![Dr Malcolm Lim](/sites/default/files/profiles/24296.jpeg)
Overview
Background
Dr Malcolm Lim is an experienced Cancer Biologist and His research interest spans cancer biology, biomarker discovery and theranostic nanomedicine.
He received his PhD from the University of Queensland (UQ) in 2022. His research, conducted in the labs of Professors Sunil Lakhani and Kristofer Thurecht, involved evaluating the efficacy of using nanomedicine for precision delivery of chemo- or radiotherapeutics against biomarkers in brain metastases. For this work, he developed a clinically-relevant brain metastasis mouse model. His research was recognised with the UQ Dean’s Award for Outstanding Thesis 2022. (DOIs: 10.1021/acs.molpharmaceut.3c00558, 10.3791/64216)
Currently, Malcolm serves as a Postdoctoral Research Fellow at the ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals (AMTAR) and the Thurecht’s Lab at UQ-Centre for Advanced Imaging (CAI) in Australian Institute for Bioengineering and Nanotechnology (AIBN), where he will apply his multidisciplinary expertise to explore radiobiology and radiation-induced biological responses and to advance targeted pharmaceuticals for challenging cancers.
Prior to joining AMTAR, Malcolm served as a Postdoctoral Researcher where he investigated the molecular mechanisms underlying Early Breast Cancers at the Molecular Breast Pathology Lab, UQ-Centre for Clinical Research, under the mentorship of Professors Sunil Lakhani and Peter Simpson. Before his academic career, Malcolm had five years of experience as a histologist, which provided him with a broad skillset in the field.
Dr Malcolm’s research is well-documented in numerous publications in biomedical research journals despite his career stage, reflecting his passion to advancing cancer research.
Availability
- Dr Malcolm Lim is:
- Available for supervision
Fields of research
Qualifications
- Diploma of Biomedical Science, unknown
- Bachelor of Science, The University of Queensland
- Bachelor (Honours) of Cancer Cell Biology, The University of Queensland
- Doctor of Philosophy of Cancer Cell Biology, The University of Queensland
Research interests
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Brain metastasis
Mechanisms underpinning the development of brain metastasis and new therapeutic strategies, CNS-penetrating targeted therapeutics, metastatic animal models
Works
Search Professor Malcolm Lim’s works on UQ eSpace
2024
Conference Publication
LobSig4 is a superior and readily implementable ILC-focussed prognostic biomarker set
Kalinowski, Lauren, Kutasovic, Jamie, Srihari, Sriganesh, Feng, Yufan, Lal, Samir, Ferguson, Kaltin, Chittoory, Haarika, Sokolova, Anna, Lim, Malcolm, De Croft, Priyakshi Kalita, Lakhani, Sunil, Simpson, Peter and Reed, Amy McCart (2024). LobSig4 is a superior and readily implementable ILC-focussed prognostic biomarker set. San Antonio Breast Cancer Symposium 2023, San Antonio, TX United States, 5-9 December 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.sabcs23-po3-15-09
2024
Journal Article
B7-H3 expression in breast cancer and brain metastasis
Joshi, Vaibhavi, Beecher, Kate, Lim, Malcolm, Stacey, Andrew, Feng, Yufan, Jat, Parmjit S., Duijf, Pascal H. G., Simpson, Peter T., Lakhani, Sunil R. and McCart Reed, Amy E. (2024). B7-H3 expression in breast cancer and brain metastasis. International Journal of Molecular Sciences, 25 (7) 3976, 1-17. doi: 10.3390/ijms25073976
2023
Journal Article
Targeted hyperbranched nanoparticles for delivery of doxorubicin in breast cancer brain metastasis
Lim, Malcolm, Fletcher, Nicholas L., Saunus, Jodi M., McCart Reed, Amy E., Chittoory, Haarika, Simpson, Peter T., Thurecht, Kristofer J. and Lakhani, Sunil R. (2023). Targeted hyperbranched nanoparticles for delivery of doxorubicin in breast cancer brain metastasis. Molecular Pharmaceutics, 20 (12), 6169-6183. doi: 10.1021/acs.molpharmaceut.3c00558
2023
Journal Article
COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis
Hancock, Janelle L., Kalimutho, Murugan, Straube, Jasmin, Lim, Malcolm, Gresshoff, Irma, Saunus, Jodi M., Lee, Jason S., Lakhani, Sunil R., Simpson, Kaylene J., Bush, Ashley I., Anderson, Robin L. and Khanna, Kum Kum (2023). COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis. Journal of Experimental and Clinical Cancer Research, 42 (1) 90, 1-16. doi: 10.1186/s13046-023-02663-8
2022
Journal Article
Modeling brain metastasis by internal carotid artery injection of cancer cells
Lim, Malcolm, Fletcher, Nicholas, Reed, Amy Mccart, Flint, Melanie, Thurecht, Kristofer, Saunus, Jodi and Lakhani, Sunil R. (2022). Modeling brain metastasis by internal carotid artery injection of cancer cells. Journal of Visualized Experiments, 2022 (186) e64216. doi: 10.3791/64216
2022
Other Outputs
Development of theranostic nanomedicines for breast cancer brain metastases
Lim, Malcolm (2022). Development of theranostic nanomedicines for breast cancer brain metastases. PhD Thesis, Medicine Faculty, The University of Queensland. doi: 10.14264/1e7615d
2022
Journal Article
Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer
Saunus, Jodi M., De Luca, Xavier M., Northwood, Korinne, Raghavendra, Ashwini, Hasson, Alexander, McCart Reed, Amy E., Lim, Malcolm, Lal, Samir, Vargas, A. Cristina, Kutasovic, Jamie R., Dalley, Andrew J., Miranda, Mariska, Kalaw, Emarene, Kalita-de Croft, Priyakshi, Gresshoff, Irma, Al-Ejeh, Fares, Gee, Julia M. W., Ormandy, Chris, Khanna, Kum Kum, Beesley, Jonathan, Chenevix-Trench, Georgia, Green, Andrew R., Rakha, Emad A., Ellis, Ian O., Nicolau, Dan V., Simpson, Peter T. and Lakhani, Sunil R. (2022). Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer. npj Breast Cancer, 8 (1) 57, 1-16. doi: 10.1038/s41523-022-00425-x
2022
Journal Article
Landscape of epidermal growth factor receptor heterodimers in brain metastases
Lim, Malcolm, Nguyen, Tam H., Niland, Colleen, Reid, Lynne E., Jat, Parmjit S., Saunus, Jodi M. and Lakhani, Sunil R. (2022). Landscape of epidermal growth factor receptor heterodimers in brain metastases. Cancers, 14 (3) ARTN 533, 533. doi: 10.3390/cancers14030533
2021
Journal Article
Characterization of immune cell subsets of tumor infiltrating lymphocytes in brain metastases
Croft, Priyakshi Kalita-de, Chittoory, Haarika, Nguyen, Tam H., Saunus, Jodi M., Kim, Woo Gyeong, Reed, Amy E. McCart, Lim, Malcolm, De Luca, Xavier M., Ferguson, Kaltin, Niland, Colleen, Mazzieri, Roberta, Dolcetti, Riccardo, Simpson, Peter T. and Lakhani, Sunil R. (2021). Characterization of immune cell subsets of tumor infiltrating lymphocytes in brain metastases. Biology, 10 (5) 425, 425. doi: 10.3390/biology10050425
2020
Journal Article
Metaplastic breast cancers frequently express immune checkpoint markers FOXP3 and PD-L1
Kalaw, Emarene, Lim, Malcolm, Kutasovic, Jamie R., Sokolova, Anna, Taege, Lucinda, Johnstone, Kate, Bennett, James, Saunus, Jodi M., Niland, Colleen, Ferguson, Kaltin, Gresshoff, Irma, Bettington, Mark, Pathmanathan, Nirmala, Tse, Gary M., Papadimos, David, Pathmanathan, Rajadurai, Harris, Gavin, Yamaguchi, Rin, Tan, Puay Hoon, Fox, Stephen, O’Toole, Sandra A., Simpson, Peter T., Lakhani, Sunil R. and McCart Reed, Amy E. (2020). Metaplastic breast cancers frequently express immune checkpoint markers FOXP3 and PD-L1. British Journal of Cancer, 123 (11), 1665-1672. doi: 10.1038/s41416-020-01065-3
2020
Journal Article
Clinicopathologic significance of nuclear HER4 and phospho-YAP(S127) in human breast cancers and matching brain metastases
Kalita-de Croft, Priyakshi, Lim, Malcolm, Chittoory, Haarika, de Luca, Xavier M., Kutasovic, Jamie R., Day, Bryan W., Al-Ejeh, Fares, Simpson, Peter T., McCart Reed, Amy E., Lakhani, Sunil R. and Saunus, Jodi M. (2020). Clinicopathologic significance of nuclear HER4 and phospho-YAP(S127) in human breast cancers and matching brain metastases. Therapeutic Advances in Medical Oncology, 12 ARTN 1758835920946259, 175883592094625. doi: 10.1177/1758835920946259
2020
Journal Article
Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancer
Adwal, Alaknanda, Kalita-de Croft, Priyakshi, Shakya, Reshma, Lim, Malcolm, Kalaw, Emarene, Taege, Lucinda D., McCart Reed, Amy E., Lakhani, Sunil R., Callen, David F. and Saunus, Jodi M. (2020). Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancer. Life Science Alliance, 3 (7) e201900562, 1-12. doi: 10.26508/lsa.201900562
2019
Journal Article
Proteomic analysis of the breast cancer brain metastasis microenvironment
Kalita-de Croft, Priyakshi, Straube, Jasmin, Lim, Malcolm, Al-Ejeh, Fares, Lakhani, Sunil R. and Saunus, Jodi M. (2019). Proteomic analysis of the breast cancer brain metastasis microenvironment. International Journal of Molecular Sciences, 20 (10) 2524, 2524. doi: 10.3390/ijms20102524
2019
Journal Article
Innovative therapeutic strategies for effective treatment of brain metastases
Lim, Malcolm, Puttick, Simon, Houston, Zachary H., Thurecht, Kristofer J., Kalita-de Croft, Priyakshi, Mahler, Stephen, Rose, Stephen E., Jeffree, Rosalind L., Mazzieri, Roberta, Dolcetti, Riccardo, Lakhani, Sunil R. and Saunus, Jodi M. (2019). Innovative therapeutic strategies for effective treatment of brain metastases. International Journal of Molecular Sciences, 20 (6) 1280, 1280. doi: 10.3390/ijms20061280
2019
Journal Article
Phenotypic and molecular dissection of Metaplastic Breast Cancer and the prognostic implications
McCart Reed, Amy Ellen, Kalaw, Emarene, Nones, Katia, Bettington, Mark, Lim, Malcolm, Bennett, James, Johnstone, Kate, Kutasovic, Jamie Rose, Saunus, Jodi Marie, Kazakoff, Stephen, Xu, Qinying, Wood, Scott, Holmes, Oliver, Leonard, Conrad, Reid, Lynne Estelle, Black, Debra, Niland, Colleen, Ferguson, Kaltin, Gresshoff, Irma, Raghavendra, Ashwini, Harvey, Kate, Cooper, Caroline, Liu, Cheng, Kalinowski, Lauren, Reid, Andrew Scott, Davidson, Morgan, Pearson, John V, Pathmanathan, Nirmala, Tse, Gary ... Lakhani, Sunil R. (2019). Phenotypic and molecular dissection of Metaplastic Breast Cancer and the prognostic implications. Journal of Pathology, 247 (2), 214-227. doi: 10.1002/path.5184
2018
Journal Article
Neuronal defects an etiological factor in congenital pelviureteric junction obstruction?
How, Guo Yuan, Chang, Kenneth Tou En, Jacobsen, Anette Sundfor, Yap, Te-Lu, Ong, Caroline Choo Phaik, Low, Yee, Allen, John Carson, Kuick, Chik Hong, Lim, Malcolm Zhun Leong and Laksmi, Narasimhan Kannan (2018). Neuronal defects an etiological factor in congenital pelviureteric junction obstruction?. Journal of Pediatric Urology, 14 (1), 51.e1-51.e7. doi: 10.1016/j.jpurol.2017.07.014
2017
Journal Article
DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer
Hernandez-Perez, S., Cabrera, E., Salido, E., Lim, M., Reid, L., Lakhani, S. R., Khanna, K. K., Saunus, J. M. and Freire, R. (2017). DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer. Oncogene, 36 (33), 4802-4809. doi: 10.1038/onc.2017.21
2017
Journal Article
Breast cancer brain metastases: clonal evolution in clinical context
Saunus, Jodi M., McCart Reed, Amy E., Lim, Zhun Leong and Lakhani, Sunil R. (2017). Breast cancer brain metastases: clonal evolution in clinical context. International Journal of Molecular Sciences, 18 (1) 152, 152. doi: 10.3390/ijms18010152
2016
Journal Article
Characterization of anaplastic lymphoma kinase-positive medulloblastomas
Yan, Benedict, Kuick, Chik Hong, Lim, Malcolm, Yong, Min Hwee, Lee, Chi Kuen, Low, Sharon Y.Y., Low, David C.Y., Lim, Diana, Soh, Shui Yen and Chang, Kenneth T.E. (2016). Characterization of anaplastic lymphoma kinase-positive medulloblastomas. Journal of Clinical Neuroscience, 23, 120-122. doi: 10.1016/j.jocn.2015.08.017
2014
Journal Article
Platform comparison for evaluation of ALK protein immunohistochemical expression, genomic copy number and hotspot mutation status in neuroblastomas
Yan, Benedict, Kuick, Chik Hong, Lim, Malcolm, Venkataraman, Kavita, Tennakoon, Chandana, Loh, Eva, Lian, Derrick, Leong, May Ying, Lakshmanan, Manikandan, Tergaonkar, Vinay, Sung, Wing-Kin, Soh, Shui Yen and Chang, Kenneth T.E. (2014). Platform comparison for evaluation of ALK protein immunohistochemical expression, genomic copy number and hotspot mutation status in neuroblastomas. PLoS ONE, 9 (9) e106575, e106575. doi: 10.1371/journal.pone.0106575
Funding
Current funding
Supervision
Availability
- Dr Malcolm Lim is:
- Available for supervision
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Available projects
-
Radiosensitising metastatic breast cancers by targeting DNA repair
-
HER3-targeting in brain metastasis
Media
Enquiries
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