proteins involved in cell death signaling biomarkers of immunotherapy response

2023

Conference Publication

Abstract 6768: The potential predictive role of spatial phenotyping in non-small cell lung cancer

Ma, Ning, Pratapa, Aditya, Monkman, James, O’Byrne, Ken, Braubach, Oliver and Kulasinghe, Arutha (2023). Abstract 6768: The potential predictive role of spatial phenotyping in non-small cell lung cancer. AACR Annual Meeting 2023, Orlando, FL United States, 14-19 April 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2023-6768

Abstract 6768: The potential predictive role of spatial phenotyping in non-small cell lung cancer

2023

Conference Publication

The development of a spatial metabolic map of immunotherapy sensitive and resistant cutaneous skin carcinoma

Jhaveri, Niyati, Klymyshyn, Dmytro, Cheikh, Bassem B., Monkman, James, Winkowski, Dan, Mansfield, James, Basu, Subham, Prater, Michael, Nelson, Nadine, Belz, Gabrielle, Braubach, Oliver and Kulasinghe, Arutha (2023). The development of a spatial metabolic map of immunotherapy sensitive and resistant cutaneous skin carcinoma. AACR Annual Meeting 2023, Orlando, FL United States, 14-19 April 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2023-6774

The development of a spatial metabolic map of immunotherapy sensitive and resistant cutaneous skin carcinoma

2023

Journal Article

Compartmentalized spatial profiling of the tumor microenvironment in head and neck squamous cell carcinoma identifies immune checkpoint molecules and tumor necrosis factor receptor superfamily members as biomarkers of response to immunotherapy

Sadeghirad, Habib, Liu, Ning, Monkman, James, Ma, Ning, Cheikh, Bassem Ben, Jhaveri, Niyati, Tan, Chin Wee, Warkiani, Majid Ebrahimi, Adams, Mark N., Nguyen, Quan, Ladwa, Rahul, Braubach, Oliver, O’Byrne, Ken, Davis, Melissa, Hughes, Brett G. M. and Kulasinghe, Arutha (2023). Compartmentalized spatial profiling of the tumor microenvironment in head and neck squamous cell carcinoma identifies immune checkpoint molecules and tumor necrosis factor receptor superfamily members as biomarkers of response to immunotherapy. Frontiers in Immunology, 14 1135489, 1-16. doi: 10.3389/fimmu.2023.1135489

Compartmentalized spatial profiling of the tumor microenvironment in head and neck squamous cell carcinoma identifies immune checkpoint molecules and tumor necrosis factor receptor superfamily members as biomarkers of response to immunotherapy

2023

Conference Publication

Polo-like kinase-1 is a novel biomarker in resected non-small cell lung cancer treated with adjuvant platinum-based chemotherapy

O'Leary, Connor, Monkman, James, Richard, Derek, O'Byrne, Kenneth, Kulasinghe, Arutha and Adams, Mark (2023). Polo-like kinase-1 is a novel biomarker in resected non-small cell lung cancer treated with adjuvant platinum-based chemotherapy. Australian Lung Cancer Conference 2023, Gold Coast, QLD Australia, 15-17 February 2023. Richmond, VIC Australia: John Wiley & Sons.

Polo-like kinase-1 is a novel biomarker in resected non-small cell lung cancer treated with adjuvant platinum-based chemotherapy

2023

Conference Publication

Multiomic dissection of immunotherapy response groups in lung cancer

Kulasinghe, Arutha (2023). Multiomic dissection of immunotherapy response groups in lung cancer. HOBOKEN: WILEY.

Multiomic dissection of immunotherapy response groups in lung cancer

2023

Journal Article

Blood transcriptome responses in patients correlate with severity of COVID-19 disease

Wang, Ya, Schughart, Klaus, Pelaia, Tiana Maria, Chew, Tracy, Kim, Karan, Karvunidis, Thomas, Knippenberg, Ben, Teoh, Sally, Phu, Amy L., Short, Kirsty R., Iredell, Jonathan, Thevarajan, Irani, Audsley, Jennifer, Macdonald, Stephen, Burcham, Jonathon, McLean, Anthony, Tang, Benjamin, Shojaei, Maryam, PREDICT-19 consortium, Kulasinghe, Arutha and Carney, Meagan E. (2023). Blood transcriptome responses in patients correlate with severity of COVID-19 disease. Frontiers in Immunology, 13 1043219, 1-18. doi: 10.3389/fimmu.2022.1043219

Blood transcriptome responses in patients correlate with severity of COVID-19 disease

2023

Journal Article

IFI27 transcription is an early predictor for COVID-19 outcomes, a multi-cohort observational study

Shojaei, Maryam, Shamshirian, Amir, Monkman, James, Grice, Laura, Tran, Minh, Tan, Chin Wee, Teo, Siok Min, Rodrigues Rossi, Gustavo, McCulloch, Timothy R., Nalos, Marek, Raei, Maedeh, Razavi, Alireza, Ghasemian, Roya, Gheibi, Mobina, Roozbeh, Fatemeh, Sly, Peter D., Spann, Kirsten M., Chew, Keng Yih, Zhu, Yanshan, Xia, Yao, Wells, Timothy J., Senegaglia, Alexandra Cristina, Kuniyoshi, Carmen Lúcia, Franck, Claudio Luciano, dos Santos, Anna Flavia Ribeiro, Noronha, Lucia de, Motamen, Sepideh, Valadan, Reza, Amjadi, Omolbanin ... Tang, Benjamin (2023). IFI27 transcription is an early predictor for COVID-19 outcomes, a multi-cohort observational study. Frontiers in Immunology, 13 1060438, 1-14. doi: 10.3389/fimmu.2022.1060438

IFI27 transcription is an early predictor for COVID-19 outcomes, a multi-cohort observational study

2023

Journal Article

Transcriptomic profiling of cardiac tissues from SARS‐CoV ‐2 patients identifies DNA damage

Kulasinghe, Arutha, Liu, Ning, Tan, Chin Wee, Monkman, James, Sinclair, Jane E., Bhuva, Dharmesh D., Godbolt, David, Pan, Liuliu, Nam, Andy, Sadeghirad, Habib, Sato, Kei, Bassi, Gianluigi Li, O'Byrne, Ken, Hartmann, Camila, Miggiolaro, Anna Flavia Ribeiro dos Santos, Marques, Gustavo Lenci, Moura, Lidia Zytynski, Richard, Derek, Adams, Mark, Noronha, Lucia de, Baena, Cristina Pellegrino, Suen, Jacky Y., Arora, Rakesh, Belz, Gabrielle T., Short, Kirsty R., Davis, Melissa J., Souza‐Fonseca Guimaraes, Fernando and Fraser, John F. (2023). Transcriptomic profiling of cardiac tissues from SARS‐CoV ‐2 patients identifies DNA damage. Immunology, 168 (3), 403-419. doi: 10.1111/imm.13577

Transcriptomic profiling of cardiac tissues from SARS‐CoV ‐2 patients identifies DNA damage

2022

Conference Publication

Decoding immunotherapy responses with high-dimensional and high-throughput spatial phenotyping of non-small cell lung cancer (NSCLC)

Ma, Ning, Pratapa, Aditya, Monkman, James, O’Byrne, Ken, Braubach, Oliver and Kulasinghe, Arutha (2022). Decoding immunotherapy responses with high-dimensional and high-throughput spatial phenotyping of non-small cell lung cancer (NSCLC). SITC 37th Annual Meeting (SITC 2022), Boston, MA USA, 8-12 November 2022. London, United Kingdom: BMJ Publishing Group. doi: 10.1136/jitc-2022-sitc2022.0120

Decoding immunotherapy responses with high-dimensional and high-throughput spatial phenotyping of non-small cell lung cancer (NSCLC)

2022

Conference Publication

High-plex spatial proteomic profiling of immunotherapy response groups in head and neck cancer identifies tissue signatures associated with therapy response

Kulasinghe, Arutha, Sadeghirad, Habib, Liu, Ning, Monkman, James, Tan, Chin Wee, Cooper, Caroline, Church, Sarah, Schneider, Fabian, Thaagard, Jeppe, Mansfield, James, O’byrne, Kenneth, Davis, Melissa and Hughes, Brett (2022). High-plex spatial proteomic profiling of immunotherapy response groups in head and neck cancer identifies tissue signatures associated with therapy response. SITC 37th Annual Meeting (SITC 2022), Boston, MA United States, 8–12 November 2022. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2022-sitc2022.0117

High-plex spatial proteomic profiling of immunotherapy response groups in head and neck cancer identifies tissue signatures associated with therapy response

2022

Conference Publication

High-dimensional spatial phenotyping of cutaneous squamous cell carcinoma from immune-competent and immunocompromised patients

Kulasinghe, Arutha, Jhaveri, Niyati, Klymyshyn, Dmytro, Cheikh, Bassem Ben, Ladwa, Rahul, Liu, Howard, Cooper, Caroline, Belz, Gabrielle, Porceddu, Sandro and Braubach, Oliver (2022). High-dimensional spatial phenotyping of cutaneous squamous cell carcinoma from immune-competent and immunocompromised patients. SITC 37th Annual Meeting (SITC 2022), Boston, MA United States, 8–12 November 2022. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2022-sitc2022.0079

High-dimensional spatial phenotyping of cutaneous squamous cell carcinoma from immune-competent and immunocompromised patients

2022

Conference Publication

Delineation of spatial tissue signatures of immunotherapy response groups in non-small cell lung cancer (NSCLC)

Kulasinghe, Arutha, Monkman, James, Kim, Honesty, Mayer, Aaron, Mehdi, Ahmed, Cumberbatch, Marie, Bhagat, Milan, Schneider, Fabian, Thaagard, Jeppe, Mansfield, James, Ladwa, Rahul, Mueller, Scott, Adams, Mark and O’byrne, Kenneth (2022). Delineation of spatial tissue signatures of immunotherapy response groups in non-small cell lung cancer (NSCLC). SITC 37th Annual Meeting (SITC 2022), Boston, MA USA, 8-12 November 2022. London, United Kingdom: BMJ Publishing Group. doi: 10.1136/jitc-2022-sitc2022.0118

Delineation of spatial tissue signatures of immunotherapy response groups in non-small cell lung cancer (NSCLC)