Overview
Background
Dr Brett Hughes graduated from the University of NSW with a Bachelor of Medical Science and Bachelor of Medicine and Surgery in 1997. He completed his postgraduate training in Canberra and Brisbane and was admitted as a Fellow of the Australian College of Physicians as a Specialist Medical Oncologist in 2005.
Dr Hughes is currently a Senior Staff Specialist Medical Oncologist at the RBWH and TPCH. He is also an Associate Professor at the University of Queensland since 2015. As the previous Clinical Director of Oncology (201-2017) and current Cancer Care Services Research lead at TPCH, Dr Hughes has established both an independent TPCH Oncology unit and continuing TPCH’s reputation as a lung cancer research centre of excellence.
Dr Hughes is an active senior member of the Thoracic Oncology Group Australasia (TOGA) and the Trans Tasman Radiation Oncology Group (TROG). He is also heavily involved in many pivotal multicentre trials of cancer therapy at both TPCH and RBWH with his principal research interests in Lung cancer, Head & Neck cancer, Mesothelioma, cutaneous SCC and Thyroid cancer. He has published over 100 peer review papers. Dr Hughes is also involved in undergraduate and post graduate teaching in his fields of research interest.
Availability
- Associate Professor Brett Hughes is:
- Available for supervision
Fields of research
Works
Search Professor Brett Hughes’s works on UQ eSpace
2018
Conference Publication
Prior or concurrent radiotherapy and nivolumab immunotherapy in non-small cell lung cancer
Ratnayake, G., Shankar, M., Roberts, K., Mason, R., Hughes, B. G. M., Lwin, Z., Jain, V., O'Byrne, K. J. and Chua, B. (2018). Prior or concurrent radiotherapy and nivolumab immunotherapy in non-small cell lung cancer. 43rd ESMO Congress (ESMO), Munich, Germany, 19-23 October 2018. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/annonc/mdy292.093
2017
Journal Article
Phase IB Trial of the Anti-Cancer Stem Cell DLL4-Binding Agent Demcizumab with Pemetrexed and Carboplatin as First-Line Treatment of Metastatic Non-Squamous NSCLC
McKeage, Mark J., Kotasek, Dusan, Markman, Ben, Hidalgo, Manuel, Millward, Michael J., Jameson, Michael B., Harris, Dean L., Stagg, Robert J., Kapoun, Ann M., Xu, Lu and Hughes, Brett G. M. (2017). Phase IB Trial of the Anti-Cancer Stem Cell DLL4-Binding Agent Demcizumab with Pemetrexed and Carboplatin as First-Line Treatment of Metastatic Non-Squamous NSCLC. Targeted Oncology, 13 (1), 1-10. doi: 10.1007/s11523-017-0543-0
2017
Journal Article
Clinical guidance for Radioiodine Refractory Differentiated Thyroid Cancer
Gild, Matti L., Topliss, Duncan J., Learoyd, Diana, Parnis, Francis, Tie, Jeanne, Hughes, Brett, Walsh, John P., McLeod, Donald Sa, Clifton-Bligh, Roderick J. and Robinson, Bruce G. (2017). Clinical guidance for Radioiodine Refractory Differentiated Thyroid Cancer. Clinical Endocrinology, 88 (4), 529-537. doi: 10.1111/cen.13508
2017
Journal Article
Impact of early prophylactic feeding on long term tube dependency outcomes in patients with head and neck cancer
Brown, Teresa, Banks, Merrilyn, Hughes, Brett G. M., Lin, Charles, Kenny, Lizbeth M. and Bauer, Judith D. (2017). Impact of early prophylactic feeding on long term tube dependency outcomes in patients with head and neck cancer. Oral Oncology, 72, 17-25. doi: 10.1016/j.oraloncology.2017.06.025
2017
Journal Article
Efficacy of alectinib in central nervous system metastases in crizotinib-resistant ALK-positive non–small-cell lung cancer: comparison of RECIST 1.1 and RANO-HGG criteria
Gandhi, Leena, Ou, Sai-Hong Ignatius, Shaw, Alice T., Barlesi, Fabrice, Dingemans, Anne-Marie C., Kim, Dong-Wan, Camidge, D. Ross, Hughes, Brett G. M., Yang, James C. -H., de Castro, Javier, Crino, Lucio, Lena, Herve, Do, Pascal, Golding, Sophie, Bordogna, Walter, Zeaiter, Ali, Kotb, Ahmed and Gadgeel, Shirish (2017). Efficacy of alectinib in central nervous system metastases in crizotinib-resistant ALK-positive non–small-cell lung cancer: comparison of RECIST 1.1 and RANO-HGG criteria. European Journal of Cancer, 82, 27-33. doi: 10.1016/j.ejca.2017.05.019
2017
Journal Article
Tube feeding during treatment for head and neck cancer – adherence and patient reported barriers
Brown, Teresa, Banks, Merrilyn, Hughes, Brett G. M., Lin, Charles, Kenny, Lizbeth and Bauer, Judith (2017). Tube feeding during treatment for head and neck cancer – adherence and patient reported barriers. Oral Oncology, 72, 140-149. doi: 10.1016/j.oraloncology.2017.07.017
2017
Conference Publication
Outcomes of Nivolumab in Metastatic NSCLC Patients via the Access Program Across Multiple Tertiary Oncology Centers
Roberts, K., Mason, R., Hughes, B., Lwin, Z., Jain, V. and O'Byrne, K. (2017). Outcomes of Nivolumab in Metastatic NSCLC Patients via the Access Program Across Multiple Tertiary Oncology Centers. HOBOKEN: WILEY.
2017
Journal Article
Immune checkpoint inhibitors: navigating a new paradigm of treatment toxicities
Roberts, Kate, Culleton, Vanessa, Lwin, Zarnie, O'Byrne, Kenneth and Hughes, Brett G. M. (2017). Immune checkpoint inhibitors: navigating a new paradigm of treatment toxicities. Asia Pacific Journal of Clinical Oncology, 13 (4), 277-288. doi: 10.1111/ajco.12698
2017
Journal Article
Randomised controlled trial of early prophylactic feeding vs standard care in patients with head and neck cancer
Brown, Teresa E., Banks, Merrilyn D., Hughes, Brett G. M., Lin, Charles Y., Kenny, Lizbeth M. and Bauer, Judith D. (2017). Randomised controlled trial of early prophylactic feeding vs standard care in patients with head and neck cancer. British Journal of Cancer, 117 (1), 15-24. doi: 10.1038/bjc.2017.138
2017
Journal Article
A phase II trial of concurrent chemotherapy with intravenous cisplatin and vinorelbine and radiotherapy followed by consolidation chemotherapy with oral vinorelbine in locally advanced non-small cell lung cancer (NSCLC): the CONCAVE study
Hughes, Brett G. M., Ahern, Elizabeth, Lehman, Margot, Pratt, Gary, Dauth, Margaret, Pritchard, Wendy, Wockner, Leesa and Horwood, Keith (2017). A phase II trial of concurrent chemotherapy with intravenous cisplatin and vinorelbine and radiotherapy followed by consolidation chemotherapy with oral vinorelbine in locally advanced non-small cell lung cancer (NSCLC): the CONCAVE study. Asia Pacific Journal of Clinical Oncology, 13 (3), 137-144. doi: 10.1111/ajco.12649
2017
Journal Article
An analysis of incidental and symptomatic pulmonary embolism (PE) in medical oncology patients
Thaker, D. A., Douglas, E., Blazak, J., Xu, W., Hughes, B., Burge, M., Steinke, K. and Wyld, D. (2017). An analysis of incidental and symptomatic pulmonary embolism (PE) in medical oncology patients. Asia-Pacific Journal of Clinical Oncology, 13 (3), 243-248. doi: 10.1111/ajco.12650
2017
Journal Article
Prospective study of definitive chemoradiation in locally or regionally advanced squamous cell carcinoma of the skin
Nottage, Michelle K., Lin, Charles, Hughes, Brett G. M., Kenny, Lizbeth, Smith, David D., Houston, Kathleen and Francesconi, Alessandra (2017). Prospective study of definitive chemoradiation in locally or regionally advanced squamous cell carcinoma of the skin. Head and Neck, 39 (4), 679-683. doi: 10.1002/hed.24662
2017
Journal Article
Investigation of p16 status, chemotherapy regimen and other nutrition markers for predicting gastrostomy in patients with head and neck cancer
Brown, Teresa E., Wittholz, Kym, Way, Mandy, Banks, Merrilyn D., Hughes, Brett G. M., Lin, Charles Y., Kenny, Lizbeth M. and Bauer, Judith D. (2017). Investigation of p16 status, chemotherapy regimen and other nutrition markers for predicting gastrostomy in patients with head and neck cancer. Head and Neck, 39 (5), 868-875. doi: 10.1002/hed.24630
2017
Journal Article
Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years
Powell, J. T., Sweeting, M. J., Ulug, P., Blankensteijn, J. D., Lederle, F. A., Becquemin, J. P., Greenhalgh, R. M., Greenhalgh, R. M., Beard, J. D., Buxton, M. J., Brown, L. C., Harris, P. L., Powell, J. T., Rose, J. D.G., Russell, I. T., Sculpher, M. J., Thompson, S. G., Lilford, R. J., Bell, P. R.F., Greenhalgh, R. M., Whitaker, S. C., Poole-Wilson, P. A., Ruckley, C. V., Campbell, W. B., Dean, M. R.E., Ruttley, M. S.T., Coles, E. C., Powell, J. T., Halliday, A. ... Chand, P. (2017). Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years. British Journal of Surgery, 104 (3), 166-178. doi: 10.1002/bjs.10430
2017
Journal Article
Patterns of dysphagia and acute toxicities in patients with head and neck cancer undergoing helical IMRT ± concurrent chemotherapy
Moroney, Laura B., Helios, Jennifer, Ward, Elizabeth C., Crombie, Jane, Wockner, Leesa F., Burns, Clare L., Spurgin, Ann-Louise, Blake, Claire, Kenny, Lizbeth and Hughes, Brett G. M. (2017). Patterns of dysphagia and acute toxicities in patients with head and neck cancer undergoing helical IMRT ± concurrent chemotherapy. Oral Oncology, 64, 1-8. doi: 10.1016/j.oraloncology.2016.11.009
2017
Conference Publication
Pembrolizumab (pembro) for relapsed malignant pleural mesothelioma (MPM): Outcomes in real-life setting in Australia (AUS) and Switzerland (CH)
Mauti, L., Rivalland, G., Klingbiel, D., Kao, S., Schmid, S., Nowak, A., Gautschi, O., Hughes, B., Bartnick, T., Pavlakis, N., Bouchaab, H., O'Byrne, K., Rothschild, S., Russell, P., Savic Prince, S., Thapa, B., Pless, M., von Moos, R., Metaxas, Y. and John, T. (2017). Pembrolizumab (pembro) for relapsed malignant pleural mesothelioma (MPM): Outcomes in real-life setting in Australia (AUS) and Switzerland (CH). ESMO Immuno Oncology Congress 2017, Geneva, Switzerland, 7–10 December 2017. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/annonc/mdx711.007
2016
Journal Article
Comparison of nutritional and clinical outcomes in patients with head and neck cancer undergoing chemoradiotherapy utilizing prophylactic versus reactive nutrition support approaches
Brown, Teresa E., Banks, Merrilyn D., Hughes, Brett G. M., Lin, Charles Y., Kenny, Lizbeth M. and Bauer, Judith D. (2016). Comparison of nutritional and clinical outcomes in patients with head and neck cancer undergoing chemoradiotherapy utilizing prophylactic versus reactive nutrition support approaches. Journal of the Academy of Nutrition and Dietetics, 118 (4), 627-636. doi: 10.1016/j.jand.2016.10.013
2016
Journal Article
Updated efficacy and safety from the global phase II NP28673 study of alectinib in patients (pts) with previously treated ALK+ non-small-cell lung cancer (NSCLC)
Barlesi, F., Dingemans, A. M.C., Yang, J. C.H., Ou, S. H.I., Ahn, J. S., De Petris, L., Hughes, B., Lena, H., Bordogna, W., Golding, S., Morcos, P. N., Balas, B., Zeaiter, A. and Kim, D. W. (2016). Updated efficacy and safety from the global phase II NP28673 study of alectinib in patients (pts) with previously treated ALK+ non-small-cell lung cancer (NSCLC). Annals of Oncology, 27 (S6), vi437. doi: 10.1093/annonc/mdw383.63
2016
Conference Publication
The Significance of Pulmonary Nodules in Head and Neck Cancer
Ladwa, R., Xu, W., Tani, D., Wockener, L., Williamson, K., Lwin, Z., Ritchie, A., Steinke, K. and Hughes, B. (2016). The Significance of Pulmonary Nodules in Head and Neck Cancer. HOBOKEN: WILEY-BLACKWELL.
2016
Conference Publication
Lean Thinking: Exploring Overhead and Supplementary Tasks (Ost) in Cancer Care (Cc) in the Oncology Outpatient Encounter (Ooe)
Peters, G., Smith, D., Rasool, M., Ladwa, R., Hughes, B. and Lwin, Z. (2016). Lean Thinking: Exploring Overhead and Supplementary Tasks (Ost) in Cancer Care (Cc) in the Oncology Outpatient Encounter (Ooe). HOBOKEN: WILEY-BLACKWELL.
Supervision
Availability
- Associate Professor Brett Hughes is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
The changing face of head and neck cancer: addressing and advancing best-practice nutritional care to improve outcomes for patients with human papillomavirus-associated disease
Associate Advisor
-
Doctor Philosophy
Developing predictive biomarkers for immunotherapy using deep spatial profiling
Associate Advisor
Other advisors: Associate Professor Arutha Kulasinghe
Completed supervision
-
2025
Doctor Philosophy
The investigation of the tumour microenvironment in head and neck squamous cell carcinoma to identify predictive biomarkers of response to immunotherapy
Associate Advisor
Other advisors: Dr Quan Nguyen, Associate Professor Arutha Kulasinghe
Media
Enquiries
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