Overview
Background
Dr Brett Hughes graduated from the University of NSW with a Bachelor of Medical Science and Bachelor of Medicine and Surgery in 1997. He completed his postgraduate training in Canberra and Brisbane and was admitted as a Fellow of the Australian College of Physicians as a Specialist Medical Oncologist in 2005.
Dr Hughes is currently a Senior Staff Specialist Medical Oncologist at the RBWH and TPCH. He is also an Associate Professor at the University of Queensland since 2015. As the previous Clinical Director of Oncology (201-2017) and current Cancer Care Services Research lead at TPCH, Dr Hughes has established both an independent TPCH Oncology unit and continuing TPCH’s reputation as a lung cancer research centre of excellence.
Dr Hughes is an active senior member of the Thoracic Oncology Group Australasia (TOGA) and the Trans Tasman Radiation Oncology Group (TROG). He is also heavily involved in many pivotal multicentre trials of cancer therapy at both TPCH and RBWH with his principal research interests in Lung cancer, Head & Neck cancer, Mesothelioma, cutaneous SCC and Thyroid cancer. He has published over 100 peer review papers. Dr Hughes is also involved in undergraduate and post graduate teaching in his fields of research interest.
Availability
- Associate Professor Brett Hughes is:
- Available for supervision
Fields of research
Works
Search Professor Brett Hughes’s works on UQ eSpace
2018
Conference Publication
Phase III study of first-line pembrolizumab (P) for recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC)
Burtness, B., Harrington, K. J., Greil, R., Soulières, D., Tahara, M., De Castro, G., Psyrri, A., Baste Rotllan, N., Neupane, P. C., Bratland,, Fuereder, T., Hughes, B. G.M., Mesia, R., Ngamphaiboon, N., Rordorf, T., Wan Ishak, W. Z., Roy, A., Cheng, J., Jin, F. and Rischin, D. (2018). Phase III study of first-line pembrolizumab (P) for recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). 43rd ESMO Congress (ESMO 2018), Munich, Germany, 19–23 October 2018. Amsterdam, Netherlands: Elsevier. doi: 10.1093/annonc/mdy424.045
2018
Journal Article
PD-1 blockade with cemiplimab in advanced cutaneous squamous-cell carcinoma
Migden, M. R., Rischin, D., Schmults, C. D., Guminski, A., Hauschild, A., Lewis, K. D., Chung, C. H., Hernandez-Aya, L., Lim, A. M., Chang, A. L. S., Rabinowits, G., Thai, A. A., Dunn, L. A., Hughes, B. G. M., Khushalani, N. I., Modi, B., Schadendorf, D., Gao, B., Seebach, F., Li, S., Li, J., Mathias, M., Booth, J., Mohan, K., Stankevich, E., Babiker, H. M., Brana, I., Gil-Martin, M., Homsi, J. ... Fury, M. G. (2018). PD-1 blockade with cemiplimab in advanced cutaneous squamous-cell carcinoma. New England Journal of Medicine, 379 (4), 341-351. doi: 10.1056/NEJMoa1805131
2018
Journal Article
Radiotherapy for cutaneous head and neck cancer and parotid tumours: a prospective investigation of treatment-related acute swallowing and toxicity patterns
Moroney, Laura B., Helios, Jennifer, Ward, Elizabeth C., Crombie, Jane, Burns, Clare L., Yeo, Shu Qi, Pelecanos, Anita, Spurgin, Ann-Louise, Blake, Claire, Kenny, Lizbeth, Chua, Benjamin and Hughes, Brett G. M. (2018). Radiotherapy for cutaneous head and neck cancer and parotid tumours: a prospective investigation of treatment-related acute swallowing and toxicity patterns. Supportive Care in Cancer, 27 (2), 1-9. doi: 10.1007/s00520-018-4352-5
2018
Journal Article
CXCR4 and PD-1 expression in head and neck cancer with perineural spread
Barnett, Catherine M., Sommerville, Ryan S., Lin, Charles, Ratnayake, Gishan, Hughes, Brett and Taheri, Touraj (2018). CXCR4 and PD-1 expression in head and neck cancer with perineural spread. Journal of Neurological Surgery, Part B: Skull Base, 80 (01), 018-022. doi: 10.1055/s-0038-1660846
2018
Journal Article
Helical intensity-modulated radiotherapy with concurrent chemotherapy for oropharyngeal squamous cell carcinoma: a prospective investigation of acute swallowing and toxicity patterns
Moroney, Laura B., Helios, Jennifer, Ward, Elizabeth C., Crombie, Jane, Pelecanos, Anita, Burns, Clare L., Spurgin, Ann-Louise, Blake, Claire, Kenny, Lizbeth, Chua, Benjamin and Hughes, Brett G. M. (2018). Helical intensity-modulated radiotherapy with concurrent chemotherapy for oropharyngeal squamous cell carcinoma: a prospective investigation of acute swallowing and toxicity patterns. Head & Neck, 40 (9), 1955-1966. doi: 10.1002/hed.25182
2018
Journal Article
Osimertinib in Untreated <i>EGFR</i>-Mutated Advanced Non-Small-Cell Lung Cancer
Soria, J. -C., Ohe, Y., Vansteenkiste, J., Reungwetwattana, T., Chewaskulyong, B., Lee, K. H., Dechaphunkul, A., Imamura, F., Nogami, N., Kurata, T., Okamoto, I., Zhou, C., Cho, B. C., Cheng, Y., Cho, E. K., Voon, P. J., Planchard, D., Su, W. -C., Gray, J. E., Lee, S. -M., Hodge, R., Marotti, M., Rukazenkov, Y., Ramalingam, S. S., Boyer, Michael, Lee, Chee, Hughes, Brett, O'Byrne, Kenneth, Briggs, Peter ... Nguyen, Nhung (2018). Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer. New England Journal of Medicine, 378 (2), 113-125. doi: 10.1056/NEJMoa1713137
2018
Conference Publication
Progression-free survival (PFS) and overall survival (OS) analysis of a randomised phase III study of atezolizumab plus carboplatin plus paclitaxel or nab-paclitaxel vs carboplatin plus nab-paclitaxel in 1L advanced squamous NSCLC
Socinski, M. A., Rittmeyer, A., Shapovalov, D., Orlandi, F., McCleod, M., Soo, R. A., Palmero, R., Kozuki, T., Migliorino, M. R., Koynov, K. D., Berard, H., Hughes, B. G. M., Yu, W., Graupner, V., Sun, S. W., Kowanetz, M., Hoang, T., Lin, W. and Jotte, R. M. (2018). Progression-free survival (PFS) and overall survival (OS) analysis of a randomised phase III study of atezolizumab plus carboplatin plus paclitaxel or nab-paclitaxel vs carboplatin plus nab-paclitaxel in 1L advanced squamous NSCLC. 43rd ESMO Congress, Munich, Germany, 19-23 October 2018. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/annonc/mdy424.077
2018
Conference Publication
BR-34-randomized trial of durvalumab and tremelimumab +/- platinum chemotherapy in patients with metastatic squamous or non-squamous NSCLC
Kulkarni, S., Laurie, S., Goss, G., Perrone, F., Hughes, B., Pavlakis, N., Stockler, M., Blais, A., Zibdawi, L., Vera-Badillo, F. and Leighl, N. (2018). BR-34-randomized trial of durvalumab and tremelimumab +/- platinum chemotherapy in patients with metastatic squamous or non-squamous NSCLC. IASLC 19th World Conference on Lung Cancer, Toronto, Canada, 23-26 September 2018. New York, NY USA: Elsevier. doi: 10.1016/j.jtho.2018.08.608
2018
Conference Publication
Prior or concurrent radiotherapy and nivolumab immunotherapy in non-small cell lung cancer
Ratnayake, G., Shankar, M., Roberts, K., Mason, R., Hughes, B. G. M., Lwin, Z., Jain, V., O'Byrne, K. J. and Chua, B. (2018). Prior or concurrent radiotherapy and nivolumab immunotherapy in non-small cell lung cancer. 43rd ESMO Congress (ESMO), Munich, Germany, 19-23 October 2018. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/annonc/mdy292.093
2017
Journal Article
Phase IB Trial of the Anti-Cancer Stem Cell DLL4-Binding Agent Demcizumab with Pemetrexed and Carboplatin as First-Line Treatment of Metastatic Non-Squamous NSCLC
McKeage, Mark J., Kotasek, Dusan, Markman, Ben, Hidalgo, Manuel, Millward, Michael J., Jameson, Michael B., Harris, Dean L., Stagg, Robert J., Kapoun, Ann M., Xu, Lu and Hughes, Brett G. M. (2017). Phase IB Trial of the Anti-Cancer Stem Cell DLL4-Binding Agent Demcizumab with Pemetrexed and Carboplatin as First-Line Treatment of Metastatic Non-Squamous NSCLC. Targeted Oncology, 13 (1), 1-10. doi: 10.1007/s11523-017-0543-0
2017
Journal Article
Clinical guidance for Radioiodine Refractory Differentiated Thyroid Cancer
Gild, Matti L., Topliss, Duncan J., Learoyd, Diana, Parnis, Francis, Tie, Jeanne, Hughes, Brett, Walsh, John P., McLeod, Donald Sa, Clifton-Bligh, Roderick J. and Robinson, Bruce G. (2017). Clinical guidance for Radioiodine Refractory Differentiated Thyroid Cancer. Clinical Endocrinology, 88 (4), 529-537. doi: 10.1111/cen.13508
2017
Journal Article
Tube feeding during treatment for head and neck cancer – adherence and patient reported barriers
Brown, Teresa, Banks, Merrilyn, Hughes, Brett G. M., Lin, Charles, Kenny, Lizbeth and Bauer, Judith (2017). Tube feeding during treatment for head and neck cancer – adherence and patient reported barriers. Oral Oncology, 72, 140-149. doi: 10.1016/j.oraloncology.2017.07.017
2017
Journal Article
Impact of early prophylactic feeding on long term tube dependency outcomes in patients with head and neck cancer
Brown, Teresa, Banks, Merrilyn, Hughes, Brett G. M., Lin, Charles, Kenny, Lizbeth M. and Bauer, Judith D. (2017). Impact of early prophylactic feeding on long term tube dependency outcomes in patients with head and neck cancer. Oral Oncology, 72, 17-25. doi: 10.1016/j.oraloncology.2017.06.025
2017
Journal Article
Efficacy of alectinib in central nervous system metastases in crizotinib-resistant ALK-positive non–small-cell lung cancer: comparison of RECIST 1.1 and RANO-HGG criteria
Gandhi, Leena, Ou, Sai-Hong Ignatius, Shaw, Alice T., Barlesi, Fabrice, Dingemans, Anne-Marie C., Kim, Dong-Wan, Camidge, D. Ross, Hughes, Brett G. M., Yang, James C. -H., de Castro, Javier, Crino, Lucio, Lena, Herve, Do, Pascal, Golding, Sophie, Bordogna, Walter, Zeaiter, Ali, Kotb, Ahmed and Gadgeel, Shirish (2017). Efficacy of alectinib in central nervous system metastases in crizotinib-resistant ALK-positive non–small-cell lung cancer: comparison of RECIST 1.1 and RANO-HGG criteria. European Journal of Cancer, 82, 27-33. doi: 10.1016/j.ejca.2017.05.019
2017
Conference Publication
Outcomes of Nivolumab in Metastatic NSCLC Patients via the Access Program Across Multiple Tertiary Oncology Centers
Roberts, K., Mason, R., Hughes, B., Lwin, Z., Jain, V. and O'Byrne, K. (2017). Outcomes of Nivolumab in Metastatic NSCLC Patients via the Access Program Across Multiple Tertiary Oncology Centers. HOBOKEN: WILEY.
2017
Journal Article
Immune checkpoint inhibitors: navigating a new paradigm of treatment toxicities
Roberts, Kate, Culleton, Vanessa, Lwin, Zarnie, O'Byrne, Kenneth and Hughes, Brett G. M. (2017). Immune checkpoint inhibitors: navigating a new paradigm of treatment toxicities. Asia Pacific Journal of Clinical Oncology, 13 (4), 277-288. doi: 10.1111/ajco.12698
2017
Journal Article
Randomised controlled trial of early prophylactic feeding vs standard care in patients with head and neck cancer
Brown, Teresa E., Banks, Merrilyn D., Hughes, Brett G. M., Lin, Charles Y., Kenny, Lizbeth M. and Bauer, Judith D. (2017). Randomised controlled trial of early prophylactic feeding vs standard care in patients with head and neck cancer. British Journal of Cancer, 117 (1), 15-24. doi: 10.1038/bjc.2017.138
2017
Journal Article
An analysis of incidental and symptomatic pulmonary embolism (PE) in medical oncology patients
Thaker, D. A., Douglas, E., Blazak, J., Xu, W., Hughes, B., Burge, M., Steinke, K. and Wyld, D. (2017). An analysis of incidental and symptomatic pulmonary embolism (PE) in medical oncology patients. Asia-Pacific Journal of Clinical Oncology, 13 (3), 243-248. doi: 10.1111/ajco.12650
2017
Journal Article
A phase II trial of concurrent chemotherapy with intravenous cisplatin and vinorelbine and radiotherapy followed by consolidation chemotherapy with oral vinorelbine in locally advanced non-small cell lung cancer (NSCLC): the CONCAVE study
Hughes, Brett G. M., Ahern, Elizabeth, Lehman, Margot, Pratt, Gary, Dauth, Margaret, Pritchard, Wendy, Wockner, Leesa and Horwood, Keith (2017). A phase II trial of concurrent chemotherapy with intravenous cisplatin and vinorelbine and radiotherapy followed by consolidation chemotherapy with oral vinorelbine in locally advanced non-small cell lung cancer (NSCLC): the CONCAVE study. Asia Pacific Journal of Clinical Oncology, 13 (3), 137-144. doi: 10.1111/ajco.12649
2017
Journal Article
Prospective study of definitive chemoradiation in locally or regionally advanced squamous cell carcinoma of the skin
Nottage, Michelle K., Lin, Charles, Hughes, Brett G. M., Kenny, Lizbeth, Smith, David D., Houston, Kathleen and Francesconi, Alessandra (2017). Prospective study of definitive chemoradiation in locally or regionally advanced squamous cell carcinoma of the skin. Head and Neck, 39 (4), 679-683. doi: 10.1002/hed.24662
Supervision
Availability
- Associate Professor Brett Hughes is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
The changing face of head and neck cancer: addressing and advancing best-practice nutritional care to improve outcomes for patients with human papillomavirus-associated disease
Associate Advisor
-
Doctor Philosophy
Developing predictive biomarkers for immunotherapy using deep spatial profiling
Associate Advisor
Other advisors: Associate Professor Arutha Kulasinghe
Completed supervision
-
2025
Doctor Philosophy
The investigation of the tumour microenvironment in head and neck squamous cell carcinoma to identify predictive biomarkers of response to immunotherapy
Associate Advisor
Other advisors: Dr Quan Nguyen, Associate Professor Arutha Kulasinghe
Media
Enquiries
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