Professor Peter Sly
Professor

Peter Sly

Email: 
Phone: 
+61 7 3069 7383

Background

Professor Peter Sly is the Director, Children's Health and Environment Program. Professor Sly is a NHMRC Leadership Fellow (L3) and an emeritus paediatric respiratory physician with extensive research experience in respiratory physiology, developmental immunology and children's environmental health. Professor Sly’s research aims to understand the mechanisms underlying chronic childhood lung diseases in order to improve clinical management and to delay or prevent their onset, with consequent reductions in adult lung diseases. A combination of basic science, longitudinal cohort studies and translation of research findings into clinical practice, including clinical trials, are included in three main areas: asthma, cystic fibrosis and children’s environmental health

Professor Sly is an advisor to the World Health Organisation Department of Public Health, Environmental and Social Determinants of Disease and currently serves on International Advisory Boards and committees, including: WHO network of Collaborating Centres in Children’s Environmental Health; Canadian Healthy Infant Longitudinal Development (CHILD) Study, Canada; the Infant Lung Health Study, Paarl, South Africa; and A SHARED Future: Achieving Strength, Health, and Autonomy, through Renewable Energy Development for the Future.

Availability

Professor Peter Sly is:
Not available for supervision
Media expert

Fields of research

Biomedical and Clinical Sciences Cardiovascular medicine and haematology Clinical sciences Environmental Sciences Immunology Respiratory diseases

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, University of Melbourne
  • Doctoral Diploma of Medicine, University of Melbourne
  • Doctoral Diploma of Science (Advanced), University of Western Australia

Research interests

  • Asthma

    Understanding mechanisms that underlie risks for developing asthma in susceptible children

  • Cystic Fibrosis

    Understanding the mechanisms underlying the development of lung disease early in life and why and how this progresses

  • Impact of environmental exposures in early life

    Improving methods of assessing environmental exposures during fetal development and in early postnatal life. Improving methods for assessing the effects of early life environmental exposures and understanding how these increase long-tern risk of chronic disease.

Search Professor Peter Sly’s works on UQ eSpace

1193 works between 1980 and 2025
All (1193) Book (3) Journal Article (948) Other Outputs (1) Conference Publication (219) Book Chapter (22)

861 - 880 of 1193 works

2004

Journal Article

Variability in preterm lamb lung mechanics after intra-amniotic endotoxin is associated with changes in surfactant pool size and morphometry

Pillow, J. Jane, Jobe, Alan H., Collins, Rachel A., Hantos, Zoltan, Ikegami, Machiko, Moss, Timothy J. M., Newnham, John P., Willet, Karen E. and Sly, Peter D. (2004). Variability in preterm lamb lung mechanics after intra-amniotic endotoxin is associated with changes in surfactant pool size and morphometry. American Journal of Physiology - Lung Cellular and Molecular Physiology, 287 (5), L992-L998. doi: 10.1152/ajplung.00158.2004

Variability in preterm lamb lung mechanics after intra-amniotic endotoxin is associated with changes in surfactant pool size and morphometry

2004

Conference Publication

Gene expression patterns in allergic disease in childhood

Holt, PG, Bosco, A, McKenna, KL, Devitt, CJ and Sly, PD (2004). Gene expression patterns in allergic disease in childhood. 1st International Conference on Basic and Clinical Immunogenomics (BCI 2004), Budapest Hungary, Oct 03-07, 2004. COPENHAGEN: BLACKWELL MUNKSGAARD.

Gene expression patterns in allergic disease in childhood

2004

Journal Article

The pattern of methacholine responsiveness in mice is dependent on antigen challenge dose

Zosky, Graeme R., von Garnier, Christophe, Stumbles, Philip A., Holt, Patrick G., Sly, Peter D. and Turner, Debra J . (2004). The pattern of methacholine responsiveness in mice is dependent on antigen challenge dose. Respiratory Research, 5 (15) 15, 1-10. doi: 10.1186/1465-9921-5-15

The pattern of methacholine responsiveness in mice is dependent on antigen challenge dose

2004

Journal Article

Enhancement of vaccine-specific cellular immunity in infants by passively acquired maternal antibody

Rowe, J., Poolman, J. T., Macaubas, C., Sly, P. D., Loh, R. and Holt, P. G. (2004). Enhancement of vaccine-specific cellular immunity in infants by passively acquired maternal antibody. Vaccine, 22 (29-30), 3986-3992. doi: 10.1016/j.vaccine.2004.03.052

Enhancement of vaccine-specific cellular immunity in infants by passively acquired maternal antibody

2004

Journal Article

The use and misuse of Penh in animal models of lung disease

Bates, J., Irvin, C., Brusasco, V., Drazen, J., Fredberg, J., Loring, S., Eidelman, D., Ludwig, M., Macklem, P., Martin, J., Hantos, Z., Hyatt, R., Lai-Fook, S., Leff, A., Solway, J., Lutchen, K., Suki, B., Mitzner, W., Pare, P., Pride, N. and Sly, P. (2004). The use and misuse of Penh in animal models of lung disease. American Journal of Respiratory Cell and Molecular Biology, 31 (3), 373-374. doi: 10.1165/ajrcmb.31.3.1

The use and misuse of Penh in animal models of lung disease

2004

Journal Article

The relation of breastfeeding and body mass index to asthma and atopy in children: A prospective cohort study to age 6 years

Oddy, WH, Sherriff, JL, de Klerk, NH, Kendall, GE, Sly, PD, Beilin, LJ, Blake, KB, Landau, LI and Stanley, FJ (2004). The relation of breastfeeding and body mass index to asthma and atopy in children: A prospective cohort study to age 6 years. American Journal of Public Health, 94 (9), 1531-1537. doi: 10.2105/AJPH.94.9.1531

The relation of breastfeeding and body mass index to asthma and atopy in children: A prospective cohort study to age 6 years

2004

Journal Article

Functional maturation of CD4 +CD25 +CTLA4 +CD45RA + T regulatory cells in human neonatal T cell responses to environmental antigens/allergens

Thornton, C. A., Upham, J. W., Wikstrom, M. E., Holt, B. J., White, G. P., Sharp, M. J., Sly, P. D. and Holt, P. G. (2004). Functional maturation of CD4 +CD25 +CTLA4 +CD45RA + T regulatory cells in human neonatal T cell responses to environmental antigens/allergens. Journal of Immunology, 173 (5), 3084-3092. doi: 10.4049/jimmunol.173.5.3084

Functional maturation of CD4 +CD25 +CTLA4 +CD45RA + T regulatory cells in human neonatal T cell responses to environmental antigens/allergens

2004

Journal Article

Prevention of bronchoconstriction in sensitized guinea pigs: efficacy of common prophylactic drugs

Schutz, Nathalie, Petak, Ferenc, Barazzone-Argiroffo, Constance, Sly, Peter D. and Habre, Walid (2004). Prevention of bronchoconstriction in sensitized guinea pigs: efficacy of common prophylactic drugs. Respiratory Physiology and Neurobiology, 141 (2), 167-178. doi: 10.1016/j.resp.2004.04.013

Prevention of bronchoconstriction in sensitized guinea pigs: efficacy of common prophylactic drugs

2004

Journal Article

Drug development strategies for asthma: In search of a new paradigm

Holt, Patrick G., Sly, Peter D., Martinez, Fernando D., Weiss, Scott T., Bjorksten, Bengt, von Mutius, Erika and Wahn, Ulrich (2004). Drug development strategies for asthma: In search of a new paradigm. Nature Immunology, 5 (7), 695-698. doi: 10.1038/ni0704-695

Drug development strategies for asthma: In search of a new paradigm

2004

Journal Article

Sensitivity analysis of respiratory parameter estimates in the constant-phase model

Thamrin, C., Janosi, T. Z., Collins, R. A., Sly, P. D. and Hantos, Z. N. (2004). Sensitivity analysis of respiratory parameter estimates in the constant-phase model. Annals of Biomedical Engineering, 32 (6), 815-822. doi: 10.1023/B:ABME.0000030257.88945.81

Sensitivity analysis of respiratory parameter estimates in the constant-phase model

2004

Journal Article

Interrupter resistance - Reply

Lombardi, E and Sly, PD (2004). Interrupter resistance - Reply. Thorax, 59 (5), 449-450.

Interrupter resistance - Reply

2004

Journal Article

Interrupter resistance [2] (multiple letters)

Dundas, I., McKenzie, S. A., Lombardi, E. and Sly, P. D. (2004). Interrupter resistance [2] (multiple letters). Thorax, 59 (5), 449-450.

Interrupter resistance [2] (multiple letters)

2004

Journal Article

High IFN-gamma production by CD8(+) T cells and early sensitization among infants at high risk of atopy

Rowe, Julie, Heaton, Tricia, Kusel, Merci, Suriyaarachchi, Devinda, Serralha, Michael, Holt, Barbara J., de Klerk, Nick, Sly, Peter D. and Holt, Patrick G. (2004). High IFN-gamma production by CD8(+) T cells and early sensitization among infants at high risk of atopy. Journal of Allergy and Clinical Immunology, 113 (4), 710-716. doi: 10.1016/j.jaci.2003.12.585

High IFN-gamma production by CD8(+) T cells and early sensitization among infants at high risk of atopy

2004

Journal Article

Lung function, bronchial responsiveness, and asthma in a community cohort of 6-year-old children

Joseph-Bowen, Jacqui, de Klerk, Nicholas H., Firth, Martin J., Kendall, Garth E., Holt, Patrick G. and Sly, Peter D. (2004). Lung function, bronchial responsiveness, and asthma in a community cohort of 6-year-old children. American Journal of Respiratory and Critical Care Medicine, 169 (7), 850-854. doi: 10.1164/rccm.200304-556OC

Lung function, bronchial responsiveness, and asthma in a community cohort of 6-year-old children

2004

Journal Article

Phase 2 evaluation of parainfluenza type 3 cold passage mutant 45 live attenuated vaccine in healthy children 6-18 months old

Belshe, R. B., Newman, F. K., Tsai, T. F., Karron, R. A., Reisinger, K., Roberton, D., Marshall, H., Schwartz, R., King, J, Henderson, F. W., Rodriguez, W., Severs, J. M., Wright, P. F., Keyserling, H., Weinberg, G. A., Bromberg, K., Loh, R., Sly, P., McIntyre, P., Ziegler, J. B., Hackell, J., Deatly, A., Georgiu, A., Paschalis, M., Wu, S. L., Tatem, J. M., Murphy, B. and Anderson, E. (2004). Phase 2 evaluation of parainfluenza type 3 cold passage mutant 45 live attenuated vaccine in healthy children 6-18 months old. Journal of Infectious Diseases, 189 (3), 462-470. doi: 10.1086/381184

Phase 2 evaluation of parainfluenza type 3 cold passage mutant 45 live attenuated vaccine in healthy children 6-18 months old

2004

Book Chapter

Extending the simple linear regression model to account for correlated responses: An introduction to generalized estimating equations and multilevel mixed modelling

Burton, Paul, Gurrin, Lyle and Sly, Peter (2004). Extending the simple linear regression model to account for correlated responses: An introduction to generalized estimating equations and multilevel mixed modelling. Tutorials in biostatistics. (pp. 1-33) edited by Ralph B. D'Agostino. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/0470023724

Extending the simple linear regression model to account for correlated responses: An introduction to generalized estimating equations and multilevel mixed modelling

2003

Journal Article

Site of inflammation influences site of hyperresponsiveness in experimental asthma

Collins, R. A., Sly, P. D., Turner, D. J., Herbert, C. and Kumar, R. K. (2003). Site of inflammation influences site of hyperresponsiveness in experimental asthma. Respiratory Physiology and Neurobiology, 139 (1), 51-61. doi: 10.1016/j.resp.2003.09.003

Site of inflammation influences site of hyperresponsiveness in experimental asthma

2003

Journal Article

Emerging concepts of T-cell regulation in asthma and allergy - New rules for an old game

Holt, Patrick G. and Sly, Peter D. (2003). Emerging concepts of T-cell regulation in asthma and allergy - New rules for an old game. Allergy and Clinical Immunology International, 15 (6), 255-260. doi: 10.1027/0838-1925.15.6.255

Emerging concepts of T-cell regulation in asthma and allergy - New rules for an old game

2003

Journal Article

Association between antenatal cytokine production and the development of atopy and asthma at age 6 years

Macaubas, C., de Klerk, N. H., Holt, B. J., Wee, C., Kendall, G., Firth, M, Sly, P. D. and Holt, P. G. (2003). Association between antenatal cytokine production and the development of atopy and asthma at age 6 years. Lancet, 362 (9391), 1192-1197. doi: 10.1016/S0140-6736(03)14542-4

Association between antenatal cytokine production and the development of atopy and asthma at age 6 years

2003

Journal Article

Tracking of airway and tissue mechanics during TLC maneuvers in mice

Hantos, Z., Collins, R. A., Turner, D. J., Janosi, T. Z. and Sly, P. D. (2003). Tracking of airway and tissue mechanics during TLC maneuvers in mice. Journal of Applied Physiology, 95 (4), 1695-1705. doi: 10.1152/japplphysiol.00104.2003

Tracking of airway and tissue mechanics during TLC maneuvers in mice

Current funding

  • 2025 - 2026
    Think ZINC: Zinc immune-related Needs in Cystic fibrosis
    Cure4CF Foundation Research Grants
    Open grant
  • 2025 - 2026
    Home based oscillometry monitoring in young childhood asthmatics: the urgently needed tool to address poor asthma control (Qld Health CRF grant administered by CHQ)
    Children's Health Queensland Hospital and Health Service
    Open grant
  • 2021 - 2025
    Early life exposures and chronic disease: mechanisms and preventative strategies
    NHMRC Investigator Grants
    Open grant
  • 2019 - 2026
    Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMAT)
    Cystic Fibrosis Foundation USA
    Open grant
  • 2019 - 2025
    Queensland cystic fibrosis research program
    The Children's Hospital Foundation
    Open grant

Past funding

  • 2021 - 2023
    Identifying preschool children with wheeze at risk of developing asthma using temporal oscillometry
    Thrasher Research Fund
    Open grant
  • 2021 - 2022
    Zinc supplementation to enhance bacterial killing ability of macrophages from cystic fibrosis (CF)
    Preclinical and Clinical Early Career Research
    Open grant
  • 2021 - 2024
    Prevention of wheeze-associated hospitalisation in preschoolers with the immunomodulator OM85: a multi-centre, randomised, double-blind... (NHMRC CTCS Administered by Deakin University)
    Deakin University
    Open grant
  • 2020 - 2025
    Exposure to Trihalomethanes in pregnancy and birth outcomes in Queensland: integrated data analysis and case studies for better policy and health outcomes
    NHMRC Partnership Projects
    Open grant
  • 2020 - 2025
    Ataxia-telangiectasia: treating mitochondrial dysfunction with a novel form of anaplerosis
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2020 - 2024
    Prenatal environments, offspring neurodevelopment and epigenetic programming (MRFF Preventative and Public Health Research Grant led by University of Melbourne)
    University of Melbourne
    Open grant
  • 2020 - 2021
    Reducing acute severe respiratory events in health care workers during the Covid-19 pandemic with OM85
    NHMRC MRFF Coronavirus Research Response
    Open grant
  • 2020 - 2022
    Development of CFTR-knockout monocytic cell line and understanding why patients with CF are vulnerable to Mycobacterium abscessus (MABS) infection
    Australian Cystic Fibrosis Research Trust Innovation Grant
    Open grant
  • 2020 - 2022
    Improving the ability of CF macrophages to handle mycobacterium abscessus (MABS)
    Vertex Innovation Awards
    Open grant
  • 2019 - 2024
    Early life origins of cystic fibrosis lung disease
    Cystic Fibrosis Foundation USA
    Open grant
  • 2019 - 2023
    Wearing masks to reduce traffic-related air pollution exposure and improve children's respiratory health
    NHMRC-NAFOSTED Joint Call for Collaborative Research Projects Grants
    Open grant
  • 2018 - 2019
    Differentiation and polarization of macrophages
    Corbus Pharmaceuticals Australia Pty Ltd
    Open grant
  • 2018 - 2021
    Macrophage Polarisation and Control of Pulmonary Inflammation
    NHMRC Project Grant
    Open grant
  • 2018 - 2021
    Maternal carriage of Prevotella during pregnancy influences offspring innate immune responses and asthma at age 7 (NHMRC Project Grant led by Deakin University)
    Deakin University
    Open grant
  • 2018 - 2022
    Multi-centre, multi-disciplinary study using a systems biology approach to investigate immunomodulation in children with acute wheeze (NHMRC Project Grant led by UWA)
    University of Western Australia
    Open grant
  • 2017 - 2019
    The impact of direct acting antivirals and inhibitors of host innate immune cell signalling (macrolide, SYK, PAD4) on innate immune cell function in response to infection of airway epithelial cells.
    Gilead Pty Ltd
    Open grant
  • 2017 - 2019
    Developing objective criteria for discharge following hospitalization for acute pulmonary exacerbation in cystic fibrosis.
    The Children's Hospital Foundation
    Open grant
  • 2017 - 2019
    A randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy and safety of dupilumab in children 6 to <12 years of age with uncontrolled persistent asthma
    Sanofi-Aventis Australia Pty Ltd
    Open grant
  • 2017
    Addressing Needs for High Nucleic Acid Quantification Accuracy and Precision in Child Health Research
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016 - 2019
    Macrophages: the forgotten cells in CF lung disease
    Cystic Fibrosis Foundation Therapeutics Inc
    Open grant
  • 2016 - 2018
    Investigation of the role of oxidative stress in pulmonary disease in ataxia-telangiectasia
    The A-T Children's Project
    Open grant
  • 2016 - 2019
    Children's Health and Environment Program
    The Children's Hospital Foundation
    Open grant
  • 2016 - 2020
    Early life exposures and chronic disease: mechanisms and preventative strategies
    NHMRC Research Fellowship
    Open grant
  • 2016
    Integrative blood coagulation research core facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2018
    Airborne transmission of microorganisms among persons with cystic fibrosis
    Queensland Institute of Medical Research
    Open grant
  • 2015 - 2019
    Immune recognition of upper airway microbiota in early life as a determinant of respiratory health in children
    NHMRC Project Grant
    Open grant
  • 2015 - 2019
    The effect of asthma control during pregnancy on markers of airways inflammation and lung function in the offspring (NHMRC Project Grant administered by The University of Newcastle)
    University of Newcastle
    Open grant
  • 2014 - 2019
    Biomonitoring early life exposure to plastic products in Australia and assessing health consequences (NHMRC Partnership Project administered by Murdoch Childrens Research Institute)
    Murdoch Childrens Research Institute
    Open grant
  • 2014 - 2015
    Microflow ultra high pressure liquid chromatography - high resolution mass spectrometry for chemical exposure monitoring
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2014 - 2015
    Efficacy of OM-85 in the reduction of lower respiratory events in atopic children with asthma
    OM Pharma SA
    Open grant
  • 2014 - 2021
    International Collaboration to Improve Respiratory Health in Children (INCIRCLE)
    European Respiratory Society - Clinical Research Collaborations
    Open grant
  • 2014 - 2015
    A Phase 1b, Randomized, Double-Blind, Placebo Controlled, Single-Dose Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GS-5806 in Subjects < 24 Months of Age [...]
    Gilead Pty Ltd
    Open grant
  • 2014 - 2017
    Antiviral defects of the airway epithelium associated with wheeze and atopy in children
    NHMRC Project Grant
    Open grant
  • 2014
    Optimising the utility of paediatric research samples using advanced liquid handling and dispensing equipment
    NHMRC Equipment Grant
    Open grant
  • 2013 - 2017
    Clinical and psychosocial changes over late childhood and adolescence and early life determinants of long term clinical outcomes in cystic fibrosis
    NHMRC Project Grant
    Open grant
  • 2013 - 2014
    A Phase 1b, Randomized, Double-Blind, Placebo Controlled, Single-Dose Ranging Study Evaluating the Safety, Tolerability, and Pharmacokinetics of GS-5806 in Subjects < 24 Months of Age [...]
    Gilead Clinical Trial
    Open grant
  • 2013 - 2015
    Characterization of cellular inflammatory responses underlying acute viral bronchiolitis in infants (NHMRC Project grant administered by The University of Western Australia)
    University of Western Australia
    Open grant
  • 2013 - 2017
    Prevention of asthma in young children via immunostimulation
    NHMRC Project Grant
    Open grant
  • 2012 - 2013
    A high-throughput screening and sequencing facility for single cell genomics
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2012
    Does Azithromycin prevent viral respiratory infection in CF infants
    Royal Children's Hospital Foundation
    Open grant
  • 2012
    Tandem fluorescent and phase-contrast imaging of live cells in real time for application to cancer cell biology, developmental biology, respiratory biology, wound healing investigation and cellular to
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2013
    The airway epithelium in paediatric respiratory diseases
    UWA-UQ Bilateral Research Collaboration Award
    Open grant
  • 2012 - 2014
    Winter-only treatment with omalizumab to prevent asthma exacerbations in children.
    NHMRC Project Grant
    Open grant
  • 2011 - 2012
    Ultra-high-performance liquid chromatography ion trap mass spectrometer to develop new capabilities in environmental and human toxicology
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2011 - 2012
    Preschool lung function in Spinal Muscular Atrophy
    ANZ Executors and Trustees' Company Ltd
    Open grant
  • 2011
    Assessing airway hyperreactivity using flexiVent
    RL Cooper Medical Research Foundation Limited
    Open grant
  • 2011 - 2016
    Children's Health and Environment Program
    Royal Children's Hospital Foundation
    Open grant
  • 2011
    Establishment of a shared multiplex molecular profiling facility for clinical and translational research in child health
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2013
    Rhinovirus impairs physiological and immunological lung development and causes exacerbation of allergic airways disease
    ARC Discovery Projects
    Open grant
  • 2010 - 2016
    Inflammatory airways disease in children with a focus on cystic fibrosis
    Royal Children's Hospital Foundation
    Open grant
  • 2010
    NHMRC Research Fellowship (SPRF)
    NHMRC Research Fellowship
    Open grant
  • 2010 - 2016
    Senior Clinical Research Fellowship
    Queensland Senior Clinical Research Fellowship
    Open grant

Availability

Professor Peter Sly is:
Not available for supervision

Supervision history

Current supervision

  • Doctor Philosophy

    Maternal exposure to phthalates and allergic disease in children

    Principal Advisor

    Other advisors: Dr Dwan Vilcins

  • Doctor Philosophy

    Role of airway obstruction in the development of asthma

    Principal Advisor

    Other advisors: Honorary Professor Zoltan Hantos, Dr Tamara Blake

  • Doctor Philosophy

    Respiratory Guidelines for the Management of Paediatric Neuromuscular Disease

    Principal Advisor

    Other advisors: Dr Zephanie Tyack

  • Doctor Philosophy

    Investigations into the importance of antimicrobial residues in the surveillance of antimicrobial resistance in peri-urban dairy farms of Nepal

    Associate Advisor

    Other advisors: Dr Deirdre Mikkelsen, Dr Nicholas Clark, Professor Ricardo Soares Magalhaes

  • Doctor Philosophy

    Improving detection of pulmonary graft-vs-host disease (pGVHD) post haematopoietic stem cell transplantation (HSCT)

    Associate Advisor

    Other advisors: Dr Tamara Blake, Professor Paul Robinson

  • Doctor Philosophy

    Providing evidence to guide public health messages during bushfire smoke events

    Associate Advisor

    Other advisors: Dr Dwan Vilcins

Completed supervision

Enquiries

Contact Professor Peter Sly directly for media enquiries about:

  • Child health
  • Children and environment
  • Cystic fibrosis
  • Paediatric asthma
  • Respiratory physiology

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