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2024 Journal Article Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assemblyLi, Y., Pacoste, L. C., Gu, W., Thygesen, S. J., Stacey, K. J., Ve, T., Kobe, B., Xu, H. and Nanson, J. D. (2024). Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assembly. Acta Crystallographica Section D Structural Biology, 80 (9), 699-712. doi: 10.1107/s2059798324008210 |
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2024 Journal Article Structural characterization of TIR-domain signalosomes through a combination of structural biology approachesBhatt, Akansha, Mishra, Biswa P., Gu, Weixi, Sorbello, Mitchell, Xu, Hongyi, Ve, Thomas and Kobe, Bostjan (2024). Structural characterization of TIR-domain signalosomes through a combination of structural biology approaches. IUCrJ, 11 (5), 695-707. doi: 10.1107/s2052252524007693 |
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2024 Journal Article Exon shuffling and alternative splicing of ROCO genes in brown algae enables a diverse repertoire of candidate immune receptorsTeng, Linhong, Sun, Yuhuan, Chen, Jiayi, Wang, Chenghui, Urbach, Jonathan M., Kobe, Bostjan, Ye, Naihao and Zeng, Qiangcheng (2024). Exon shuffling and alternative splicing of ROCO genes in brown algae enables a diverse repertoire of candidate immune receptors. Frontiers in Plant Science, 15 1445022, 1-14. doi: 10.3389/fpls.2024.1445022 |
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2024 Journal Article The JAK-STAT pathway: from structural biology to cytokine engineeringLv, You, Qi, Jianxun, Babon, Jeffrey J., Cao, Longxing, Fan, Guohuang, Lang, Jiajia, Zhang, Jin, Mi, Pengbing, Kobe, Bostjan and Wang, Faming (2024). The JAK-STAT pathway: from structural biology to cytokine engineering. Signal Transduction and Targeted Therapy, 9 (1) 221, 221. doi: 10.1038/s41392-024-01934-w |
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2024 Journal Article SARM1-dependent axon degeneration: nucleotide signaling, neurodegenerative disorders, toxicity, and therapeutic opportunitiesMcGuinness, Helen Y., Gu, Weixi, Shi, Yun, Kobe, Bostjan and Ve, Thomas (2024). SARM1-dependent axon degeneration: nucleotide signaling, neurodegenerative disorders, toxicity, and therapeutic opportunities. The Neuroscientist, 30 (4), 473-492. doi: 10.1177/10738584231162508 |
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2024 Journal Article Structural characterization of macro domain–containing Thoeris antiphage defense systemsShi, Yun, Masic, Veronika, Mosaiab, Tamim, Rajaratman, Premraj, Hartley-Tassell, Lauren, Sorbello, Mitchell, Goulart, Cassia C., Vasquez, Eduardo, Mishra, Biswa P., Holt, Stephanie, Gu, Weixi, Kobe, Bostjan and Ve, Thomas (2024). Structural characterization of macro domain–containing Thoeris antiphage defense systems. Science Advances, 10 (26) eadn3310, eadn3310. doi: 10.1126/sciadv.adn3310 |
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2024 Journal Article Small molecule drug discovery targeting the JAK-STAT pathwayLv, You, Mi, Pengbing, Babon, Jeffrey J., Fan, Guohuang, Qi, Jianxun, Cao, Longxing, Lang, Jiajia, Zhang, Jin, Wang, Faming and Kobe, Bostjan (2024). Small molecule drug discovery targeting the JAK-STAT pathway. Pharmacological Research, 204 107217, 107217. doi: 10.1016/j.phrs.2024.107217 |
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2024 Journal Article o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2Rahaman, Md. Habibur, Thygesen, Sara J., Maxwell, Michael J., Kim, Hyoyoung, Mudai, Prerna, Nanson, Jeffrey D., Jia, Xinying, Vajjhala, Parimala R., Hedger, Andrew, Vetter, Irina, Haselhorst, Thomas, Robertson, Avril A. B., Dymock, Brian, Ve, Thomas, Mobli, Mehdi, Stacey, Katryn J. and Kobe, Bostjan (2024). o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2. Journal of Enzyme Inhibition and Medicinal Chemistry, 39 (1) 2313055, 2313055. doi: 10.1080/14756366.2024.2313055 |
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2024 Journal Article Mixed-organism enzyme in plant defenseThynne, Elisha and Kobe, Bostjan (2024). Mixed-organism enzyme in plant defense. Science, 383 (6684), 707-708. doi: 10.1126/science.adn8306 |
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2024 Journal Article Hfe permease and Haemophilus influenzae manganese homeostasisGanio, Katherine, Nasreen, Marufa, Yang, Zihao, Maunders, Eve A., Luo, Zhenyao, Hossain, Sheikh Imamul, Ngu, Dalton H. Y., Ellis, Daniel, Gu, Jin, Neville, Stephanie L., Wilksch, Jonathan, Gunn, Adam P., Whittall, Jonathan J., Kobe, Boštjan, Deplazes, Evelyne, Kappler, Ulrike and McDevitt, Christopher A. (2024). Hfe permease and Haemophilus influenzae manganese homeostasis. ACS Infectious Diseases, 10 (2), 436-452. doi: 10.1021/acsinfecdis.3c00407 |
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2024 Journal Article TIR-mediated immune signalling through the EDS1:PAD4:ADR1 node is conserved in monocots and dicotsMaruta, Natsumi, Sorbello, Mitchell and Kobe, Bostjan (2024). TIR-mediated immune signalling through the EDS1:PAD4:ADR1 node is conserved in monocots and dicots. Molecular Plant, 18 (2), 192-194. doi: 10.1016/j.molp.2024.12.017 |
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2023 Journal Article Mildew RALPHs up in arms with cerealsMaruta, Natsumi, Outram, Megan A. and Kobe, Bostjan (2023). Mildew RALPHs up in arms with cereals. Proceedings of the National Academy of Sciences, 120 (36) e2311817120, 1-3. doi: 10.1073/pnas.2311817120 |
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2023 Conference Publication Structural and functional analysis of the TIR-domain in Toll-like receptors 7, 8 and 9 signaling and the interactions with adaptor proteinsQian, Xiaoqi, Nanson, Jeffrey and Kobe, Boštjan (2023). Structural and functional analysis of the TIR-domain in Toll-like receptors 7, 8 and 9 signaling and the interactions with adaptor proteins. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s205327332308662x |
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2023 Conference Publication Activated bacterial TIR proteins: NADase activity and filamentous assembliesLi, Sulin, Manik, Mohammad Kawsar, Ve, Thomas, Nanson, Jeffrey D. and Kobe, Bostjan (2023). Activated bacterial TIR proteins: NADase activity and filamentous assemblies. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323086904 |
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2023 Conference Publication Structural basis for activation and inhibition of the pro-neurodegenerative NADase SARM1Shi, Y., Nanson, J., Gu, W., Masic, V., Mosaiab, T., Landsberg, M., Kobe, B. and Ve, T. (2023). Structural basis for activation and inhibition of the pro-neurodegenerative NADase SARM1. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323087776 |
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2023 Conference Publication Characterisation of the solute-binding protein ModA from Pseudomonas aeruginosa and its role in molybdenum homeostasisNgu, Dalton H. Y., Maunders, Eve. A., Lim, Bryan Y. J., Luo, Zhenyao, McDevitt, Christopher A. and Kobe, Boštjan (2023). Characterisation of the solute-binding protein ModA from Pseudomonas aeruginosa and its role in molybdenum homeostasis. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323089477 |
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2023 Conference Publication TLR4 TIR domain higher-order assemblies reveal the structural basis of adaptor recruitment in Toll-like receptor signaling pathwaysNanson, J. D., Muusse, T. W., Li, Y., Pan, M., Landsberg, M. J., Vajjhala, P. R., Ve, T., Stacey, K. J. and Kobe, B. (2023). TLR4 TIR domain higher-order assemblies reveal the structural basis of adaptor recruitment in Toll-like receptor signaling pathways. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323086631 |
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2023 Conference Publication Structural and functional characterization of interleukin-1 receptor 8Alenzi, Athyah, Nimma, Surekha and Kobe, Bostjan (2023). Structural and functional characterization of interleukin-1 receptor 8. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323086667 |
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2023 Conference Publication Structural and functional characterisation of plant innate immune receptorsMaruta, Natsumi, Burdett, Hayden, Sorbello, Mitchell, Lim, Bryan Ying Jie, Ngu, Dalton and Kobe, Bostjan (2023). Structural and functional characterisation of plant innate immune receptors. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323087764 |
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2023 Conference Publication Structural evolution of TIR-domain signalosomes in mammalian, plant and bacterial immunity characterized by integrative structural biologyKobe, Bostjan, Nanson, Jeffrey D., Manik, Mohammad K., Li, Sulin, Gu, Weixi, Pan, Mengqi, Li, Yan, Muusse, Timothy W., Vajjhala, Parimala R, Stacey, Katryn J., Holmes, Susannah, Darmanin, Connie, Clabbers, Max T. B., Xu, Hongyi, Shi, Yun and Ve, Thomas (2023). Structural evolution of TIR-domain signalosomes in mammalian, plant and bacterial immunity characterized by integrative structural biology. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323093658 |
