Overview
Background
I am a medicinal and organic chemist
Studied organic chemistry at the University of Sydney, moved to UQ in 1993, then worked for Bayer in Germany, before moving back to Australia in 1996. Worked in Melbourne at the Victorian College of Pharmacy (now MIPS). I then returned to UQ in 2000 to the Fairlie lab where we design and synthesise new chemical entities to tackle human disease. Since 2012 I have been on extended medical leave and am currently an Adjunct Research Fellow, researching proteins from flaviviruses such as Dengue, West Nile, and Zika viruses, and the coronaviruses SARS, MERS, and SARS-CoV-2.
Availability
- Dr Martin Stoermer is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), University of Sydney
- Doctor of Philosophy, University of Sydney
Research interests
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Viral Proteases
I study the proteases from Flaviviruses such as Dengue and West Nile virus, and Coronaviruses like SARS, and SARS-CoV-2, using a combination of chemical synthesis and molecular modelling. Previously I worked on the design and synthesis of inhibitors of HIV protease.
Works
Search Professor Martin Stoermer’s works on UQ eSpace
2008
Journal Article
Potent cationic inhibitors of West Nile Virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activity
Stoermer, Martin J., Chappell, Keith J., Liebscher, Susann, Jensen, Christina M., Gan, Chun H., Gupta, Praveer K., Xu, Wei-Jun, Young, Paul R. and Fairlie, David P. (2008). Potent cationic inhibitors of West Nile Virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activity. Journal of Medicinal Chemistry, 51 (18), 5714-5721. doi: 10.1021/jm800503y
2008
Journal Article
ChemInform Abstract: Synthesis and Cannabinoid Activity of 1-Substituted-indole-3-oxadiazole Derivatives: Novel Agonists for the CB1Receptor
Moloney, Gerard P., Angus, James A., Robertson, Alan D., Stoermer, Martin J., Robinson, Michael, Wright, Christine E., McRae, Ken and Christopoulos, Arthur (2008). ChemInform Abstract: Synthesis and Cannabinoid Activity of 1-Substituted-indole-3-oxadiazole Derivatives: Novel Agonists for the CB1Receptor. ChemInform, 39 (31) doi: 10.1002/chin.200831222
2008
Journal Article
Mutagenesis of the West Nile virus NS2B cofactor domain reveals two regions essential for protease activity
Chappell, Keith J., Stoermer, Martin J., Fairlie, David P. and Young, Paul R. (2008). Mutagenesis of the West Nile virus NS2B cofactor domain reveals two regions essential for protease activity. Journal of General Virology, 89 (4), 1010-1014. doi: 10.1099/vir.0.83447-0
2008
Journal Article
Synthesis and cannabinoid activity of 1-substituted-Indole-3-oxadiazole derivatives: Novel agonists for the CB1 Receptor
Moloney, Gerard P., Angus, James A., Robertson, Alan D., Stoermer, Martin J., Robinson, Michael, Lay, Lucy, Wright, Christine E., McRae, Ken and Christopoulos, Arthur (2008). Synthesis and cannabinoid activity of 1-substituted-Indole-3-oxadiazole derivatives: Novel agonists for the CB1 Receptor. European Journal of Medicinal Chemistry, 43 (3), 513-539. doi: 10.1016/j.ejmech.2007.04.007
2008
Conference Publication
COMP 264-Unraveling the mechanism of antagonism for human C5a receptor: Comparison of three structurally different antagonists
Madala, P. K., Stoermer, M., Tyndall, J. D. A., Monk, P. N., Higginbottom, A. and Fairlie, D. P. (2008). COMP 264-Unraveling the mechanism of antagonism for human C5a receptor: Comparison of three structurally different antagonists. 236th National Meeting of the American Chemical Society, Philadelphia, USA, 17-21 August, 2008. Washington, D. C., USA: American Chemical Society.
2008
Journal Article
Synthesis and cannabinoid activity of a variety of 2,3-substituted 1-Benzo[b]thiophen derivatives and 2,3-substituted benzofuran: Novel agonists for the CB1 receptor
Moloney, Gerard P., Angus, James A., Robertson, Alan D., Stoermer, Martin J., Robinson, Michael, Lay, Lucy, Wright, Christine E., McRae, Ken and Christopoulos, Arthur (2008). Synthesis and cannabinoid activity of a variety of 2,3-substituted 1-Benzo[b]thiophen derivatives and 2,3-substituted benzofuran: Novel agonists for the CB1 receptor. Australian Journal of Chemistry, 61 (7), 484-499. doi: 10.1071/CH07412
2007
Other Outputs
Compounds and inhibitors of phospholipases
Reid, Robert C., Clark, Christopher I., Hansford, Karl, Stoermer, Martin J., McGeary, Ross P., Fairlie, David P. and Schafer, Karl (2007). Compounds and inhibitors of phospholipases. US7253194.
2007
Other Outputs
New amino acid derivatives useful for the treatment of inflammatory disease or condition e.g. rheumatic arthritis
Clark, C. I., Fairlie, D. P., Hansford, K., McGeary, R. P., Reid, R. C. and Stoermer, M. J. (2007). New amino acid derivatives useful for the treatment of inflammatory disease or condition e.g. rheumatic arthritis.
2007
Journal Article
Generation and characterization of proteolytically active and highly stable truncated and full-length recombinant West Nile virus NS3
Chappell, K. J., Stoermer, M. J., Fairlie, D. P. and Young, P. R. (2007). Generation and characterization of proteolytically active and highly stable truncated and full-length recombinant West Nile virus NS3. Protein Expression and Purification, 53 (1), 87-96. doi: 10.1016/j.pep.2006.10.022
2006
Conference Publication
Defining the ligand binding site on the human C5a receptor
Monk, Peter N., Higginbottom, Adrian, Madala, Praveen K., Tyndall, Joel D. A., Stoermer, Martin and Fairlie, David P. (2006). Defining the ligand binding site on the human C5a receptor. 231st National Meeting of the American-Chemical-Society, Atlanta Ga, Mar 26-30, 2006. WASHINGTON: AMER CHEMICAL SOC.
2006
Journal Article
Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria
Andrews, Katherine T., Fairlie, David P., Madala, Praveen K., Ray, John, Wyatt, David M., Hilton, Petrina M., Melville, Lewis A., Beattie, Lynette, Gardiner, Donald L., Reid, Robert C., Stoermer, Martin J., Skinner-Adams, Tina, Berry, Colin and McCarthy, James S. (2006). Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria. Antimicrobial Agents And Chemotherapy, 50 (2), 639-648. doi: 10.1128/AAC.50.2.639-648.2006
2006
Conference Publication
Multiple targets for antiviral inhibitors
Young, P. R., Chappell, K. J., Stoermer, M. J., Fairlie, D., Kampmann, T. and Kobe, B. (2006). Multiple targets for antiviral inhibitors. 7th Asia Pacific Congress of Virology, New Delhi, 13-15 Nov, 2006.
2006
Journal Article
Current Status of Virtual Screening as Analysed by Target Classes
Stoermer, M J (2006). Current Status of Virtual Screening as Analysed by Target Classes. Medicinal Chemistry, 2 (1), 89-112. doi: 10.2174/157340606775197750
2006
Conference Publication
Defining the ligand binding site on the human C5a receptor
Monk, Peter N., Higginbottom, Adrian, Madala, Praveen K., Tyndall, Joel D. A., Stoermer, Martin and Fairlie, David P. (2006). Defining the ligand binding site on the human C5a receptor. The 231st ACS National Meeting, Atlanta, GA, U.S.A., 26-30 March 2006. Washington, D.C.: American Chemical Society.
2006
Journal Article
Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studies
Chappell, K. J., Stoermer, M. J., Fairlie, D. P. and Young, P. R. (2006). Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studies. Journal of Biological Chemistry, 281 (50), 38448-38458. doi: 10.1074/jbc.M607641200
2006
Conference Publication
Investigation of the West Nile virus NS3 protease by tandem use of site-directed mutagenesis and substrate modification
Chappell, K. J., Stoermer, M J, Fairlie, D and Young, P R (2006). Investigation of the West Nile virus NS3 protease by tandem use of site-directed mutagenesis and substrate modification. Australian Society for Microbiology Annual Scientific Meeting, Gold Coast, Qld, 2-6 July, 2006.
2005
Journal Article
Site-directed mutagenesis and kinetic studies of the West Nile virus NS3 protease identify key enzyme-substrate interactions
Chappell, Keith J., Nall, Tessa A., Stoermer, Martin J., Fang, Ning-Xia, Tyndall, Joel D. A., Fairlie, David P. and Young, Paul R. (2005). Site-directed mutagenesis and kinetic studies of the West Nile virus NS3 protease identify key enzyme-substrate interactions. Journal of Biological Chemistry, 280 (4), 2896-2903. doi: 10.1074/jbc.M409931200
2005
Journal Article
Structural mimicry of two cytochrome b(562) interhelical loops using macrocycles constrained by oxazoles and thiazoles
Singh, Y, Stoermer, MJ, Lucke, AJ, Guthrie, T and Fairlie, DP (2005). Structural mimicry of two cytochrome b(562) interhelical loops using macrocycles constrained by oxazoles and thiazoles. Journal of The American Chemical Society, 127 (18), 6563-6572. doi: 10.1021/ja0455300
2005
Conference Publication
Development of antiviral drugs targeting the flavivirus fusion mechanism
Kampmann, T., Yennamalli Madhava R, R., Stoermer, M. J., Kobe, B. and Young, P. R. (2005). Development of antiviral drugs targeting the flavivirus fusion mechanism. 30th Lorne Conference on Protein Structure & Function, Lorne, 6-10 Feb, 2005.
2005
Conference Publication
Development of a catalytically active recombinant West Nile NS3 protease and the identification of key enzyme-substrate interactions by site-directed mutagenesis
Chappell, K. J., Stoermer, M. J., Fairlie, D. and Young, P. R. (2005). Development of a catalytically active recombinant West Nile NS3 protease and the identification of key enzyme-substrate interactions by site-directed mutagenesis. International Congress of Virology, San Francisco, 23-27 July, 2005.
Funding
Past funding
Supervision
Availability
- Dr Martin Stoermer is:
- Available for supervision
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Supervision history
Completed supervision
-
2014
Doctor Philosophy
Towards Serine Protease Inhibitors
Associate Advisor
Other advisors: Professor David Fairlie
-
2008
Doctor Philosophy
Computer Aided Drug Design: GPCRs and Proteases
Associate Advisor
Other advisors: Professor David Fairlie
-
2015
Doctor Philosophy
Towards inhibitors of hydrolytic enzymes involved in inflammation
Joint Principal Advisor
Other advisors: Professor David Fairlie
Media
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