Overview
Availability
- Dr Jennifer Smith is:
- Available for supervision
Qualifications
- Masters (Research) of Molecular Biology, The University of Queensland
- Doctor of Philosophy of Immunology, The University of Queensland
Works
Search Professor Jennifer Smith’s works on UQ eSpace
2025
Journal Article
Autoimmune origin for immune checkpoint inhibitor-diabetes revealed by deep immune phenotyping of the pancreas
Quandt, Zoe, Young, Arabella, Barlow, Graham Larson, Smith, Jennifer A, Kusmartseva, Irina, Dong, Shen, Shapiro, Melanie R, Kang, Jee Hye, Felton, Jamie L, Nguyen, Vinh Q, Szot, Greg, Hassoun, Assad A, Perdigoto, Ana Luisa, Herold, Kevan C, Nolan, Garry, Bollyky, Paul L, Brusko, Todd M, Nakayama, Maki, Cooper, Stewart and Anderson, Mark S (2025). Autoimmune origin for immune checkpoint inhibitor-diabetes revealed by deep immune phenotyping of the pancreas. Journal for immunotherapy of cancer, 13 (8) e011818, 1-9. doi: 10.1136/jitc-2025-011818
2024
Journal Article
Aire mediates tolerance to insulin through thymic trimming of high-affinity T cell clones
Smith, Jennifer A., Yuen, Benjamin T. K., Purtha, Whitney, Balolong, Jared M., Phipps, Jonah D., Crawford, Frances, Bluestone, Jeffrey A., Kappler, John W. and Anderson, Mark S. (2024). Aire mediates tolerance to insulin through thymic trimming of high-affinity T cell clones. Proceedings of the National Academy of Sciences of the United States of America, 121 (20) e2320268121, 1-10. doi: 10.1073/pnas.2320268121
2024
Journal Article
Tracking the role of Aire in immune tolerance to the eye with a TCR transgenic mouse model
Yin, Mianmian, Smith, Jennifer A, Chou, Marissa, Chan, Jackie, Jittayasothorn, Yingyos, Gould, Douglas B, Caspi, Rachel R, Anderson, Mark S and DeFranco, Anthony L (2024). Tracking the role of Aire in immune tolerance to the eye with a TCR transgenic mouse model. Proceedings of the National Academy of Sciences of the United States of America, 121 (5) e2311487121, 1-12. doi: 10.1073/pnas.2311487121
2023
Journal Article
Tuning peptide specificity for T cell tolerance in Type 1 diabetes
Smith, Jennifer Anne, Balolong, Jared, Jin, Nijun, Whitty, Caroline, Kappler, John W and Anderson, Mark S (2023). Tuning peptide specificity for T cell tolerance in Type 1 diabetes. The Journal of Immunology, 210 (Supplement_1). doi: 10.4049/jimmunol.210.supp.78.09
2022
Journal Article
Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection
VanDyke, Derek, Iglesias, Marcos, Tomala, Jakub, Young, Arabella, Smith, Jennifer, Perry, Joseph A., Gebara, Edward, Cross, Amy R., Cheung, Laurene S., Dykema, Arbor G., Orcutt-Jahns, Brian T., Henclova, Tereza, Golias, Jaroslav, Balolong, Jared, Tomasovic, Luke M., Funda, David, Meyer, Aaron S., Pardoll, Drew M., Hester, Joanna, Issa, Fadi, Hunter, Christopher A., Anderson, Mark S., Bluestone, Jeffrey A., Raimondi, Giorgio and Spangler, Jamie B. (2022). Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection. Cell Reports, 41 (3) 111478, 111478. doi: 10.1016/j.celrep.2022.111478
2022
Journal Article
Immune-profiling of pancreatic tissue affected by immune checkpoint inhibitor-induced diabetes (CPI-D)
Quandt, Zoe, Young, Arabella, Barlow, Graham, Dong, Shen, Smith, Jennifer, Kusmartseva, Irina, Brusko, Todd M., Cooper, Stewart and Anderson, Mark S. (2022). Immune-profiling of pancreatic tissue affected by immune checkpoint inhibitor-induced diabetes (CPI-D). Diabetes, 71 (S1). doi: 10.2337/db22-189-or
2022
Conference Publication
Autoantigen specific T-cell receptor induces organ-specific autoimmunity by escaping T-cell negative selection
Yin, Mianmian, Smith, Jennifer A., Chou, Marissa, Chan, Jackie, Hu, Yongmei, Lowell, Clifford A., Gould, Douglas B., Anderson, Mark S. and DeFranco, Anthony L. (2022). Autoantigen specific T-cell receptor induces organ-specific autoimmunity by escaping T-cell negative selection. Immunology 2022™ Meeting, Portland, OR, United States, 6-10 May 2022. Cary, NC, United States: Oxford University Press. doi: 10.4049/jimmunol.208.supp.104.02
2021
Journal Article
A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance
Warshauer, Jeremy T, Belk, Julia A, Chan, Alice Y, Wang, Jiaxi, Gupta, Alexander R, Shi, Quanming, Skartsis, Nikolaos, Peng, Yani, Phipps, Jonah D, Acenas, Dante, Smith, Jennifer A, Tamaki, Stanley J, Tang, Qizhi, Gardner, James M, Satpathy, Ansuman T and Anderson, Mark S (2021). A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance. The Journal of Experimental Medicine, 218 (8) e20210759, 1-18. doi: 10.1084/jem.20210759
2021
Journal Article
Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree
Hendley, Audrey M, Rao, Arjun A, Leonhardt, Laura, Ashe, Sudipta, Smith, Jennifer A, Giacometti, Simone, Peng, Xianlu L, Jiang, Honglin, Berrios, David I, Pawlak, Mathias, Li, Lucia Y, Lee, Jonghyun, Collisson, Eric A, Anderson, Mark S, Fragiadakis, Gabriela K, Yeh, Jen Jen, Ye, Chun Jimmie, Kim, Grace E, Weaver, Valerie M and Hebrok, Matthias (2021). Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree. eLife, 10 e67776, 1-29. doi: 10.7554/eLife.67776
2021
Conference Publication
The role of Aire in the selection of regulatory T cells in type 1 diabetes
Bridge, Jennifer Anne, Balolong, Jared, Belk, Julia, Dong, Shen, Cramer, Nathan, Mowery, Cody, Crawford, Frances, Ye, Jimmy, Satpathy, Ansuman, Kappler, John W, Bluestone, Jeffrey A and Anderson, Mark S (2021). The role of Aire in the selection of regulatory T cells in type 1 diabetes. Immunology 2021™ Meeting, Virtual, 10-15 May 2021. Cary, NC, United States: Oxford University Press. doi: 10.4049/jimmunol.206.supp.51.07
2021
Journal Article
T-cell receptor repertoire of mice with organ-specific autoimmunity resulting from a partial defect in T cell negative selection and dendritic cell enhancement
Yin, Mianmian, Smith, Jennifer A, Chou, Marissa, Chan, Jackie, Hu, Yongmei, Lowell, Clifford A, Gould, Douglas B, Anderson, Mark S and DeFranco, Anthony L (2021). T-cell receptor repertoire of mice with organ-specific autoimmunity resulting from a partial defect in T cell negative selection and dendritic cell enhancement. The Journal of Immunology, 206 (1_Supplement), 51.06-51.06. doi: 10.4049/jimmunol.206.supp.51.06
2020
Journal Article
Regulatory T cell control of systemic immunity and immunotherapy response in liver metastasis
Lee, James C., Mehdizadeh, Sadaf, Smith, Jennifer, Young, Arabella, Mufazalov, Ilgiz A., Mowery, Cody T., Daud, Adil and Bluestone, Jeffrey A. (2020). Regulatory T cell control of systemic immunity and immunotherapy response in liver metastasis. Science Immunology, 5 (52) eaba0759, 1-14. doi: 10.1126/sciimmunol.aba0759
2020
Journal Article
Evaluation of SARS-CoV-2 serology assays reveals a range of test performance
Whitman, Jeffrey D., Hiatt, Joseph, Mowery, Cody T., Shy, Brian R., Yu, Ruby, Yamamoto, Tori N., Rathore, Ujjwal, Goldgof, Gregory M., Whitty, Caroline, Woo, Jonathan M., Gallman, Antonia E., Miller, Tyler E., Levine, Andrew G., Nguyen, David N., Bapat, Sagar P., Balcerek, Joanna, Bylsma, Sophia A., Lyons, Ana M., Li, Stacy, Wong, Allison Wai-yi, Gillis-Buck, Eva Mae, Steinhart, Zachary B., Lee, Youjin, Apathy, Ryan, Lipke, Mitchell J., Smith, Jennifer Anne, Zheng, Tina, Boothby, Ian C., Isaza, Erin ... Marson, Alexander (2020). Evaluation of SARS-CoV-2 serology assays reveals a range of test performance. Nature Biotechnology, 38 (10), 1174-1183. doi: 10.1038/s41587-020-0659-0
2020
Conference Publication
Liver metastasis mediated control of distant tumor-specific immunity and response to checkpoint immunotherapy
Lee, James C., Mehdizadeh, Sadaf, Young, Arabella, Bridge, Jennifer, Mufazalov, Ilgiz A., Daud, Adil and Bluestone, Jeffrey A. (2020). Liver metastasis mediated control of distant tumor-specific immunity and response to checkpoint immunotherapy. AACR Annual Meeting, Electr Network, 22-24 June 2020. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2020-1031
2020
Conference Publication
The role of Aire in the selection of regulatory T cells in diabetes
Bridge, Jennifer Anne, Balolong, Jared, Dong, Shen, Cramer, Nathan, Mowery, Cody, Crawford, Frances, Ye, Jimmie, Kappler, John W, Bluestone, Jeffrey A and Anderson, Mark S (2020). The role of Aire in the selection of regulatory T cells in diabetes. Immunology 2020™ Meeting, Honolulu, HI, United States, 8-12 May 2020. Oxford, United Kingdom: Oxford University Press. doi: 10.4049/jimmunol.204.supp.143.9
2019
Journal Article
Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage
Tuong, Zewen, Lewandowski, Andrew, Bridge, Jennifer, Gonzalez-Cruz, Jazmina, Yamada, Miko, Lambie, Duncan, Lewandowski, Richard, Steptoe, Raymond, Leggatt, Graham, Simpson, Fiona, Frazer, Ian, Soyer, Peter and Wells, James W. (2019). Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage. Scientific Reports, 9 (1) 17754, 17754. doi: 10.1038/s41598-019-54435-0
2018
Journal Article
Cytokines, chemokines, and other biomarkers of response for checkpoint inhibitor therapy in skin cancer
Bridge, Jennifer A., Lee, James C., Daud, Adil, Wells, James W. and Bluestone, Jeffrey A. (2018). Cytokines, chemokines, and other biomarkers of response for checkpoint inhibitor therapy in skin cancer. Frontiers in Medicine, 5 (DEC) 351, 351. doi: 10.3389/fmed.2018.00351
2018
Conference Publication
Aire-dependent thymic FoxP3+ regulatory T cells in Type 1 Diabetes
Bridge, Jennifer Anne, Yuen, Benjamin, Dong, Shen, Ye, Jimmy, Kappler, John W, Bluestone, Jeffrey A and Anderson, Mark S (2018). Aire-dependent thymic FoxP3+ regulatory T cells in Type 1 Diabetes. Immunology 2018™ Meeting, Austin, TX, United States, 4-8 May 2018. Cary, NC, United States: Oxford University Press. doi: 10.4049/jimmunol.200.supp.101.10
2018
Conference Publication
Antigen discovery for regulatory T cells (Tregs) in type-1 diabetes (T1D)
Dong, Shen, Xu, Daqi, Bridge, Jennifer Anne, Purtha, Whitney, Spence, Allyson, Wells, Danny, Wang, Xiao Hua, Tang, Qizhi, Anderson, Mark S and Bluestone, Jeffrey A (2018). Antigen discovery for regulatory T cells (Tregs) in type-1 diabetes (T1D). Immunology 2018™ Meeting, Austin, TX, United States, 4-8 May 2018. Cary, NC, United States: Oxford University Press. doi: 10.4049/jimmunol.200.supp.101.12
2017
Journal Article
CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin
Overgaard, Nana H., Cruz, Jazmina L., Bridge, Jennifer A., Nel, Hendrik J., Frazer, Ian H., La Gruta, Nicole K., Blumenthal, Antje, Steptoe, Raymond J. and Wells, James W. (2017). CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin. Journal of Leukocyte Biology, 102 (3), 837-844. doi: 10.1189/jlb.1AB0217-065R
Funding
Current funding
Supervision
Availability
- Dr Jennifer Smith is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Restoration of regulatory T cell responses in type 1 diabetes
Associate Advisor
Other advisors: Dr Janin Chandra, Dr Anne-Sophie Bergot, Professor Emma Hamilton-Williams
Media
Enquiries
For media enquiries about Dr Jennifer Smith's areas of expertise, story ideas and help finding experts, contact our Media team: