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2020

Journal Article

Mepolizumab effectiveness and identification of super-responders in severe asthma

Harvey, Erin S., Langton, David, Katelaris, Constance, Stevens, Sean, Farah, Claude S., Gillman, Andrew, Harrington, John, Hew, Mark, Kritikos, Vicky, Radhakrishna, Naghmeh, Bardin, Philip, Peters, Matthew, Reynolds, Paul N., Upham, John W., Baraket, Melissa, Bowler, Simon, Bowden, Jeffrey, Chien, Jimmy, Chung, Li Ping, Grainge, Christopher, Jenkins, Christine, Katsoulotos, Gregory P., Lee, Joy, McDonald, Vanessa M., Reddel, Helen K., Rimmer, Janet, Wark, Peter A B and Gibson, Peter G. (2020). Mepolizumab effectiveness and identification of super-responders in severe asthma. The European Respiratory Journal, 55 (5) 1902420, 1902420. doi: 10.1183/13993003.02420-2019

Mepolizumab effectiveness and identification of super-responders in severe asthma

2020

Journal Article

Asthma in children and adults – what are the differences and what can they tell us about asthma?

Turner, Steve and Upham, John W. (2020). Asthma in children and adults – what are the differences and what can they tell us about asthma?. Frontiers in Pediatrics, 8 141, 141. doi: 10.3389/fped.2020.00141

Asthma in children and adults – what are the differences and what can they tell us about asthma?

2020

Journal Article

Severe Asthma Toolkit: An online resource for multidisciplinary health professionals - Needs assessment, development process and user analytics with survey feedback

Maltby, Steven, Gibson, Peter G., Reddel, Helen K., Smith, Lorraine, Wark, Peter A. B., King, Gregory G., Upham, John W., Clark, Vanessa L., Hew, Mark, Owens, Louisa, Oo, Stephen, James, Alan L., Thompson, Bruce, Marks, Guy B. and McDonald, Vanessa M. (2020). Severe Asthma Toolkit: An online resource for multidisciplinary health professionals - Needs assessment, development process and user analytics with survey feedback. BMJ Open, 10 (3) e032877, 1-10. doi: 10.1136/bmjopen-2019-032877

Severe Asthma Toolkit: An online resource for multidisciplinary health professionals - Needs assessment, development process and user analytics with survey feedback

2020

Journal Article

Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthma

Lynch, Jason P., Werder, Rhiannon B., Curren, Bodie F., Sikder, Md. Al Amin, Ullah, Ashik, Sebina, Ismail, Rashid, Ridwan B., Zhang, Vivian, Upham, John W., Hill, Geoff R., Steptoe, Raymond J. and Phipps, Simon (2020). Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthma. Mucosal Immunology, 13 (4), 652-664. doi: 10.1038/s41385-020-0268-8

Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthma

2020

Journal Article

Biogeographical variation in specific IgE recognition of temperate and subtropical grass pollen allergens in allergic rhinitis patients : Regional IgE specificity for grass pollens

Kailaivasan, Thina H, Timbrell, Victoria L, Solley, Graham, Smith, William B, McLean-Tooke, Andrew, van Nunen, Sheryl, Smith, Peter, Upham, John W, Langguth, Daman and Davies, Janet M (2020). Biogeographical variation in specific IgE recognition of temperate and subtropical grass pollen allergens in allergic rhinitis patients : Regional IgE specificity for grass pollens. Clinical and Translational Immunology, 9 (2) e01103, e01103. doi: 10.1002/cti2.1103

Biogeographical variation in specific IgE recognition of temperate and subtropical grass pollen allergens in allergic rhinitis patients : Regional IgE specificity for grass pollens

2020

Conference Publication

Blocking endogenous IL-22 is associated with reduced viral load and improved lung pathology in respiratory viral infections

Wang, R., Moniruzzaman, M., Wang, K., Upham, J. W., McGuckin, M., Phipps, S. and Hasnain, S. Z. (2020). Blocking endogenous IL-22 is associated with reduced viral load and improved lung pathology in respiratory viral infections. International Conference of the American-Thoracic-Society (ATS), Online, 10 November 2020. New York, NY, United States: American Thoracic Society. doi: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6530

Blocking endogenous IL-22 is associated with reduced viral load and improved lung pathology in respiratory viral infections

2020

Conference Publication

Harnessing the therapeutic potential of interleukin-22 in neonatal respiratory viral infection

Hasnain, S., Wang, R., Taylor, S., Wong, K. Y., Moniruzzaman, M., Upham, J., Spann, K., Mcguckin, M. A., Burr, L. and Phipps, S. (2020). Harnessing the therapeutic potential of interleukin-22 in neonatal respiratory viral infection. TSANZSRS 2020 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science, Melbourne, VIC, Australia, 27–31 March 2020. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.13777

Harnessing the therapeutic potential of interleukin-22 in neonatal respiratory viral infection

2020

Journal Article

The impact of new universal child influenza programs in Australia: Vaccine coverage, effectiveness and disease epidemiology in hospitalised children in 2018

Blyth, Christopher C., Cheng, Allen C., Crawford, Nigel W., Clark, Julia E., Buttery, Jim P., Marshall, Helen S., Francis, Joshua R., McRae, Jocelynne, Kotsimbos, Tom, Kelly, Paul M., Macartney, Kristine K., on behalf of the Paediatric Active Enhanced Disease Surveillance (PAEDS), Influenza Complications Alert Network (FluCAN) Collaboration and Upham, John (2020). The impact of new universal child influenza programs in Australia: Vaccine coverage, effectiveness and disease epidemiology in hospitalised children in 2018. Vaccine, 38 (13), 2779-2787. doi: 10.1016/j.vaccine.2020.02.031

The impact of new universal child influenza programs in Australia: Vaccine coverage, effectiveness and disease epidemiology in hospitalised children in 2018

2020

Conference Publication

FC Gamma receptor (FCGR) I expression is increased in severe asthma particularly in participants with non-eosinophilic airway inflammation

Gupta, S., Fricker, M., Xi, Y., Grainge, C., Upham, J. and Simpson, J. (2020). FC Gamma receptor (FCGR) I expression is increased in severe asthma particularly in participants with non-eosinophilic airway inflammation. TSANZSRS 2020 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science, Melbourne, QLD Australia, 27-31 March 2020. Hoboken, NJ USA: Wiley.

FC Gamma receptor (FCGR) I expression is increased in severe asthma particularly in participants with non-eosinophilic airway inflammation

2020

Conference Publication

Factors associated with respiratory infection frequency in healthy and asthmatic adults differ between women and men

Upham, J., Murray, L. and Xi, Y. (2020). Factors associated with respiratory infection frequency in healthy and asthmatic adults differ between women and men. TSANZSRS 2020 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science, Melbourne, QLD Australia, 27-31 March 2020. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia.

Factors associated with respiratory infection frequency in healthy and asthmatic adults differ between women and men

2019

Journal Article

Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2018: the Influenza Complications Alert Network (FluCAN)

Cheng, Allen C., Holmes, Mark, Dwyer, Dominic E., Senanayake, Sanjaya, Cooley, Louise, Irving, Louis B., Simpson, Graham, Korman, Tony, Macartney, Kristine, Friedman, N. Deborah, Wark, Peter, Howell, Anna, Blyth, Christopher C., Crawford, Nigel, Buttery, Jim, Bowler, Simon, Upham, John W., Waterer, Grant W., Kotsimbos, Tom and Kelly, Paul M. (2019). Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2018: the Influenza Complications Alert Network (FluCAN). Communicable Diseases Intelligence Quarterly Report, 43. doi: 10.33321/cdi.2019.43.48

Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2018: the Influenza Complications Alert Network (FluCAN)

2019

Journal Article

Rational oral corticosteroid use in adult severe asthma: a narrative review

Chung, Li Ping, Upham, John W., Bardin, Philip G. and Hew, Mark (2019). Rational oral corticosteroid use in adult severe asthma: a narrative review. Respirology, 25 (2) resp.13730, 161-172. doi: 10.1111/resp.13730

Rational oral corticosteroid use in adult severe asthma: a narrative review

2019

Journal Article

The effect of glucocorticoids on Thrombospondin-1, Osteocalcin and the Thrombospondin-1:Osteocalcin ratio in humans

Cesana-Nigro, Nicole, Keshvari, Sahar, Barclay, Johanna L., Sorbello, Jane, Upham, John W., Benham, Helen, Anderson, Stephen T., Steiger, Natasha, Prins, Johannes B. and Inder, Warrick J. (2019). The effect of glucocorticoids on Thrombospondin-1, Osteocalcin and the Thrombospondin-1:Osteocalcin ratio in humans. Clinical Endocrinology, 91 (6) cen.14108, 728-736. doi: 10.1111/cen.14108

The effect of glucocorticoids on Thrombospondin-1, Osteocalcin and the Thrombospondin-1:Osteocalcin ratio in humans

2019

Journal Article

Airway pharmacology: treatment options and algorithms to treat patients with chronic obstructive pulmonary disease

Kerstjens, Huib A. M., Upham, John W. and Yang, Ian A. (2019). Airway pharmacology: treatment options and algorithms to treat patients with chronic obstructive pulmonary disease. Journal of Thoracic Disease, 11 (S17), S2200-S2209. doi: 10.21037/jtd.2019.10.57

Airway pharmacology: treatment options and algorithms to treat patients with chronic obstructive pulmonary disease

2019

Journal Article

Efficacy of azithromycin in severe asthma from the AMAZES randomised trial

Gibson, Peter G., Yang, Ian A., Upham, John W., Reynolds, Paul N., Hodge, Sandra, James, Alan L., Jenkins, Christine, Peters, Matthew J., Marks, Guy B., Baraket, Melissa, Powell, Heather and Simpson, Jodie L. (2019). Efficacy of azithromycin in severe asthma from the AMAZES randomised trial. ERJ Open Research, 5 (4) 00056-2019, 00056-2019. doi: 10.1183/23120541.00056-2019

Efficacy of azithromycin in severe asthma from the AMAZES randomised trial

2019

Conference Publication

Azithromycin add-on therapy reduces airway inflammation and extracellular DNA: An AMAZES sub-study

Simpson, Jodie, Barker, Daniel, Yang, Ian, Upham, John, Reynolds, Paul, Hodge, Sandra, James, Alan, Jenkins, Christine, Peters, Matthew, Marks, Guy, Baraket, Melissa and Gibson, Peter (2019). Azithromycin add-on therapy reduces airway inflammation and extracellular DNA: An AMAZES sub-study. European-Respiratory-Society (ERS) International Congress, Madrid, Spain, 28 September-2 October 2019. Sheffield, United Kingdom: European Respiratory Society. doi: 10.1183/13993003.congress-2019.OA5338

Azithromycin add-on therapy reduces airway inflammation and extracellular DNA: An AMAZES sub-study

2019

Conference Publication

Baseline predictors of being exacerbation-free during 2 years of benralizumab treatment

Upham, John W., Jackson, David J., Barker, Peter, Newbold, Paul and Cook, William (2019). Baseline predictors of being exacerbation-free during 2 years of benralizumab treatment. European-Respiratory-Society (ERS) International Congress, Madrid, Spain, 28 September - 2 October 2019. Sheffield, United Kingdom: European Respiratory Society. doi: 10.1183/13993003.congress-2019.OA5337

Baseline predictors of being exacerbation-free during 2 years of benralizumab treatment

2019

Journal Article

Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2017: the Influenza Complications Alert Network (FluCAN)

Cheng, Allen C., Holmes, Mark, Dwyer, Dominic E., Senanayake, Sanjaya, Cooley, Louise, Irving, Louis B., Simpson, Graham, Korman, Tony, Macartney, Kristine, Friedman, N Deborah, Wark, Peter, Howell, Anna, Blyth, Christopher C., Bowler, Simon, Upham, John, Waterer, Grant W., Kotsimbos, Tom and Kelly, Paul M. (2019). Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2017: the Influenza Complications Alert Network (FluCAN). Communicable Diseases Intelligence, 43. doi: 10.33321/cdi.2019.43.39

Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2017: the Influenza Complications Alert Network (FluCAN)

2019

Journal Article

Long-term azithromycin reduces Haemophilus influenzae and increases antibiotic resistance in severe asthma

Taylor, Steven L., Leong, Lex E. X., Mobegi, Fredrick M., Choo, Jocelyn M., Wesselingh, Steve, Yang, Ian A., Upham, John W., Reynolds, Paul N., Hodge, Sandra, James, Alan L., Jenkins, Christine, Peters, Matthew J., Baraket, Melissa, Marks, Guy B., Gibson, Peter G., Rogers, Geraint B. and Simpson, Jodie L. (2019). Long-term azithromycin reduces Haemophilus influenzae and increases antibiotic resistance in severe asthma. American Journal of Respiratory and Critical Care Medicine, 200 (3), 309-317. doi: 10.1164/rccm.201809-1739OC

Long-term azithromycin reduces Haemophilus influenzae and increases antibiotic resistance in severe asthma

2019

Journal Article

Effects of interleukin‐6 receptor blockade on allergen‐induced airway responses in mild asthmatics

Revez, Joana A., Bain, Lisa M., Watson, Rick M., Towers, Michelle, Collins, Tina, Killian, Kieran J., O'Byrne, Paul M., Gauvreau, Gail M., Upham, John W. and Ferreira, Manuel A. R. (2019). Effects of interleukin‐6 receptor blockade on allergen‐induced airway responses in mild asthmatics. Clinical & Translational Immunology, 8 (6) e1044, e1044. doi: 10.1002/cti2.1044

Effects of interleukin‐6 receptor blockade on allergen‐induced airway responses in mild asthmatics