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2012

Journal Article

Therapeutic potential of conopeptides

Schroeder, Christina I. and Craik, David J. (2012). Therapeutic potential of conopeptides. Future Medicinal Chemistry, 4 (10), 1243-1255. doi: 10.4155/FMC.12.70

Therapeutic potential of conopeptides

2012

Journal Article

Discovery and applications of naturally occurring cyclic peptides

Thorstholm, L. and Craik, D. J. (2012). Discovery and applications of naturally occurring cyclic peptides. Drug Discovery Today: Technologies, 9 (1), e13-e21. doi: 10.1016/j.ddtec.2011.07.005

Discovery and applications of naturally occurring cyclic peptides

2012

Journal Article

Dermatophytic defensin with antiinfective potential

Zhu, Shunyi, Gao, Bin, Harvey, Peta J. and Craik, David J. (2012). Dermatophytic defensin with antiinfective potential. Proceedings of the National Academy of Sciences of the United States of America, 109 (22), 8495-8500. doi: 10.1073/pnas.1201263109

Dermatophytic defensin with antiinfective potential

2012

Journal Article

Delineation of the unbinding pathway of alpha-conotoxin Iml from the a7 nicotinic acetylcholine receptor

Yu, Rilei, Kaas, Quentin and Craik, David J. (2012). Delineation of the unbinding pathway of alpha-conotoxin Iml from the a7 nicotinic acetylcholine receptor. The Journal of Physical Chemistry B, 116 (21), 6097-6105. doi: 10.1021/jp301352d

Delineation of the unbinding pathway of alpha-conotoxin Iml from the a7 nicotinic acetylcholine receptor

2012

Journal Article

Importance of the cell membrane on the mechanism of action of cyclotides

Henriques, Sonia Troeira and Craik, David J. (2012). Importance of the cell membrane on the mechanism of action of cyclotides. ACS Chemical Biology, 7 (4), 626-636. doi: 10.1021/cb200395f

Importance of the cell membrane on the mechanism of action of cyclotides

2012

Journal Article

Cyclization of conotoxins to improve their biopharmaceutical properties

Clark, Richard J., Akcan, Muharrem, Kaas, Quentin, Daly, Norelle L. and Craik, David J. (2012). Cyclization of conotoxins to improve their biopharmaceutical properties. Toxicon, 59 (4), 446-455. doi: 10.1016/j.toxicon.2010.12.003

Cyclization of conotoxins to improve their biopharmaceutical properties

2012

Journal Article

Cyclotides as a basis for drug design

Craik, David J., Swedberg, Joakim E., Mylne, Joshua S. and Cemazar, Masa (2012). Cyclotides as a basis for drug design. Expert Opinion On Drug Discovery, 7 (3), 179-194. doi: 10.1517/17460441.2012.661554

Cyclotides as a basis for drug design

2012

Journal Article

Corrigendum: Engineering of Conotoxins for the Treatment of Pain (Current Pharmaceutical Design, (2011), 17, 38)

Carstens, Bodil B., Clark, Richard J., Daly, Norelle L., Harvey, Peta J., Kaas, Quentin and Craik, David J. (2012). Corrigendum: Engineering of Conotoxins for the Treatment of Pain (Current Pharmaceutical Design, (2011), 17, 38). Current Pharmaceutical Design, 18 (8) doi: 10.2174/138161212799315858

Corrigendum: Engineering of Conotoxins for the Treatment of Pain (Current Pharmaceutical Design, (2011), 17, 38)

2012

Journal Article

Host-defense activities of cyclotides

Craik, David J. (2012). Host-defense activities of cyclotides. Toxins, 4 (2), 139-156. doi: 10.3390/toxins4020139

Host-defense activities of cyclotides

2012

Journal Article

RegIIA: An alpha 4/7-conotoxin from the venom of Conus regius that potently blocks alpha 3 beta 4 nAChRs

Franco, Aldo, Kompella, Shiva N., Akondi, Kalyana B., Melaun, Christian, Daly, Norelle L., Luetje, Charles W., Alewood, Paul F., Craik, David J., Adams. David J. and Mari, Frank (2012). RegIIA: An alpha 4/7-conotoxin from the venom of Conus regius that potently blocks alpha 3 beta 4 nAChRs. Biochemical Pharmacology, 83 (3), 419-426. doi: 10.1016/j.bcp.2011.11.006

RegIIA: An alpha 4/7-conotoxin from the venom of Conus regius that potently blocks alpha 3 beta 4 nAChRs

2012

Journal Article

Identification and structural characterization of a novel cyclotide with activity against an insect pest of sugar cane

Pinto, Michelle F. S., Fensterseifer, Isabel C. M., Migliolo, Ludovico, Sousa, Daniel A., de Capdville, Guy, Arboleda, Jorge W., Colgrave, Michelle, Craik, David J., Magalhaes, Beatriz S., Dias, Simoni C. and Franco, Octavio L. (2012). Identification and structural characterization of a novel cyclotide with activity against an insect pest of sugar cane. The Journal of Biological Chemistry, 287 (1), 134-147. doi: 10.1074/jbc.M111.294009

Identification and structural characterization of a novel cyclotide with activity against an insect pest of sugar cane

2012

Conference Publication

Engineering pro-angiogenic peptides using stable disulfide-rich scaffolds

Chan, L. A., Gunasekera, S., Henriques, S. T., Worth, N. F., Le, S., Clark, R. J., Campbell, J. H., Craik, D. J. and Daly, N. L. (2012). Engineering pro-angiogenic peptides using stable disulfide-rich scaffolds. 32nd European Peptide Symposium, Athens, Greece, 2-7 September 2012. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2448

Engineering pro-angiogenic peptides using stable disulfide-rich scaffolds

2012

Conference Publication

The Importance of the cell membrane on the mechanism of action of cyclotides

Henriques, S. T., Huang, Y. -H., Castanho, M. A. R. B., Daly, N. L. and Craik, D. J. (2012). The Importance of the cell membrane on the mechanism of action of cyclotides. 32nd European Peptide Symposium "Peptides 2012", Athens, Greece, 02-07 September 2012. West Sussex, United Kingdom: John Wiley and Sons. doi: 10.1002/psc.2449

The Importance of the cell membrane on the mechanism of action of cyclotides

2012

Journal Article

Engineering cyclic peptide toxins

Clark, Richard J. and Craik, David J. (2012). Engineering cyclic peptide toxins. Methods in Enzymology, 503, 57-74. doi: 10.1016/B978-0-12-396962-0.00003-3

Engineering cyclic peptide toxins

2012

Conference Publication

Discovery, characterization, and functional implications of conotoxins from cone snails species of the Americas

Franco, Aldo, Heighinian, Mari, Mejia, Monica, McCall, Jessica, Nag, Shiva, Akondi, Kalyana, Melaun, Christian, Daly, Norelle, Luetje, Charles W., Alewood, Paul F., Craik, David J., Godenschwege, Tanja, Adams, David J. and Mari, Frank (2012). Discovery, characterization, and functional implications of conotoxins from cone snails species of the Americas. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, 8-13 July 2012. Kidlington, Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.106

Discovery, characterization, and functional implications of conotoxins from cone snails species of the Americas

2012

Conference Publication

Pharmacological characterization of circular plant peptides with oxytocin-like activity

Koehbach, J., O'Brien, M., Miazzo, M., Muttenthaler, M., Akcan, M., Smith, T. J., Craik, D. J., Freissmuth, M. and Gruber, C. W. (2012). Pharmacological characterization of circular plant peptides with oxytocin-like activity. 32nd European Peptide Symposium "Peptides 2012", Athens, Greece, 02-07 September 2012. West Sussex, United Kingdom: John Wiley and Sons. doi: 10.1002/psc.2449

Pharmacological characterization of circular plant peptides with oxytocin-like activity

2012

Journal Article

Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID

Schroeder, Christina I., Nielsen, Katherine J., Adams, Denise A., Loughnan, Marion L., Thomas, Linda, Alewood, Paul F., Lewis, Richard J. and Craik, David J. (2012). Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID. Biopolymers, 98 (4), 345-356. doi: 10.1002/bip.22031

Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID

2012

Journal Article

ConoServer: updated content, knowledge, and discovery tools in the conopeptide database

Kaas, Quentin, Yu, Rilei, Jin, Ai-Hua, Dutertre, Sebastien and Craik, David J. (2012). ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research, 40 (D1), D325-D330. doi: 10.1093/nar/gkr886

ConoServer: updated content, knowledge, and discovery tools in the conopeptide database

2012

Book Chapter

Cyclotide isolation and characterization

Craik, David J., Henriques, Sonia Troeira, Mylne, Joshua S. and Wang, Conan K. (2012). Cyclotide isolation and characterization. Natural product biosynthesis by microorganisms and plants, part B. (pp. 37-62) edited by David A. Hopwood. Burlington, USA: Elsevier. doi: 10.1016/B978-0-12-394291-3.00024-1

Cyclotide isolation and characterization

2012

Conference Publication

Biological evaluation of cyclized cystine knot peptides targeting human melanocortin receptors

Bao, Jennifer, Cai, Minying, Craik, David and Hruby, Victor (2012). Biological evaluation of cyclized cystine knot peptides targeting human melanocortin receptors. Experimental Biology Meeting, San Diego Ca, 21-25 April 2012. Bethesda, MD, United States: Federation of American Societies for Experimental Biology (FASEB).

Biological evaluation of cyclized cystine knot peptides targeting human melanocortin receptors