Overview
Background
Dr Brett Hughes graduated from the University of NSW with a Bachelor of Medical Science and Bachelor of Medicine and Surgery in 1997. He completed his postgraduate training in Canberra and Brisbane and was admitted as a Fellow of the Australian College of Physicians as a Specialist Medical Oncologist in 2005.
Dr Hughes is currently a Senior Staff Specialist Medical Oncologist at the RBWH and TPCH. He is also an Associate Professor at the University of Queensland since 2015. As the previous Clinical Director of Oncology (201-2017) and current Cancer Care Services Research lead at TPCH, Dr Hughes has established both an independent TPCH Oncology unit and continuing TPCH’s reputation as a lung cancer research centre of excellence.
Dr Hughes is an active senior member of the Thoracic Oncology Group Australasia (TOGA) and the Trans Tasman Radiation Oncology Group (TROG). He is also heavily involved in many pivotal multicentre trials of cancer therapy at both TPCH and RBWH with his principal research interests in Lung cancer, Head & Neck cancer, Mesothelioma, cutaneous SCC and Thyroid cancer. He has published over 100 peer review papers. Dr Hughes is also involved in undergraduate and post graduate teaching in his fields of research interest.
Availability
- Associate Professor Brett Hughes is:
- Available for supervision
Fields of research
Works
Search Professor Brett Hughes’s works on UQ eSpace
2017
Journal Article
Investigation of p16 status, chemotherapy regimen and other nutrition markers for predicting gastrostomy in patients with head and neck cancer
Brown, Teresa E., Wittholz, Kym, Way, Mandy, Banks, Merrilyn D., Hughes, Brett G. M., Lin, Charles Y., Kenny, Lizbeth M. and Bauer, Judith D. (2017). Investigation of p16 status, chemotherapy regimen and other nutrition markers for predicting gastrostomy in patients with head and neck cancer. Head and Neck, 39 (5), 868-875. doi: 10.1002/hed.24630
2017
Journal Article
Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years
Powell, J. T., Sweeting, M. J., Ulug, P., Blankensteijn, J. D., Lederle, F. A., Becquemin, J. P., Greenhalgh, R. M., Greenhalgh, R. M., Beard, J. D., Buxton, M. J., Brown, L. C., Harris, P. L., Powell, J. T., Rose, J. D.G., Russell, I. T., Sculpher, M. J., Thompson, S. G., Lilford, R. J., Bell, P. R.F., Greenhalgh, R. M., Whitaker, S. C., Poole-Wilson, P. A., Ruckley, C. V., Campbell, W. B., Dean, M. R.E., Ruttley, M. S.T., Coles, E. C., Powell, J. T., Halliday, A. ... Chand, P. (2017). Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years. British Journal of Surgery, 104 (3), 166-178. doi: 10.1002/bjs.10430
2017
Journal Article
Patterns of dysphagia and acute toxicities in patients with head and neck cancer undergoing helical IMRT ± concurrent chemotherapy
Moroney, Laura B., Helios, Jennifer, Ward, Elizabeth C., Crombie, Jane, Wockner, Leesa F., Burns, Clare L., Spurgin, Ann-Louise, Blake, Claire, Kenny, Lizbeth and Hughes, Brett G. M. (2017). Patterns of dysphagia and acute toxicities in patients with head and neck cancer undergoing helical IMRT ± concurrent chemotherapy. Oral Oncology, 64, 1-8. doi: 10.1016/j.oraloncology.2016.11.009
2017
Conference Publication
Pembrolizumab (pembro) for relapsed malignant pleural mesothelioma (MPM): Outcomes in real-life setting in Australia (AUS) and Switzerland (CH)
Mauti, L., Rivalland, G., Klingbiel, D., Kao, S., Schmid, S., Nowak, A., Gautschi, O., Hughes, B., Bartnick, T., Pavlakis, N., Bouchaab, H., O'Byrne, K., Rothschild, S., Russell, P., Savic Prince, S., Thapa, B., Pless, M., von Moos, R., Metaxas, Y. and John, T. (2017). Pembrolizumab (pembro) for relapsed malignant pleural mesothelioma (MPM): Outcomes in real-life setting in Australia (AUS) and Switzerland (CH). ESMO Immuno Oncology Congress 2017, Geneva, Switzerland, 7–10 December 2017. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/annonc/mdx711.007
2016
Journal Article
Comparison of nutritional and clinical outcomes in patients with head and neck cancer undergoing chemoradiotherapy utilizing prophylactic versus reactive nutrition support approaches
Brown, Teresa E., Banks, Merrilyn D., Hughes, Brett G. M., Lin, Charles Y., Kenny, Lizbeth M. and Bauer, Judith D. (2016). Comparison of nutritional and clinical outcomes in patients with head and neck cancer undergoing chemoradiotherapy utilizing prophylactic versus reactive nutrition support approaches. Journal of the Academy of Nutrition and Dietetics, 118 (4), 627-636. doi: 10.1016/j.jand.2016.10.013
2016
Journal Article
Updated efficacy and safety from the global phase II NP28673 study of alectinib in patients (pts) with previously treated ALK+ non-small-cell lung cancer (NSCLC)
Barlesi, F., Dingemans, A. M.C., Yang, J. C.H., Ou, S. H.I., Ahn, J. S., De Petris, L., Hughes, B., Lena, H., Bordogna, W., Golding, S., Morcos, P. N., Balas, B., Zeaiter, A. and Kim, D. W. (2016). Updated efficacy and safety from the global phase II NP28673 study of alectinib in patients (pts) with previously treated ALK+ non-small-cell lung cancer (NSCLC). Annals of Oncology, 27 (S6), vi437. doi: 10.1093/annonc/mdw383.63
2016
Conference Publication
The Significance of Pulmonary Nodules in Head and Neck Cancer
Ladwa, R., Xu, W., Tani, D., Wockener, L., Williamson, K., Lwin, Z., Ritchie, A., Steinke, K. and Hughes, B. (2016). The Significance of Pulmonary Nodules in Head and Neck Cancer. HOBOKEN: WILEY-BLACKWELL.
2016
Conference Publication
Lean Thinking: Exploring Overhead and Supplementary Tasks (Ost) in Cancer Care (Cc) in the Oncology Outpatient Encounter (Ooe)
Peters, G., Smith, D., Rasool, M., Ladwa, R., Hughes, B. and Lwin, Z. (2016). Lean Thinking: Exploring Overhead and Supplementary Tasks (Ost) in Cancer Care (Cc) in the Oncology Outpatient Encounter (Ooe). HOBOKEN: WILEY-BLACKWELL.
2016
Journal Article
Single institution retrospective review of perioperative chemotherapy in adult and adolescent patients with operable osteosarcoma
Hansen, Aaron R., Hughes, Brett G., Paul, Sanjoy, Steadman, Peter, Sommerville, Scott, Dickinson, Ian C., Walpole, Euan T., Thomson, Damien B., Mar Fan, Helen G. and Joubert, Warren L. (2016). Single institution retrospective review of perioperative chemotherapy in adult and adolescent patients with operable osteosarcoma. Asia-Pacific Journal of Clinical Oncology, 12 (2), e222-e228. doi: 10.1111/ajco.12167
2016
Journal Article
Alectinib in crizotinib-refractory alk-rearranged non-small-cell lung cancer: a phase II global study
Ou, Sai-Hong Ignatius, Ahn, Jin Seok, De Petris, Luigi, Govindan, Ramaswamy, Yang, James Chin-Hsin, Hughes, Brett, Lena, Herve, Moro-Sibilot, Denis, Bearz, Alessandra, Ramirez, Santiago Viteri, Mekhail, Tarek, Spira, Alexander, Bordogna, Walter, Balas, Bogdana, Morcos, Peter N., Monnet, Annabelle, Zeaiter, Ali and Kim, Dong-Wan (2016). Alectinib in crizotinib-refractory alk-rearranged non-small-cell lung cancer: a phase II global study. Journal of Clinical Oncology, 34 (7), 661-668. doi: 10.1200/JCO.2015.63.9443
2016
Journal Article
Validation of an updated evidence-based protocol for proactive gastrostomy tube insertion in patients with head and neck cancer
Brown, T. E., Getliffe, V., Banks, M. D., Hughes, B. G. M., Lin, C. Y., Kenny L. M. and Bauer, J. (2016). Validation of an updated evidence-based protocol for proactive gastrostomy tube insertion in patients with head and neck cancer. European Journal of Clinical Nutrition, 70 (5), 1-8. doi: 10.1038/ejcn.2015.230
2016
Conference Publication
Pneumocystis pneumonia (Pjp) in lung cancer patients
Chavalertsakul, Nuttaya, Lwin, Zarnie, Hay, Karen and Hughes, Brett (2016). Pneumocystis pneumonia (Pjp) in lung cancer patients. COSA's 43rd and ANZBCTG's 38th Annual Scientific Meetings. Partners for Progress in Breast Cancer Research and Care, Gold Coast, QLD Australia, 15-17 November 2016. HOBOKEN: WILEY-BLACKWELL.
2016
Conference Publication
Understanding Initiation of Nutrition Support in Patients with Head and Neck Cancer (Hnc) and Adherence to Recommendations-A Patient Perspective
Brown, Teresa, Banks, Merrilyn, Hughes, Brett, Lin, Charles, Kenny, Lizbeth and Bauer, Judith (2016). Understanding Initiation of Nutrition Support in Patients with Head and Neck Cancer (Hnc) and Adherence to Recommendations-A Patient Perspective. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.
2016
Conference Publication
Nutrition Outcomes and Toxicities Following Helical-Intensity Modulated Radiotherapy (H-Imrt) in Patients with Head and Neck Cancer
Blake, Claire, Lai, Rainbow, Moroney, Laura, Helios, Jennifer, Hughes, Brett, Chua, Ben, Bauer, Judy and Brown, Teresa (2016). Nutrition Outcomes and Toxicities Following Helical-Intensity Modulated Radiotherapy (H-Imrt) in Patients with Head and Neck Cancer. COSA's 43rd and ANZBCTG's 38th Annual Scientific Meetings. Partners for Progress in Breast Cancer Research and Care, Gold Coast, QLD, Australia, 15-17 November 2016. Chichester, West Sussex United Kingdom: Wiley.
2015
Journal Article
A phase III randomized trial of adding topical nitroglycerin to first-line chemotherapy for advanced nonsmall-cell lung cancer: The Australasian lung cancer trials group NITRO trial
Davidson, A., Veillard, A. -S., Tognela, A., Chan, M. M. K., Hughes, B. G. M., Boyer, M., Briscoe, K., Begbie, S., Abdi, E., Crombie, C., Long, J., Boyce, A., Lewis, C. R., Varma, S., Broad, A., Muljadi, N., Chinchen, S., Espinoza, D., Coskinas, X., Pavlakis, N., Millward, M. and Stockler, M. R. (2015). A phase III randomized trial of adding topical nitroglycerin to first-line chemotherapy for advanced nonsmall-cell lung cancer: The Australasian lung cancer trials group NITRO trial. Annals of Oncology, 26 (11) mdv373, 2280-2286. doi: 10.1093/annonc/mdv373
2015
Journal Article
Improving guideline sensitivity and specificity for the identification of proactive gastrostomy placement in patients with head and neck cancer
Brown, Teresa E., Crombie, Jane, Spurgin, Ann-Louise, Tripcony, Lee, Keller, Jacqui, Hughes, Brett G. M., Dickie, Graeme, Kenny, Lizbeth Moria and Hodge, Robert A. (2015). Improving guideline sensitivity and specificity for the identification of proactive gastrostomy placement in patients with head and neck cancer. Head and Neck, 38 Suppl 1, 1-9. doi: 10.1002/hed.24184
2015
Journal Article
Patients' and doctors' preferences for adjuvant chemotherapy in resected non-small-cell lung cancer: what makes it worthwhile?
Blinman, Prunella, Hughes, Brett, Crombie, Catherine, Christmas, Tim, Hudson, Malcolm, Veillard, Anne-Sophie, Muljadi, Nick, Millward, Michael, Wright, Gavin, Flynn, Peter, Windsor, Morgan, Stockler, Martin and Mclachlan, Sue-Anne (2015). Patients' and doctors' preferences for adjuvant chemotherapy in resected non-small-cell lung cancer: what makes it worthwhile?. European Journal of Cancer, 51 (12) 9495, 1529-1537. doi: 10.1016/j.ejca.2015.05.022
2015
Journal Article
Swallowing outcomes and PEG dependence in head and neck cancer patients receiving definitive or adjuvant radiotherapy +/− chemotherapy with a proactive PEG: a prospective study with long term follow up
Crombie, Jane M., Ng, Stephanie, Spurgin, Ann-Louise, Ward, Elizabeth C., Brown, Teresa E. and Hughes, Brett G. M. (2015). Swallowing outcomes and PEG dependence in head and neck cancer patients receiving definitive or adjuvant radiotherapy +/− chemotherapy with a proactive PEG: a prospective study with long term follow up. Oral Oncology, 51 (6) 3212, 622-628. doi: 10.1016/j.oraloncology.2015.03.006
2015
Journal Article
Targeted therapy for non-small cell lung cancer: Current standards and the promise of the future
Chan, Bryan A. and Hughes, Brett G.M. (2015). Targeted therapy for non-small cell lung cancer: Current standards and the promise of the future. Translational Lung Cancer Research, 4 (1), 36-54. doi: 10.3978/j.issn.2218-6751.2014.05.01
2015
Conference Publication
The Wau (weighted activity unit) effect: evaluating the cost of Drg (Diagnosis related group) coding
Tan, J. Y., Bennett, R., Power, J., Thompson, L., Hughes, B. and Lwin, Z. (2015). The Wau (weighted activity unit) effect: evaluating the cost of Drg (Diagnosis related group) coding. The Medical Oncology Group of Australia 2015 ASM, Pathways in Medical Oncology – The Path Less Travelled, Hobart, Australia, 5‐7 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.
Supervision
Availability
- Associate Professor Brett Hughes is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Developing predictive biomarkers for immunotherapy using deep spatial profiling
Associate Advisor
Other advisors: Associate Professor Arutha Kulasinghe
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Doctor Philosophy
The changing face of head and neck cancer: addressing and advancing best-practice nutritional care to improve outcomes for patients with human papillomavirus-associated disease
Associate Advisor
Completed supervision
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2025
Doctor Philosophy
The investigation of the tumour microenvironment in head and neck squamous cell carcinoma to identify predictive biomarkers of response to immunotherapy
Associate Advisor
Other advisors: Dr Quan Nguyen, Associate Professor Arutha Kulasinghe
Media
Enquiries
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