Overview
Background
I am a medicinal and organic chemist
Studied organic chemistry at the University of Sydney, moved to UQ in 1993, then worked for Bayer in Germany, before moving back to Australia in 1996. Worked in Melbourne at the Victorian College of Pharmacy (now MIPS). I then returned to UQ in 2000 to the Fairlie lab where we design and synthesise new chemical entities to tackle human disease. Since 2012 I have been on extended medical leave and am currently an Adjunct Research Fellow, researching proteins from flaviviruses such as Dengue, West Nile, and Zika viruses, and the coronaviruses SARS, MERS, and SARS-CoV-2.
Availability
- Dr Martin Stoermer is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), University of Sydney
- Doctor of Philosophy, University of Sydney
Research interests
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Viral Proteases
I study the proteases from Flaviviruses such as Dengue and West Nile virus, and Coronaviruses like SARS, and SARS-CoV-2, using a combination of chemical synthesis and molecular modelling. Previously I worked on the design and synthesis of inhibitors of HIV protease.
Works
Search Professor Martin Stoermer’s works on UQ eSpace
2014
Conference Publication
Mining physicochemical features that contribute to oral bioavailability in peptide middle space
Plisson, Fabien , Lucke, Andrew, Nielsen, Daniel , Stoermer, Martin J. and Fairlie, David (2014). Mining physicochemical features that contribute to oral bioavailability in peptide middle space. European QSAR Symposium, St Petersburg, Russia, September 2014.
2013
Journal Article
Lithium perchlorate accelerated Friedel-Crafts addition of furans to β-nitrostyrenes
Stoermer, Martin J., Richter, Hans-Matthias and Kaufmann, Dieter E. (2013). Lithium perchlorate accelerated Friedel-Crafts addition of furans to β-nitrostyrenes. Tetrahedron Letters, 54 (49), 6776-6778. doi: 10.1016/j.tetlet.2013.10.018
2013
Journal Article
Downsizing a human inflammatory protein to a small molecule with equal potency and functionality
Reid, Robert C., Yau, Mei-Kwan, Singh, Ranee, Hamidon, Johan K., Reed, Anthony N., Chu, Peifei, Suen, Jacky Y., Stoermer, Martin J., Blakeney, Jade S., Lim, Junxian, Faber, Jonathan M. and David P. Fairlie, (2013). Downsizing a human inflammatory protein to a small molecule with equal potency and functionality. Nature Communications, 4 (2802) 2802, 1-9. doi: 10.1038/ncomms3802
2013
Conference Publication
Novel inhibitors of DENV NS2B/NS3pro protease
Chow, Shiao Yun, Stoermer, Martin J., Chappell, Keith J., Young, Paul R. and Fairlie, David P. (2013). Novel inhibitors of DENV NS2B/NS3pro protease. 246th National Meeting of the American-Chemical-Society (ACS), Indianapolis in, Sep 08-12, 2013. WASHINGTON: AMER CHEMICAL SOC.
2013
Journal Article
An interaction between the methyltransferase and RNA dependent RNA polymerase domains of the West Nile virus NS5 protein
Tan, Cindy S. E., Hobson-Peters, Jody M., Stoermer, Martin J., Fairlie, David P., Khromykh, Alexander A. and Hall, Roy A. (2013). An interaction between the methyltransferase and RNA dependent RNA polymerase domains of the West Nile virus NS5 protein. Journal of General Virology, 94 (Pt. 9), 1961-1971. doi: 10.1099/vir.0.054395-0
2013
Journal Article
Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds
Ngoei, Kevin R. W., Ng, Dominic C. H., Gooley, Paul R., Fairlie, David P., Stoermer, Martin J. and Bogoyevitch, Marie A. (2013). Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1834 (6), 1077-1088. doi: 10.1016/j.bbapap.2013.02.001
2013
Conference Publication
Toward more orally bioavailable inhibitors of phospholipase A(2) GIIA (pla2g2a) to treat chronic inflammation
Barbero, Sheila, Reid, Robert C., Stoermer, Martin J., Lohman, Rink J. and Fairlie, David P. (2013). Toward more orally bioavailable inhibitors of phospholipase A(2) GIIA (pla2g2a) to treat chronic inflammation. 246th National Meeting of the American-Chemical-Society (ACS), Indianapolis, IN, United States, 8-12 September 2013. Washington, DC, United States: American Chemical Society.
2012
Journal Article
Identification of crotonyl glycine in urine of sheep after 48h road transport
Li, Juan, Schirra, Horst Joachim, Yu, Yihua, Colgrave, Michelle L., Stoermer, Martin J. and Wijffels, Gene (2012). Identification of crotonyl glycine in urine of sheep after 48h road transport. Journal of Pharmaceutical and Biomedical Analysis, 67–68, 129-136. doi: 10.1016/j.jpba.2012.04.028
2012
Journal Article
Structures of peptide agonists for human protease activated receptor 2
Stoermer, Martin J., Flanagan, Bernadine, Beyer, Renée L., Madala, Praveen K. and Fairlie, David P. (2012). Structures of peptide agonists for human protease activated receptor 2. Bioorganic and Medicinal Chemistry Letters, 22 (2), 916-919. doi: 10.1016/j.bmcl.2011.12.029
2011
Conference Publication
Towards orally bioavailable peptides and peptidomimetics
Fairlie, David P., Stoermer, Martin, Lucke, Andrew, Lohman, Rink-Jan, Liu, Ligong and Ruiz-Gomez, Gloria (2011). Towards orally bioavailable peptides and peptidomimetics. 241st National Meeting and Exposition of the American-Chemical-Society (ACS), Anaheim, CA, United States, 27-31 March 2011. Washington, DC, United States: American Chemical Society.
2010
Conference Publication
Sneaking up on West Nile Virus NS2B/NS3 protease subcellular activity utilising dye-quenched substrates
Liebscher, Susan, Chappell, K. J., Stoermer, Martin J., Watterson, Daniel, Webb, Richard I., Khromykh, Alexander A., Fairlie, David P. and Young, Paul R. (2010). Sneaking up on West Nile Virus NS2B/NS3 protease subcellular activity utilising dye-quenched substrates. PlusStrand 2010: The Ninth International Symposium on Positive-Strand RNA Viruses, Atlanta, GA, U.S.A., 17-21 May 2010.
2010
Conference Publication
Potent inhibitors of West Nile Virus NS2B/NS3 protease
Chappell, K. J., Fairlie, D. P., Gan, C. H., Gupta, P. K., Hu, S., Jensen, C. M., Liebscher, S., Martin, J. L., Robin, G., Stoermer M. J., Xu, W. and Young, P. R. (2010). Potent inhibitors of West Nile Virus NS2B/NS3 protease. 6th General Meeting of the International Proteolysis Society, Gold Coast, QLD, Australia, 26-30 October 2009. Berlin, Germany: Walter De Gruyter.
2010
Conference Publication
Identification of crotonyl glycine in sheep urine using RP-HPLC, NMR and ESI-MS
Li, J., Wijffels, G., Colgrave, M., Stoermer, M.J. and Schirra, H.J. (2010). Identification of crotonyl glycine in sheep urine using RP-HPLC, NMR and ESI-MS. Metabolomics and More - 1st International Metabolomics Symposium in Germany, Freising, Germany, 10-12 March, 2010.
2009
Journal Article
In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses
Kampmann, T., Yennamalli, R., Campbell, P., Stoermer, M. J., Fairlie, D. P., Kobe, B. and Young, P. R. (2009). In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses. Antiviral Research, 84 (3), 234-241. doi: 10.1016/j.antiviral.2009.09.007
2009
Journal Article
Base-sensitivity of arginine alpha-ketoamide inhibitors of serine proteases
Stoermer, Martin J., Leung, Donmienne, Young, Paul R. and Fairlie, David P. (2009). Base-sensitivity of arginine alpha-ketoamide inhibitors of serine proteases. Australian Journal of Chemistry, 62 (9), 988-992. doi: 10.1071/CH09150
2009
Journal Article
Structure of West Nile virus NS3 protease: Ligand stabilization of the catalytic conformation
Robin, Gautier, Chappell, Keith, Stoermer, Martin J., Hu, Shu-Hong, Young, Paul R., Fairlie, David P. and Martin, Jennifer L. (2009). Structure of West Nile virus NS3 protease: Ligand stabilization of the catalytic conformation. Journal of Molecular Biology, 385 (5), 1568-1577. doi: 10.1016/j.jmb.2008.11.026
2009
Conference Publication
Potent inhibitors of West Nile Virus NS2B/NS3 protease
Stoermer, Martin , Chappell, Keith J. , Jensen, Christina M. , Liebscher, Susann , Gan, Chun H. , Gupta, Praveer K. , Xu, Wei-Jun , Young, Paul R. , Fairlie, David P. and Watterson, Dan (2009). Potent inhibitors of West Nile Virus NS2B/NS3 protease. 6th General Meeting of the International Proteolysis Society, Gold Coast, QLD, Australia, 26-30 October 2009.
2009
Conference Publication
Antiviral activity in cell culture of potent inhibitors targeting the West Nile Virus NS2B/NS3 protease
Liebscher, S., Chappell, K.J., Stoermer, M.J., Fairlie, D.P. and Young, P.R (2009). Antiviral activity in cell culture of potent inhibitors targeting the West Nile Virus NS2B/NS3 protease. 6th General Meeting of the International Proteolysis Society, Gold Coast , QLD, Australia, 26-30 October, 2009.
2009
Conference Publication
Regulating protein and peptide activated GPCRs
Fairlie, David P., Madala, Praveen K., Stoermer, Martin J., Suen, Jacky, Barry, Grant and Lohman, Rink-Jan (2009). Regulating protein and peptide activated GPCRs. 229th National Meeting of the American Chemical Society, San Diego, California, 13-17 March 2005. Washington DC, United States: American Chemical Society.
2008
Journal Article
West Nile Virus NS2B/NS3 protease as an antiviral target
Chappell, K. J., Stoermer, M. J., Fairlie, D. P. and Young, P. R. (2008). West Nile Virus NS2B/NS3 protease as an antiviral target. Current Medicinal Chemistry, 15 (27), 2771-2784. doi: 10.2174/092986708786242804
Funding
Past funding
Supervision
Availability
- Dr Martin Stoermer is:
- Available for supervision
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Supervision history
Completed supervision
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2014
Doctor Philosophy
Towards Serine Protease Inhibitors
Associate Advisor
Other advisors: Professor David Fairlie
-
2008
Doctor Philosophy
Computer Aided Drug Design: GPCRs and Proteases
Associate Advisor
Other advisors: Professor David Fairlie
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2015
Doctor Philosophy
Towards inhibitors of hydrolytic enzymes involved in inflammation
Joint Principal Advisor
Other advisors: Professor David Fairlie
Media
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