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2012 Journal Article mTOR complex 1 plays critical roles in hematopoiesis and pten-loss-evoked leukemogenesisKalaitzidis, Demetrios, Sykes, Stephen M., Wang, Zhu, Punt, Natalie, Tang, Yuefeng, Ragu, Christine, Sinha, Amit U., Lane, Steven W., Souza, Amanda L., Clish, Clary B., Anastasiou, Dimitrios, Gilliland, D. Gary, Scadden, David T., Guertin, David A. and Armstrong, Scott A. (2012). mTOR complex 1 plays critical roles in hematopoiesis and pten-loss-evoked leukemogenesis. Cell Stem Cell, 11 (3), 429-439. doi: 10.1016/j.stem.2012.06.009 |
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2012 Journal Article Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia veraMullally, Ann, Poveromo, Luke, Schneider, Rebekka K., Al-Shahrour, Fatima, Lane, Steven W. and Ebert, Benjamin L. (2012). Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera. Blood, 120 (1), 166-172. doi: 10.1182/blood-2012-01-402396 |
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2012 Journal Article Valproic acid combined with cytosine arabinoside in elderly patients with acute myeloid leukemia has in vitro but limited clinical activityLane, Steven, Gill, Devinder, McMillan, Nigel A. J., Saunders, Nicholas, Murphy, Rachel, Spurr, Terrence, Keane, Colm, Fan, Helen Mar and Mollee, Peter (2012). Valproic acid combined with cytosine arabinoside in elderly patients with acute myeloid leukemia has in vitro but limited clinical activity. Leukemia & Lymphoma, 53 (6), 1077-1083. doi: 10.3109/10428194.2011.642302 |
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2012 Journal Article Genetic and pharmacologic inhibition of beta-catenin targets imatinib-resistant leukemia stem cells in CMLHeidel, Florian H., Bullinger, Lars, Feng, Zhaohui, Wang, Zhu, Neff, Tobias A., Stein, Lauren, Kalaitzidis, Demetrios, Lane, Steve W. and Armstrong, Scott A. (2012). Genetic and pharmacologic inhibition of beta-catenin targets imatinib-resistant leukemia stem cells in CML. Cell Stem Cell, 10 (4), 412-424. doi: 10.1016/j.stem.2012.02.017 |
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2012 Journal Article WT1 expression as a marker of minimal residual disease predicts outcome in acute myeloid leukemia when measured post-consolidationGray, James X., McMillen, Lyle, Mollee, Peter, Paul, Sanjoy, Lane, Steven, Bird, Robert, Gill, Devinder, Saal, Russell and Marlton, Paula (2012). WT1 expression as a marker of minimal residual disease predicts outcome in acute myeloid leukemia when measured post-consolidation. Leukemia Research, 36 (4), 453-458. doi: 10.1016/j.leukres.2011.09.005 |
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2012 Conference Publication Structure and RNA Recognition in Recombinant STNV CapsidsPhillips, Simon Edward Victor, Lane, Stephen W., Dennis, Caitriona A., Lane, Claire L., Trinh, Chi H., Rizkallah, Pierre J., Bunka, David H., Dykeman, Eric C., Ford, Robert, Barker, Amy, Twarock, Reidun and Stockley, Peter G. (2012). Structure and RNA Recognition in Recombinant STNV Capsids. 56th Annual Meeting of the Biophysical-Society, San Diego Ca, Feb 25-29, 2012. CAMBRIDGE: CELL PRESS. |
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2012 Journal Article Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic developmentLane, Steven W., De Vita, Serena, Alexander, Kylie A., Karaman, Ruchan, Milsom, Michael D., Dorrance, Adrienne M., Purdon, Amy, Louis, Leeann, Bouxsein, Mary L. and Williams, David A. (2012). Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development. Blood, 119 (3), 736-744. doi: 10.1182/blood-2011-07-368753 |
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2012 Journal Article Bad to the boneLane, Steven W. (2012). Bad to the bone. Blood, 119 (2), 323-325. doi: 10.1182/blood-2011-10-383901 |
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2012 Journal Article The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factorsLane, Steven, Al-Zubiedi, Sameh, Hatch, Ellen, Matthews, Ivan, Jorgensen, Andrea L., Deloukas, Panos, Daly, Ann K., Park, B. Kevin, Aarons, Leon, Ogungbenro, Kayode, Kamali, Farhad, Hughes, Dyfrig and Pirmohamed, Munir (2012). The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors. British Journal of Clinical Pharmacology, 73 (1), 66-76. doi: 10.1111/j.1365-2125.2011.04051.x |
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2012 Journal Article Mechanism-Based Approach to the Economic Evaluation of Pharmaceuticals Pharmacokinetic/Pharmacodynamic/Pharmacoeconomic Analysis of Rituximab for Follicular LymphomaPink, Joshua, Lane, Steven and Hughes, Dyfrig A. (2012). Mechanism-Based Approach to the Economic Evaluation of Pharmaceuticals Pharmacokinetic/Pharmacodynamic/Pharmacoeconomic Analysis of Rituximab for Follicular Lymphoma. Pharmacoeconomics, 30 (5), 413-429. doi: 10.2165/11591540-000000000-00000 |
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2011 Journal Article Construction and Crystal Structure of Recombinant STNV CapsidsLane, Stephen W., Dennis, Caitriona A., Lane, Claire L., Trinh, Chi H., Rizkallah, Pierre J., Stockley, Peter G. and Phillips, Simon E. V. (2011). Construction and Crystal Structure of Recombinant STNV Capsids. Journal of Molecular Biology, 413 (1), 41-50. doi: 10.1016/j.jmb.2011.07.062 |
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2011 Journal Article Degenerate RNA packaging signals in the genome of satellite tobacco necrosis virus: Implications for the assembly of a T = 1 capsidBunka, David H. J., Lane, Stephen W., Lane, Claire L., Dykeman, Eric C., Ford, Robert J., Barker, Amy M., Twarock, Reidun, Phillips, Simon E. V. and Stockley, Peter G. (2011). Degenerate RNA packaging signals in the genome of satellite tobacco necrosis virus: Implications for the assembly of a T = 1 capsid. Journal of Molecular Biology, 413 (1), 51-65. doi: 10.1016/j.jmb.2011.07.063 |
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2011 Journal Article Differential niche and Wnt requirements during acute myeloid leukemia progressionLane, Steven W., Wang, Yingzi J., Lo Celso, Cristina, Ragu, Christine, Bullinger, Lars, Sykes, Stephen M., Ferraro, Francesca, Shterental, Sebastian, Lin, Charles P., Gilliland, D. Gary, Scadden, David T., Armstrong, Scott A. and Williams, David A. (2011). Differential niche and Wnt requirements during acute myeloid leukemia progression. Blood, 118 (10), 2849-2856. doi: 10.1182/blood-2011-03-345165 |
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2011 Journal Article AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemiasSykes, Stephen M., Lane, Steven W., Bullinger, Lars, Kalaitzidis, Demetrios, Yusuf, Rushdia, Saez, Borja, Ferraro, Francesca, Mercier, Francois, Singh, Harshabad, Brumme, Kristina M., Acharya, Sanket S., Schoell, Claudia, Tothova, Zuzana, Attar, Eyal C., Froehling, Stefan, DePinho, Ronald A., Armstrong, Scott A., Gilliland, D. Gary and Scadden, David T. (2011). AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell, 146 (5), 697-708. doi: 10.1016/j.cell.2011.07.032 |
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2011 Conference Publication Myeloid leukemogenesis driven by aberrant CDX2 expression involves transcriptional repression of KLF4 and deregulated PPAR gamma signalingFaber, Katrin, Bullinger, Lars, Garding, Angela, Mertens, Daniel, Martin, Daniela, Walcher, Daniel, Doehner, Konstanze, Doehner, Hartmut, Sykes, Stephen M., Claus, Rainer, Plass, Christoph, Lane, Steven W., Scholl, Claudia and Froehling, Stefan (2011). Myeloid leukemogenesis driven by aberrant CDX2 expression involves transcriptional repression of KLF4 and deregulated PPAR gamma signaling. 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, San Diego, CA, United States, 10-13 Dec 2011. Washington, DC, United States: American Society of Hematology. |
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2011 Conference Publication Mtor complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesisKalaitzidis, Demetrios, Sykes, Stephen M., Punt, Natalie, Tang, Yuefeng, Lane, Steven W., Clish, Clary, Gilliland, D. Gary, Scadden, David T., Guertin, David and Armstrong, Scott A. (2011). Mtor complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, San Diego, CA, United States, 10-13 Dec 2011. Washington, DC, United States: American Society of Hematology. |
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2011 Conference Publication Evaluating clonal dominance in a murine knock-in model of Jak2V617F MPNMullally, Ann, Poveromo, Luke, Brumme, Kristina, Al-Shahrour, Fatima, Lane, Steven W., Shih, Alan H., Aifantis, Iannis, Levine, Ross L. and Ebert, Benjamin L. (2011). Evaluating clonal dominance in a murine knock-in model of Jak2V617F MPN. 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, San Diego, CA, United States, 10-13 Dec 2011. Washington, DC, United States: American Society of Hematology. |
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2011 Conference Publication Pak A proteins are essential for hematopoietic stem/progenitor cell (HSC/P) engraftment through regulation of signaling pathways controlling HSC/P proliferation, survival, migration, and the actin cytoskeletonDorrance, Adrienne M., Kosoff', Rachelle, McGuinness, Meaghan, Harris, Chad, De Vita, Serena, Mathieu, Ronald, Lane, Steven W., Milsom, Michael D., Chernoff, Jonathan and Williams, David A. (2011). Pak A proteins are essential for hematopoietic stem/progenitor cell (HSC/P) engraftment through regulation of signaling pathways controlling HSC/P proliferation, survival, migration, and the actin cytoskeleton. 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, San Diego, CA, United States, 10-13 Dec 2011. Washington, DC, United States: American Society of Hematology. |
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2011 Conference Publication Akt/foxo signaling pathway enforces the differentiation blockade in myeloid leukemiasSykes, S. M., Lane, S. W., Bullinger, L., Demetrios, K., Yusuf, R., Saez, B., Ferraro, F., Mercier, F., Singh, H., Brumme, K. M., Acharya, S., Scholl, C., Tothova, Z., Attar, E., Froehling, S., DePinho, R. A., Gilliland, D. G., Armstrong, S. A. and Sca, D. T. (2011). Akt/foxo signaling pathway enforces the differentiation blockade in myeloid leukemias. ISEH 40th Annual Scientific Meeting, -, 25 - 28 August 2011. Philadelphia, PA, United States: Elsevier. |
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2010 Journal Article Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemiaKharas, Michael G., Lengner, Christopher J., Al-Shahrour, Fatima, Bullinger, Lars, Ball, Brian, Zaidi, Samir, Morgan, Kelly, Tam, Winnie, Paktinat, Mahnaz, Okabe, Rachel, Gozo, Maricel, Einhorn, William, Lane, Steven W., Scholl, Claudia, Froehling, Stefan, Fleming, Mark, Ebert, Benjamin L., Gilliland, D. Gary, Jaenisch, Rudolf and Daley, George Q. (2010). Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nature Medicine, 16 (8), 903-908. doi: 10.1038/nm.2187 |
