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2025 Journal Article Transport of DNA repair proteins to the cell nucleus by the classical nuclear importin pathway – a structural overviewFontes, Marcos R.M., Cardoso, Fábio F. and Kobe, Bostjan (2025). Transport of DNA repair proteins to the cell nucleus by the classical nuclear importin pathway – a structural overview. DNA Repair, 149 103828, 103828. doi: 10.1016/j.dnarep.2025.103828 |
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2025 Journal Article TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activationSchultz, Thomas E, Mathmann, Carmen D, Domínguez Cadena, Leslie C, Muusse, Timothy W, Kim, Hyoyoung, Wells, James W, Ulett, Glen C, Hamerman, Jessica A, Brooks, Andrew J, Kobe, Bostjan, Sweet, Matthew J, Stacey, Katryn J and Blumenthal, Antje (2025). TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation. EMBO Reports 2250056, 1-27. doi: 10.1038/s44319-025-00444-2 |
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2025 Journal Article Signalling by co-operative higher-order assembly formation: linking evidence at molecular and cellular levelsKobe, Bostjan, Nanson, Jeffrey D., Hoad, Mikayla, Blumenthal, Antje, Gambin, Yann, Sierecki, Emma, Stacey, Katryn J., Ve, Thomas and Halfmann, Randal (2025). Signalling by co-operative higher-order assembly formation: linking evidence at molecular and cellular levels. Biochemical Journal, 482 (05), 275-294. doi: 10.1042/bcj20220094 |
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2025 Journal Article Gold Nanoparticles as a Platform for Delivery of Immunogenic Peptides to THP-1 Derived Macrophages: Insights into NanotoxicityZúñiga, Eduardo, Contreras-Trigo, Braulio, Buchert, Jorge, Sáez-Ahumada, Fabián, Hernández, Leonardo, Fica-León, Víctor, Nova-Lamperti, Estefania, Kobe, Bostjan, Guzmán, Fanny, Diaz-García, Víctor, Guzmán-Gutiérrez, Enrique and Oyarzún, Patricio (2025). Gold Nanoparticles as a Platform for Delivery of Immunogenic Peptides to THP-1 Derived Macrophages: Insights into Nanotoxicity. Vaccines, 13 (2) 119, 119. doi: 10.3390/vaccines13020119 |
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2025 Journal Article Structural basis for TIR domain–mediated innate immune signaling by Toll-like receptor adaptors TRIF and TRAMManik, Mohammad K., Pan, Mengqi, Xiao, Le, Gu, Weixi, Kim, Hyoyoung, Pospich, Sabrina, Hedger, Andrew, Vajjhala, Parimala R., Lee, Morris Y. L., Qian, Xiaoqi, Landsberg, Michael J., Ve, Thomas, Nanson, Jeffrey D., Raunser, Stefan, Stacey, Katryn J., Wu, Hao and Kobe, Bostjan (2025). Structural basis for TIR domain–mediated innate immune signaling by Toll-like receptor adaptors TRIF and TRAM. Proceedings of the National Academy of Sciences, 122 (2) e2418988122, e2418988122-2. doi: 10.1073/pnas.2418988122 |
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2025 Journal Article The design, synthesis, and biological evaluation of 5,6,7,8-tetrahydropteridines as anti-inflammatory compoundsChen, Rachel M., Emming, Stefan, Cinnamon, Roseanna, Cameron, Jacob P., Schroder, Kate, Kobe, Bostjan and Robertson, Avril A. B. (2025). The design, synthesis, and biological evaluation of 5,6,7,8-tetrahydropteridines as anti-inflammatory compounds. Organic & Biomolecular Chemistry, 23 (1), 174-182. doi: 10.1039/d4ob01453g |
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2025 Book Chapter Bacterial TIR domain-containing proteins as drug targets Li, Sulin, Singh, Mandeep, Liu, Siyuan, Pandey, Vishal, Ve, Thomas and Kobe, Bostjan (2025). Bacterial TIR domain-containing proteins as drug targets . Bacterial enzymes as targets for drug discovery: meeting the challenges of antibiotic resistance. (pp. 419-428) edited by Punit Kaur and Priyanka Sharma. London, United Kingdom: Elsevier. doi: 10.1016/b978-0-443-22222-1.00022-2 |
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2025 Conference Publication Development of 3DED/MicroED Facility at the University of QueenslandArachchige, Kasun. S. Athukorala, Koifman, Na’ama, Floetenmeyer, Matthias, Clegg, Jack K., Gu, Weixi, Kobe, Bostjan, Xu, Hongyi and Wepf, Roger (2025). Development of 3DED/MicroED Facility at the University of Queensland. 13th Asia Pacific Microscopy Congress 2025 (APMC13), Brisbane, QLD Australia, 2-7 Febuary 2025. Lexington, MA United States: ScienceOpen. doi: 10.14293/apmc13-2025-0350 |
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2024 Journal Article Correction to: The JAK-STAT pathway: from structural biology to cytokine engineering (Signal Transduction and Targeted Therapy, (2024), 9, 1, (221), 10.1038/s41392-024-01934-w)Lv, You, Qi, Jianxun, Babon, Jeffrey J., Cao, Longxing, Fan, Guohuang, Lang, Jiajia, Zhang, Jin, Mi, Pengbing, Kobe, Bostjan and Wang, Faming (2024). Correction to: The JAK-STAT pathway: from structural biology to cytokine engineering (Signal Transduction and Targeted Therapy, (2024), 9, 1, (221), 10.1038/s41392-024-01934-w). Signal Transduction and Targeted Therapy, 9 (1) 290, 290. doi: 10.1038/s41392-024-01975-1 |
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2024 Journal Article TIR-mediated immune signalling through the EDS1:PAD4:ADR1 node is conserved in monocots and dicotsMaruta, Natsumi, Sorbello, Mitchell and Kobe, Bostjan (2024). TIR-mediated immune signalling through the EDS1:PAD4:ADR1 node is conserved in monocots and dicots. Molecular Plant, 18 (2), 192-194. doi: 10.1016/j.molp.2024.12.017 |
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2024 Journal Article Structural characterization of TIR-domain signalosomes through a combination of structural biology approachesBhatt, Akansha, Mishra, Biswa P., Gu, Weixi, Sorbello, Mitchell, Xu, Hongyi, Ve, Thomas and Kobe, Bostjan (2024). Structural characterization of TIR-domain signalosomes through a combination of structural biology approaches. IUCrJ, 11 (5), 695-707. doi: 10.1107/s2052252524007693 |
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2024 Journal Article Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assemblyLi, Y., Pacoste, L. C., Gu, W., Thygesen, S. J., Stacey, K. J., Ve, T., Kobe, B., Xu, H. and Nanson, J. D. (2024). Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assembly. Acta Crystallographica Section D Structural Biology, 80 (9), 699-712. doi: 10.1107/s2059798324008210 |
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2024 Journal Article Exon shuffling and alternative splicing of ROCO genes in brown algae enables a diverse repertoire of candidate immune receptorsTeng, Linhong, Sun, Yuhuan, Chen, Jiayi, Wang, Chenghui, Urbach, Jonathan M., Kobe, Bostjan, Ye, Naihao and Zeng, Qiangcheng (2024). Exon shuffling and alternative splicing of ROCO genes in brown algae enables a diverse repertoire of candidate immune receptors. Frontiers in Plant Science, 15 1445022, 1-14. doi: 10.3389/fpls.2024.1445022 |
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2024 Journal Article The JAK-STAT pathway: from structural biology to cytokine engineeringLv, You, Qi, Jianxun, Babon, Jeffrey J., Cao, Longxing, Fan, Guohuang, Lang, Jiajia, Zhang, Jin, Mi, Pengbing, Kobe, Bostjan and Wang, Faming (2024). The JAK-STAT pathway: from structural biology to cytokine engineering. Signal Transduction and Targeted Therapy, 9 (1) 221, 221. doi: 10.1038/s41392-024-01934-w |
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2024 Journal Article SARM1-dependent axon degeneration: nucleotide signaling, neurodegenerative disorders, toxicity, and therapeutic opportunitiesMcGuinness, Helen Y., Gu, Weixi, Shi, Yun, Kobe, Bostjan and Ve, Thomas (2024). SARM1-dependent axon degeneration: nucleotide signaling, neurodegenerative disorders, toxicity, and therapeutic opportunities. The Neuroscientist, 30 (4), 473-492. doi: 10.1177/10738584231162508 |
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2024 Journal Article Structural characterization of macro domain–containing Thoeris antiphage defense systemsShi, Yun, Masic, Veronika, Mosaiab, Tamim, Rajaratman, Premraj, Hartley-Tassell, Lauren, Sorbello, Mitchell, Goulart, Cassia C., Vasquez, Eduardo, Mishra, Biswa P., Holt, Stephanie, Gu, Weixi, Kobe, Bostjan and Ve, Thomas (2024). Structural characterization of macro domain–containing Thoeris antiphage defense systems. Science Advances, 10 (26) eadn3310, eadn3310. doi: 10.1126/sciadv.adn3310 |
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2024 Journal Article Small molecule drug discovery targeting the JAK-STAT pathwayLv, You, Mi, Pengbing, Babon, Jeffrey J., Fan, Guohuang, Qi, Jianxun, Cao, Longxing, Lang, Jiajia, Zhang, Jin, Wang, Faming and Kobe, Bostjan (2024). Small molecule drug discovery targeting the JAK-STAT pathway. Pharmacological Research, 204 107217. doi: 10.1016/j.phrs.2024.107217 |
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2024 Journal Article o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2Rahaman, Md. Habibur, Thygesen, Sara J., Maxwell, Michael J., Kim, Hyoyoung, Mudai, Prerna, Nanson, Jeffrey D., Jia, Xinying, Vajjhala, Parimala R., Hedger, Andrew, Vetter, Irina, Haselhorst, Thomas, Robertson, Avril A. B., Dymock, Brian, Ve, Thomas, Mobli, Mehdi, Stacey, Katryn J. and Kobe, Bostjan (2024). o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2. Journal of Enzyme Inhibition and Medicinal Chemistry, 39 (1) 2313055, 2313055. doi: 10.1080/14756366.2024.2313055 |
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2024 Journal Article Mixed-organism enzyme in plant defenseThynne, Elisha and Kobe, Bostjan (2024). Mixed-organism enzyme in plant defense. Science, 383 (6684), 707-708. doi: 10.1126/science.adn8306 |
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2024 Journal Article Hfe permease and Haemophilus influenzae manganese homeostasisGanio, Katherine, Nasreen, Marufa, Yang, Zihao, Maunders, Eve A., Luo, Zhenyao, Hossain, Sheikh Imamul, Ngu, Dalton H. Y., Ellis, Daniel, Gu, Jin, Neville, Stephanie L., Wilksch, Jonathan, Gunn, Adam P., Whittall, Jonathan J., Kobe, Boštjan, Deplazes, Evelyne, Kappler, Ulrike and McDevitt, Christopher A. (2024). Hfe permease and Haemophilus influenzae manganese homeostasis. ACS Infectious Diseases, 10 (2), 436-452. doi: 10.1021/acsinfecdis.3c00407 |
