Overview
Background
Dr Brett Hughes graduated from the University of NSW with a Bachelor of Medical Science and Bachelor of Medicine and Surgery in 1997. He completed his postgraduate training in Canberra and Brisbane and was admitted as a Fellow of the Australian College of Physicians as a Specialist Medical Oncologist in 2005.
Dr Hughes is currently a Senior Staff Specialist Medical Oncologist at the RBWH and TPCH. He is also an Associate Professor at the University of Queensland since 2015. As the previous Clinical Director of Oncology (201-2017) and current Cancer Care Services Research lead at TPCH, Dr Hughes has established both an independent TPCH Oncology unit and continuing TPCH’s reputation as a lung cancer research centre of excellence.
Dr Hughes is an active senior member of the Thoracic Oncology Group Australasia (TOGA) and the Trans Tasman Radiation Oncology Group (TROG). He is also heavily involved in many pivotal multicentre trials of cancer therapy at both TPCH and RBWH with his principal research interests in Lung cancer, Head & Neck cancer, Mesothelioma, cutaneous SCC and Thyroid cancer. He has published over 100 peer review papers. Dr Hughes is also involved in undergraduate and post graduate teaching in his fields of research interest.
Availability
- Associate Professor Brett Hughes is:
- Available for supervision
Fields of research
Works
Search Professor Brett Hughes’s works on UQ eSpace
2015
Journal Article
An unusual recurrence of adenosquamous carcinoma of the lung
Pokharel, Khageshwor, Godbolt, David and Hughes, Brett G. M. (2015). An unusual recurrence of adenosquamous carcinoma of the lung. Cancer Treatment Communications, 4, 37-40. doi: 10.1016/j.ctrc.2015.03.006
2014
Journal Article
First-Line Crizotinib versus Chemotherapy in ALK-Positive Lung Cancer
Solomon, Benjamin J., Mok, Tony, Kim, Dong-Wan, Wu, Yi-Long, Nakagawa, Kazuhiko, Mekhail, Tarek, Felip, Enriqueta, Cappuzzo, Federico, Paolini, Jolanda, Usari, Tiziana, Iyer, Shrividya, Reisman, Arlene, Wilner, Keith D., Tursi, Jennifer, Blackhall, Fiona, Boyer, M., Ganju, V., Hughes, B., Pavlakis, N., Solomon, B., Varma, S., Berghmans, T., Canon, J-L, Demedts, I., Janssens, A., Louis, R., Pieters, T., Schallier, D., Surmont, V. ... Waqar, S. (2014). First-Line Crizotinib versus Chemotherapy in ALK-Positive Lung Cancer. New England Journal of Medicine, 371 (23), 2167-2177. doi: 10.1056/NEJMoa1408440
2014
Journal Article
Phase II study of single-agent panitumumab in patients with incurable cutaneous squamous cell carcinoma
Foote, M. C., McGrath, M., Guminski, A., Hughes, B. G. M., Meakin, J., Thomson, D., Zarate, D., Simpson, F. and Porceddu, S. V. (2014). Phase II study of single-agent panitumumab in patients with incurable cutaneous squamous cell carcinoma. Annals of Oncology, 25 (10), 2047-2052. doi: 10.1093/annonc/mdu368
2014
Journal Article
Nutrition outcomes following implementation of validated swallowing and nutrition guidelines for patients with head and neck cancer
Brown, Teresa, Ross, Lynda, Jones, Lee, Hughes, Brett and Banks, Merrilyn (2014). Nutrition outcomes following implementation of validated swallowing and nutrition guidelines for patients with head and neck cancer. Supportive Care in Cancer, 22 (9), 2381-2391. doi: 10.1007/s00520-014-2180-9
2014
Journal Article
Protocol for a randomized controlled trial of early prophylactic feeding via gastrostomy versus standard care in high risk patients with head and neck cancer
Brown, Teresa, Banks, Merrilyn, Hughes, Brett, Kenny, Lizbeth, Lin, Charles and Bauer, Judith (2014). Protocol for a randomized controlled trial of early prophylactic feeding via gastrostomy versus standard care in high risk patients with head and neck cancer. BMC Nursing, 13 (1) 17, 17.1-17.10. doi: 10.1186/1472-6955-13-17
2014
Journal Article
The ENHANCES study-enhancing head and neck cancer patients' experiences of survivorship: study protocol for a randomized controlled trial
Turner, Jane, Yates, Patsy, Kenny, Lizbeth, Gordon, Louisa G., Burmeister, Bryan, Thomson, Damien, Hughes, Brett, McCarthy, Alexandra L., Perry, Chris, Chan, Raymond J., Fraser, Alana, Skerman, Helen, Batstone, Martin and Carswell, Kathryn (2014). The ENHANCES study-enhancing head and neck cancer patients' experiences of survivorship: study protocol for a randomized controlled trial. Trials, 15 (1) 191. doi: 10.1186/1745-6215-15-191
2014
Journal Article
Myocardial infarction secondary to 5-fluorouracil: not an absolute contraindication to rechallenge?
Rateesh, Shruti, Luis, Sushil A., Luis, Chris R., Hughes, Brett and Nicolae, Mugur (2014). Myocardial infarction secondary to 5-fluorouracil: not an absolute contraindication to rechallenge?. International Journal of Cardiology, 172 (2), E331-E333. doi: 10.1016/j.ijcard.2013.12.274
2014
Journal Article
Pertuzumab and erlotinib in patients with relapsed non-small cell lung cancer: a phase II study using 18F-fluorodeoxyglucose positron emission tomography/computed tomography imaging
Hughes, Brett, Mileshkin, Linda, Townley, Peter, Gitlitz, Barbara, Eaton, Keith, Mitchell, Paul, Hicks, Rodney, Wood, Katie, Amler, Lucas, Fine, Bernard M., Loecke, David and Pirzkall, Andrea (2014). Pertuzumab and erlotinib in patients with relapsed non-small cell lung cancer: a phase II study using 18F-fluorodeoxyglucose positron emission tomography/computed tomography imaging. Oncologist, 19 (2), 175-176. doi: 10.1634/theoncologist.2013-0026
2014
Conference Publication
Single Agent Panitumumab in Patients With Incurable Cutaneous Squamous Cell Carcinoma: A Single-Center Phase 2 Study
Porceddu, S., Foote, M., McGrath, M., Guminski, A., Hughes, B., Meakin, J., Thomson, D., Thomson, D. and Simpson, F. (2014). Single Agent Panitumumab in Patients With Incurable Cutaneous Squamous Cell Carcinoma: A Single-Center Phase 2 Study. ELSEVIER SCIENCE INC. doi: 10.1016/j.ijrobp.2013.11.179
2013
Journal Article
Validated swallowing and nutrition guidelines for patients with head and neck cancer: Identification of high-risk patients for proactive gastrostomy
Brown, Teresa E., Spurgin, Ann-Louise, Ross, Lynda, Tripcony, Lee, Keller, Jacqui, Hughes, Brett G. M., Hodge, Rob, Walker, Quenten, Banks, Merrilyn, Kenny, Lizbeth Moira and Crombie, Jane (2013). Validated swallowing and nutrition guidelines for patients with head and neck cancer: Identification of high-risk patients for proactive gastrostomy. Head and Neck, 35 (10), 1385-1391. doi: 10.1002/hed.23146
2013
Journal Article
A phase II clinical trial of the vascular disrupting agent BNC105P as second line chemotherapy for advanced malignant pleural mesothelioma
Nowak, Anna K., Brown, Chris, Millward, Michael J., Creaney, Jenette, Byrne, Michael J., Hughes, Brett, Kremmidiotis, Gabriel, Bibby, David C., Leske, Annabell F., Mitchell, Paul L. R., Pavlakis, Nick, Boyer, Michael and Stockler, Martin R. (2013). A phase II clinical trial of the vascular disrupting agent BNC105P as second line chemotherapy for advanced malignant pleural mesothelioma. Lung Cancer, 81 (3), 422-427. doi: 10.1016/j.lungcan.2013.05.006
2013
Journal Article
Comment on 'The efficacy and toxicity of gemcitabine, carboplatin and bevacizumab in metastatic breast cancer'
Kitchen, D., O'Brien, M., Hughes, B., Gill, I., Rumbles, S., Ellis, P. and Stebbing, J. (2013). Comment on 'The efficacy and toxicity of gemcitabine, carboplatin and bevacizumab in metastatic breast cancer'. British Journal of Cancer, 109 (2), 526-528. doi: 10.1038/bjc.2013.279
2013
Journal Article
Other novel molecular targets in non-small cell lung cancer: it's not all about EGFR
Cruikshank, Ross and Hughes, Brett (2013). Other novel molecular targets in non-small cell lung cancer: it's not all about EGFR. Cancer Forum, 37 (2), 170-174.
2013
Journal Article
Decreased hospital stay and significant cost savings after routine use of prophylactic gastrostomy for high-risk patients with head and neck cancer receiving chemoradiotherapy at a tertiary cancer institution
Hughes, B. G. M., Jain, V. K., Brown, T., Spurgin, A. L., Hartnett, G., Keller, J., Tripcony, L., Appleyard, M. and Hodge, R. (2013). Decreased hospital stay and significant cost savings after routine use of prophylactic gastrostomy for high-risk patients with head and neck cancer receiving chemoradiotherapy at a tertiary cancer institution. Dysphagia, 28 (3). doi: 10.1007/s00455-013-9468-7
2013
Conference Publication
Single agent panitumumab in patients with incurable cutaneous squamous cell carcinoma: A single centre phase II study
Foote, M., McGrath, M., Guminski, A., Hughes, B., Meakin, J., Thomson, D., Simpson, F. and Porceddu, S. (2013). Single agent panitumumab in patients with incurable cutaneous squamous cell carcinoma: A single centre phase II study. 17th ECCO / 38th ESMO / 32nd ESTRO European Cancer Congress on Reinforcing Multidisciplinarity, Amsterdam Netherlands, Sep 27-Oct 01, 2013. Oxford United Kingdom: Pergamon Press. doi: 10.1016/S0959-8049(13)70065-0
2013
Journal Article
Decreased hospital stay and significant cost savings after routine use of prophylactic gastrostomy for high-risk patients with head and neck cancer receiving chemoradiotherapy at a tertiary cancer institution
Hughes, Brett G. M., Jain, Vikram K., Brown, Teresa, Spurgin, Ann-Louise, Hartnett, Gemma, Keller, Jacqui, Tripcony, Lee, Appleyard, Mark and Hodge, Robert (2013). Decreased hospital stay and significant cost savings after routine use of prophylactic gastrostomy for high-risk patients with head and neck cancer receiving chemoradiotherapy at a tertiary cancer institution. Head and Neck, 35 (3), 436-442. doi: 10.1002/hed.22992
2013
Journal Article
Targeted therapy in lung cancer: IPASS and beyond, keeping abreast of the explosion of targeted therapies for lung cancer
Savas, Peter, Hughes, Brett and Solomon, Benjamin (2013). Targeted therapy in lung cancer: IPASS and beyond, keeping abreast of the explosion of targeted therapies for lung cancer. Journal of Thoracic Disease, 5 (5), S579-S592. doi: 10.3978/j.issn.2072-1439.2013.08.52
2012
Journal Article
Challenging the distal-to-proximal cannulation technique for administration of anticancer therapies: A prospective cohort study
Chan, Raymond Javan, Alexander, Alison, Bransdon, Maree, Webster, Joan, Hughes, Brett Gordon Maxwell, Brown, Leisa and Graham, Therese (2012). Challenging the distal-to-proximal cannulation technique for administration of anticancer therapies: A prospective cohort study. Cancer Nursing, 35 (5), E35-E40. doi: 10.1097/NCC.0b013e3182352916
2012
Conference Publication
Pulmonary Embolism in Medical Oncology Patients: Symptomatic Versus Incidental
Thaker, D. A., Blazak, J., Wyld, D., Steinke, K., Hughes, B. and Burge, M. (2012). Pulmonary Embolism in Medical Oncology Patients: Symptomatic Versus Incidental. HOBOKEN: WILEY-BLACKWELL.
2012
Journal Article
The relationship between vitamin D and chemotherapy-induced toxicity-a pilot study
Kitchen, D., Hughes, B., Gill, I., O'Brien, M., Rumbles, S., Ellis, P., Harper, P., Stebbing, J. and Rohatgi, N. (2012). The relationship between vitamin D and chemotherapy-induced toxicity-a pilot study. British Journal of Cancer, 107 (1), 158-160. doi: 10.1038/bjc.2012.194
Supervision
Availability
- Associate Professor Brett Hughes is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
The changing face of head and neck cancer: addressing and advancing best-practice nutritional care to improve outcomes for patients with human papillomavirus-associated disease
Associate Advisor
-
Doctor Philosophy
Developing predictive biomarkers for immunotherapy using deep spatial profiling
Associate Advisor
Other advisors: Associate Professor Arutha Kulasinghe
Completed supervision
-
2025
Doctor Philosophy
The investigation of the tumour microenvironment in head and neck squamous cell carcinoma to identify predictive biomarkers of response to immunotherapy
Associate Advisor
Other advisors: Dr Quan Nguyen, Associate Professor Arutha Kulasinghe
Media
Enquiries
For media enquiries about Associate Professor Brett Hughes's areas of expertise, story ideas and help finding experts, contact our Media team: