Professor Peter Sly
Professor

Peter Sly

Email: 
Phone: 
+61 7 3069 7383

Background

Professor Peter Sly is the Director, Children's Health and Environment Program. Professor Sly is a NHMRC Leadership Fellow (L3) and an emeritus paediatric respiratory physician with extensive research experience in respiratory physiology, developmental immunology and children's environmental health. Professor Sly’s research aims to understand the mechanisms underlying chronic childhood lung diseases in order to improve clinical management and to delay or prevent their onset, with consequent reductions in adult lung diseases. A combination of basic science, longitudinal cohort studies and translation of research findings into clinical practice, including clinical trials, are included in three main areas: asthma, cystic fibrosis and children’s environmental health

Professor Sly is an advisor to the World Health Organisation Department of Public Health, Environmental and Social Determinants of Disease and currently serves on International Advisory Boards and committees, including: WHO network of Collaborating Centres in Children’s Environmental Health; Canadian Healthy Infant Longitudinal Development (CHILD) Study, Canada; the Infant Lung Health Study, Paarl, South Africa; and A SHARED Future: Achieving Strength, Health, and Autonomy, through Renewable Energy Development for the Future.

Availability

Professor Peter Sly is:
Not available for supervision
Media expert

Fields of research

Biomedical and Clinical Sciences Cardiovascular medicine and haematology Clinical sciences Environmental Sciences Immunology Respiratory diseases

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, University of Melbourne
  • Doctoral Diploma of Medicine, University of Melbourne
  • Doctoral Diploma of Science (Advanced), University of Western Australia

Research interests

  • Asthma

    Understanding mechanisms that underlie risks for developing asthma in susceptible children

  • Cystic Fibrosis

    Understanding the mechanisms underlying the development of lung disease early in life and why and how this progresses

  • Impact of environmental exposures in early life

    Improving methods of assessing environmental exposures during fetal development and in early postnatal life. Improving methods for assessing the effects of early life environmental exposures and understanding how these increase long-tern risk of chronic disease.

Search Professor Peter Sly’s works on UQ eSpace

1176 works between 1980 and 2025
All (1176) Journal Article (939) Book Chapter (22) Conference Publication (204) Book (3) Other Outputs (8)

941 - 960 of 1176 works

2000

Journal Article

Sevoflurane for patients with asthma - Response

Habre, W and Sly, PD (2000). Sevoflurane for patients with asthma - Response. Anesthesia and Analgesia, 91 (1), 245-246. doi: 10.1097/00000539-200007000-00051

Sevoflurane for patients with asthma - Response

2000

Journal Article

Development of immunologic memory against tetanus toxoid and pertactin antigens from the diphtheria-tetanus-pertussis vaccine in atopic versus nonatopic children

Holt, Patrick G., Rudin, Anna, Macaubas, Claudia, Holt, Barbara J., Rowe, Julie, Loh, Richard and Sly, Peter D. (2000). Development of immunologic memory against tetanus toxoid and pertactin antigens from the diphtheria-tetanus-pertussis vaccine in atopic versus nonatopic children. Journal of Allergy and Clinical Immunology, 105 (6), 1117-1122. doi: 10.1067/mai.2000.105804

Development of immunologic memory against tetanus toxoid and pertactin antigens from the diphtheria-tetanus-pertussis vaccine in atopic versus nonatopic children

2000

Journal Article

Differential effects of nitric oxide synthase inhibitors in an in vivo allergic rat model

Tulic, M.K., Wale, J.L., Holt, P.G. and Sly, P.D. (2000). Differential effects of nitric oxide synthase inhibitors in an in vivo allergic rat model. European Respiratory Journal, 15 (5), 870-877. doi: 10.1183/09031936.00.15587000

Differential effects of nitric oxide synthase inhibitors in an in vivo allergic rat model

2000

Journal Article

Modification of the inflammatory response to allergen challenge after exposure to bacterial lipopolysaccharide

Tulic, M.K., Wale, J.L., Holt, P.G. and Sly, P.D. (2000). Modification of the inflammatory response to allergen challenge after exposure to bacterial lipopolysaccharide. American Journal of Respiratory Cell and Molecular Biology, 22 (5), 604-612.

Modification of the inflammatory response to allergen challenge after exposure to bacterial lipopolysaccharide

2000

Journal Article

Pulmonary vascular congestion selectively potentiates airway responsiveness in piglets

Uhlig, T., Wildhaber, J.H., Carroll, N., Turner, D.J., Gray, P.R., Dore, N., James, A.L. and Sly, P.D. (2000). Pulmonary vascular congestion selectively potentiates airway responsiveness in piglets. American Journal of Respiratory and Critical Care Medicine, 161 (4), 1306-1313. doi: 10.1164/ajrccm.161.4.9707115

Pulmonary vascular congestion selectively potentiates airway responsiveness in piglets

2000

Conference Publication

Influence of lung mechanics on pressure transmission during HFOV in preterm lambs

Pillow, JJ, Hantos, Z and Sly, PD (2000). Influence of lung mechanics on pressure transmission during HFOV in preterm lambs. BALTIMORE: INT PEDIATRIC RESEARCH FOUNDATION, INC.

Influence of lung mechanics on pressure transmission during HFOV in preterm lambs

2000

Conference Publication

Inflammatory changes in the fetal sheep lung after in utero endotoxin exposure

Willet, KE, Jobe, AH, Ikegami, M, Newnham, JP and Sly, PD (2000). Inflammatory changes in the fetal sheep lung after in utero endotoxin exposure. BALTIMORE: INT PEDIATRIC RESEARCH FOUNDATION, INC.

Inflammatory changes in the fetal sheep lung after in utero endotoxin exposure

2000

Journal Article

In vitro assessment of an ultrasonic flowmeter for use in ventilated infants

Scalfaro, P., Cotting, J. and Sly, P. D. (2000). In vitro assessment of an ultrasonic flowmeter for use in ventilated infants. European Respiratory Journal, 15 (3), 566-569. doi: 10.1034/j.1399-3003.2000.15.23.x

In vitro assessment of an ultrasonic flowmeter for use in ventilated infants

2000

Journal Article

Effects of antenatal endotoxin and glucocorticoids on the lungs of preterm lambs

Jobe, Alan H., Newnham, John P., Willet, Karen E., Sly, Peter, Ervin, M.Gore, Bachurski, Cindy, Possmayer, Fred, Hallman, Mikko and Ikegami, Machiko (2000). Effects of antenatal endotoxin and glucocorticoids on the lungs of preterm lambs. American Journal of Obstetrics and Gynecology, 182 (2), 401-408. doi: 10.1016/S0002-9378(00)70231-6

Effects of antenatal endotoxin and glucocorticoids on the lungs of preterm lambs

2000

Conference Publication

The raised volume rapid thoracoabdominal compression technique

Allen, J., Castile, R., Gappa, M., Henschen, M., Lesouef, P., McNamara, J., Morgan, W., Morris, M., Panitch, H., Silverman, M., Sly, P., Stocks, J. and Tepper, R. (2000). The raised volume rapid thoracoabdominal compression technique. American Lung Association. doi: 10.1164/ajrccm.161.5.ats700

The raised volume rapid thoracoabdominal compression technique

2000

Conference Publication

Protective effects of volatile agents against methacholine-induced bronchoconstriction in rats

Habre, W., Petak, F., Sly, P.D., Hantos, Z. and Morel, D.R. (2000). Protective effects of volatile agents against methacholine-induced bronchoconstriction in rats. American Society of Anesthesiologist Annual Meeting, San Francisco, CA, United States, 14-18 October 2000. Philadelphia, PA, United States: Lippincott Williams & Wilkins.

Protective effects of volatile agents against methacholine-induced bronchoconstriction in rats

1999

Journal Article

Development of allergen-specific T-cell memory in atopic and normal children

Prescott, S. L., Macaubas, C., Smallacombe, T., Holt, B. J., Sly, P. D. and Holt, P. G. (1999). Development of allergen-specific T-cell memory in atopic and normal children. Pneumologie, 53 (5)

Development of allergen-specific T-cell memory in atopic and normal children

1999

Journal Article

Low frequency forced oscillation technique in infants

Hall, Graham L., Hantos, Zoltan, Pelak, Ferenc, Wildhaber, Johannes and Sly, Peter D. (1999). Low frequency forced oscillation technique in infants. Respirology, 4 (SUPPL. 1)

Low frequency forced oscillation technique in infants

1999

Journal Article

Unrecognised implications of ventilatory settings and lung mechanics on pressure during high frequency oscillation

Pillow, Jane, Bates, Jason, Sly, Peter, Wilkinson, Mal and Ramsden, Andrew (1999). Unrecognised implications of ventilatory settings and lung mechanics on pressure during high frequency oscillation. Respirology, 4 (SUPPL. 1)

Unrecognised implications of ventilatory settings and lung mechanics on pressure during high frequency oscillation

1999

Journal Article

Respiratory mechanics during sevoflurane anesthesia in children with and without asthma

Habre, Walid, Scalfaro, Pietro, Sims, Craig, Tiller, Katrina and Sly, Peter D. (1999). Respiratory mechanics during sevoflurane anesthesia in children with and without asthma. Anesthesia and Analgesia, 89 (5), 1177-1181.

Respiratory mechanics during sevoflurane anesthesia in children with and without asthma

1999

Journal Article

The role of allergy in the development of asthma

Holt, P.G., Macaubas, C., Stumbles, P.A. and Sly, P.D. (1999). The role of allergy in the development of asthma. Nature, 402 (6760 Supp.1), B12-B17.

The role of allergy in the development of asthma

1999

Journal Article

Effects of salbutamol and Ro-20-1724 on airway and parenchymal mechanics in rats

Petak, F., Wale, J. L. and Sly, P. D. (1999). Effects of salbutamol and Ro-20-1724 on airway and parenchymal mechanics in rats. Journal of Applied Physiology, 87 (4), 1373-1380.

Effects of salbutamol and Ro-20-1724 on airway and parenchymal mechanics in rats

1999

Journal Article

big gammadelta T cells provide a breath of fresh air for asthma research

Holt, Patrick G. and Sly, P.D. (1999). big gammadelta T cells provide a breath of fresh air for asthma research. Nature Medicine, 5 (10), 1127-1128. doi: 10.1038/13447

big gammadelta T cells provide a breath of fresh air for asthma research

1999

Journal Article

Regulation of T-helper cell responses to inhalant allergen during early childhood

Macaubas, C., Sly, P.D., Burton, P., Tiller, K., Yabuhara, A., Holt, B.J., Smallacombe, T.B., Kendall, G., Jenmalm, M.C. and Holt, PG (1999). Regulation of T-helper cell responses to inhalant allergen during early childhood. Clinical And Experimental Allergy, 29 (9), 1223-1231. doi: 10.1046/j.1365-2222.1999.00654.x

Regulation of T-helper cell responses to inhalant allergen during early childhood

1999

Journal Article

Association between breast feeding and asthma in 6 year old children: findings of a prospective birth cohort study

Oddy, W.H., Holt, P.G., Sly, P.D., Read, A.W., Landau, L.I., Stanley, F.J., Kendall, G.E. and Burton, P.R. (1999). Association between breast feeding and asthma in 6 year old children: findings of a prospective birth cohort study. BMJ, 319 (7213), 815-819. doi: 10.1136/bmj.319.7213.815

Association between breast feeding and asthma in 6 year old children: findings of a prospective birth cohort study

Current funding

  • 2025 - 2026
    Think ZINC: Zinc immune-related Needs in Cystic fibrosis
    Cure4CF Foundation Research Grants
    Open grant
  • 2021 - 2025
    Early life exposures and chronic disease: mechanisms and preventative strategies
    NHMRC Investigator Grants
    Open grant
  • 2020 - 2025
    Exposure to Trihalomethanes in pregnancy and birth outcomes in Queensland: integrated data analysis and case studies for better policy and health outcomes
    NHMRC Partnership Projects
    Open grant
  • 2020 - 2025
    Ataxia-telangiectasia: treating mitochondrial dysfunction with a novel form of anaplerosis
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2019 - 2025
    Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMAT)
    Cystic Fibrosis Foundation USA
    Open grant
  • 2019 - 2025
    Queensland cystic fibrosis research program
    The Children's Hospital Foundation
    Open grant

Past funding

  • 2021 - 2023
    Identifying preschool children with wheeze at risk of developing asthma using temporal oscillometry
    Thrasher Research Fund
    Open grant
  • 2021 - 2022
    Zinc supplementation to enhance bacterial killing ability of macrophages from cystic fibrosis (CF)
    Preclinical and Clinical Early Career Research
    Open grant
  • 2021 - 2024
    Prevention of wheeze-associated hospitalisation in preschoolers with the immunomodulator OM85: a multi-centre, randomised, double-blind... (NHMRC CTCS Administered by Deakin University)
    Deakin University
    Open grant
  • 2020 - 2024
    Prenatal environments, offspring neurodevelopment and epigenetic programming (MRFF Preventative and Public Health Research Grant led by University of Melbourne)
    University of Melbourne
    Open grant
  • 2020 - 2021
    Reducing acute severe respiratory events in health care workers during the Covid-19 pandemic with OM85
    NHMRC MRFF Coronavirus Research Response
    Open grant
  • 2020 - 2022
    Development of CFTR-knockout monocytic cell line and understanding why patients with CF are vulnerable to Mycobacterium abscessus (MABS) infection
    Australian Cystic Fibrosis Research Trust Innovation Grant
    Open grant
  • 2020 - 2022
    Improving the ability of CF macrophages to handle mycobacterium abscessus (MABS)
    Vertex Innovation Awards
    Open grant
  • 2019 - 2024
    Early life origins of cystic fibrosis lung disease
    Cystic Fibrosis Foundation USA
    Open grant
  • 2019 - 2023
    Wearing masks to reduce traffic-related air pollution exposure and improve children's respiratory health
    NHMRC-NAFOSTED Joint Call for Collaborative Research Projects Grants
    Open grant
  • 2018 - 2019
    Differentiation and polarization of macrophages
    Corbus Pharmaceuticals Australia Pty Ltd
    Open grant
  • 2018 - 2021
    Macrophage Polarisation and Control of Pulmonary Inflammation
    NHMRC Project Grant
    Open grant
  • 2018 - 2021
    Maternal carriage of Prevotella during pregnancy influences offspring innate immune responses and asthma at age 7 (NHMRC Project Grant led by Deakin University)
    Deakin University
    Open grant
  • 2018 - 2022
    Multi-centre, multi-disciplinary study using a systems biology approach to investigate immunomodulation in children with acute wheeze (NHMRC Project Grant led by UWA)
    University of Western Australia
    Open grant
  • 2017 - 2019
    The impact of direct acting antivirals and inhibitors of host innate immune cell signalling (macrolide, SYK, PAD4) on innate immune cell function in response to infection of airway epithelial cells.
    Gilead Pty Ltd
    Open grant
  • 2017 - 2019
    Developing objective criteria for discharge following hospitalization for acute pulmonary exacerbation in cystic fibrosis.
    The Children's Hospital Foundation
    Open grant
  • 2017 - 2019
    A randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy and safety of dupilumab in children 6 to <12 years of age with uncontrolled persistent asthma
    Sanofi-Aventis Australia Pty Ltd
    Open grant
  • 2017
    Addressing Needs for High Nucleic Acid Quantification Accuracy and Precision in Child Health Research
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016 - 2019
    Macrophages: the forgotten cells in CF lung disease
    Cystic Fibrosis Foundation Therapeutics Inc
    Open grant
  • 2016 - 2018
    Investigation of the role of oxidative stress in pulmonary disease in ataxia-telangiectasia
    The A-T Children's Project
    Open grant
  • 2016 - 2019
    Children's Health and Environment Program
    The Children's Hospital Foundation
    Open grant
  • 2016 - 2020
    Early life exposures and chronic disease: mechanisms and preventative strategies
    NHMRC Research Fellowship
    Open grant
  • 2016
    Integrative blood coagulation research core facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2018
    Airborne transmission of microorganisms among persons with cystic fibrosis
    Queensland Institute of Medical Research
    Open grant
  • 2015 - 2019
    Immune recognition of upper airway microbiota in early life as a determinant of respiratory health in children
    NHMRC Project Grant
    Open grant
  • 2015 - 2019
    The effect of asthma control during pregnancy on markers of airways inflammation and lung function in the offspring (NHMRC Project Grant administered by The University of Newcastle)
    University of Newcastle
    Open grant
  • 2014 - 2019
    Biomonitoring early life exposure to plastic products in Australia and assessing health consequences (NHMRC Partnership Project administered by Murdoch Childrens Research Institute)
    Murdoch Childrens Research Institute
    Open grant
  • 2014 - 2015
    Microflow ultra high pressure liquid chromatography - high resolution mass spectrometry for chemical exposure monitoring
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2014 - 2015
    Efficacy of OM-85 in the reduction of lower respiratory events in atopic children with asthma
    OM Pharma SA
    Open grant
  • 2014 - 2021
    International Collaboration to Improve Respiratory Health in Children (INCIRCLE)
    European Respiratory Society - Clinical Research Collaborations
    Open grant
  • 2014 - 2015
    A Phase 1b, Randomized, Double-Blind, Placebo Controlled, Single-Dose Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GS-5806 in Subjects < 24 Months of Age [...]
    Gilead Pty Ltd
    Open grant
  • 2014 - 2017
    Antiviral defects of the airway epithelium associated with wheeze and atopy in children
    NHMRC Project Grant
    Open grant
  • 2014
    Optimising the utility of paediatric research samples using advanced liquid handling and dispensing equipment
    NHMRC Equipment Grant
    Open grant
  • 2013 - 2017
    Clinical and psychosocial changes over late childhood and adolescence and early life determinants of long term clinical outcomes in cystic fibrosis
    NHMRC Project Grant
    Open grant
  • 2013 - 2014
    A Phase 1b, Randomized, Double-Blind, Placebo Controlled, Single-Dose Ranging Study Evaluating the Safety, Tolerability, and Pharmacokinetics of GS-5806 in Subjects < 24 Months of Age [...]
    Gilead Clinical Trial
    Open grant
  • 2013 - 2015
    Characterization of cellular inflammatory responses underlying acute viral bronchiolitis in infants (NHMRC Project grant administered by The University of Western Australia)
    University of Western Australia
    Open grant
  • 2013 - 2017
    Prevention of asthma in young children via immunostimulation
    NHMRC Project Grant
    Open grant
  • 2012 - 2013
    A high-throughput screening and sequencing facility for single cell genomics
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2012
    Does Azithromycin prevent viral respiratory infection in CF infants
    Royal Children's Hospital Foundation
    Open grant
  • 2012
    Tandem fluorescent and phase-contrast imaging of live cells in real time for application to cancer cell biology, developmental biology, respiratory biology, wound healing investigation and cellular to
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2013
    The airway epithelium in paediatric respiratory diseases
    UWA-UQ Bilateral Research Collaboration Award
    Open grant
  • 2012 - 2014
    Winter-only treatment with omalizumab to prevent asthma exacerbations in children.
    NHMRC Project Grant
    Open grant
  • 2011 - 2012
    Ultra-high-performance liquid chromatography ion trap mass spectrometer to develop new capabilities in environmental and human toxicology
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2011 - 2012
    Preschool lung function in Spinal Muscular Atrophy
    ANZ Executors and Trustees' Company Ltd
    Open grant
  • 2011
    Assessing airway hyperreactivity using flexiVent
    RL Cooper Medical Research Foundation Limited
    Open grant
  • 2011 - 2016
    Children's Health and Environment Program
    Royal Children's Hospital Foundation
    Open grant
  • 2011
    Establishment of a shared multiplex molecular profiling facility for clinical and translational research in child health
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2013
    Rhinovirus impairs physiological and immunological lung development and causes exacerbation of allergic airways disease
    ARC Discovery Projects
    Open grant
  • 2010 - 2016
    Inflammatory airways disease in children with a focus on cystic fibrosis
    Royal Children's Hospital Foundation
    Open grant
  • 2010
    NHMRC Research Fellowship (SPRF)
    NHMRC Research Fellowship
    Open grant
  • 2010 - 2016
    Senior Clinical Research Fellowship
    Queensland Senior Clinical Research Fellowship
    Open grant

Availability

Professor Peter Sly is:
Not available for supervision

Supervision history

Current supervision

  • Doctor Philosophy

    Role of airway obstruction in the development of asthma

    Principal Advisor

    Other advisors: Dr Tamara Blake

  • Doctor Philosophy

    Characterising the Environmental Burden of E-waste and its Impacts on Children¿s and Women's Health

    Principal Advisor

  • Doctor Philosophy

    Maternal exposure to phthalates and allergic disease in children

    Principal Advisor

    Other advisors: Dr Dwan Vilcins

  • Doctor Philosophy

    Respiratory Guidelines for the Management of Paediatric Neuromuscular Disease

    Principal Advisor

    Other advisors: Dr Zephanie Tyack

  • Doctor Philosophy

    Characterizing the Environmental Burden and Health Impact of Electronic Waste (e-waste) in Bangladesh

    Principal Advisor

  • Doctor Philosophy

    Mitigating the health impacts of air pollution in Australia: From research to policy.

    Associate Advisor

    Other advisors: Professor Brian Head, Associate Professor Nina Lansbury

  • Doctor Philosophy

    Mitigating the health impacts of air pollution in Australia. From research to policy

    Associate Advisor

    Other advisors: Professor Brian Head, Associate Professor Nina Lansbury

  • Doctor Philosophy

    Epidemiological investigations into avian influenza virus environmental contamination in live bird markets of Dhaka's metropolitan area, Bangladesh

    Associate Advisor

    Other advisors: Dr Nicholas Clark, Professor Ricardo Soares Magalhaes

  • Doctor Philosophy

    Improving detection of pulmonary graft-vs-host disease (pGVHD) post haematopoietic stem cell transplantation (HSCT)

    Associate Advisor

    Other advisors: Dr Tamara Blake, Professor Paul Robinson

  • Doctor Philosophy

    Mitigating the health impacts of air pollution in Australia: From research to policy.

    Associate Advisor

    Other advisors: Professor Brian Head, Associate Professor Nina Lansbury

  • Doctor Philosophy

    Providing evidence to guide public health messages during bushfire smoke events

    Associate Advisor

    Other advisors: Dr Dwan Vilcins

  • Doctor Philosophy

    Evaluation of Integrated Surveillance of Antimicrobial Resistance in South and South East Asian Countries

    Associate Advisor

    Other advisors: Dr Deirdre Mikkelsen, Dr Nicholas Clark, Professor Ricardo Soares Magalhaes

  • Doctor Philosophy

    Epidemiological investigations into avian influenza virus environmental contamination in live bird markets of Dhaka's metropolitan area, Bangladesh

    Associate Advisor

    Other advisors: Dr Nicholas Clark, Professor Ricardo Soares Magalhaes

  • Doctor Philosophy

    Epidemiological investigations into avian influenza virus environmental contamination in live bird markets of Dhaka¿s metropolitan area, Bangladesh

    Associate Advisor

    Other advisors: Dr Nicholas Clark, Professor Ricardo Soares Magalhaes

  • Doctor Philosophy

    Investigations into the importance of antimicrobial residues in the surveillance of antimicrobial resistance in peri-urban dairy farms of Nepal

    Associate Advisor

    Other advisors: Dr Deirdre Mikkelsen, Dr Nicholas Clark, Professor Ricardo Soares Magalhaes

  • Doctor Philosophy

    Air pollution, oxidative stress and dietary antioxidants

    Associate Advisor

    Other advisors: Dr Dwan Vilcins

  • Doctor Philosophy

    Epidemiological investigations into avian influenza virus environmental contamination in live bird markets of Dhaka¿s metropolitan area, Bangladesh

    Associate Advisor

    Other advisors: Dr Nicholas Clark, Professor Ricardo Soares Magalhaes

Completed supervision

Enquiries

Contact Professor Peter Sly directly for media enquiries about:

  • Child health
  • Children and environment
  • Cystic fibrosis
  • Paediatric asthma
  • Respiratory physiology

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