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Dr Malcolm Lim
Dr

Malcolm Lim

Email: 
Phone: 
+61 7 334 66120

Overview

Background

Dr Malcolm Lim is an experienced Cancer Biologist and His research interest spans cancer biology, biomarker discovery and theranostic nanomedicine.

He received his PhD from the University of Queensland (UQ) in 2022. His research, conducted in the labs of Professors Sunil Lakhani and Kristofer Thurecht, involved evaluating the efficacy of using nanomedicine for precision delivery of chemo- or radiotherapeutics against biomarkers in brain metastases. For this work, he developed a clinically-relevant brain metastasis mouse model. His research was recognised with the UQ Dean’s Award for Outstanding Thesis 2022. (DOIs: 10.1021/acs.molpharmaceut.3c00558, 10.3791/64216)

Currently, Malcolm serves as a Postdoctoral Research Fellow at the ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals (AMTAR) and the Thurecht’s Lab at UQ-Centre for Advanced Imaging (CAI) in Australian Institute for Bioengineering and Nanotechnology (AIBN), where he will apply his multidisciplinary expertise to explore radiobiology and radiation-induced biological responses and to advance targeted pharmaceuticals for challenging cancers.

Prior to joining AMTAR, Malcolm served as a Postdoctoral Researcher where he investigated the molecular mechanisms underlying Early Breast Cancers at the Molecular Breast Pathology Lab, UQ-Centre for Clinical Research, under the mentorship of Professors Sunil Lakhani and Peter Simpson. Before his academic career, Malcolm had five years of experience as a histologist, which provided him with a broad skillset in the field.

Dr Malcolm’s research is well-documented in numerous publications in biomedical research journals despite his career stage, reflecting his passion to advancing cancer research.

Availability

Dr Malcolm Lim is:
Available for supervision

Qualifications

  • Diploma of Biomedical Science, unknown
  • Bachelor of Science, The University of Queensland
  • Bachelor (Honours) of Cancer Cell Biology, The University of Queensland
  • Doctor of Philosophy of Cancer Cell Biology, The University of Queensland

Research interests

  • Brain metastasis

    Mechanisms underpinning the development of brain metastasis and new therapeutic strategies, CNS-penetrating targeted therapeutics, metastatic animal models

Works

Search Professor Malcolm Lim’s works on UQ eSpace

21 works between 2013 and 2024

1 - 20 of 21 works

2024

Conference Publication

LobSig4 is a superior and readily implementable ILC-focussed prognostic biomarker set

Kalinowski, Lauren, Kutasovic, Jamie, Srihari, Sriganesh, Feng, Yufan, Lal, Samir, Ferguson, Kaltin, Chittoory, Haarika, Sokolova, Anna, Lim, Malcolm, De Croft, Priyakshi Kalita, Lakhani, Sunil, Simpson, Peter and Reed, Amy McCart (2024). LobSig4 is a superior and readily implementable ILC-focussed prognostic biomarker set. San Antonio Breast Cancer Symposium 2023, San Antonio, TX United States, 5-9 December 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.sabcs23-po3-15-09

LobSig4 is a superior and readily implementable ILC-focussed prognostic biomarker set

2024

Journal Article

B7-H3 expression in breast cancer and brain metastasis

Joshi, Vaibhavi, Beecher, Kate, Lim, Malcolm, Stacey, Andrew, Feng, Yufan, Jat, Parmjit S., Duijf, Pascal H. G., Simpson, Peter T., Lakhani, Sunil R. and McCart Reed, Amy E. (2024). B7-H3 expression in breast cancer and brain metastasis. International Journal of Molecular Sciences, 25 (7) 3976, 1-17. doi: 10.3390/ijms25073976

B7-H3 expression in breast cancer and brain metastasis

2023

Journal Article

Targeted hyperbranched nanoparticles for delivery of doxorubicin in breast cancer brain metastasis

Lim, Malcolm, Fletcher, Nicholas L., Saunus, Jodi M., McCart Reed, Amy E., Chittoory, Haarika, Simpson, Peter T., Thurecht, Kristofer J. and Lakhani, Sunil R. (2023). Targeted hyperbranched nanoparticles for delivery of doxorubicin in breast cancer brain metastasis. Molecular Pharmaceutics, 20 (12), 6169-6183. doi: 10.1021/acs.molpharmaceut.3c00558

Targeted hyperbranched nanoparticles for delivery of doxorubicin in breast cancer brain metastasis

2023

Journal Article

COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis

Hancock, Janelle L., Kalimutho, Murugan, Straube, Jasmin, Lim, Malcolm, Gresshoff, Irma, Saunus, Jodi M., Lee, Jason S., Lakhani, Sunil R., Simpson, Kaylene J., Bush, Ashley I., Anderson, Robin L. and Khanna, Kum Kum (2023). COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis. Journal of Experimental and Clinical Cancer Research, 42 (1) 90, 1-16. doi: 10.1186/s13046-023-02663-8

COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis

2022

Journal Article

Modeling brain metastasis by internal carotid artery injection of cancer cells

Lim, Malcolm, Fletcher, Nicholas, Reed, Amy Mccart, Flint, Melanie, Thurecht, Kristofer, Saunus, Jodi and Lakhani, Sunil R. (2022). Modeling brain metastasis by internal carotid artery injection of cancer cells. Journal of Visualized Experiments, 2022 (186) e64216. doi: 10.3791/64216

Modeling brain metastasis by internal carotid artery injection of cancer cells

2022

Other Outputs

Development of theranostic nanomedicines for breast cancer brain metastases

Lim, Malcolm (2022). Development of theranostic nanomedicines for breast cancer brain metastases. PhD Thesis, Medicine Faculty, The University of Queensland. doi: 10.14264/1e7615d

Development of theranostic nanomedicines for breast cancer brain metastases

2022

Journal Article

Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer

Saunus, Jodi M., De Luca, Xavier M., Northwood, Korinne, Raghavendra, Ashwini, Hasson, Alexander, McCart Reed, Amy E., Lim, Malcolm, Lal, Samir, Vargas, A. Cristina, Kutasovic, Jamie R., Dalley, Andrew J., Miranda, Mariska, Kalaw, Emarene, Kalita-de Croft, Priyakshi, Gresshoff, Irma, Al-Ejeh, Fares, Gee, Julia M. W., Ormandy, Chris, Khanna, Kum Kum, Beesley, Jonathan, Chenevix-Trench, Georgia, Green, Andrew R., Rakha, Emad A., Ellis, Ian O., Nicolau, Dan V., Simpson, Peter T. and Lakhani, Sunil R. (2022). Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer. npj Breast Cancer, 8 (1) 57, 1-16. doi: 10.1038/s41523-022-00425-x

Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer

2022

Journal Article

Landscape of epidermal growth factor receptor heterodimers in brain metastases

Lim, Malcolm, Nguyen, Tam H., Niland, Colleen, Reid, Lynne E., Jat, Parmjit S., Saunus, Jodi M. and Lakhani, Sunil R. (2022). Landscape of epidermal growth factor receptor heterodimers in brain metastases. Cancers, 14 (3) ARTN 533, 533. doi: 10.3390/cancers14030533

Landscape of epidermal growth factor receptor heterodimers in brain metastases

2021

Journal Article

Characterization of immune cell subsets of tumor infiltrating lymphocytes in brain metastases

Croft, Priyakshi Kalita-de, Chittoory, Haarika, Nguyen, Tam H., Saunus, Jodi M., Kim, Woo Gyeong, Reed, Amy E. McCart, Lim, Malcolm, De Luca, Xavier M., Ferguson, Kaltin, Niland, Colleen, Mazzieri, Roberta, Dolcetti, Riccardo, Simpson, Peter T. and Lakhani, Sunil R. (2021). Characterization of immune cell subsets of tumor infiltrating lymphocytes in brain metastases. Biology, 10 (5) 425, 425. doi: 10.3390/biology10050425

Characterization of immune cell subsets of tumor infiltrating lymphocytes in brain metastases

2020

Journal Article

Metaplastic breast cancers frequently express immune checkpoint markers FOXP3 and PD-L1

Kalaw, Emarene, Lim, Malcolm, Kutasovic, Jamie R., Sokolova, Anna, Taege, Lucinda, Johnstone, Kate, Bennett, James, Saunus, Jodi M., Niland, Colleen, Ferguson, Kaltin, Gresshoff, Irma, Bettington, Mark, Pathmanathan, Nirmala, Tse, Gary M., Papadimos, David, Pathmanathan, Rajadurai, Harris, Gavin, Yamaguchi, Rin, Tan, Puay Hoon, Fox, Stephen, O’Toole, Sandra A., Simpson, Peter T., Lakhani, Sunil R. and McCart Reed, Amy E. (2020). Metaplastic breast cancers frequently express immune checkpoint markers FOXP3 and PD-L1. British Journal of Cancer, 123 (11), 1665-1672. doi: 10.1038/s41416-020-01065-3

Metaplastic breast cancers frequently express immune checkpoint markers FOXP3 and PD-L1

2020

Journal Article

Clinicopathologic significance of nuclear HER4 and phospho-YAP(S127) in human breast cancers and matching brain metastases

Kalita-de Croft, Priyakshi, Lim, Malcolm, Chittoory, Haarika, de Luca, Xavier M., Kutasovic, Jamie R., Day, Bryan W., Al-Ejeh, Fares, Simpson, Peter T., McCart Reed, Amy E., Lakhani, Sunil R. and Saunus, Jodi M. (2020). Clinicopathologic significance of nuclear HER4 and phospho-YAP(S127) in human breast cancers and matching brain metastases. Therapeutic Advances in Medical Oncology, 12 ARTN 1758835920946259, 175883592094625. doi: 10.1177/1758835920946259

Clinicopathologic significance of nuclear HER4 and phospho-YAP(S127) in human breast cancers and matching brain metastases

2020

Journal Article

Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancer

Adwal, Alaknanda, Kalita-de Croft, Priyakshi, Shakya, Reshma, Lim, Malcolm, Kalaw, Emarene, Taege, Lucinda D., McCart Reed, Amy E., Lakhani, Sunil R., Callen, David F. and Saunus, Jodi M. (2020). Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancer. Life Science Alliance, 3 (7) e201900562, 1-12. doi: 10.26508/lsa.201900562

Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancer

2019

Journal Article

Proteomic analysis of the breast cancer brain metastasis microenvironment

Kalita-de Croft, Priyakshi, Straube, Jasmin, Lim, Malcolm, Al-Ejeh, Fares, Lakhani, Sunil R. and Saunus, Jodi M. (2019). Proteomic analysis of the breast cancer brain metastasis microenvironment. International Journal of Molecular Sciences, 20 (10) 2524, 2524. doi: 10.3390/ijms20102524

Proteomic analysis of the breast cancer brain metastasis microenvironment

2019

Journal Article

Innovative therapeutic strategies for effective treatment of brain metastases

Lim, Malcolm, Puttick, Simon, Houston, Zachary H., Thurecht, Kristofer J., Kalita-de Croft, Priyakshi, Mahler, Stephen, Rose, Stephen E., Jeffree, Rosalind L., Mazzieri, Roberta, Dolcetti, Riccardo, Lakhani, Sunil R. and Saunus, Jodi M. (2019). Innovative therapeutic strategies for effective treatment of brain metastases. International Journal of Molecular Sciences, 20 (6) 1280, 1280. doi: 10.3390/ijms20061280

Innovative therapeutic strategies for effective treatment of brain metastases

2019

Journal Article

Phenotypic and molecular dissection of Metaplastic Breast Cancer and the prognostic implications

McCart Reed, Amy Ellen, Kalaw, Emarene, Nones, Katia, Bettington, Mark, Lim, Malcolm, Bennett, James, Johnstone, Kate, Kutasovic, Jamie Rose, Saunus, Jodi Marie, Kazakoff, Stephen, Xu, Qinying, Wood, Scott, Holmes, Oliver, Leonard, Conrad, Reid, Lynne Estelle, Black, Debra, Niland, Colleen, Ferguson, Kaltin, Gresshoff, Irma, Raghavendra, Ashwini, Harvey, Kate, Cooper, Caroline, Liu, Cheng, Kalinowski, Lauren, Reid, Andrew Scott, Davidson, Morgan, Pearson, John V, Pathmanathan, Nirmala, Tse, Gary ... Lakhani, Sunil R. (2019). Phenotypic and molecular dissection of Metaplastic Breast Cancer and the prognostic implications. Journal of Pathology, 247 (2), 214-227. doi: 10.1002/path.5184

Phenotypic and molecular dissection of Metaplastic Breast Cancer and the prognostic implications

2018

Journal Article

Neuronal defects an etiological factor in congenital pelviureteric junction obstruction?

How, Guo Yuan, Chang, Kenneth Tou En, Jacobsen, Anette Sundfor, Yap, Te-Lu, Ong, Caroline Choo Phaik, Low, Yee, Allen, John Carson, Kuick, Chik Hong, Lim, Malcolm Zhun Leong and Laksmi, Narasimhan Kannan (2018). Neuronal defects an etiological factor in congenital pelviureteric junction obstruction?. Journal of Pediatric Urology, 14 (1), 51.e1-51.e7. doi: 10.1016/j.jpurol.2017.07.014

Neuronal defects an etiological factor in congenital pelviureteric junction obstruction?

2017

Journal Article

DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer

Hernandez-Perez, S., Cabrera, E., Salido, E., Lim, M., Reid, L., Lakhani, S. R., Khanna, K. K., Saunus, J. M. and Freire, R. (2017). DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer. Oncogene, 36 (33), 4802-4809. doi: 10.1038/onc.2017.21

DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer

2017

Journal Article

Breast cancer brain metastases: clonal evolution in clinical context

Saunus, Jodi M., McCart Reed, Amy E., Lim, Zhun Leong and Lakhani, Sunil R. (2017). Breast cancer brain metastases: clonal evolution in clinical context. International Journal of Molecular Sciences, 18 (1) 152, 152. doi: 10.3390/ijms18010152

Breast cancer brain metastases: clonal evolution in clinical context

2016

Journal Article

Characterization of anaplastic lymphoma kinase-positive medulloblastomas

Yan, Benedict, Kuick, Chik Hong, Lim, Malcolm, Yong, Min Hwee, Lee, Chi Kuen, Low, Sharon Y.Y., Low, David C.Y., Lim, Diana, Soh, Shui Yen and Chang, Kenneth T.E. (2016). Characterization of anaplastic lymphoma kinase-positive medulloblastomas. Journal of Clinical Neuroscience, 23, 120-122. doi: 10.1016/j.jocn.2015.08.017

Characterization of anaplastic lymphoma kinase-positive medulloblastomas

2014

Journal Article

Platform comparison for evaluation of ALK protein immunohistochemical expression, genomic copy number and hotspot mutation status in neuroblastomas

Yan, Benedict, Kuick, Chik Hong, Lim, Malcolm, Venkataraman, Kavita, Tennakoon, Chandana, Loh, Eva, Lian, Derrick, Leong, May Ying, Lakshmanan, Manikandan, Tergaonkar, Vinay, Sung, Wing-Kin, Soh, Shui Yen and Chang, Kenneth T.E. (2014). Platform comparison for evaluation of ALK protein immunohistochemical expression, genomic copy number and hotspot mutation status in neuroblastomas. PLoS ONE, 9 (9) e106575, e106575. doi: 10.1371/journal.pone.0106575

Platform comparison for evaluation of ALK protein immunohistochemical expression, genomic copy number and hotspot mutation status in neuroblastomas

Funding

Current funding

  • 2023 - 2025
    The molecular basis of breast cancer in young women
    National Breast Cancer Foundation Investigator Initiated Research Scheme
    Open grant

Supervision

Availability

Dr Malcolm Lim is:
Available for supervision

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Available projects

  • Radiosensitising metastatic breast cancers by targeting DNA repair

  • HER3-targeting in brain metastasis

Media

Enquiries

For media enquiries about Dr Malcolm Lim's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au