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2011 Journal Article Understanding the structure/activity relationships of the iron regulatory peptide hepcidinClark, Richard J., Tan, Chia Chia, Preza, Gloria C., Nemeth, Elizabeta, Ganz, Tomas and Craik, David J. (2011). Understanding the structure/activity relationships of the iron regulatory peptide hepcidin. Chemistry and Biology, 18 (3), 336-343. doi: 10.1016/j.chembiol.2010.12.009 |
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2011 Journal Article Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapyAkcan, M, Stroud, MR, Hansen, SJ, Clark, RJ, Daly, NL, Craik, DJ and Olson, JM (2011). Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy. Journal of Medicinal Chemistry, 54 (3), 782-787. doi: 10.1021/jm101018r |
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2011 Conference Publication Scanning mutagenesis of alpha-conotoxin AuIB reveals a critical residue for activity at the alpha-3-beta-4 nicotinic acetylcholine receptorAdams, D. J., Grishin, A. A., Hung, A., Clark, R. J., Akondi, K., Alewood, P. F. and Craik, D. J. (2011). Scanning mutagenesis of alpha-conotoxin AuIB reveals a critical residue for activity at the alpha-3-beta-4 nicotinic acetylcholine receptor. nAChR2011: Nicotinic Acetylcholine Receptors as Therapeutic Targets: Emerging Frontiers in Basic Research & Clinical Science, Washington, DC, U.S.A., 9-11 November 2011. Philadelphia, PA, U.S.A.: Elsevier. doi: 10.1016/j.bcp.2011.07.017 |
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2011 Journal Article Interlocking Disulfides in Circular Proteins: Toward Efficient Oxidative Folding of CyclotidesAboye, Teshome Leta, Clark, Richard J., Burman, Robert, Roig, Marta Bajona, Craik, David J. and Goransson, Ulf (2011). Interlocking Disulfides in Circular Proteins: Toward Efficient Oxidative Folding of Cyclotides. Antioxidants & Redox Signaling, 14 (1), 77-86. doi: 10.1089/ars.2010.3112 |
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2011 Journal Article Stabilization of α-conotoxin AuIB: Influences of disulfide connectivity and backbone cyclizationLovelace, Erica S., Gunasekera, Sunithi, Alvarmo, Charlotta, Clark, Richard J., Nevin, Simon T., Grishin, Anton A., Adams, David J., Craik, David J. and Daly, Norelle L. (2011). Stabilization of α-conotoxin AuIB: Influences of disulfide connectivity and backbone cyclization. Antioxidants and Redox Signaling, 14 (1), 87-95. doi: 10.1089/ars.2009.3068 |
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2010 Journal Article Structural and functional analysis of human liver-expressed antimicrobial peptide 2Henriques, Sonia Troeira, Tan, Chia Chia, Craik, David J. and Clark, Richard J. (2010). Structural and functional analysis of human liver-expressed antimicrobial peptide 2. ChemBioChem, 11 (15), 2148-2157. doi: 10.1002/cbic.201000400 |
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2010 Journal Article Isolation, sequencing, and structure - Activity relationships of cyclotidesIreland, David C., Clark, Richard J., Daly, Norelle L. and Craik, David J. (2010). Isolation, sequencing, and structure - Activity relationships of cyclotides. Journal of Natural Products, 73 (9), 1610-1622. doi: 10.1021/np1000413 |
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2010 Journal Article The engineering of an orally active conotoxin for the treatment of neuropathic painClark, Richard J., Jensen, Jonas, Nevin, Simon T., Callaghan, Brid P., Adams, David J. and Craik, David J. (2010). The engineering of an orally active conotoxin for the treatment of neuropathic pain. Angewandte Chemie (International Edition), 49 (37), 6545-6548. doi: 10.1002/anie.201000620 |
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2010 Journal Article Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activityHuang, Yen-Hua (黃彥華), Colgrave, Michelle L., Clark, Richard J., Kotze, Andrew C. and Craik, David J. (2010). Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity. Journal of Biological Chemistry, 285 (14), 10797-10805. doi: 10.1074/jbc.M109.089854 |
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2010 Journal Article Native chemical ligation applied to the synthesis and bioengineering of circular peptides and proteinsClark, Richard J. and Craik, David J. (2010). Native chemical ligation applied to the synthesis and bioengineering of circular peptides and proteins. Biopolymers, 94 (4), 414-422. doi: 10.1002/bip.21372 |
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2010 Conference Publication The engineering of an orally active conotoxin for the treatment of neuropathic painClark, J., Jensen, J., Nevin, S., Brid, C., Adams, D. and Craik, D. (2010). The engineering of an orally active conotoxin for the treatment of neuropathic pain. EPS 2010: The 31st European Peptide Symposium, Copenhagen, Denmark, 5-9 September 2010. Bognor Regis, West Sussex, U.K.: John Wiley & Sons. doi: 10.1002/psc.1302 |
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2010 Book Chapter NMR-based screening and drug discoveryCraik, David J., Smith, Philippa A. and Clark, Richard James (2010). NMR-based screening and drug discovery. Burger's medicinal chemistry, drug discovery, and development. (pp. 359-437) edited by Donald J. Abraham, David P. Rotella and Alfred Burger. Hoboken, N.J.: Wiley. doi: 10.1002/0471266949 |
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2010 Conference Publication Evaluation of toxicity and antitumor activity of cycloviolacin O2 in miceBurman, Robert, Svedlund, Erika, Felth, Jenny, Hassan, Saadia, Hermann, Anders, Clark, Richard James, Craik, David J., Bohlin, Lars, Claeson, Per, Goransson, Ulf and Gullbo, Joachim (2010). Evaluation of toxicity and antitumor activity of cycloviolacin O2 in mice. 1st International Conference on Circular Proteins, Heron Island, Qld, Australia, 18-21 October, 2009. Hoboken, NJ, U.S.A: Wiley Interscience. doi: 10.1002/bip.21408 |
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2010 Conference Publication Sunflower trypsin inhibitor-1, proteolytic studies on a trypsin inhibitor peptide and its analogsColgrave, Michelle, Korsinczky, Michael Laszlo Jonas, Clark, Richard James, Foley, Fiona and Craik, David J. (2010). Sunflower trypsin inhibitor-1, proteolytic studies on a trypsin inhibitor peptide and its analogs. 1st International Conference on Circular Proteins, Heron Island, Qld, Australia, 18-21 October 2009. Hoboken, N.J., U.S.: John Wiley & Sons. doi: 10.1002/bip.21415 |
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2009 Journal Article Beta-arrestin 2 is required for complement C1q expression in macrophages and constrains factor-independent survivalLattin, J. E., Greenwood, K. P., Daly, N. L., Kelly, G, Zidar, D. A., Clark, R. J., Thomas, W. G., Kellie, Stuart, Craik, D. J., Hume, D. A. and Sweet, M. J. (2009). Beta-arrestin 2 is required for complement C1q expression in macrophages and constrains factor-independent survival. Molecular Immunology, 47 (2-3), 340-347. doi: 10.1016/j.molimm.2009.09.012 |
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2009 Journal Article A synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonistsArmishaw, Christopher J., Singh, Narender, Medina-Franco, Jose L., Clark, Richard J., Scott, Krystle C. M., Houghten, Richard A. and Jensen, Anders A. (2009). A synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonists. Journal of Biological Chemistry, 285 (3), 1809-1821. doi: 10.1074/jbc.M109.071183 |
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2009 Journal Article Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha-9 alpha-10 nicotinic acetylcholine receptorHalai, Reena, Clark, Richard J., Nevin, Simon T., Jensen, Jonas E., Adams, David J. and Craik, David J. (2009). Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha-9 alpha-10 nicotinic acetylcholine receptor. Journal of Biological Chemistry, 284 (30), 20275-20284. doi: 10.1074/jbc.M109.015339 |
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2009 Journal Article Dissecting the oxidative folding of circular cystine knot miniproteinsGunasekera, Sunithi, Daly, Norelle L., Clark, Richard J. and Craik, David J. (2009). Dissecting the oxidative folding of circular cystine knot miniproteins. Antioxidants and Redox Signalling, 11 (5), 971-980. doi: 10.1089/ars.2008.2295 |
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2009 Journal Article Rational design of alpha-conotoxin analogues targeting alpha 7 nicotinic acetylcholine receptors: Improved antagonistic activity by incorporation of proline derivativesArmishaw, Christopher, Jensen, Anders A., Balle, Thomas, Clark, Richard J., Harpsøe, Kasper, Skonberg, Christian, Liljefors, Tommy and Strømgaard, Kristian (2009). Rational design of alpha-conotoxin analogues targeting alpha 7 nicotinic acetylcholine receptors: Improved antagonistic activity by incorporation of proline derivatives. Journal of Biological Chemistry, 284 (14), 9498-9512. doi: 10.1074/jbc.M806136200 |
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2009 Journal Article Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-conotoxin GID and analoguesMillard, Emma L., Nevin, Simon T., Loughnan, Marion L., Nicke, Annette, Clark, Richard J., Alewood, Paul F., Lewis, Richard J., Adams, David J., Craik, David J. and Daly, Norelle L. (2009). Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-conotoxin GID and analogues. Journal of Biological Chemistry, 284 (8), 4944-4951. doi: 10.1074/jbc.M804950200 |
