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2018 Journal Article The use of SWATH to analyse the dynamic changes of bacterial proteome of carbapanemase-producing Escherichia coli under antibiotic pressureSidjabat, Hanna E., Gien, Jolene, Kvaskoff, David, Ashman, Keith, Vaswani, Kanchan, Reed, Sarah, McGeary, Ross P., Paterson, David L., Bordin, Amanda and Schenk, Gerhard (2018). The use of SWATH to analyse the dynamic changes of bacterial proteome of carbapanemase-producing Escherichia coli under antibiotic pressure. Scientific Reports, 8 (1) 3871, 3871. doi: 10.1038/s41598-018-21984-9 |
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2018 Journal Article Copper ions and coordination complexes as novel carbapenem adjuvantsDjoko, Karrera Y., Achard, Maud E. S., Phan, Minh-Duy, Lo, Alvin W., Miraula, Manfredi, Prombhul, Sasiprapa, Hancock, Steven J., Peters, Kate M., Sidjabat, Hanna E., Harris, Patrick N., Mitić, Nataša, Walsh, Timothy R., Anderson, Gregory J., Shafer, William M., Paterson, David L., Schenk, Gerhard, McEwan, Alastair G. and Schembri, Mark A. (2018). Copper ions and coordination complexes as novel carbapenem adjuvants. Antimicrobial Agents and Chemotherapy, 62 (2) e02280-17. doi: 10.1128/AAC.02280-17 |
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2018 Journal Article Processivity and enzymatic mechanism of a multifunctional family 5 endoglucanase from Bacillus subtilis BS-5 with potential applications in the saccharification of cellulosic substratesWu, Bin, Zheng, Shan, Pedroso, Marcelo Monteiro, Guddat, Luke W., Chang, Siyuan, He, Bingfang and Schenk, Gerhard (2018). Processivity and enzymatic mechanism of a multifunctional family 5 endoglucanase from Bacillus subtilis BS-5 with potential applications in the saccharification of cellulosic substrates. Biotechnology for Biofuels, 11 (1) 20, 1-15. doi: 10.1186/s13068-018-1022-2 |
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2017 Journal Article Crystal structures of Staphylococcus aureus ketol-acid reductoisomerase in complex with two transition state analogs that have biocidal activityPatel, Khushboo, Teran, David, Zheng, Shan, Kandale, Ajit, Garcia, Mario, Lv, You, Schembri, Mark A, McGeary, Ross P, Schenk, Gerhard and Guddat, Luke William (2017). Crystal structures of Staphylococcus aureus ketol-acid reductoisomerase in complex with two transition state analogs that have biocidal activity. Chemistry- A European Journal, 23 (72), 18289-18295. doi: 10.1002/chem.201704481 |
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2017 Journal Article Second-Sphere Effects in Dinuclear FeIIIZnII Hydrolase Biomimetics: Tuning Binding and Reactivity PropertiesCamargo, Tiago Pacheco, Neves, Ademir, Peralta, Rosely A., Chaves, Cláudia, Maia, Elene C. P., Lizarazo-Jaimes, Edgar H., Gomes, Dawidson A., Bortolotto, Tiago, Norberto, Douglas R., Terenzi, Hernán, Tierney, David L. and Schenk, Gerhard (2017). Second-Sphere Effects in Dinuclear FeIIIZnII Hydrolase Biomimetics: Tuning Binding and Reactivity Properties. Inorganic Chemistry, 57 (1), 187-203. doi: 10.1021/acs.inorgchem.7b02384 |
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2017 Journal Article Deacidification of grass silage press juice by continuous production of acetoin from its lactate via an immobilized enzymatic reaction cascadeHohagen, Hendrik, Schwarz, Dominik, Schenk, Gerhard, Guddat, Luke W., Schieder, Doris, Carsten, Jörg and Sieber, Volker (2017). Deacidification of grass silage press juice by continuous production of acetoin from its lactate via an immobilized enzymatic reaction cascade. Bioresource Technology, 245 (Pt A), 1084-1092. doi: 10.1016/j.biortech.2017.08.203 |
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2017 Journal Article Characterization of a highly efficient antibiotic-degrading metallo-β-lactamase obtained from an uncultured member of a permafrost communityPedroso, Marcelo Monteiro, Selleck, Christopher, Enculescu, Charmaine, Harmer, Jeffrey R., Mitic, Natasa, Craig, Whitney R., Helweh, Waleed, Hugenholtz, Philip, Tyson, Gene W., Tierney, David L., Larrabee, James A. and Schenk, Gerhard (2017). Characterization of a highly efficient antibiotic-degrading metallo-β-lactamase obtained from an uncultured member of a permafrost community. Metallomics, 9 (8), 1157-1168. doi: 10.1039/c7mt00195a |
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2017 Journal Article Mechanistic insight from calorimetric measurements of the assembly of the binuclear metal active site of glycerophosphodiesterase (GpdQ) from Enterobacter aerogenesPedroso, Marcelo M., Ely, Fernanda, Carpenter, Margaret C., Mitic, Natasa, Gahan, Lawrence R., Ollis, David L., Wilcox, Dean E. and Schenk, Gerhard (2017). Mechanistic insight from calorimetric measurements of the assembly of the binuclear metal active site of glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes. Biochemistry, 56 (26), 3328-3336. doi: 10.1021/acs.biochem.6b01200 |
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2017 Journal Article High resolution crystal structure of a fluoride-inhibited organophosphate-degrading metallohydrolaseSelleck, Christopher , Guddat, Luke W., Ollis, David L., Schenk, Gerhard and Pedroso, Marcelo Monteiro (2017). High resolution crystal structure of a fluoride-inhibited organophosphate-degrading metallohydrolase. Journal of Inorganic Biochemistry, 177, 287-290. doi: 10.1016/j.jinorgbio.2017.06.013 |
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2017 Journal Article Structure-activity relationship study and optimisation of 2-aminopyrrole-1-benzyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile as a broad spectrum metallo-β-lactamase inhibitorMcGeary, Ross P., Tan, Daniel T. C., Selleck, Christopher, Monteiro Pedroso, Marcelo, Sidjabat, Hanna E. and Schenk, Gerhard (2017). Structure-activity relationship study and optimisation of 2-aminopyrrole-1-benzyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile as a broad spectrum metallo-β-lactamase inhibitor. European Journal of Medicinal Chemistry, 137, 351-364. doi: 10.1016/j.ejmech.2017.05.061 |
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2017 Journal Article Reaction mechanism of the metallohydrolase CpsB from Streptococcus pneumoniae, a promising target for novel antimicrobial agentsMonteiro Pedroso, Marcelo, Selleck, Christopher, Bilyj, Jessica, Harmer, Jeffrey R. , Gahan, Lawrence R. , Mitić, Natasa, Standish, Alistair J. , Tierney, David L. , Larrabee, James A. and Schenk, Gerhard (2017). Reaction mechanism of the metallohydrolase CpsB from Streptococcus pneumoniae, a promising target for novel antimicrobial agents. Dalton Transactions, 46 (39), 13194-13201. doi: 10.1039/c7dt01350g |
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2017 Journal Article Progress toward inhibitors of metallo-β-lactamasesMcGeary, Ross P., Tan, Daniel T. C. and Schenk, Gerhard (2017). Progress toward inhibitors of metallo-β-lactamases. Future Medicinal Chemistry, 9 (7), 673-691. doi: 10.4155/fmc-2017-0007 |
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2017 Journal Article Is CuII coordinated to patellamides inside Prochloron cells?Comba, Peter, Eisenschmidt, Annika, Gahan, Lawrence R., Herten, Dirk-Peter , Nette, Geoffrey, Schenk, Gerhard and Seefeld, Martin (2017). Is CuII coordinated to patellamides inside Prochloron cells?. Chemistry - A European Journal, 23 (50), 12264-12274. doi: 10.1002/chem.201700895 |
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2017 Journal Article Visualization of the reaction trajectory and transition state in a hydrolytic reaction catalyzed by a metalloenzymeSelleck, Christopher, Clayton, Daniel, Gahan, Lawrence R., Mitic, Nataša, McGeary, Ross P., Pedroso, Marcelo Monteiro, Guddat, Luke W. and Schenk, Gerhard (2017). Visualization of the reaction trajectory and transition state in a hydrolytic reaction catalyzed by a metalloenzyme. Chemistry: A European Journal, 23 (20), 4778-4781. doi: 10.1002/chem.201700866 |
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2017 Journal Article Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studiesMöhler, Jasper S., Kolmar, Theresa, Synnatschke, Kevin, Hergert, Marcel, Wilson, Liam A., Ramu, Soumya, Elliott, Alysha G., Blaskovich, Mark A.T., Sidjabat, Hanna E., Paterson, David L., Schenk, Gerhard, Cooper, Matthew A. and Ziora, Zyta M. (2017). Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studies. Journal of Inorganic Biochemistry, 167, 134-141. doi: 10.1016/j.jinorgbio.2016.11.028 |
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2017 Journal Article Insights into an evolutionary strategy leading to antibiotic resistanceHou, Chun-Feng D., Liu, Jian-wei, Collyer, Charles, Mitić, Natasha, Pedroso, Marcelo Monteiro, Schenk, Gerhard and Ollis, David L. (2017). Insights into an evolutionary strategy leading to antibiotic resistance. Scientific Reports, 7 (1) 40357, 40357.1-40357.13. doi: 10.1038/srep40357 |
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2017 Conference Publication Polymorphisms in Gabra and Rgs Genes Are Associated with Alcoholism and a Secondary Diagnosis of Liver Cirrhosis: Results Are Sex-LinkedEnculescu, C. V., Ho, A. M. C., Rueda, A. V., Fortes, M. R. S., Shamsollahi, G., James, D. P., Schenk, G., Camarini, R., Dodd, P. R. and Stadlin, A. (2017). Polymorphisms in Gabra and Rgs Genes Are Associated with Alcoholism and a Secondary Diagnosis of Liver Cirrhosis: Results Are Sex-Linked. 40th Annual Scientific Meeting of the Research-Society-on-Alcoholism (RSA), Denver CO, United States, 24-28 June 2017. Hoboken, NJ United States: Wiley. |
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2017 Journal Article Mammalian agmatinases constitute unusual members in the family of Mn2+-dependent ureahydrolasesRomero, Nicol, Benitez, José, Garcia, David, Gonzalez, Arlette, Bennun, Leonardo, Garcia-Robles, María A., Lopez, Vasthi, Wilson, Liam A., Schenk, Gerhard, Carvajal, Nelson and Uribe, Elena (2017). Mammalian agmatinases constitute unusual members in the family of Mn2+-dependent ureahydrolases. Journal of Inorganic Biochemistry, 166, 122-125. doi: 10.1016/j.jinorgbio.2016.11.015 |
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2017 Conference Publication Ketol-acid-reductoisomerase, an emerging target for herbicides and novel antimicrobial agentsSchenk, Gerhard and Guddat, Luke W. (2017). Ketol-acid-reductoisomerase, an emerging target for herbicides and novel antimicrobial agents. 18th International Conference on Biological Inorganic Chemistry (ICBIC), Florianopolis Brazil, 31 July - 4 August 2017. New York, NY United States: Springer. |
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2016 Journal Article AIM-1: an antibiotic-degrading metallohydrolase that displays mechanistic flexibilitySelleck, Christopher, Larrabee James A., Harmer, Jeffrey, Guddat, Luke W., Mitić, Natasa, Helweh, Waleed, Ollis, David L., Craig, Whitney R., Tierney, David L., Monteiro Pedroso, Marcelo and Schenk, Gerhard (2016). AIM-1: an antibiotic-degrading metallohydrolase that displays mechanistic flexibility. Chemistry, 22 (49), 17704-17714. doi: 10.1002/chem.201602762 |
