Overview
Background
I am a medicinal and organic chemist
Studied organic chemistry at the University of Sydney, moved to UQ in 1993, then worked for Bayer in Germany, before moving back to Australia in 1996. Worked in Melbourne at the Victorian College of Pharmacy (now MIPS). I then returned to UQ in 2000 to the Fairlie lab where we design and synthesise new chemical entities to tackle human disease. Since 2012 I have been on extended medical leave and am currently an Adjunct Research Fellow, researching proteins from flaviviruses such as Dengue, West Nile, and Zika viruses, and the coronaviruses SARS, MERS, and SARS-CoV-2.
Availability
- Dr Martin Stoermer is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), University of Sydney
- Doctor of Philosophy, University of Sydney
Research interests
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Viral Proteases
I study the proteases from Flaviviruses such as Dengue and West Nile virus, and Coronaviruses like SARS, and SARS-CoV-2, using a combination of chemical synthesis and molecular modelling. Previously I worked on the design and synthesis of inhibitors of HIV protease.
Works
Search Professor Martin Stoermer’s works on UQ eSpace
2005
Conference Publication
Development of a catalytically active recombinant West Nile NS3 protease and the identification of key enzyme-substrate interactions by site-directed mutagenesis
Chappell, K. J., Stoermer, M. J., Fairlie, D. and Young, P. R. (2005). Development of a catalytically active recombinant West Nile NS3 protease and the identification of key enzyme-substrate interactions by site-directed mutagenesis. International Congress of Virology, San Francisco, 23-27 July, 2005.
2005
Conference Publication
Development of antiviral drugs targeting the flaviviruses fusion mechanism
Kampmann, T., Yennamalli, R., Stoermer, M., Kobe, B. and Young, P. (2005). Development of antiviral drugs targeting the flaviviruses fusion mechanism. 30th FEBS Congress - 9th IUBMB Conference, Budapest, Hungary, 2-7tJuly 2005. Oxford, England: Blackwell Publishing. doi: 10.1111/j.1742-4658.2005.4739_15.x
2005
Conference Publication
Development of a catalytically active recombinant West Nile NS3 protease and the identification of key enzyme-substrate interactions by site-directed mutagenesis
Chappell, K. J., Stoermer, M. J., Fairlie, D. and Young, P. R. (2005). Development of a catalytically active recombinant West Nile NS3 protease and the identification of key enzyme-substrate interactions by site-directed mutagenesis. 30th Lorne Conference on Protein Structure & Function, Lorne, 6-10 Feb, 2005.
2005
Conference Publication
Development of a catalytically active recombinant West Nile virus NS3 protease and the identification of key enzyme-substrate and enzyme-cofactor interactions by site-directed mutagenesis
Chappell, K. J., Stoermer, M. J., Fairlie, D. and Young, P. R. (2005). Development of a catalytically active recombinant West Nile virus NS3 protease and the identification of key enzyme-substrate and enzyme-cofactor interactions by site-directed mutagenesis. 3rd Australian Virology Group Meeting, Phillip Island, Vic., 9-12 Dec, 2005.
2004
Other Outputs
Compounds and inhibitors of phospholipases
Reid, Robert C., Clark, Christopher I., Hansford, Karl, Stoermer, Martin J., McGeary, Ross P., Fairlie, David P. and Schafer, Karl (2004). Compounds and inhibitors of phospholipases. US2004033995.
2004
Journal Article
Potent cyclic antagonists of the complement C5a receptor on human polymorphonulcear leukocytes. Relationships between structures and activity
March, Darren R., Proctor, Lavinia M., Stoermer, Martin J., Sbaglia, Robert, Abbenante, Giovanni, Reid, Robert C., Woodruff, Trent M., Wadi, Khemar, Paczkowski, Natalii, Tyndall, Joel D. A., Taylor, Stephen M. and Fairlie, David P. (2004). Potent cyclic antagonists of the complement C5a receptor on human polymorphonulcear leukocytes. Relationships between structures and activity. Molecular Pharmacology, 65 (4), 868-879. doi: 10.1124/mol.65.4.868
2004
Journal Article
Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 protease
Nall, T. A., Chappell, K. J., Stoermer, M. J., Fang, N. X., Tyndall, J. D. A., Young, P. R. and Fairlie, D. P. (2004). Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 protease. Journal of Biological Chemistry, 279 (47), 48535-48542. doi: 10.1074/jbc.M406810200
2003
Conference Publication
Template-assembled peptide loops, helices, sheets and nanofibres
Fairlie, DP, Singh, Y, Sharpe, P and Stoermer, M (2003). Template-assembled peptide loops, helices, sheets and nanofibres. 225th National Meeting of the American-Chemical-Society, New Orleans Louisiana, Mar 23-27, 2003. WASHINGTON: AMER CHEMICAL SOC.
2003
Journal Article
Cycloadditions of isobenzofuran to a constrained template bearing neighboring dienophiles
Stoermer, M. J., Butler, D. N., Warrener, R. N., Weerasuria, K. D. V. and Fairlie, D. P. (2003). Cycloadditions of isobenzofuran to a constrained template bearing neighboring dienophiles. Chemistry-a European Journal, 9 (9), 2068-2071. doi: 10.1002/chem.200204619
2003
Conference Publication
Template-assembled peptide loops, helices, sheets, and nanofibers
Fairlie, David P ., Singh, Yogendra, Sharpe, Philip and Stoermer, Martin (2003). Template-assembled peptide loops, helices, sheets, and nanofibers. 225th ACS National Meeting, New Orleans, LA, United States, 23-27 March 2003.
2003
Conference Publication
Macrocyclic peptides as ligands for cellular receptors. When a little rigidity is just right...
Martin J. Stoermer (2003). Macrocyclic peptides as ligands for cellular receptors. When a little rigidity is just right.... Brisbane Biological and Organic Symposium (BBOCS) 2003, Brisbane, 28 November 2003. doi: 10.6084/m9.figshare.7849310
2002
Other Outputs
Compounds and inhibitors of phospholipases
Reid, Robert C., Clark, Christopher I., Hansford, Karl, Stoermer, Martin J., McGeary, Ross P. and Fairlie, David P. (2002). Compounds and inhibitors of phospholipases. WO0208189.
2002
Journal Article
Regioselective synthesis of antiparallel loops on a macrocyclic scaffold constrained by oxazoles and thiazoles
Singh, Y, Stoermer, MJ, Lucke, AJ, Glenn, MP and Fairlie, DP (2002). Regioselective synthesis of antiparallel loops on a macrocyclic scaffold constrained by oxazoles and thiazoles. Organic Letters, 4 (20), 3367-3370. doi: 10.1021/ol026463m
2001
Journal Article
Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors
Leung, D., Schroder, K., White, H., Fang, N. X., Stoermer, M. J., Abbenante, G., Martin, J. L., Young, P. R. and Fairlie, D. P. (2001). Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors. Journal of Biological Chemistry, 276 (49), 45762-45771. doi: 10.1074/jbc.M107360200
2001
Conference Publication
Are ketoamides suitable electrophilic isosteres for incorporation in inhibitors of serine proteases?
Stoermer, Martin , Leung, Donmienne and Fairlie, David (2001). Are ketoamides suitable electrophilic isosteres for incorporation in inhibitors of serine proteases?. Brisbane Biological & Organic Chemistry Symposium 2001(BBOCS 2001), University of Queensland, Australia, 30 November, 2001.
2001
Conference Publication
In vitro catalytic activity of recombinant forms of the dengue virus NS3 protease
Young, P. R., Fang, N., Leung, D., Arakaki, T., Stoermer, M. J., Fairlie, D. and Martin, J. L. (2001). In vitro catalytic activity of recombinant forms of the dengue virus NS3 protease. 6th International Symposium on Positive Strand Viruses, Paris, France, 28 May - 2 June, 2001.
2000
Conference Publication
Towards Arginine Mimetics
Stoermer, Martin and Fairlie, David (2000). Towards Arginine Mimetics. The First Brisbane Biological and Organic Chemistry Symposium, Griifith University, Brisbane, Queensland, Australia, 27th November 2000. doi: 10.6084/m9.figshare.7836131
2000
Conference Publication
Synthesis, SAR, and Pharmacological Activities of a Series of Tyrosine-Derived Inhibitors of Human Nonpancreatic Secretory Phospholipase A2
Hansford, Karl A. , Clark, Chris I. , Reid, Robert C. , Stoermer, Martin J. , Shiels, Ian , Taylor, Stephen and Fairlie, David P. (2000). Synthesis, SAR, and Pharmacological Activities of a Series of Tyrosine-Derived Inhibitors of Human Nonpancreatic Secretory Phospholipase A2. First Brisbane Biological and Organic Chemistry Symposium, Griffith University, Brisbane, 27 November 2000.
2000
Conference Publication
Inhibition of Human Secretory Phospholipase A2 (Type IIA)
Clark, Chris , Reid, Bob , Hansford, Karl , Stoermer, Martin and Fairlie, David (2000). Inhibition of Human Secretory Phospholipase A2 (Type IIA). First Brisbane Biological and Organic Chemistry Symposium, Griffith University, Brisbane, 27 November 2000.
1998
Journal Article
2-(Het)aryl-Substituted 7-Azabicyclo[2.2.1]heptane Systems
Otten, Albert, Namyslo, Jan Christoph, Stoermer, Martin and Kaufmann, Dieter E. (1998). 2-(Het)aryl-Substituted 7-Azabicyclo[2.2.1]heptane Systems. European Journal of Organic Chemistry, 1998 (9), 1997-2001. doi: 10.1002/(sici)1099-0690(199809)1998:93.0.co;2-a
Funding
Past funding
Supervision
Availability
- Dr Martin Stoermer is:
- Available for supervision
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Supervision history
Completed supervision
-
2014
Doctor Philosophy
Towards Serine Protease Inhibitors
Associate Advisor
Other advisors: Professor David Fairlie
-
2008
Doctor Philosophy
Computer Aided Drug Design: GPCRs and Proteases
Associate Advisor
Other advisors: Professor David Fairlie
-
2015
Doctor Philosophy
Towards inhibitors of hydrolytic enzymes involved in inflammation
Joint Principal Advisor
Other advisors: Professor David Fairlie
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