Overview
Background
I am a medicinal and organic chemist
Studied organic chemistry at the University of Sydney, moved to UQ in 1993, then worked for Bayer in Germany, before moving back to Australia in 1996. Worked in Melbourne at the Victorian College of Pharmacy (now MIPS). I then returned to UQ in 2000 to the Fairlie lab where we design and synthesise new chemical entities to tackle human disease. Since 2012 I have been on extended medical leave and am currently an Adjunct Research Fellow, researching proteins from flaviviruses such as Dengue, West Nile, and Zika viruses, and the coronaviruses SARS, MERS, and SARS-CoV-2.
Availability
- Dr Martin Stoermer is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), University of Sydney
- Doctor of Philosophy, University of Sydney
Research interests
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Viral Proteases
I study the proteases from Flaviviruses such as Dengue and West Nile virus, and Coronaviruses like SARS, and SARS-CoV-2, using a combination of chemical synthesis and molecular modelling. Previously I worked on the design and synthesis of inhibitors of HIV protease.
Works
Search Professor Martin Stoermer’s works on UQ eSpace
2020
Other Outputs
Homology Models of the Papain-Like Protease PLpro from Coronavirus 2019-nCoV
Stoermer, Martin J. (2020). Homology Models of the Papain-Like Protease PLpro from Coronavirus 2019-nCoV.
2020
Other Outputs
Homology Models of Coronavirus 2019-nCoV 3CLpro Protease
Stoermer, Martin J. (2020). Homology Models of Coronavirus 2019-nCoV 3CLpro Protease.
2020
Other Outputs
Supporting Raw Molecular Dynamics Data for Homology models of Coronavirus 2019-nCoV 3CLpro Protease
Stoermer, Martin J. (2020). Supporting Raw Molecular Dynamics Data for Homology models of Coronavirus 2019-nCoV 3CLpro Protease. The University of Queensland. (Dataset) doi: 10.14264/uql.2020.155
2020
Conference Publication
Homology Models and Molecular Dynamics of SARS-CoV-2 Coronaviral Protease 3CLpro
Stoermer, Martin J. (2020). Homology Models and Molecular Dynamics of SARS-CoV-2 Coronaviral Protease 3CLpro. Royal Society of Chemistry Twitter Conference 2020, London (but held online), 3rd-4th March 2020. London, United Kingdom: Royal Society of Chemistry.
2019
Journal Article
(Z)-N'-(1H-Benzo[d]imidazol-2-Yl)-arylimidamide adducts of 2-aminobenzimidazole and aromatic nitriles: structural and spectroscopic proof of regiochemical and stereochemical outcomes
Stoermer, Martin J., Egan, Simon, Forsyth, Craig M. and Moloney, Gerard P. (2019). (Z)-N'-(1H-Benzo[d]imidazol-2-Yl)-arylimidamide adducts of 2-aminobenzimidazole and aromatic nitriles: structural and spectroscopic proof of regiochemical and stereochemical outcomes. doi: 10.26434/chemrxiv.7777085.v1
2019
Conference Publication
Molecular dynamics study of the UQ construct of West Nile Virus NS2B/NS3 protease and it’s interactions with inhibitors
Stoermer, Martin J. (2019). Molecular dynamics study of the UQ construct of West Nile Virus NS2B/NS3 protease and it’s interactions with inhibitors. 2019 Royal Society of Chemistry Twitter Conference, London (but held online), 5-6 March 2019. London, United Kingdom: Royal Society of Chemistry.
2019
Other Outputs
Supplementary Data tables for: Orally absorbed cyclic peptides
Nielsen, Daniel S., Shepherd, Nicholas E., Xu, Weijun, Lucke, Andrew J., Stoermer, Martin J. and Fairlie, David P. (2019). Supplementary Data tables for: Orally absorbed cyclic peptides. The University of Queensland. (Dataset) doi: 10.14264/uql.2019.213
2018
Conference Publication
Stereoelectronic effects on dienophile separation influence the Diels–Alder synthesis of molecular clefts
Stoermer, Martin J., Wickramasinghe, Wasantha A., Byriel, Karl A., Hockless, David C. R., Skelton, Brian W., Sobolev, Alexandre N., White, Alan H., Mak, Jeffrey Y. W. and Fairlie, David P. (2018). Stereoelectronic effects on dienophile separation influence the Diels–Alder synthesis of molecular clefts. 2018 Royal Society of Chemistry Twitter Conference, London, United Kingdom (held online), 6-7 March 2018. London, United Kingdom: Royal Society of Chemistry.
2017
Journal Article
Stereoelectronic Effects on Dienophile Separation Influence the Diels–Alder Synthesis of Molecular Clefts
Stoermer, Martin J., Wickramasinghe, Wasantha A., Byriel, Karl A., Hockless, David C. R., Skelton, Brian W., Sobolev, Alexandre N., White, Allan H., Mak, Jeffrey Y. W. and Fairlie, David P. (2017). Stereoelectronic Effects on Dienophile Separation Influence the Diels–Alder Synthesis of Molecular Clefts. European Journal of Organic Chemistry, 2017 (45), 6793-6796. doi: 10.1002/ejoc.201701319
2017
Journal Article
Orally absorbed cyclic peptides
Nielsen, Daniel S., Shepherd, Nicholas E., Xu, Weijun, Lucke, Andrew J., Stoermer, Martin J. and Fairlie, David P. (2017). Orally absorbed cyclic peptides. Chemical Reviews, 117 (12), 8094-8128. doi: 10.1021/acs.chemrev.6b00838
2017
Conference Publication
Flaviviral virus proteases. What do crystal structures and homology models actually tell us?
Stoermer, Martin J. (2017). Flaviviral virus proteases. What do crystal structures and homology models actually tell us?. Royal Society of Chemistry Twitter Conference 2017, London (but held online), 20-21 March 2017. London, United Kingdom: Royal Society of Chemistry. doi: 10.6084/m9.figshare.7823423
2016
Journal Article
Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists
Seow, Vernon, Lim, Junxian, Cotterell, Adam J., Yau, Mei-Kwan, Xu, Weijun, Lohman, Rink-Jan, Kok, W. Mei, Stoermer, Martin J., Sweet, Matthew J., Reid, Robert C., Suen, Jacky Y. and Farilie, David P. (2016). Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists. Scientific Reports, 6 (1) 24575, 24575.1-24575.12. doi: 10.1038/srep24575
2016
Conference Publication
Why are there so few Australian chemists on Twitter?
Stoermer, Martin (2016). Why are there so few Australian chemists on Twitter?. Queensland Annual Chemistry Symposium, Hawken Building, University of Queensland, 25th November 2016. doi: 10.6084/m9.figshare.7849403
2015
Journal Article
Simultaneous uncoupled expression and purification of the Dengue virus NS3 protease and NS2B co-factor domain.
Shannon, A. E, Chappell, K. J., Stoermer, M. J., Chow, S. Y., Kok, W. M., Fairlie, D. P. and Young, P. R. (2015). Simultaneous uncoupled expression and purification of the Dengue virus NS3 protease and NS2B co-factor domain.. Protein Expression and Purification, 119, 124-129. doi: 10.1016/j.pep.2015.11.022
2015
Journal Article
Virtual Screening of Peptide and Peptidomimetic Fragments Targeted to Inhibit Bacterial Dithiol Oxidase DsbA
Duprez, Wilko, Bachu, Prabhakar, Stoermer, Martin J, Tay, Stephanie, McMahon, Roisin M, Fairlie, David P and Martin, Jennifer L (2015). Virtual Screening of Peptide and Peptidomimetic Fragments Targeted to Inhibit Bacterial Dithiol Oxidase DsbA. Plos One, 10 (7) e0133805, e0133805. doi: 10.1371/journal.pone.0133805
2015
Journal Article
Three homology models for PAR2 derived from different templates: Application to antagonist discovery
Perry, Samuel R., Xu, Weijun, Wirija, Anna, Lim, Junxian, Yau, Mei-Kwan, Stoermer, Martin J., Lucke, Andrew J. and Fairlie, David P. (2015). Three homology models for PAR2 derived from different templates: Application to antagonist discovery. Journal of Chemical Information And Modeling, 55 (6), 1181-1191. doi: 10.1021/acs.jcim.5b00087
2015
Conference Publication
Downsizing Proteins Without Losing Potency or Function
Fairlie, David P. , Yau, Mei-Kwan , Hamidon, Johan K. , Singh, Ranee , Lim, Junxian , Suen, Jacky Y. , Rowley, Jessica A. , Lohman, Rink-Jan , Stoermer, Martin J. , Iyer, Abishek and Reid, Robert C. (2015). Downsizing Proteins Without Losing Potency or Function. American Peptide Symposium 2015, Orlando , Florida, United States, 20-25 June 2015. American Peptide Society. doi: 10.17952/24APS.2015.016
2014
Journal Article
Potent heterocyclic ligands for human complement C3a receptor
Reid, Robert C., Yau, Mei-Kwan, Singh, Ranee, Hamidon, Johan K., Lim, Junxian, Stoermer, Martin J. and Fairlie, David P. (2014). Potent heterocyclic ligands for human complement C3a receptor. Journal of Medicinal Chemistry, 57 (20), 8459-8470. doi: 10.1021/jm500956p
2014
Journal Article
Cyclic penta- and hexaleucine peptides without N-methylation are orally absorbed
Hill, Timothy A., Lohman, Rink-Jan, Hoang, Huy N., Nielsen, Daniel S., Scully, Conor C. G., Kok, W. Mei, Liu, Ligong, Lucke, Andrew J., Stoermer, Martin J., Schroeder, Christina I., Chaousis, Stephanie, Colless, Barbara, Bernhardt, Paul V., Edmonds, David J., Griffith, David A., Rotter, Charles J., Ruggeri, Roger B., Price, David A., Liras, Spiros, Craik, David J. and Fairlie, David P. (2014). Cyclic penta- and hexaleucine peptides without N-methylation are orally absorbed. ACS Medicinal Chemistry Letters, 5 (10), 1148-1151. doi: 10.1021/ml5002823
2014
Journal Article
ChemInform Abstract: Lithium Perchlorate Accelerated Friedel-Crafts Addition of Furans to β-Nitrostyrenes
Stoermer, Martin J., Richter, Hans-Matthias and Kaufmann, Dieter E. (2014). ChemInform Abstract: Lithium Perchlorate Accelerated Friedel-Crafts Addition of Furans to β-Nitrostyrenes. ChemInform, 45 (15), no-no. doi: 10.1002/chin.201415112
Funding
Past funding
Supervision
Availability
- Dr Martin Stoermer is:
- Available for supervision
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Supervision history
Completed supervision
-
2014
Doctor Philosophy
Towards Serine Protease Inhibitors
Associate Advisor
Other advisors: Professor David Fairlie
-
2008
Doctor Philosophy
Computer Aided Drug Design: GPCRs and Proteases
Associate Advisor
Other advisors: Professor David Fairlie
-
2015
Doctor Philosophy
Towards inhibitors of hydrolytic enzymes involved in inflammation
Joint Principal Advisor
Other advisors: Professor David Fairlie
Media
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