Overview
Background
After completing an honours year in genetics in the lab of Professor Paul Ebert (The University of Queensland), Dr Fotheringham obtained a research assistant position in the field of diabetes, sparking a passionate interest in diabetes and diabetes complications, particularly diabetic nephropathy. This led her to undertake and complete a PhD, examining the influence of dietary factors, in particularly advanced glycation end products and macronutrients on renal function in diabetes and aging. Since completing her PhD in 2020, Dr Amelia Fotheringham has worked as a Research Officer in the Glycation and Diabetes Complications Laboratory at Mater Research-UQ. Here she has undertaken projects examining novel treatments for mitochondrial dysfunction in diabetic nephropathy and targeting the AGE-RAGE pathway for type 1 diabetes prevention.
Availability
- Dr Amelia Fotheringham is:
- Available for supervision
Works
Search Professor Amelia Fotheringham’s works on UQ eSpace
2024
Journal Article
Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis
Sajiir, Haressh, Keshvari, Sahar, Wong, Kuan Yau, Borg, Danielle J., Steyn, Frederik J., Fercher, Christian, Taylor, Karin, Taylor, Breten, Barnard, Ross T., Müller, Alexandra, Moniruzzaman, Md, Miller, Gregory, Wang, Ran, Fotheringham, Amelia, Schreiber, Veronika, Sheng, Yong Hua, Hancock, Janelle Louise, Loo, Dorothy, Burr, Lucy, Huynh, Tony, Lockett, Jack, Ramm, Grant A., Macdonald, Graeme A., Prins, Johannes B., McGuckin, Michael A. and Hasnain, Sumaira Z. (2024). Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis. Nature Communications, 15 (1) 4528, 4528. doi: 10.1038/s41467-024-48317-x
2023
Conference Publication
Targeted interleukin-22 therapy improves glycemic control, steatohepatitis, and fibrosis in experimental models of metabolic dysfunction-associated steatohepatitis
Sajiir, H., Keshvari, S., Wong, K. Y., Borg, D., Mueller, A., Moniruzzaman, M., Wang, R., Fotheringham, A., Schreiber, V., Sheng, Y., Lockett, J., Ramm, G., Macdonald, G., Prins, J. B., Mcguckin, M. A. and Hasnain, S. Z. (2023). Targeted interleukin-22 therapy improves glycemic control, steatohepatitis, and fibrosis in experimental models of metabolic dysfunction-associated steatohepatitis. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2023, Brisbane, QLD, Australia, 2 - 5 September 2023. Richmond, VIC, Australia: John Wiley & Sons. doi: 10.1111/jgh.16288
2023
Conference Publication
Youth with type 1 diabetes at higher risk of developing diabetic kidney disease have alterations in their urine and plasma metabolomic and mitochondrial dna profiles
Sullivan, Mitchell, Pham, Uyen, McCarthy, Domenica, Flemming, Nicole, Fotheringham, Amelia, Chandrashekar, Preeti, Whiddett, Rani, Buckle, Irina, Summers, Kim, Hodson, Mark, de Silva, Neisha, Nisbet, Janelle, Morton, Adam, Teasedale, Stephanie, Doomun, Sheik, de Souza, David, Isbel, Nicole, Jones, Timothy, Couper, Jennifer, Coughlan, Melinda, Johnson, David, O'Moore-Sullivan, Trisha, Barret, Helen, Marcovecchio, M. Loredana, Donaghue, Kim and Forbes, Josephine (2023). Youth with type 1 diabetes at higher risk of developing diabetic kidney disease have alterations in their urine and plasma metabolomic and mitochondrial dna profiles. 58th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Christchurch, New Zealand, 4-6 September 2023. Richmond, VIC Australia: John Wiley & Sons.
2022
Journal Article
Advanced glycation end products and inflammation in type 1 diabetes development
Du, Chenping, Whiddett, Rani O., Buckle, Irina, Chen, Chen, Forbes, Josephine M. and Fotheringham, Amelia K. (2022). Advanced glycation end products and inflammation in type 1 diabetes development. Cells, 11 (21) 3503, 1-18. doi: 10.3390/cells11213503
2022
Conference Publication
Mitochondrial dysfunction aligns with risk for diabetic kidney disease in youth with type 1 diabetes
Sullivan, Mitchell, McCarthy, Domenica, Flemming, Nicole, Chandrashekar, Preeti, Hodson, Mark, Fotheringham, Amelia, Whiddett, Rani, De Silva, Neisha, Nisbet, Jinelle, Morton, Adam, Teasdale, Stephanie, Isbel, Nicole, Jones, Timothy, Couper, Jennier, Thorburn, David, Johnson, David, Cotterill, Andrew, Barrett, Helen, O'Moore-Sullivan, Trisha, Donaghue, Kim and Forbes, Josephine (2022). Mitochondrial dysfunction aligns with risk for diabetic kidney disease in youth with type 1 diabetes. 57th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Sydney, NSW, Australia, 17–19 October 2022. Richmond, VIC, Australia: John Wiley & Sons.
2022
Journal Article
Advanced glycation end products (AGEs) and chronic kidney disease: does the modern diet AGE the kidney?
Fotheringham, Amelia K., Gallo, Linda A., Borg, Danielle J. and Forbes, Josephine M. (2022). Advanced glycation end products (AGEs) and chronic kidney disease: does the modern diet AGE the kidney?. Nutrients, 14 (13) 2675, 1-28. doi: 10.3390/nu14132675
2022
Journal Article
Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells
Leung, Sherman S., Borg, Danielle J., McCarthy, Domenica A., Boursalian, Tamar E., Cracraft, Justen, Zhuang, Aowen, Fotheringham, Amelia K., Flemming, Nicole, Watkins, Thomas, Miles, John J., Groop, Per-Henrik, Scheijen, Jean L., Schalkwijk, Casper G., Steptoe, Raymond J., Radford, Kristen J., Knip, Mikael and Forbes, Josephine M. (2022). Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells. Diabetes, 71 (9), 1994-2008. doi: 10.2337/db22-0177
2021
Journal Article
Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure
Fotheringham, Amelia K., Solon-Biet, Samantha M., Bielefeldt-Ohmann, Helle, McCarthy, Domenica A., McMahon, Aisling C., Ruohonen, Kari, Li, Isaac, Sullivan, Mitchell A., Whiddett, Rani O., Borg, Danielle J., Cogger, Victoria C., Ballard, William O., Turner, Nigel, Melvin, Richard G., Raubenheimer, David, Le Couteur, David G., Simpson, Stephen J. and Forbes, Josephine M. (2021). Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure. iScience, 24 (11) 103308, 103308. doi: 10.1016/j.isci.2021.103308
2021
Journal Article
Adherence to dietary and physical activity guidelines in Australian undergraduate biomedical students and associations with body composition and metabolic health: a cross-sectional study
Gallo, Linda A., Gallo, Tania F., Young, Sophia L., Fotheringham, Amelia K., Barclay, Johanna L., Walker, Jacqueline L., Moritz, Karen M. and Akison, Lisa K. (2021). Adherence to dietary and physical activity guidelines in Australian undergraduate biomedical students and associations with body composition and metabolic health: a cross-sectional study. Nutrients, 13 (10) 3500, 3500. doi: 10.3390/nu13103500
2021
Journal Article
T cell expression and release of kidney injury molecule-1 in response to glucose variations initiates kidney injury in early diabetes
Forbes, Josephine M., McCarthy, Domenica A., Kassianos, Andrew J., Baskerville, Tracey, Fotheringham, Amelia J., Giuliani, Kurt T. K., Grivei, Anca, Murphy, Andrew J., Flynn, Michelle C., Sullivan, Mitchell A., Chandrashekar, Preeti, Whiddett, Rani, Radford, Kristen J., Flemming, Nicole, Beard, Sam S., D’Silva, Neisha, Nisbet, Janelle, Morton, Adam, Teasdale, Stephanie, Russell, Anthony, Isbel, Nicole, Jones, Timothy, Couper, Jennifer, Healy, Helen, Harris, Mark, Donaghue, Kim, Johnson, David W., Cotterill, Andrew, Barrett, Helen L. and O’Moore-Sullivan, Trisha (2021). T cell expression and release of kidney injury molecule-1 in response to glucose variations initiates kidney injury in early diabetes. Diabetes, 70 (8), 1754-1766. doi: 10.2337/db20-1081
2021
Journal Article
Short duration alagebrium chloride therapy prediabetes does not inhibit progression to autoimmune diabetes in an experimental model
Borg, Danielle J., Faridi, Pouya, Giam, Kai Lin, Reeves, Peta, Fotheringham, Amelia K., McCarthy, Domenica A., Leung, Sherman, Ward, Micheal S., Harcourt, Brooke E., Ayala, Rochelle, Scheijen, Jean L., Briskey, David, Dudek, Nadine L., Schalkwijk, Casper G., Steptoe, Raymond, Purcell, Anthony W. and Forbes, Josephine M. (2021). Short duration alagebrium chloride therapy prediabetes does not inhibit progression to autoimmune diabetes in an experimental model. Metabolites, 11 (7) 426, 1-21. doi: 10.3390/metabo11070426
2021
Journal Article
Advanced glycation end products as predictors of renal function in youth with type 1 diabetes
Forbes, Josephine M., Le Bagge, Selena, Righi, Samuel, Fotheringham, Amelia K., Gallo, Linda A., McCarthy, Domenica A., Leung, Sherman, Baskerville, Tracey, Nisbett, Janelle, Morton, Adam, Teasdale, Stephanie, D'Silva, Neisha, Barrett, Helen, Jones, Timothy, Couper, Jennifer, Donaghue, Kim, Isbel, Nicole, Johnson, David W., Donnellan, Leigh, Deo, Permal, Akison, Lisa K., Moritz, Karen M. and O'Moore-Sullivan, Trisha (2021). Advanced glycation end products as predictors of renal function in youth with type 1 diabetes. Scientific Reports, 11 (1) 9422, 9422. doi: 10.1038/s41598-021-88786-4
2021
Journal Article
The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition)
Zhuang, Aowen, Yap, Felicia Y. T., Borg, Danielle J., McCarthy, Domenica, Fotheringham, Amelia, Leung, Sherman, Penfold, Sally A., Sourris, Karly C., Coughlan, Melinda T., Schulz, Benjamin L. and Forbes, Josephine M. (2021). The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition). Endocrinology, Diabetes and Metabolism, 4 (3) e00278, e00278. doi: 10.1002/edm2.278
2020
Journal Article
Circulating levels of the soluble receptor for AGE (sRAGE) during escalating oral glucose dosages and corresponding isoglycaemic i.v. glucose infusions in individuals with and without type 2 diabetes
Fotheringham, Amelia K., Bagger, Jonatan I., Borg, Danielle J., McCarthy, Domenica A., Holst, Jens J., Vilsbøll, Tina, Knop, Filip K. and Forbes, Josephine M. (2020). Circulating levels of the soluble receptor for AGE (sRAGE) during escalating oral glucose dosages and corresponding isoglycaemic i.v. glucose infusions in individuals with and without type 2 diabetes. Nutrients, 12 (10) 2928, 2928-12. doi: 10.3390/nu12102928
2020
Journal Article
Targeting the receptor for advanced glycation end products (RAGE) in type 1 diabetes
Le Bagge, Selena, Fotheringham, Amelia K., Leung, Sherman S. and Forbes, Josephine M. (2020). Targeting the receptor for advanced glycation end products (RAGE) in type 1 diabetes. Medicinal Research Reviews, 40 (4) med.21654, 1200-1219. doi: 10.1002/med.21654
2020
Other Outputs
Novel dietary factors in diabetic and non-diabetic kidney disease
Fotheringham, Amelia Katherine (2020). Novel dietary factors in diabetic and non-diabetic kidney disease. PhD Thesis, Faculty of Medicine, The University of Queensland. doi: 10.14264/uql.2020.117
2019
Other Outputs
Novel dietary factors in diabetic and non-diabetic kidney disease
Fotheringham, Amelia (2019). Novel dietary factors in diabetic and non-diabetic kidney disease. PhD Thesis, Faculty of Medicine, The University of Queensland.
2019
Other Outputs
Novel dietary factors in diabetic and non-diabetic kidney disease
Fotheringham, Amelia (2019). Novel dietary factors in diabetic and non-diabetic kidney disease. PhD Thesis, School of Biomedical Sciences and School of Psychology, The University of Queensland.
2019
Conference Publication
Exploring AGE and sRAGE regulation in response to oral and intravenous glucose loads in individuals with recently diagnosed type 2 diabetes
Fotheringham, A. K., Bagger, J. I., Borg, D. J., McCarthy, D., Vilsboll, T., Knop, F. K. and Forbes, J. M. (2019). Exploring AGE and sRAGE regulation in response to oral and intravenous glucose loads in individuals with recently diagnosed type 2 diabetes. 55th Annual Meeting of the European Association for the Study of Diabetes (EASD), Barcelona, Spain, 16-20 September 2019 . New York, NY, United States: Springer.
2018
Book Chapter
Dietary AGEs in the development and progression of chronic kidney disease
Fotheringham, Amelia K., Gallo, Linda A. and Forbes, Josephine M. (2018). Dietary AGEs in the development and progression of chronic kidney disease. Dietary AGEs and their role in health and disease. (pp. 213-224) edited by Jaime Uribarri. Boca Raton, FI, United States: CRC Press. doi: 10.1201/9781315120041
Funding
Current funding
Supervision
Availability
- Dr Amelia Fotheringham is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
The receptor for advanced glycation end products and its role in Type 1 diabetes development
Associate Advisor
Other advisors: Associate Professor Emma Hamilton-Williams, Dr Irina Buckle, Dr Sherman Leung, Honorary Professor Josephine Forbes
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Doctor Philosophy
Early mitochondrial dysfunction in diabetic kidney
Associate Advisor
Other advisors: Dr Irina Buckle, Honorary Professor Josephine Forbes
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Doctor Philosophy
The Characterisation of Immune Cells in Response To RAGE Antagonism Therapy in Mouse Models of Type 1 Diabetes
Associate Advisor
Other advisors: Professor Benjamin Schulz, Honorary Professor Josephine Forbes, Dr Irina Buckle
Media
Enquiries
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