Professor

Barbara Leggett

Email: 
Phone: 
+61 7 3362 0170

Availability

Professor Barbara Leggett is:
Available for supervision

Fields of research

Biological Sciences Psychology Sports science and exercise

Qualifications

  • Bachelor (Honours) of Medicine Surgery, The University of Queensland
  • Doctoral Diploma of Medicine, The University of Queensland
  • Royal Australasian College of Physicians, Royal Australasian College of Physicians
  • Royal College of Physicians, Royal College of Physicians

Search Professor Barbara Leggett’s works on UQ eSpace

170 works between 1990 and 2024
All (170) Journal Article (124) Book Chapter (1) Conference Publication (45)

21 - 40 of 170 works

2020

Journal Article

Traditional serrated adenoma-like lesions in patients with inflammatory bowel disease:

Miller, Gregory C., Liu, Cheng, Bettington, Mark L., Leggett, Barbara, Whitehall, Vicki L.J. and Rosty, Christophe (2020). Traditional serrated adenoma-like lesions in patients with inflammatory bowel disease:. Human Pathology, 97, 19-28. doi: 10.1016/j.humpath.2019.12.005

Traditional serrated adenoma-like lesions in patients with inflammatory bowel disease:

2019

Journal Article

BRAF V600E immunohistochemistry demonstrates that some sessile serrated lesions with adenomatous dysplasia may represent collision lesions

Bettington, Mark, Liu, Cheng, Gill, Anthony, Walker, Neal, Leggett, Barbara, Whitehall, Vicki and Rosty, Christophe (2019). BRAF V600E immunohistochemistry demonstrates that some sessile serrated lesions with adenomatous dysplasia may represent collision lesions. Histopathology, 75 (1), 81-87. doi: 10.1111/his.13851

BRAF V600E immunohistochemistry demonstrates that some sessile serrated lesions with adenomatous dysplasia may represent collision lesions

2019

Journal Article

DNA methylation changes that precede onset of dysplasia in advanced sessile serrated adenomas

Liu, Cheng, Fennell, Lochlan J., Bettington, Mark L., Walker, Neal I., Dwine, Joel, Leggett, Barbara A. and Whitehall, Vicki L. J. (2019). DNA methylation changes that precede onset of dysplasia in advanced sessile serrated adenomas. Clinical Epigenetics, 11 (1) 90, 90. doi: 10.1186/s13148-019-0691-4

DNA methylation changes that precede onset of dysplasia in advanced sessile serrated adenomas

2019

Journal Article

Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis

Lannagan, Tamsin R. M., Lee, Young K., Wang, Tongtong, Roper, Jatin, Bettington, Mark L., Fennell, Lochlan, Vrbanac, Laura, Jonavicius, Lisa, Somashekar, Roshini, Gieniec, Krystyna, Yang, Miao, Ng, Jia Q., Suzuki, Nobumi, Ichinose, Mari, Wright, Josephine A., Kobayashi, Hiroki, Putoczki, Tracey L., Hayakawa, Yoku, Leedham, Simon J., Abud, Helen E., Yilmaz, Omer H., Marker, Julie, Klebe, Sonja, Wirapati, Pratyaksha, Mukherjee, Siddhartha, Tejpar, Sabine, Leggett, Barbara A., Whitehall, Vicki L. J., Worthley, Daniel L. and Woods, Susan L. (2019). Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis. Gut, 68 (4), 684-692. doi: 10.1136/gutjnl-2017-315920

Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis

2019

Journal Article

Integrative genome-scale DNA methylation analysis of a large and unselected cohort reveals five distinct subtypes of colorectal adenocarcinomas

Fennell, Lochlan, Dumenil, Troy, Wockner, Leesa, Hartel, Gunter, Nones, Katia, Bond, Catherine, Borowsky, Jennifer, Liu, Cheng, McKeone, Diane, Bowdler, Lisa, Montgomery, Grant, Klein, Kerenaftali, Hoffmann, Isabell, Patch, Ann-Marie, Kazakoff, Stephen, Pearson, John, Waddell, Nicola, Wirapati, Pratyaksha, Lochhead, Paul, Imamura, Yu, Ogino, Shuji, Shao, Renfu, Tejpar, Sabine, Leggett, Barbara and Whitehall, Vicki (2019). Integrative genome-scale DNA methylation analysis of a large and unselected cohort reveals five distinct subtypes of colorectal adenocarcinomas. Cellular and Molecular Gastroenterology and Hepatology, 8 (2), 269-290. doi: 10.1016/j.jcmgh.2019.04.002

Integrative genome-scale DNA methylation analysis of a large and unselected cohort reveals five distinct subtypes of colorectal adenocarcinomas

2019

Journal Article

Five‐year conditional survival for patients with hepatocellular carcinoma in Queensland, Australia

Valery, Patricia C., Baade, Peter A., Stuart, Katherine A., Leggett, Barbara A., Macdonald, Graeme A., Whiteman, David C., Crawford, Darrell H. and Clark, Paul J. (2019). Five‐year conditional survival for patients with hepatocellular carcinoma in Queensland, Australia. GastroHep, 1 (2), 61-69. doi: 10.1002/ygh2.327

Five‐year conditional survival for patients with hepatocellular carcinoma in Queensland, Australia

2018

Journal Article

CpG island methylation in sessile serrated adenomas increases with age, indicating lower risk of malignancy in young patients

Liu, Cheng, Bettington, Mark L., Walker, Neal I., Dwine, Joel, Hartel, Gunter F., Leggett, Barbara A. and Whitehall, Vicki L. J. (2018). CpG island methylation in sessile serrated adenomas increases with age, indicating lower risk of malignancy in young patients. Gastroenterology, 155 (5), 1362-1365. doi: 10.1053/j.gastro.2018.07.012

CpG island methylation in sessile serrated adenomas increases with age, indicating lower risk of malignancy in young patients

2018

Journal Article

NGM282 for treatment of patients with primary biliary cholangitis: a multicenter, randomized, double blind placebo controlled trial

Mayo, Marlyn J., Wigg, Alan J., Leggett, Barbara A., Arnold, Hays, Thompson, Alexander J., Weltman, Martin, Carey, Elizabeth J., Muir, Andrew J., Ling, Lei, Rossi, Stephen J. and Depaoli, Alex M. (2018). NGM282 for treatment of patients with primary biliary cholangitis: a multicenter, randomized, double blind placebo controlled trial. Hepatology Communications, 2 (9), 1037-1050. doi: 10.1002/hep4.1209

NGM282 for treatment of patients with primary biliary cholangitis: a multicenter, randomized, double blind placebo controlled trial

2018

Journal Article

A morphological and molecular study of proposed early forms of the traditional serrated adenoma

Bettington, Mark, Rosty, Christophe, Whitehall, Vicki, Leggett, Barbara, McKeone, Diane, Pearson, Sally-Ann and Walker, Neal (2018). A morphological and molecular study of proposed early forms of the traditional serrated adenoma. Histopathology, 73 (6), 1023-1029. doi: 10.1111/his.13714

A morphological and molecular study of proposed early forms of the traditional serrated adenoma

2018

Journal Article

Sessile serrated adenomas in young patients may have limited risk of malignant progression

Bettington, Mark, Brown, Ian, Rosty, Christophe, Walker, Neal, Liu, Cheng, Croese, John, Rahman, Tony, Pearson, Sally-Ann, McKeone, Diane, Leggett, Barbara and Whitehall, Vicki (2018). Sessile serrated adenomas in young patients may have limited risk of malignant progression. Journal of Clinical Gastroenterology, 53 (3), 1-e116. doi: 10.1097/MCG.0000000000001014

Sessile serrated adenomas in young patients may have limited risk of malignant progression

2018

Journal Article

The role of APC in WNT pathway activation in serrated neoplasia

Borowsky, Jennifer, Dumenil, Troy, Bettington, Mark, Pearson, Sally-Ann, Bond, Catherine, Fennell, Lochlan, Liu, Cheng, McKeone, Diane, Rosty, Christophe, Brown, Ian, Walker, Neal, Leggett, Barbara and Whitehall, Vicki (2018). The role of APC in WNT pathway activation in serrated neoplasia. Modern Pathology, 31 (3), 495-504. doi: 10.1038/modpathol.2017.150

The role of APC in WNT pathway activation in serrated neoplasia

2018

Journal Article

Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasia

Bond, Catherine E., Liu, Cheng, Kawamata, Futoshi, McKeone, Diane M., Fernando, Winnie, Jamieson, Saara, Pearson, Sally-Ann, Kane, Alexandra, Woods, Susan L., Lannagan, Tamsin R. M., Somashekar, Roshini, Lee, Young, Dumenil, Troy, Hartel, Gunter, Spring, Kevin J., Borowsky, Jennifer, Fennell, Lochlan, Bettington, Mark, Lee, Jason, Worthley, Daniel L., Leggett, Barbara A. and Whitehall, Vicki L. J. (2018). Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasia. Epigenetics, 13 (1), 40-48. doi: 10.1080/15592294.2017.1411446

Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasia

2018

Journal Article

MLH1-93 G/a polymorphism is associated with MLH1 promoter methylation and protein loss in dysplastic sessile serrated adenomas with BRAFV600E mutation

Fennell, Lochlan J., Jamieson, Saara, McKeone, Diane, Corish, Tracie, Rohdmann, Megan, Furner, Tori, Bettington, Mark, Liu, Cheng, Kawamata, Futoshi, Bond, Catherine, Van De Pols, Jolieke, Leggett, Barbara and Whitehall, Vicki (2018). MLH1-93 G/a polymorphism is associated with MLH1 promoter methylation and protein loss in dysplastic sessile serrated adenomas with BRAFV600E mutation. BMC Cancer, 18 (1) 35, 1-7. doi: 10.1186/s12885-017-3946-5

MLH1-93 G/a polymorphism is associated with MLH1 promoter methylation and protein loss in dysplastic sessile serrated adenomas with BRAFV600E mutation

2018

Journal Article

Copy number profiles of paired primary and metastatic colorectal cancers

Kawamata, Futoshi, Patch, Ann-Marie, Nones, Katia, Bond, Catherine, McKeone, Diane, Pearson, Sally-Ann, Homma, Shigenori, Liu, Cheng, Fennell, Lochlan, Dumenil, Troy, Hartel, Gunter, Kobayasi, Nozomi, Yokoo, Hideki, Fukai, Moto, Nishihara, Hiroshi, Kamiyama, Toshiya, Burge, Matthew E., Karapetis, Christos S., Taketomi, Akinobu, Leggett, Barbara, Waddell, Nicola and Whitehall, Vicki (2018). Copy number profiles of paired primary and metastatic colorectal cancers. Oncotarget, 9 (3), 3394-3405. doi: 10.18632/oncotarget.23277

Copy number profiles of paired primary and metastatic colorectal cancers

2017

Journal Article

Sessile serrated adenomas with dysplasia: morphological patterns and correlations with MLH1 immunohistochemistry

Liu, Cheng, Walker, Neal I., Leggett, Barbara A., Whitehall, Vicki L. J., Bettington, Mark L. and Rosty, Christophe (2017). Sessile serrated adenomas with dysplasia: morphological patterns and correlations with MLH1 immunohistochemistry. Modern Pathology, 30 (12), 1728-1738. doi: 10.1038/modpathol.2017.92

Sessile serrated adenomas with dysplasia: morphological patterns and correlations with MLH1 immunohistochemistry

2017

Journal Article

RNF43 is mutated less frequently in Lynch Syndrome compared with sporadic microsatellite unstable colorectal cancers

Fennell, Lochlan J. , Clendenning, Mark, McKeone, Diane M. , Jamieson, Saara H., Balachandran, Samanthy, Borowsky, Jennifer, Liu, John, Kawamata, Futoshi, Bond, Catherine E., Rosty, Christophe, Burge, Matthew E., Buchanan, Daniel D., Leggett, Barbara A.  and Whitehall, Vicki L. J. (2017). RNF43 is mutated less frequently in Lynch Syndrome compared with sporadic microsatellite unstable colorectal cancers. Familial Cancer, 17 (1), 1-7. doi: 10.1007/s10689-017-0003-0

RNF43 is mutated less frequently in Lynch Syndrome compared with sporadic microsatellite unstable colorectal cancers

2017

Journal Article

GNAS mutations are present in colorectal traditional serrated adenomas, serrated tubulovillous adenomas and serrated adenocarcinomas with adverse prognostic features

Liu, Cheng, Mckeone, Diane M., Walker, Neal I., Bettington, Mark L., Leggett, Barbara A. and Whitehall, Vicki L. J. (2017). GNAS mutations are present in colorectal traditional serrated adenomas, serrated tubulovillous adenomas and serrated adenocarcinomas with adverse prognostic features. Histopathology, 70 (7), 1079-1088. doi: 10.1111/his.13180

GNAS mutations are present in colorectal traditional serrated adenomas, serrated tubulovillous adenomas and serrated adenocarcinomas with adverse prognostic features

2017

Journal Article

Whole-genome landscape of pancreatic neuroendocrine tumours

Scarpa, Aldo, Chang, David K., Nones, Katia, Corbo, Vincenzo, Patch, Ann-Marie, Bailey, Peter, Lawlor, Rita T., Johns, Amber L., Miller, David K., Mafficini, Andrea, Rusev, Borislav, Scardoni, Maria, Antonello, Davide, Barbi, Stefano, Sikora, Katarzyna O., Cingarlini, Sara, Vicentini, Caterina, McKay, Skye, Quinn, Michael C.J., Bruxner, Timothy J.C., Christ, Angelika N., Harliwong, Ivon, Idrisoglu, Senel, McLean, Suzanne, Nourse, Craig, Nourbakhsh, Ehsan, Wilson, Peter J., Anderson, Matthew J., Fink, J. Lynn ... Grimmond, Sean M. (2017). Whole-genome landscape of pancreatic neuroendocrine tumours. Nature, 543 (7643), 65-71. doi: 10.1038/nature21063

Whole-genome landscape of pancreatic neuroendocrine tumours

2017

Journal Article

High prevalence of sessile serrated adenomas in contemporary outpatient colonoscopy practice

Bettington, Mark, Walker, Neal, Rahman, Tony, Vandeleur, Ann, Whitehall, Vicki, Leggett, Barbara and Croese, John (2017). High prevalence of sessile serrated adenomas in contemporary outpatient colonoscopy practice. Internal Medicine Journal, 47 (3), 318-323. doi: 10.1111/imj.13329

High prevalence of sessile serrated adenomas in contemporary outpatient colonoscopy practice

2017

Conference Publication

Sessile serrated adenomas with dysplasia: morphological patterns and correlations with MLH1 immunohistochemistry

Liu, C., Walker, N. I., Leggett, B. A., Whitehall, V. L. J., Bettington, M. L. and Rosty, C. (2017). Sessile serrated adenomas with dysplasia: morphological patterns and correlations with MLH1 immunohistochemistry. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, Gold Coast, QLD Australia, 20-22 August 2017. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia.

Sessile serrated adenomas with dysplasia: morphological patterns and correlations with MLH1 immunohistochemistry

Past funding

  • 2006 - 2007
    A Double-blind, randomized, placebo-controlled multi-center, Phase II parallel dose-ranging study to assess the antifibrotic activity of G1262570 in chronic hepatitis C subjects with hepatic fibrosis
    Glaxo Smith Kline Aust. Pty Ltd
    Open grant

Availability

Professor Barbara Leggett is:
Available for supervision

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Supervision history

Current supervision

  • Master Philosophy

    Yield of neoplastic lesions in a prospective Australian cohort undergoing colonoscopic surveillance in the context of high-quality colonoscopy

    Principal Advisor

  • Master Philosophy

    Yield of neoplastic lesions in a prospective Australian cohort undergoing colonoscopic surveillance in the context of high-quality colonoscopy

    Principal Advisor

  • Master Philosophy

    Yield of neoplastic lesions in a prospective Australian cohort undergoing colonoscopic surveillance in the context of high-quality colonoscopy

    Principal Advisor

Completed supervision

Enquiries

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