Professor Peter Sly
Professor

Peter Sly

Email: 
Phone: 
+61 7 3069 7383

Background

Professor Peter Sly is the Director, Children's Health and Environment Program. Professor Sly is a NHMRC Leadership Fellow (L3) and an emeritus paediatric respiratory physician with extensive research experience in respiratory physiology, developmental immunology and children's environmental health. Professor Sly’s research aims to understand the mechanisms underlying chronic childhood lung diseases in order to improve clinical management and to delay or prevent their onset, with consequent reductions in adult lung diseases. A combination of basic science, longitudinal cohort studies and translation of research findings into clinical practice, including clinical trials, are included in three main areas: asthma, cystic fibrosis and children’s environmental health

Professor Sly is an advisor to the World Health Organisation Department of Public Health, Environmental and Social Determinants of Disease and currently serves on International Advisory Boards and committees, including: WHO network of Collaborating Centres in Children’s Environmental Health; Canadian Healthy Infant Longitudinal Development (CHILD) Study, Canada; the Infant Lung Health Study, Paarl, South Africa; and A SHARED Future: Achieving Strength, Health, and Autonomy, through Renewable Energy Development for the Future.

Availability

Professor Peter Sly is:
Not available for supervision
Media expert

Fields of research

Biomedical and Clinical Sciences Cardiovascular medicine and haematology Clinical sciences Environmental Sciences Immunology Respiratory diseases

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, University of Melbourne
  • Doctoral Diploma of Medicine, University of Melbourne
  • Doctoral Diploma of Science (Advanced), University of Western Australia

Research interests

  • Asthma

    Understanding mechanisms that underlie risks for developing asthma in susceptible children

  • Cystic Fibrosis

    Understanding the mechanisms underlying the development of lung disease early in life and why and how this progresses

  • Impact of environmental exposures in early life

    Improving methods of assessing environmental exposures during fetal development and in early postnatal life. Improving methods for assessing the effects of early life environmental exposures and understanding how these increase long-tern risk of chronic disease.

Search Professor Peter Sly’s works on UQ eSpace

1180 works between 1980 and 2025
All (1180) Journal Article (944) Book Chapter (22) Conference Publication (210) Book (3) Other Outputs (1)

901 - 920 of 1180 works

2001

Journal Article

Factors associated with airway responsiveness to methacholine in asthmatic children and their families

Mutch, R., Callaghan, A., Kendall, G., Stick, S., Franklin, P., De Klerk, N. and Sly, P. D. (2001). Factors associated with airway responsiveness to methacholine in asthmatic children and their families. Respirology, 6 (SUPPL. 1)

Factors associated with airway responsiveness to methacholine in asthmatic children and their families

2001

Journal Article

Antenatal inflammation and the developing lamb lung

Willet, K., Collins, R., Jobe, A., Ikegami, M., Newnham, J., Moss, T. and Sly, P. (2001). Antenatal inflammation and the developing lamb lung. Respirology, 6 (SUPPL. 1)

Antenatal inflammation and the developing lamb lung

2001

Journal Article

Effects of antenatal lipopolysaccharide on lung structural development

Collins, Rachel and Sly, Peter (2001). Effects of antenatal lipopolysaccharide on lung structural development. Respirology, 6 (SUPPL. 1)

Effects of antenatal lipopolysaccharide on lung structural development

2001

Journal Article

"Bystander" amplification of PBMC cytokine responses to seasonal allergen in polysensitized atopic children

Rudin, A., Macaubas, C., Wee, C., Holt, B.J., Sly, P.D. and Holt, P.G. (2001). "Bystander" amplification of PBMC cytokine responses to seasonal allergen in polysensitized atopic children. Allergy, 56 (11), 1042-1048. doi: 10.1034/j.1398-9995.2001.00991.x

"Bystander" amplification of PBMC cytokine responses to seasonal allergen in polysensitized atopic children

2001

Journal Article

Is home monitoring of lung function worthwhile for children with asthma?

Sly, P.D. and Flack, F. (2001). Is home monitoring of lung function worthwhile for children with asthma?. Western Journal of Medicine, 175 (5), 344-345. doi: 10.1136/ewjm.175.5.344

Is home monitoring of lung function worthwhile for children with asthma?

2001

Journal Article

Improved safety with equivalent asthma control in adults with chronic severe asthma on high-dose fluticasone propionate

Berend, Norbert, Kellett, Bruce, Kent, Neil and Sly, Peter D. (2001). Improved safety with equivalent asthma control in adults with chronic severe asthma on high-dose fluticasone propionate. Respirology, 6 (3), 237-246. doi: 10.1046/j.1440-1843.2001.00329.x

Improved safety with equivalent asthma control in adults with chronic severe asthma on high-dose fluticasone propionate

2001

Journal Article

Reliable tidal volume estimates at the airway opening with an infant monitor during high-frequency oscillatory ventilation

Scalfaro, P., Pillow, J. J., Sly, P. D. and Cotting, J. (2001). Reliable tidal volume estimates at the airway opening with an infant monitor during high-frequency oscillatory ventilation. Critical Care Medicine, 29 (10), 1925-1930. doi: 10.1097/00003246-200110000-00013

Reliable tidal volume estimates at the airway opening with an infant monitor during high-frequency oscillatory ventilation

2001

Journal Article

Viscosity and density of common anaesthetic gases: implications for flow measurements

Habre, W., Asztalos, T., Sly, P.D. and Petak, F. (2001). Viscosity and density of common anaesthetic gases: implications for flow measurements. British Journal of Anaesthesia, 87 (4), 602-607. doi: 10.1093/bja/87.4.602

Viscosity and density of common anaesthetic gases: implications for flow measurements

2001

Journal Article

Salbutamol prevents the increase of respiratory resistance caused by tracheal intubation during sevoflurane anesthesia in asthmatic children

Scalfaro, P., Sly, P.D., Sims, C. and Habre, W. (2001). Salbutamol prevents the increase of respiratory resistance caused by tracheal intubation during sevoflurane anesthesia in asthmatic children. Anesthesia and Analgesia, 93 (4), 898-902. doi: 10.1097/00000539-200110000-00019

Salbutamol prevents the increase of respiratory resistance caused by tracheal intubation during sevoflurane anesthesia in asthmatic children

2001

Journal Article

Altered respiratory tissue mechanics in asymptomatic wheezy infants

Hall, G.L., Hantos, Z. and Sly, P.D (2001). Altered respiratory tissue mechanics in asymptomatic wheezy infants. American Journal of Respiratory and Critical Care Medicine, 164 (8), 1387-1391. doi: 10.1164/ajrccm.164.8.2012148

Altered respiratory tissue mechanics in asymptomatic wheezy infants

2001

Journal Article

Dose and time response after intraamniotic endotoxin in preterm lambs

Kramer, B.W., Moss, T.J., Willet, K.E., Newnham, J.P., Sly, P.D., Kallapur, S.G., Ikegami, M. and Jobe, A.H. (2001). Dose and time response after intraamniotic endotoxin in preterm lambs. American Journal of Respiratory and Critical Care Medicine, 164 (6), 982-988. doi: 10.1164/ajrccm.164.6.2103061

Dose and time response after intraamniotic endotoxin in preterm lambs

2001

Journal Article

Reference values of interrupter respiratory resistance in healthy preschool white children

Lombardi, E., Sly, P.D., Concutelli, G., Novembre, E., Veneruso, G., Frongia, G., Bernardini, R. and Vierucci, A. (2001). Reference values of interrupter respiratory resistance in healthy preschool white children. Thorax, 56 (9), 691-695. doi: 10.1136/thorax.56.9.691

Reference values of interrupter respiratory resistance in healthy preschool white children

2001

Journal Article

Height and weight fail to detect early signs of malnutrition in children with cystic fibrosis

Stapleton, Denise, Kerr, Deborah, Gurrin, Lyle, Sherriff, Jill and Sly, Peter (2001). Height and weight fail to detect early signs of malnutrition in children with cystic fibrosis. Journal of Pediatric Gastroenterology and Nutrition, 33 (3), 319-325. doi: 10.1097/00005176-200109000-00017

Height and weight fail to detect early signs of malnutrition in children with cystic fibrosis

2001

Journal Article

Sex differences in response to steroids in preterm sheep lungs are not explained by glucocorticoid receptor number or binding affinity

Kovar, Jana, Waddell, rendan J., Sly, Peter D. and Willet, Karen E. (2001). Sex differences in response to steroids in preterm sheep lungs are not explained by glucocorticoid receptor number or binding affinity. Pediatric Pulmonology, 32 (1), 8-13. doi: 10.1002/ppul.1082

Sex differences in response to steroids in preterm sheep lungs are not explained by glucocorticoid receptor number or binding affinity

2001

Journal Article

The interactive effects of endotoxin with prenatal glucocorticoids on short-term lung function in sheep

Newnham, John P., Moss, Timothy J., Padbury, James F., Willet, Karen E., Ikegami, Machiko, Ervin, M.Gore, Sly, Peter and Jobe, Alan (2001). The interactive effects of endotoxin with prenatal glucocorticoids on short-term lung function in sheep. American Journal of Obstetrics and Gynecology, 185 (1), 190-197. doi: 10.1067/mob.2001.114500

The interactive effects of endotoxin with prenatal glucocorticoids on short-term lung function in sheep

2001

Journal Article

Heterogeneity in diphtheria-tetanus-acellular pertussis vaccine-specific cellular immunity during infancy: Relationship to variations in the kinetics of postnatal maturation of systemic Th1 function

Rowe, J, Macaubas, C, Monger, T, Holt, BJ, Harvey, J, Poolman, JT, Loh, R, Sly, PD and Holt, PG (2001). Heterogeneity in diphtheria-tetanus-acellular pertussis vaccine-specific cellular immunity during infancy: Relationship to variations in the kinetics of postnatal maturation of systemic Th1 function. Journal of Infectious Diseases, 184 (1), 80-88. doi: 10.1086/320996

Heterogeneity in diphtheria-tetanus-acellular pertussis vaccine-specific cellular immunity during infancy: Relationship to variations in the kinetics of postnatal maturation of systemic Th1 function

2001

Journal Article

Lung morphometry after repetitive antenatal glucocorticoid treatment in preterm sheep

Willet, K.E., Jobe, A.H., Ikegami, M., Kovar, J. and Sly, P.D. (2001). Lung morphometry after repetitive antenatal glucocorticoid treatment in preterm sheep. American Journal of Respiratory and Critical Care Medicine, 163 (6), 1437-1443. doi: 10.1164/ajrccm.163.6.2003098

Lung morphometry after repetitive antenatal glucocorticoid treatment in preterm sheep

2001

Journal Article

Altered stability of pulmonary surfactant in SP-C-deficient mice

Glasser, Stephan W., Burhans, Michael S., Korfhagen, Thomas R., Na, Cheng-Lun, Sly, Peter D., Ross, Gary F., Ikegami, Machiko and Whitsett, Jeffrey A. (2001). Altered stability of pulmonary surfactant in SP-C-deficient mice. Proceedings of the National Academy of Sciences of the United States of America, 98 (11), 6366-6371. doi: 10.1073/pnas.101500298

Altered stability of pulmonary surfactant in SP-C-deficient mice

2001

Journal Article

Lipopolysaccharide inhibits the late-phase response to allergen by altering nitric oxide synthase activity and interleukin-10

Tulic, M.K., Knight, D.A., Holt, P.G. and Sly, P.D. (2001). Lipopolysaccharide inhibits the late-phase response to allergen by altering nitric oxide synthase activity and interleukin-10. American Journal of Respiratory Cell and Molecular Biology, 24 (5), 640-646. doi: 10.1165/ajrcmb.24.5.4265

Lipopolysaccharide inhibits the late-phase response to allergen by altering nitric oxide synthase activity and interleukin-10

2001

Journal Article

Effects of gestation and antenatal steroid on airway and tissue mechanics in newborn lambs

Pillow, J.J., Hall, G.L., Willet, K.E., Jobe, A.H., Hantos, Z. and Sly, P.D. (2001). Effects of gestation and antenatal steroid on airway and tissue mechanics in newborn lambs. American Journal of Respiratory and Critical Care Medicine, 163 (5), 1158-1163.

Effects of gestation and antenatal steroid on airway and tissue mechanics in newborn lambs

Current funding

  • 2025 - 2026
    Think ZINC: Zinc immune-related Needs in Cystic fibrosis
    Cure4CF Foundation Research Grants
    Open grant
  • 2021 - 2025
    Early life exposures and chronic disease: mechanisms and preventative strategies
    NHMRC Investigator Grants
    Open grant
  • 2020 - 2025
    Exposure to Trihalomethanes in pregnancy and birth outcomes in Queensland: integrated data analysis and case studies for better policy and health outcomes
    NHMRC Partnership Projects
    Open grant
  • 2019 - 2025
    Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMAT)
    Cystic Fibrosis Foundation USA
    Open grant
  • 2019 - 2025
    Queensland cystic fibrosis research program
    The Children's Hospital Foundation
    Open grant

Past funding

  • 2021 - 2023
    Identifying preschool children with wheeze at risk of developing asthma using temporal oscillometry
    Thrasher Research Fund
    Open grant
  • 2021 - 2022
    Zinc supplementation to enhance bacterial killing ability of macrophages from cystic fibrosis (CF)
    Preclinical and Clinical Early Career Research
    Open grant
  • 2021 - 2024
    Prevention of wheeze-associated hospitalisation in preschoolers with the immunomodulator OM85: a multi-centre, randomised, double-blind... (NHMRC CTCS Administered by Deakin University)
    Deakin University
    Open grant
  • 2020 - 2025
    Ataxia-telangiectasia: treating mitochondrial dysfunction with a novel form of anaplerosis
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2020 - 2024
    Prenatal environments, offspring neurodevelopment and epigenetic programming (MRFF Preventative and Public Health Research Grant led by University of Melbourne)
    University of Melbourne
    Open grant
  • 2020 - 2021
    Reducing acute severe respiratory events in health care workers during the Covid-19 pandemic with OM85
    NHMRC MRFF Coronavirus Research Response
    Open grant
  • 2020 - 2022
    Development of CFTR-knockout monocytic cell line and understanding why patients with CF are vulnerable to Mycobacterium abscessus (MABS) infection
    Australian Cystic Fibrosis Research Trust Innovation Grant
    Open grant
  • 2020 - 2022
    Improving the ability of CF macrophages to handle mycobacterium abscessus (MABS)
    Vertex Innovation Awards
    Open grant
  • 2019 - 2024
    Early life origins of cystic fibrosis lung disease
    Cystic Fibrosis Foundation USA
    Open grant
  • 2019 - 2023
    Wearing masks to reduce traffic-related air pollution exposure and improve children's respiratory health
    NHMRC-NAFOSTED Joint Call for Collaborative Research Projects Grants
    Open grant
  • 2018 - 2019
    Differentiation and polarization of macrophages
    Corbus Pharmaceuticals Australia Pty Ltd
    Open grant
  • 2018 - 2021
    Macrophage Polarisation and Control of Pulmonary Inflammation
    NHMRC Project Grant
    Open grant
  • 2018 - 2021
    Maternal carriage of Prevotella during pregnancy influences offspring innate immune responses and asthma at age 7 (NHMRC Project Grant led by Deakin University)
    Deakin University
    Open grant
  • 2018 - 2022
    Multi-centre, multi-disciplinary study using a systems biology approach to investigate immunomodulation in children with acute wheeze (NHMRC Project Grant led by UWA)
    University of Western Australia
    Open grant
  • 2017 - 2019
    The impact of direct acting antivirals and inhibitors of host innate immune cell signalling (macrolide, SYK, PAD4) on innate immune cell function in response to infection of airway epithelial cells.
    Gilead Pty Ltd
    Open grant
  • 2017 - 2019
    Developing objective criteria for discharge following hospitalization for acute pulmonary exacerbation in cystic fibrosis.
    The Children's Hospital Foundation
    Open grant
  • 2017 - 2019
    A randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy and safety of dupilumab in children 6 to <12 years of age with uncontrolled persistent asthma
    Sanofi-Aventis Australia Pty Ltd
    Open grant
  • 2017
    Addressing Needs for High Nucleic Acid Quantification Accuracy and Precision in Child Health Research
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016 - 2019
    Macrophages: the forgotten cells in CF lung disease
    Cystic Fibrosis Foundation Therapeutics Inc
    Open grant
  • 2016 - 2018
    Investigation of the role of oxidative stress in pulmonary disease in ataxia-telangiectasia
    The A-T Children's Project
    Open grant
  • 2016 - 2019
    Children's Health and Environment Program
    The Children's Hospital Foundation
    Open grant
  • 2016 - 2020
    Early life exposures and chronic disease: mechanisms and preventative strategies
    NHMRC Research Fellowship
    Open grant
  • 2016
    Integrative blood coagulation research core facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2018
    Airborne transmission of microorganisms among persons with cystic fibrosis
    Queensland Institute of Medical Research
    Open grant
  • 2015 - 2019
    Immune recognition of upper airway microbiota in early life as a determinant of respiratory health in children
    NHMRC Project Grant
    Open grant
  • 2015 - 2019
    The effect of asthma control during pregnancy on markers of airways inflammation and lung function in the offspring (NHMRC Project Grant administered by The University of Newcastle)
    University of Newcastle
    Open grant
  • 2014 - 2019
    Biomonitoring early life exposure to plastic products in Australia and assessing health consequences (NHMRC Partnership Project administered by Murdoch Childrens Research Institute)
    Murdoch Childrens Research Institute
    Open grant
  • 2014 - 2015
    Microflow ultra high pressure liquid chromatography - high resolution mass spectrometry for chemical exposure monitoring
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2014 - 2015
    Efficacy of OM-85 in the reduction of lower respiratory events in atopic children with asthma
    OM Pharma SA
    Open grant
  • 2014 - 2021
    International Collaboration to Improve Respiratory Health in Children (INCIRCLE)
    European Respiratory Society - Clinical Research Collaborations
    Open grant
  • 2014 - 2015
    A Phase 1b, Randomized, Double-Blind, Placebo Controlled, Single-Dose Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GS-5806 in Subjects < 24 Months of Age [...]
    Gilead Pty Ltd
    Open grant
  • 2014 - 2017
    Antiviral defects of the airway epithelium associated with wheeze and atopy in children
    NHMRC Project Grant
    Open grant
  • 2014
    Optimising the utility of paediatric research samples using advanced liquid handling and dispensing equipment
    NHMRC Equipment Grant
    Open grant
  • 2013 - 2017
    Clinical and psychosocial changes over late childhood and adolescence and early life determinants of long term clinical outcomes in cystic fibrosis
    NHMRC Project Grant
    Open grant
  • 2013 - 2014
    A Phase 1b, Randomized, Double-Blind, Placebo Controlled, Single-Dose Ranging Study Evaluating the Safety, Tolerability, and Pharmacokinetics of GS-5806 in Subjects < 24 Months of Age [...]
    Gilead Clinical Trial
    Open grant
  • 2013 - 2015
    Characterization of cellular inflammatory responses underlying acute viral bronchiolitis in infants (NHMRC Project grant administered by The University of Western Australia)
    University of Western Australia
    Open grant
  • 2013 - 2017
    Prevention of asthma in young children via immunostimulation
    NHMRC Project Grant
    Open grant
  • 2012 - 2013
    A high-throughput screening and sequencing facility for single cell genomics
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2012
    Does Azithromycin prevent viral respiratory infection in CF infants
    Royal Children's Hospital Foundation
    Open grant
  • 2012
    Tandem fluorescent and phase-contrast imaging of live cells in real time for application to cancer cell biology, developmental biology, respiratory biology, wound healing investigation and cellular to
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2013
    The airway epithelium in paediatric respiratory diseases
    UWA-UQ Bilateral Research Collaboration Award
    Open grant
  • 2012 - 2014
    Winter-only treatment with omalizumab to prevent asthma exacerbations in children.
    NHMRC Project Grant
    Open grant
  • 2011 - 2012
    Ultra-high-performance liquid chromatography ion trap mass spectrometer to develop new capabilities in environmental and human toxicology
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2011 - 2012
    Preschool lung function in Spinal Muscular Atrophy
    ANZ Executors and Trustees' Company Ltd
    Open grant
  • 2011
    Assessing airway hyperreactivity using flexiVent
    RL Cooper Medical Research Foundation Limited
    Open grant
  • 2011 - 2016
    Children's Health and Environment Program
    Royal Children's Hospital Foundation
    Open grant
  • 2011
    Establishment of a shared multiplex molecular profiling facility for clinical and translational research in child health
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2013
    Rhinovirus impairs physiological and immunological lung development and causes exacerbation of allergic airways disease
    ARC Discovery Projects
    Open grant
  • 2010 - 2016
    Inflammatory airways disease in children with a focus on cystic fibrosis
    Royal Children's Hospital Foundation
    Open grant
  • 2010
    NHMRC Research Fellowship (SPRF)
    NHMRC Research Fellowship
    Open grant
  • 2010 - 2016
    Senior Clinical Research Fellowship
    Queensland Senior Clinical Research Fellowship
    Open grant

Availability

Professor Peter Sly is:
Not available for supervision

Supervision history

Current supervision

  • Doctor Philosophy

    Role of airway obstruction in the development of asthma

    Principal Advisor

    Other advisors: Dr Tamara Blake

  • Doctor Philosophy

    Respiratory Guidelines for the Management of Paediatric Neuromuscular Disease

    Principal Advisor

    Other advisors: Dr Zephanie Tyack

  • Doctor Philosophy

    Maternal exposure to phthalates and allergic disease in children

    Principal Advisor

    Other advisors: Dr Dwan Vilcins

  • Doctor Philosophy

    Improving detection of pulmonary graft-vs-host disease (pGVHD) post haematopoietic stem cell transplantation (HSCT)

    Associate Advisor

    Other advisors: Dr Tamara Blake, Professor Paul Robinson

  • Doctor Philosophy

    Providing evidence to guide public health messages during bushfire smoke events

    Associate Advisor

    Other advisors: Dr Dwan Vilcins

  • Doctor Philosophy

    Investigations into the importance of antimicrobial residues in the surveillance of antimicrobial resistance in peri-urban dairy farms of Nepal

    Associate Advisor

    Other advisors: Dr Deirdre Mikkelsen, Dr Nicholas Clark, Professor Ricardo Soares Magalhaes

Completed supervision

Enquiries

Contact Professor Peter Sly directly for media enquiries about:

  • Child health
  • Children and environment
  • Cystic fibrosis
  • Paediatric asthma
  • Respiratory physiology

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